[go: up one dir, main page]

NO20060279L - Thienopyridonderivater som kinaseinhibitorer - Google Patents

Thienopyridonderivater som kinaseinhibitorer

Info

Publication number
NO20060279L
NO20060279L NO20060279A NO20060279A NO20060279L NO 20060279 L NO20060279 L NO 20060279L NO 20060279 A NO20060279 A NO 20060279A NO 20060279 A NO20060279 A NO 20060279A NO 20060279 L NO20060279 L NO 20060279L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
thienopyridone derivatives
derivatives
thienopyridone
inhibitors
Prior art date
Application number
NO20060279A
Other languages
English (en)
Inventor
Jeremy Martin Davis
Daniel Christopher Brookings
Barry John Langham
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0314492A external-priority patent/GB0314492D0/en
Priority claimed from GB0329485A external-priority patent/GB0329485D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of NO20060279L publication Critical patent/NO20060279L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En serie av tieno[2,3-b]pyridin-6(7H)-on-derivater, substituert i 2-stillingen med en karbonyl- eller sulfonyl-kjedet pyrrolidin-1-yl eller beslektet gruppe er inhibitorer av p38 MAP-kinase, og er følgelig anvendbare innen medisin, for eksempel ved behandling og/eller forhindring av immun- eller inflammatoriske sykdommer
NO20060279A 2003-06-20 2006-01-19 Thienopyridonderivater som kinaseinhibitorer NO20060279L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0314492A GB0314492D0 (en) 2003-06-20 2003-06-20 Chemical compounds
GB0329485A GB0329485D0 (en) 2003-12-19 2003-12-19 Chemical compounds
PCT/GB2004/002621 WO2004113347A1 (en) 2003-06-20 2004-06-18 Thienopyridone derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20060279L true NO20060279L (no) 2006-03-20

Family

ID=33542685

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060279A NO20060279L (no) 2003-06-20 2006-01-19 Thienopyridonderivater som kinaseinhibitorer

Country Status (12)

Country Link
US (1) US7521460B2 (no)
EP (1) EP1641804A1 (no)
JP (1) JP2007516161A (no)
KR (1) KR20060021905A (no)
AU (1) AU2004249495A1 (no)
BR (1) BRPI0410653A (no)
CA (1) CA2528602A1 (no)
EA (1) EA010297B1 (no)
IL (1) IL172132A0 (no)
MX (1) MXPA05013227A (no)
NO (1) NO20060279L (no)
WO (1) WO2004113347A1 (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
JP2007516162A (ja) * 2003-06-20 2007-06-21 セルテック アール アンド ディ リミテッド キナーゼ阻害剤としてのチエノピリドン誘導体
EP1680429A1 (en) * 2003-10-24 2006-07-19 Celltech R & D Limited Thieno-pyridinone derivatives as kinase inhibitors
ES2524922T3 (es) 2005-05-10 2014-12-15 Intermune, Inc. Derivados de piridona para modular el sistema de proteína cinasa activada por estrés
CA3052368A1 (en) 2005-10-07 2007-04-19 Exelixis, Inc. Azetidines as mek inhibitors
EP1960405A2 (en) * 2005-11-23 2008-08-27 Intermune, Inc. Method of modulating stress-activated protein kinase system
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
EP2004656B1 (en) * 2006-04-07 2013-07-10 Boehringer Ingelheim International GmbH Thienopyrimidines having mnk1 /mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
US20100179185A1 (en) * 2006-11-30 2010-07-15 Ucb Pharma, S.A. Novel Aminothienopyridinone Derivatives Processes for Preparing Them and Pharmaceutical Compositions Thereof
WO2008076415A1 (en) * 2006-12-14 2008-06-26 Exelixis, Inc. Methods of using mek inhibitors
WO2008124085A2 (en) * 2007-04-03 2008-10-16 Exelixis, Inc. Methods of using combinations of mek and jak-2 inhibitors
GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
WO2009093008A1 (en) 2008-01-21 2009-07-30 Ucb Pharma S.A. Thieno-pyridine derivatives as mek inhibitors
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
GB0811304D0 (en) 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
AU2009286734A1 (en) 2008-08-26 2010-03-04 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
US8754079B2 (en) 2010-02-26 2014-06-17 Boehringer Ingelheim International Gmbh Cycloalkyl containing thienopyrimidines for pharmaceutical compositions
UY33245A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
CA2806670A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
TR201807861T4 (tr) 2012-10-12 2018-06-21 Exelixis Inc Kanser tedavisinde kullanım için bileşikler yapmak için yeni işlem.
CN104918944B (zh) * 2012-11-21 2017-05-10 硕腾服务有限责任公司 螺环异噁唑啉衍生物的合成
EP3249054A1 (en) 2012-12-20 2017-11-29 Biomatrica, INC. Formulations and methods for stabilizing pcr reagents
EP3007556B1 (en) 2013-06-13 2020-05-20 Biomatrica, INC. Cell stabilization
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
EP3154338B1 (en) 2014-06-10 2020-01-29 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
KR102787387B1 (ko) 2015-12-08 2025-03-26 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
EP3558363A1 (en) 2016-12-21 2019-10-30 Amgen Inc. Anti-tnf alpha antibody formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048863A (en) 1994-04-19 2000-04-11 Takeda Chemical Industries, Ltd. Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
JP2002517486A (ja) 1998-06-12 2002-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド ｐ３８のインヒビター
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
JP2007516162A (ja) 2003-06-20 2007-06-21 セルテック アール アンド ディ リミテッド キナーゼ阻害剤としてのチエノピリドン誘導体
EP1680429A1 (en) 2003-10-24 2006-07-19 Celltech R & D Limited Thieno-pyridinone derivatives as kinase inhibitors

