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NO20060307L - Anvendelse av kinoazolinderivatet ZD6474 kombinert med platinaforbindelser og eventuelt ioniserende straling i behandling av sykdommer assosoiert med angiogenese og/eller okt vaskulaert permeabilitet - Google Patents

Anvendelse av kinoazolinderivatet ZD6474 kombinert med platinaforbindelser og eventuelt ioniserende straling i behandling av sykdommer assosoiert med angiogenese og/eller okt vaskulaert permeabilitet

Info

Publication number
NO20060307L
NO20060307L NO20060307A NO20060307A NO20060307L NO 20060307 L NO20060307 L NO 20060307L NO 20060307 A NO20060307 A NO 20060307A NO 20060307 A NO20060307 A NO 20060307A NO 20060307 L NO20060307 L NO 20060307L
Authority
NO
Norway
Prior art keywords
combination
treatment
vascular permeability
quinoazoline
angiogenesis
Prior art date
Application number
NO20060307A
Other languages
English (en)
Other versions
NO333122B1 (no
Inventor
Stephen Robert Wedge
Anderson Joseph Ryan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0316176A external-priority patent/GB0316176D0/en
Priority claimed from GB0406546A external-priority patent/GB0406546D0/en
Priority claimed from GB0407753A external-priority patent/GB0407753D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20060307L publication Critical patent/NO20060307L/no
Publication of NO333122B1 publication Critical patent/NO333122B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår en metode for å produsere en antiangiogen og/eller vaskulær permeabilitetsreduserende effekt hos et varmblodig dyr så som et menneske som eventuelt behandles med ioniserende stiåling, spesielt en metode for behandling av kreft, spesielt kreft som involverer en fast tumor, som omfatter administiering av ZD6474 i kombinasjon med et platina-antitumor-middel; et farmasøytisk preparat omfattende ZD6474 og et platina-antitumor-middel; et kombinasjonsprodukt omfattende ZD6474 og et platina-antitumor-middel for anvendelse ved en metode for behandling av en menneske- eller dyrekropp ved terapi; et sett omfattende ZD6474 og et platina-antitumor-middel; anvendelse av ZD6474 og et platina-antitumor-middel ved fremstilling av et medikament for anvendelse for å produsere en antiangiogen og/eller vaskulær permeabilitetsreduserende effekt hos et varmblodig dyr så som et menneske som eventuelt behandles med ioniserende stiåling.
NO20060307A 2003-07-10 2006-01-20 Anvendelse av 4-(4-brom-2-fluoranilino)-6-metoksy-7-(1-metylpiperidin-4-ylmetoksy)kinazolin kombinert med platinaforbindelser ved fremstilling av medikamenter for a produsere en antikreft-effekt eller antitumor-effekt hos et varmblodig dyr sa som et menneske samt farmasoytisk preparat inneholdende samme NO333122B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0316176A GB0316176D0 (en) 2003-07-10 2003-07-10 Combination therapy
GB0406546A GB0406546D0 (en) 2004-03-24 2004-03-24 Combination therapy
GB0407753A GB0407753D0 (en) 2004-04-06 2004-04-06 Combination therapy
PCT/GB2004/002932 WO2005004870A1 (en) 2003-07-10 2004-07-07 Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability

Publications (2)

Publication Number Publication Date
NO20060307L true NO20060307L (no) 2006-02-08
NO333122B1 NO333122B1 (no) 2013-03-04

Family

ID=34068756

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060307A NO333122B1 (no) 2003-07-10 2006-01-20 Anvendelse av 4-(4-brom-2-fluoranilino)-6-metoksy-7-(1-metylpiperidin-4-ylmetoksy)kinazolin kombinert med platinaforbindelser ved fremstilling av medikamenter for a produsere en antikreft-effekt eller antitumor-effekt hos et varmblodig dyr sa som et menneske samt farmasoytisk preparat inneholdende samme

Country Status (14)

Country Link
US (3) US20060167027A1 (no)
EP (1) EP1648465B1 (no)
JP (1) JP2007526886A (no)
KR (2) KR20060033782A (no)
AT (1) ATE478671T1 (no)
AU (1) AU2004255022B2 (no)
BR (1) BRPI0412426A (no)
CA (1) CA2531862C (no)
DE (1) DE602004028834D1 (no)
IL (1) IL172853A (no)
MX (1) MXPA06000114A (no)
NO (1) NO333122B1 (no)
NZ (1) NZ544458A (no)
WO (1) WO2005004870A1 (no)

