NO20062672L - Interleukin-10-antistoffer - Google Patents
Interleukin-10-antistofferInfo
- Publication number
- NO20062672L NO20062672L NO20062672A NO20062672A NO20062672L NO 20062672 L NO20062672 L NO 20062672L NO 20062672 A NO20062672 A NO 20062672A NO 20062672 A NO20062672 A NO 20062672A NO 20062672 L NO20062672 L NO 20062672L
- Authority
- NO
- Norway
- Prior art keywords
- antibodies
- interleukin
- methods
- humanized
- pathogen
- Prior art date
Links
- 102000003814 Interleukin-10 Human genes 0.000 title abstract 4
- 108090000174 Interleukin-10 Proteins 0.000 title abstract 4
- 229940076144 interleukin-10 Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51899903P | 2003-11-10 | 2003-11-10 | |
| PCT/US2004/037518 WO2005047326A2 (en) | 2003-11-10 | 2004-11-09 | Interleukin-10 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062672L true NO20062672L (no) | 2006-06-09 |
Family
ID=34590335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062672A NO20062672L (no) | 2003-11-10 | 2006-06-09 | Interleukin-10-antistoffer |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US20050101770A1 (es) |
| EP (4) | EP2292661A3 (es) |
| JP (4) | JP4762148B2 (es) |
| KR (3) | KR20120025618A (es) |
| CN (2) | CN100595212C (es) |
| AR (3) | AR046833A1 (es) |
| AT (1) | ATE440867T1 (es) |
| AU (2) | AU2004290044B2 (es) |
| CA (2) | CA2812856A1 (es) |
| CY (1) | CY1110557T1 (es) |
| DE (1) | DE602004022855D1 (es) |
| DK (1) | DK1694705T3 (es) |
| ES (1) | ES2329907T3 (es) |
| HR (1) | HRP20090517T1 (es) |
| IL (3) | IL175523A (es) |
| NO (1) | NO20062672L (es) |
| NZ (1) | NZ546632A (es) |
| PE (3) | PE20090047A1 (es) |
| PL (1) | PL1694705T3 (es) |
| PT (1) | PT1694705E (es) |
| RS (1) | RS51180B (es) |
| SG (1) | SG155205A1 (es) |
| SI (1) | SI1694705T1 (es) |
| WO (2) | WO2005047324A2 (es) |
| ZA (1) | ZA200603681B (es) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020183271A1 (en) * | 2000-12-07 | 2002-12-05 | Sunil Chada | Methods of treatment involving human MDA-7 |
| WO2002057283A1 (en) * | 2001-01-19 | 2002-07-25 | Baylor College Of Medecine | Methods and compositions in breast cancer diagnosis and therapeutics |
| EP1490101A4 (en) * | 2002-03-05 | 2006-09-20 | Univ Texas | METHODS OF IMPROVING INDUCTION OF IMMUNE RESPONSE INVOLVING MDA-7 |
| CA2548220A1 (en) * | 2003-12-01 | 2005-09-09 | Introgen Therapeutics, Inc. | Use of mda-7 to inhibit infection by pathogenic organisms |
| PL212656B1 (pl) * | 2004-02-23 | 2012-11-30 | Synthes Gmbh | Urzadzenie do ustalania kosci |
| US20070281041A1 (en) * | 2004-03-02 | 2007-12-06 | Introgen Therapeutics, Inc. | Compositions and Methods Involving MDA-7 for the Treatment of Cancer |
| EP1863516A2 (en) * | 2005-02-08 | 2007-12-12 | Board of Regents, The University of Texas System | Compositions and methods involving mda-7 for the treatment of cancer |
| US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| EP2354160A1 (en) | 2005-08-31 | 2011-08-10 | Schering Corporation | Engineered anti-IL-23-antibodies |
| WO2007092944A2 (en) * | 2006-02-08 | 2007-08-16 | Introgen Therapeutics, Inc. | Compositions and methods involving gene therapy and proteasome modulation |
| UA98308C2 (en) * | 2006-09-05 | 2012-05-10 | Эли Лилли Энд Компани | Anti-myostatin antibody |
