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NO20062664L - Process for the preparation of 4-pentafluoride-sulfanyl-benzoylguanidines - Google Patents

Process for the preparation of 4-pentafluoride-sulfanyl-benzoylguanidines

Info

Publication number
NO20062664L
NO20062664L NO20062664A NO20062664A NO20062664L NO 20062664 L NO20062664 L NO 20062664L NO 20062664 A NO20062664 A NO 20062664A NO 20062664 A NO20062664 A NO 20062664A NO 20062664 L NO20062664 L NO 20062664L
Authority
NO
Norway
Prior art keywords
benzoylguanidines
pentafluoride
sulfanyl
preparation
formula
Prior art date
Application number
NO20062664A
Other languages
Norwegian (no)
Inventor
Gerrit Schubert
Heinz-Werner Kleemann
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of NO20062664L publication Critical patent/NO20062664L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Det er beskrevet en fremgangsmåte for fremstilling av 4-pentafluoridsulfanylbenzoylguanidiner med formel I, hvor R1 til R4 har betydningen angitt i kravene. Forbindelsene med formel I er NHE1-inhibitorer og kan eksempelvis anvendes for behandling av hjertekretsløpsykdommer.A process for the preparation of 4-pentafluoride sulfanyl benzoylguanidines of formula I is disclosed, wherein R 1 to R 4 have the meaning given in the claims. The compounds of formula I are NHE1 inhibitors and can be used, for example, for the treatment of cardiovascular diseases.

NO20062664A 2003-11-13 2006-06-09 Process for the preparation of 4-pentafluoride-sulfanyl-benzoylguanidines NO20062664L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353204A DE10353204A1 (en) 2003-11-13 2003-11-13 Process for the preparation of 4-pentafluorosulfanyl-benzoylguanidines
PCT/EP2004/012395 WO2005047241A1 (en) 2003-11-13 2004-11-03 Method for producing 4-pentafluoride-sulfanyl-benzoylguanidines

Publications (1)

Publication Number Publication Date
NO20062664L true NO20062664L (en) 2006-08-10

Family

ID=34585095

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062664A NO20062664L (en) 2003-11-13 2006-06-09 Process for the preparation of 4-pentafluoride-sulfanyl-benzoylguanidines

Country Status (22)

Country Link
EP (1) EP1685097B1 (en)
JP (1) JP4658955B2 (en)
KR (1) KR101207223B1 (en)
CN (2) CN100480237C (en)
AR (1) AR046374A1 (en)
AT (1) ATE386019T1 (en)
AU (1) AU2004288760B2 (en)
BR (1) BRPI0416570A (en)
CA (1) CA2545291C (en)
CY (1) CY1107922T1 (en)
DE (2) DE10353204A1 (en)
DK (1) DK1685097T3 (en)
ES (1) ES2298838T3 (en)
IL (1) IL175238A (en)
NO (1) NO20062664L (en)
NZ (1) NZ547170A (en)
PL (1) PL1685097T3 (en)
PT (1) PT1685097E (en)
RU (1) RU2382030C2 (en)
TW (1) TWI334859B (en)
WO (1) WO2005047241A1 (en)
ZA (1) ZA200602575B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7317124B2 (en) 2003-11-13 2008-01-08 Sanofi-Aventis Deutschland Gmbh Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
JP2011527677A (en) * 2008-07-08 2011-11-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyrrolidinyl and piperidinyl compounds useful as NHE-1 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3721268A1 (en) * 1987-06-27 1989-01-12 Merck Patent Gmbh ARYL SULFUR PENTAFLUORIDE
ES2097409T3 (en) * 1992-09-22 1997-04-01 Hoechst Ag BENZOILGUANIDINES, PROCEDURE FOR ITS PREPARATION, AS WELL AS ITS USE AS ANTIARRHYTHMIC.
GB9306183D0 (en) * 1993-03-25 1993-05-19 Zeneca Ltd Novel compounds
DE4417004A1 (en) * 1994-05-13 1995-11-16 Hoechst Ag Perfluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE19517848A1 (en) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorine-containing benzoylguanidines
GB9606015D0 (en) * 1996-03-22 1996-05-22 Rhone Poulenc Agriculture New herbicides
DE10222192A1 (en) * 2002-05-18 2003-11-27 Aventis Pharma Gmbh New pentafluorosulfanylbenzoylguanidine compound useful for treating e.g. infarction, angina pectoris and stroke

Also Published As

Publication number Publication date
CY1107922T1 (en) 2013-09-04
DE10353204A1 (en) 2005-06-16
IL175238A0 (en) 2006-09-05
IL175238A (en) 2011-06-30
AU2004288760A1 (en) 2005-05-26
CN100480237C (en) 2009-04-22
CA2545291A1 (en) 2005-05-26
CA2545291C (en) 2012-10-30
DK1685097T3 (en) 2008-06-09
CN101475519A (en) 2009-07-08
EP1685097A1 (en) 2006-08-02
AU2004288760B2 (en) 2011-04-07
RU2006120473A (en) 2007-12-27
ATE386019T1 (en) 2008-03-15
HK1133870A1 (en) 2010-04-09
WO2005047241A1 (en) 2005-05-26
PL1685097T3 (en) 2008-06-30
AR046374A1 (en) 2005-12-07
HK1095582A1 (en) 2007-05-11
EP1685097B1 (en) 2008-02-13
JP2007510685A (en) 2007-04-26
NZ547170A (en) 2009-12-24
CN1878754A (en) 2006-12-13
PT1685097E (en) 2008-04-10
RU2382030C2 (en) 2010-02-20
TWI334859B (en) 2010-12-21
JP4658955B2 (en) 2011-03-23
DE502004006216D1 (en) 2008-03-27
TW200530161A (en) 2005-09-16
BRPI0416570A (en) 2007-01-23
CN101475519B (en) 2012-04-25
KR20060122849A (en) 2006-11-30
ES2298838T3 (en) 2008-05-16
ZA200602575B (en) 2007-05-30
KR101207223B1 (en) 2012-12-03

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application