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GB0008269D0 (en) 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
MX242553B (es) 2000-10-20 2006-12-06 Eisai Co Ltd Derivados aromaticos que contienen nitrogeno.
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
MXPA05008583A (es) * 2003-02-13 2005-11-04 Astrazeneca Ab Terapia de combinacion de zd6474 con 5-fu y/o cpt-11.
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
WO2005004870A1 (en) * 2003-07-10 2005-01-20 Astrazeneca Ab Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
KR20060130764A (ko) * 2004-03-23 2006-12-19 아스트라제네카 아베 병용 요법
WO2006030826A1 (ja) 2004-09-17 2006-03-23 Eisai R & D Management Co., Ltd. 医薬組成物
MX2007003505A (es) * 2004-09-27 2007-05-10 Astrazeneca Ab Combinacion que comprende zd6474 e imatinib.
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
EP2281901B1 (en) 2005-08-02 2013-11-27 Eisai R&D Management Co., Ltd. Anti-tumour pharmaceutical composition with angiogenesis inhibitors
GB0519879D0 (en) 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
KR101353763B1 (ko) 2005-11-07 2014-01-21 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 신생 저해 물질과 ｃ―ｋｉｔ 키나아제 저해 물질의병용
PL1971338T3 (pl) * 2005-12-22 2011-07-29 Astrazeneca Ab Połączenie ZD6474 i premetreksedu
AU2007252506C1 (en) 2006-05-18 2012-07-19 Eisai R & D Management Co., Ltd. Antitumor agent for thyroid cancer
CN1899616A (zh) * 2006-07-20 2007-01-24 中国人民解放军军事医学科学院生物工程研究所 非受体酪氨酸激酶c－Abl特异性抑制剂的新用途
EP2065372B1 (en) 2006-08-28 2012-11-28 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
EP2066353B1 (en) * 2006-09-29 2013-01-02 AstraZeneca AB Combination of zd6474 and bevacizumab for cancer therapy
CN101600694A (zh) 2007-01-29 2009-12-09 卫材R&D管理有限公司 未分化型胃癌治疗用组合物
JP2008291017A (ja) * 2007-04-25 2008-12-04 Nissei Marine Kogyo Kk Ｗｉｐ１発現増強剤及び癌治療増感剤
AU2008325608B2 (en) 2007-11-09 2013-03-14 Eisai R & D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
US20100075916A1 (en) * 2008-09-05 2010-03-25 Auspex Pharmaceuticals, Inc. Substituted quinazoline inhibitors of growth factor receptor tyrosine kinases
KR101677790B1 (ko) 2010-06-25 2016-11-18 에자이 알앤드디 매니지먼트 가부시키가이샤 키나제 저해 작용을 갖는 화합물의 병용에 의한 항종양제
KR101762999B1 (ko) 2011-04-18 2017-07-28 에자이 알앤드디 매니지먼트 가부시키가이샤 종양 치료제
US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
CA2889866A1 (en) 2012-12-21 2014-06-26 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same
NZ714049A (en) 2013-05-14 2020-05-29 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
US10386359B2 (en) * 2014-05-23 2019-08-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for determining whether a patient will achieve a response after radiation therapy
HRP20221047T1 (hr) 2014-08-28 2022-11-11 Eisai R&D Management Co., Ltd. Derivat kinolina visoke čistoće i postupak za njegovu proizvodnju
HUE064614T2 (hu) 2015-02-25 2024-04-28 Eisai R&D Man Co Ltd Eljárás egy kinolin-származék keserû ízének elnyomására
CA2978226C (en) 2015-03-04 2025-02-18 Eisai R&D Management Co., Ltd. COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER
BR112017027227B1 (pt) 2015-06-16 2023-12-12 Eisai R&D Management Co., Ltd Agente anti-câncer
MX381976B (es) 2015-08-20 2025-03-13 Eisai R&D Man Co Ltd Agente terapéutico contra tumores.
KR102539920B1 (ko) 2017-02-08 2023-06-05 에자이 알앤드디 매니지먼트 가부시키가이샤 종양-치료용 약제학적 조성물
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы

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JP3522727B2 (ja) * 1999-11-05 2004-04-26 アストラゼネカ アクチボラグ Ｖｅｇｆ阻害剤としてのキナゾリン誘導体
GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
WO2004014383A1 (en) * 2002-08-09 2004-02-19 Astrazeneca Ab Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
MXPA05008583A (es) * 2003-02-13 2005-11-04 Astrazeneca Ab Terapia de combinacion de zd6474 con 5-fu y/o cpt-11.
WO2005004870A1 (en) * 2003-07-10 2005-01-20 Astrazeneca Ab Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
KR20060130764A (ko) * 2004-03-23 2006-12-19 아스트라제네카 아베 병용 요법
MX2007003505A (es) * 2004-09-27 2007-05-10 Astrazeneca Ab Combinacion que comprende zd6474 e imatinib.
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
PL1971338T3 (pl) * 2005-12-22 2011-07-29 Astrazeneca Ab Połączenie ZD6474 i premetreksedu
EP2066353B1 (en) * 2006-09-29 2013-01-02 AstraZeneca AB Combination of zd6474 and bevacizumab for cancer therapy

Also Published As

Publication number Publication date
NO333122B1 (no) 2013-03-04
WO2005004870A1 (en) 2005-01-20
KR20060033782A (ko) 2006-04-19
MXPA06000114A (es) 2006-04-27
IL172853A (en) 2012-05-31
AU2004255022B2 (en) 2007-08-23
IL172853A0 (en) 2006-06-11
US20100215773A1 (en) 2010-08-26
CA2531862A1 (en) 2005-01-20
ATE478671T1 (de) 2010-09-15
EP1648465A1 (en) 2006-04-26
AU2004255022A1 (en) 2005-01-20
NZ544458A (en) 2009-04-30
BRPI0412426A (pt) 2006-09-05
DE602004028834D1 (de) 2010-10-07
KR20120093411A (ko) 2012-08-22
US20120263802A1 (en) 2012-10-18
EP1648465B1 (en) 2010-08-25
US20060167027A1 (en) 2006-07-27
CA2531862C (en) 2011-10-25
JP2007526886A (ja) 2007-09-20
HK1089378A1 (en) 2006-12-01

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