| KR20090088950A (ko) | 2006-12-14 | 2009-08-20 | 쉐링 코포레이션 | 가공된 항-tslp 항체 |
| CA2673282A1 (en) * | 2006-12-22 | 2008-07-03 | Schering Corporation | Antibodies to cd200r |
| CA2673254C (en) * | 2006-12-22 | 2013-09-10 | Schering Corporation | 4,5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
| RU2009127855A (ru) | 2006-12-22 | 2011-01-27 | Шеринг Корпорейшн (US) | 4,5 циклоаннелированные производные индола для лечения или предотвращения вируса гепатита с (hcv) и родственных вирусных инфекций |
| MX2009006877A (es) | 2006-12-22 | 2009-09-28 | Schering Corp | Derivados indolicos con anillo unido en las posiciones 5,6 y metodos de uso de los mismos. |
| MX2009009079A (es) | 2007-02-23 | 2009-08-31 | Schering Corp | Anticuerpos anti-il-23p19 de ingenieria. |
| CA2678863A1 (en) | 2007-02-23 | 2008-08-28 | Schering Corporation | Engineered anti-il-23p19 antibodies |
| CN101675076B (zh) | 2007-02-28 | 2013-09-18 | 默沙东公司 | 工程化的抗il-23r抗体 |
| CN101821252A (zh) * | 2007-08-29 | 2010-09-01 | 先灵公司 | 取代的吲哚衍生物及其使用方法 |
| PE20090994A1 (es) * | 2007-08-29 | 2009-08-03 | Schering Corp | Derivados de azaindol 2,3-sustituidos como agentes antivirales |
| PE20090995A1 (es) * | 2007-08-29 | 2009-08-03 | Schering Corp | Derivados indolicos 2,3-sustituidos como inhibidores del virus de la hepatitis c (vhc) |
| WO2009064852A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| WO2009064848A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| CN102159579B (zh) * | 2008-06-13 | 2015-03-25 | 默沙东公司 | 三环吲哚衍生物及其使用方法 |
| US8337842B2 (en) * | 2008-09-04 | 2012-12-25 | Vet Therapeutics, Inc. | Monoclonal antibodies |
| WO2010095031A2 (en) * | 2009-02-23 | 2010-08-26 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to cd19 and their uses |
| EP2435424B1 (en) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| CA2772613C (en) | 2009-09-03 | 2020-03-10 | Schering Corporation | Anti-gitr antibodies |
| CA2782024A1 (en) | 2009-11-25 | 2011-06-03 | Schering Corporation | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
| NZ600894A (en) * | 2009-11-30 | 2014-09-26 | Biotest Ag | Humanized anti-il-10 antibodies for the treatment of systemic lupus erythematosus (sle) |
| WO2011087740A1 (en) | 2009-12-22 | 2011-07-21 | Schering Corporation | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
| WO2011103441A1 (en) | 2010-02-18 | 2011-08-25 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| CN102918049A (zh) | 2010-03-09 | 2013-02-06 | 默沙东公司 | 稠合三环甲硅烷基化合物及其用于治疗病毒性疾病的方法 |
| AU2011268110B2 (en) | 2010-06-19 | 2016-05-19 | Memorial Sloan-Kettering Cancer Center | Anti-GD2 antibodies |
| US20140377223A1 (en) | 2010-07-26 | 2014-12-25 | Joseph A. Kozlowski | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
| JP2013540122A (ja) | 2010-09-29 | 2013-10-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合四環式化合物誘導体およびウィルス疾患治療のためのそれの使用方法 |
| SI2643352T1 (sl) * | 2010-11-23 | 2018-12-31 | Glaxo Group Limited | Antigen-vezavni proteini na onkostatin M (OSM) |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
| WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| CN102250243B (zh) * | 2011-07-01 | 2013-08-28 | 华绍炳 | 抗白细胞介素-15抗体 |
| WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
| EP2755981A4 (en) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | SILICULAR HETEROCYCLIC DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
| US9512405B2 (en) | 2011-12-14 | 2016-12-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Non-enzymatic method for isolating human adipose-derived stromal stem cells |
| RU2680267C2 (ru) | 2013-03-15 | 2019-02-19 | Мемориал Слоан Кеттеринг Кэнсер Сентер | Высокоаффинные антитела к gd2 |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| CN105277638A (zh) * | 2014-07-22 | 2016-01-27 | 沈鹤霄 | 一种单克隆抗体IgG质谱测序方法 |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| MX2017015308A (es) | 2015-05-29 | 2018-07-06 | Merck Sharp & Dohme | Combinacion de un antagonista de pd-1 y un oligonucleotido tipo cpg-c para tratar cancer. |
| BR112017025533A2 (pt) * | 2015-05-29 | 2018-08-07 | Dynavax Tech Corp | método para tratar câncer em um paciente humano |
| SG10201911035QA (en) | 2015-11-18 | 2020-01-30 | Merck Sharp & Dohme | Pd1 and/or lag3 binders |
| MX2018007406A (es) | 2015-12-16 | 2018-08-15 | Merck Sharp & Dohme | Anticuerpos anti-lag3 y fragmentos de enlace al antigeno. |
| WO2017112621A1 (en) * | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Formulations of engineered anti-il-10 antibodies |
| SG11201909955XA (en) | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| EP3697425A1 (en) | 2017-10-18 | 2020-08-26 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Methods and compounds for improved immune cell therapy |
| EP3768725A4 (en) * | 2018-03-20 | 2021-06-02 | Wuxi Biologics Ireland Limited | NEW ANTI-TIM-3 ANTIBODIES |
| EP3876990A4 (en) | 2018-11-07 | 2023-09-06 | Merck Sharp & Dohme LLC | CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES |
| WO2021072225A1 (en) * | 2019-10-09 | 2021-04-15 | Rush University Medical Center | Modulating interleukin-10 signaling to boost healing in diabetic wounds |
| US20240327529A1 (en) | 2020-11-18 | 2024-10-03 | Astrazeneca Ab | Steroid sparing |
| CN118043349B (zh) * | 2021-06-11 | 2024-11-15 | 丰华生物有限公司 | 一种人源化抗人GPVI单克隆抗体Fab片段及其应用 |
| KR20250093374A (ko) * | 2022-10-24 | 2025-06-24 | 머크 샤프 앤드 돔 엘엘씨 | 인간 히알루로니다제 1 돌연변이체 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP0438310A1 (en) | 1990-01-19 | 1991-07-24 | Merck & Co. Inc. | Method for producing recombinant immunoglobuline |
| US6018036A (en) | 1990-06-29 | 2000-01-25 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (Interleukin-10) |
| EP0590058B1 (en) * | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| CZ281796B6 (cs) * | 1991-08-06 | 1997-02-12 | Schering Corporation | Použití interleukinu-10, jeho analoga, agonisty nebo antagonisty pro výrobu léčiva a farmaceutický přípravek je obsahující |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| KR0170037B1 (ko) * | 1992-08-20 | 1999-02-01 | 에릭 에스. 딕커 | 인터루킨-4 및/또는 인터루킨-10을 함유하는 약제학적 조성물 |
| DE19529026C2 (de) * | 1995-07-28 | 1997-06-19 | Robert Sabat | Monoklonale Antikörper gegen humanes Interleukin-10 |
| JP2003520828A (ja) * | 2000-01-27 | 2003-07-08 | ジェネティクス インスティテュート,エルエルシー | Ctla4(cd152)に対する抗体、これを含む結合体、およびその使用 |
| PE20020574A1 (es) * | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| WO2004006955A1 (en) * | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