Also Published As

Publication number Publication date
IL172132A0 (en) 2006-04-10
AU2004249495A1 (en) 2004-12-29
CA2528602A1 (en) 2004-12-29
WO2004113347A1 (en) 2004-12-29
EA010297B1 (ru) 2008-08-29
BRPI0410653A (pt) 2006-07-04
JP2007516161A (ja) 2007-06-21
US7521460B2 (en) 2009-04-21
EA200600064A1 (ru) 2006-08-25
KR20060021905A (ko) 2006-03-08
MXPA05013227A (es) 2006-03-09
US20070099894A1 (en) 2007-05-03
EP1641804A1 (en) 2006-04-05

Similar Documents

Publication Publication Date Title
NO20060279L (no) Thienopyridonderivater som kinaseinhibitorer
UA95939C2 (en) Thieno-pyridine derivatives as mek inhibitors
ATE466012T1 (de) Pyrazolo 3,4-b pyridinverbindungen und ihre verwendung als phosphodiesterase inhibitoren
ECSP088324A (es) 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas
MXPA06001134A (es) Inhibidores de la actividad de la proteina cinasa b.
MX2021014674A (es) Pirrolo [2,3-b] piridina sustituida y derivados de pirazolo [3,4-b] piridina como inhibidores de proteinas quinasas.
GB0312832D0 (en) 2-amino-pyridine derivatives useful for the treatment of diseases
WO2001064214A3 (en) Compositions and methods for the treatment of inflammatory diseases using topoisomerase inhibitors
ATE304355T1 (de) Pharmazeutische zusammensetzungen, enthaltend pyridin- oder pyrimidin-derivate, zur hemmung der produktion und sekretion von cytokinen
GB0428475D0 (en) Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
WO2007013896A3 (en) Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY133311A (en) Novel imidazopyridines as cyclin dependent kinase inhibitors
WO2005009367A3 (en) Treatment of diseases with kinase inhibitors
TW200504062A (en) Novel pyridopyrazines and the use thereof as kinase inhibitors
DK1325011T3 (da) Fremgangsmåder og forbindelser til behandling af proliferative sygdomme
NO20080418L (no) Pyrido[2,3-D]pyrimidiriderivater, fremgangsmate for fremstilling derav og terapeutisk anvendelse av samme
CY1105097T1 (el) Χρηση παραγωγων ν-φαινυλο-2-πυριμιδιναμινης στην αγωγη εναντι φλεγμονωδων ασθενειων
TW200508233A (en) Chk-1 inhibitors
AU2003300324A1 (en) Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
DK2185561T3 (da) Derivater af 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid og 2,3,4,5-tetrahydroprrolo(1,2-a)-diazepin-7-carboxamid, fremstilling deraf og terapeutisk anvendelse deraf
NO20062878L (no) Isoflavonoidpromedikamenter, terapeutiske sammensetninger derav og terapeutiske fremgangsmater som innbefatter de samme
ATE414081T1 (de) Bizyklische heteroaromatische verbindungen als kinase hemmstoffe
DE60127131D1 (de) Tricyclische imidazopyridine
NO20023175D0 (no) Camptothecin beta-alaninestere med topoisomerase I inhibering
ATE535530T1 (de) 7-substituierte camptothecin- und camptothecin- analoga und herstellungsverfahren dafür

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application