| ATE524196T1 (de) * | 2001-10-16 | 2011-09-15 | Macrogenics West Inc | An das krebsassoziierte antigen cd46 bindende antikörper und verwendungsverfahren dafür |
| MXPA04009418A (es) * | 2002-03-29 | 2005-06-08 | Schering Corp | Anticuerpos monoclonales humanos par interleucina-5, y metodos y composiciones que comprenden los mismos. |
-
2004
- 2004-11-08 WO PCT/US2004/037013 patent/WO2005047324A2/en not_active Ceased
- 2004-11-08 PE PE2008001585A patent/PE20090047A1/es not_active Application Discontinuation
- 2004-11-08 PE PE2004001085A patent/PE20050925A1/es active IP Right Grant
- 2004-11-08 AR ARP040104114A patent/AR046833A1/es active IP Right Grant
- 2004-11-08 PE PE2008001584A patent/PE20090046A1/es not_active Application Discontinuation
- 2004-11-09 PT PT04810674T patent/PT1694705E/pt unknown
- 2004-11-09 EP EP10013136A patent/EP2292661A3/en not_active Withdrawn
- 2004-11-09 CA CA2812856A patent/CA2812856A1/en not_active Abandoned
- 2004-11-09 AU AU2004290044A patent/AU2004290044B2/en not_active Expired
- 2004-11-09 WO PCT/US2004/037518 patent/WO2005047326A2/en not_active Ceased
- 2004-11-09 DK DK04810674T patent/DK1694705T3/da active
- 2004-11-09 EP EP09010835A patent/EP2123678A1/en not_active Withdrawn
- 2004-11-09 CN CN200480040148A patent/CN100595212C/zh not_active Expired - Lifetime
- 2004-11-09 CN CN2010100045818A patent/CN102010471A/zh active Pending
- 2004-11-09 PL PL04810674T patent/PL1694705T3/pl unknown
- 2004-11-09 EP EP09010836A patent/EP2128175A1/en not_active Ceased
- 2004-11-09 SI SI200431289T patent/SI1694705T1/sl unknown
- 2004-11-09 US US10/985,584 patent/US20050101770A1/en not_active Abandoned
- 2004-11-09 CA CA2545255A patent/CA2545255C/en not_active Expired - Lifetime
- 2004-11-09 JP JP2006539809A patent/JP4762148B2/ja not_active Expired - Lifetime
- 2004-11-09 EP EP04810674A patent/EP1694705B1/en not_active Expired - Lifetime
- 2004-11-09 SG SG200905318-2A patent/SG155205A1/en unknown
- 2004-11-09 AT AT04810674T patent/ATE440867T1/de active
- 2004-11-09 NZ NZ546632A patent/NZ546632A/en not_active IP Right Cessation
- 2004-11-09 ES ES04810674T patent/ES2329907T3/es not_active Expired - Lifetime
- 2004-11-09 HR HR20090517T patent/HRP20090517T1/xx unknown
- 2004-11-09 DE DE602004022855T patent/DE602004022855D1/de not_active Expired - Lifetime
- 2004-11-09 RS RSP-2009/0439A patent/RS51180B/sr unknown
- 2004-11-09 KR KR1020127001620A patent/KR20120025618A/ko not_active Abandoned
- 2004-11-09 KR KR1020127001612A patent/KR20120023858A/ko not_active Ceased
-
2006
- 2006-05-09 ZA ZA200603681A patent/ZA200603681B/xx unknown
- 2006-05-09 IL IL175523A patent/IL175523A/en active IP Right Grant
- 2006-05-10 KR KR1020067009074A patent/KR101175055B1/ko not_active Expired - Lifetime
- 2006-06-09 NO NO20062672A patent/NO20062672L/no not_active Application Discontinuation
-
2007
- 2007-01-12 US US11/623,006 patent/US7662379B2/en not_active Expired - Lifetime
-
2009
- 2009-10-20 CY CY20091101088T patent/CY1110557T1/el unknown
- 2009-12-10 IL IL202682A patent/IL202682A0/en active IP Right Grant
- 2009-12-10 IL IL202681A patent/IL202681A/en active IP Right Grant
- 2009-12-17 AR ARP090104951A patent/AR074780A2/es not_active Application Discontinuation
- 2009-12-17 AR ARP090104950A patent/AR074779A2/es unknown
-
2010
- 2010-02-05 US US12/701,386 patent/US8226947B2/en not_active Expired - Lifetime
- 2010-11-30 JP JP2010267845A patent/JP2011087590A/ja not_active Withdrawn
- 2010-11-30 JP JP2010267846A patent/JP2011062211A/ja not_active Withdrawn
-
2011
- 2011-02-14 AU AU2011200606A patent/AU2011200606B2/en not_active Ceased
-
2012
- 2012-07-19 US US13/553,554 patent/US8624013B2/en not_active Expired - Lifetime
-
2013
- 2013-07-24 JP JP2013153356A patent/JP2014014361A/ja not_active Withdrawn
- 2013-12-23 US US14/138,486 patent/US20140112919A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20062672L (no) | Interleukin-10-antistoffer | |
| EP1553975B8 (en) | Optimized fc variants and methods for their generation | |
| EA200800812A1 (ru) | Композиции антитела против cd3 | |
| EA201300481A1 (ru) | АНТИТЕЛА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ АФФИННОСТЬЮ К СВЯЗЫВАНИЮ С Fc-РЕЦЕПТОРОМ И ЭФФЕКТОРНОЙ ФУНКЦИЕЙ | |
| WO2004099249A3 (en) | Optimized fc variants and methods for their generation | |
| MY163480A (en) | Sclerostin binding agents | |
| AU2004215120A8 (en) | Human antibodies specific for interleukin 15 (IL-15) | |
| NO20083062L (no) | Humane monoklonale antistoffer mot fukosyl-GM1 og fremgangsmater for anvendelse av anti-fukosyl-GM1 | |
| EA200300464A1 (ru) | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО ПРОТИВ РЕЦЕПТОРА ЛИМФОТОКСИНА-β (ВАРИАНТЫ), КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ СНИЖЕНИЯ РИСКА РАЗВИТИЯ, ТЯЖЕСТИ ИЛИ ПОСЛЕДСТВИЙ НЕОПЛАЗИИ У ЧЕЛОВЕКА, ВЫДЕЛЕННАЯ НУКЛЕИНОВАЯ КИСЛОТА (ВАРИАНТЫ), КЛЕТКА КЛЕТОЧНОЙ ЛИНИИ | |
| LTPA2017022I1 (lt) | Antikūnai prieš Clostridium difficile toksinus ir jų panaudojimas | |
| NO20060236L (no) | Antistoffer spesifikke for sklerostinro og fremgangsmate for a oke benmineralisering | |
| DK3085783T3 (da) | Bispecifikt antistof som substitution for funktionelle proteiner | |
| NO20040752L (no) | Humane antistoffer spesifikke for interleukin 15 (IL-15) | |
| NZ599196A (en) | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors | |
| WO2004035742A3 (en) | Sets of digital antibodies directed against short epitopes, and methods using same | |
| DE60333732D1 (de) | Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen | |
| ATE248605T1 (de) | Für e-selectin und p-selectin spezifische kreuzreaktive monoklonale antikörper | |
| TW200510459A (en) | RG1 antibodies and uses thereof | |
| AU2003215188A1 (en) | Fusion proteins of humanized g250 specific antibodies and uses thereof | |
| NO20081987L (no) | Humane, monoklonale antistoffer mot CD70 | |
| WO2005046597A3 (en) | Antibodies to cd44 glycoforms and uses thereof | |
| WO2004113500A3 (en) | B7s1: an immune modulator | |
| EA200700876A1 (ru) | Агенты, специфически связывающие ангиопоэтин-2 | |
| WO2006009525A3 (en) | P. aeruginosa mucoid exopolysaccharide specific binding peptides | |
| NO20061412L (no) | Terapi av okulaere foretyrrelser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: MERCK SHARP AND DOHME CORP, US Free format text: NEW ADDRESS: 126 EAST LINCOLN AVENUE, US-NJ07065 RAHWAY |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |