NO20055150L - Benzotiazolderivater som adenosin-reseptorligander - Google Patents
Benzotiazolderivater som adenosin-reseptorliganderInfo
- Publication number
- NO20055150L NO20055150L NO20055150A NO20055150A NO20055150L NO 20055150 L NO20055150 L NO 20055150L NO 20055150 A NO20055150 A NO 20055150A NO 20055150 A NO20055150 A NO 20055150A NO 20055150 L NO20055150 L NO 20055150L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- lower alkyl
- aza
- halogen
- alkyl
- Prior art date
Links
- 102000009346 Adenosine receptors Human genes 0.000 title 1
- 108050000203 Adenosine receptors Proteins 0.000 title 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- -1 1,4-dioxepanyl Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 3
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- KPKNTUUIEVXMOH-UHFFFAOYSA-N 1,4-dioxa-8-azaspiro[4.5]decane Chemical group O1CCOC11CCNCC1 KPKNTUUIEVXMOH-UHFFFAOYSA-N 0.000 abstract 1
- KVYOWXUQJLOCIA-UHFFFAOYSA-N 1-oxa-8-azaspiro[4.5]decane Chemical group C1CCOC21CCNCC2 KVYOWXUQJLOCIA-UHFFFAOYSA-N 0.000 abstract 1
- DIQOUXNTSMWQSA-UHFFFAOYSA-N 2-oxa-5-azabicyclo[2.2.1]heptane Chemical group C1OC2CNC1C2 DIQOUXNTSMWQSA-UHFFFAOYSA-N 0.000 abstract 1
- 101150051188 Adora2a gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Oppfinnelsen angår forbindelser med den generelle formel hvor R1 er 1,4-dioksepanyl eller tetrahydropyran-4-yl; R2 er -N(R)-(CH2)n-5-eller 6-leddet ikke-aromatisk heterocyklisk gruppe, eventuelt substituert med én eller flere substituenter, valgt fra gruppen bestående av lavere alkyl eller-NR2, eller er -(CH2)n-5-eller 6 leddet ikke-aromatisk heterocyklisk gruppe, eventuelt substituert med -(CH2)n-OH, lavere alkyl, lavere alkoksy, eller er -CH2)n-5-eller 6-leddet aromatisk heterocyklisk gruppe, eventuelt substituert med lavere alkyl, lavere alkoksy, halogen, halogen-lavere alkyl, -CH2N(R)(CH2)2OCH3, -N(R)(CH2)2OCH3, -CH2-morfolinyl eller-CH2-pyrrolidinyl, eller er (CH2)n-cykloalkyl, eventuelt substituert med hydroksy eller er -N(R)-cykloalkyl, eventuelt substituert med hydroksy eller lavere alkyl, eller erfenyl, eventuelt substituert med lavere alkoksy, halogen, halogen-lavere-alkyl, lavere alkyl, -CH2-pyrrolidin-1-yl, -CH2-morfolinyl, -CH2N(R)(CH2)2OCH3 eller-CH2- N(R)C(O)-lavere alkyl, eller er 1,4-dioksa-8-aza-spiro[4.5]dekan, eller er2-oksa-5-aza-bicyklo[2.2.1]heptan, eller er 1-oksa-8-aza-spiro[4.5]dekan, eller er-N(R)-7-oksa-bicyklo[2.2.1]hept-2-yl eller er 2-aza-bicyklo[2.2.2]dekan; R er hydrogen eller lavere alkyl; n er 0 eller 1; og farmasøytisk akseptable syreaddisjonssalter derav for behandling av sykdommer, som angår A2A-reseptoren.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03011039 | 2003-05-19 | ||
| PCT/EP2004/005178 WO2005000842A1 (en) | 2003-05-19 | 2004-05-14 | Benzothiazole derivatives as adenosine receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20055150L true NO20055150L (no) | 2005-11-04 |
Family
ID=33442729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055150A NO20055150L (no) | 2003-05-19 | 2005-11-03 | Benzotiazolderivater som adenosin-reseptorligander |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7371748B2 (no) |
| EP (1) | EP1636223B1 (no) |
| JP (1) | JP4444290B2 (no) |
| KR (1) | KR100859886B1 (no) |
| CN (1) | CN100528871C (no) |
| AR (1) | AR044362A1 (no) |
| AT (1) | ATE389652T1 (no) |
| AU (1) | AU2004251814B2 (no) |
| BR (1) | BRPI0410440A (no) |
| CA (1) | CA2524366C (no) |
| CL (1) | CL2004001067A1 (no) |
| CO (1) | CO5630031A2 (no) |
| DE (1) | DE602004012555T2 (no) |
| DK (1) | DK1636223T3 (no) |
| ES (1) | ES2301991T3 (no) |
| HR (1) | HRP20080207T3 (no) |
| IL (1) | IL171686A (no) |
| MX (1) | MXPA05012360A (no) |
| NO (1) | NO20055150L (no) |
| NZ (1) | NZ543074A (no) |
| PL (1) | PL1636223T3 (no) |
| PT (1) | PT1636223E (no) |
| RU (1) | RU2351597C2 (no) |
| SI (1) | SI1636223T1 (no) |
| TW (1) | TW200505882A (no) |
| WO (1) | WO2005000842A1 (no) |
| ZA (1) | ZA200509294B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008052930A2 (en) * | 2006-11-03 | 2008-05-08 | F. Hoffmann-La Roche Ag | Preparation of 4-alk0xy-7- (tetrahydropyran-4-yl) benzothiazol-2-amine derivatives |
| EP3661941B1 (en) * | 2017-08-01 | 2022-12-14 | Merck Patent GmbH | Thiazolopyridine derivatives as adenosine receptor antagonists |
| CN110997662B (zh) | 2017-08-21 | 2023-10-31 | 默克专利股份公司 | 作为腺苷受体拮抗剂的苯并咪唑衍生物 |
| US11192899B2 (en) | 2017-08-21 | 2021-12-07 | Merck Patent Gmbh | Quinoxaline derivatives as adenosine receptor antagonists |
| WO2019141096A1 (zh) * | 2018-01-19 | 2019-07-25 | 四川科伦博泰生物医药股份有限公司 | 取代脲类化合物及其制备方法和用途 |
| BR112021007435A2 (pt) | 2018-10-25 | 2021-08-03 | Merck Patent Gmbh | derivados de 5-azaindazol como antagonistas de receptor de adenosina |
| WO2020083856A1 (en) | 2018-10-25 | 2020-04-30 | Merck Patent Gmbh | 5-azaindazole derivatives as adenosine receptor antagonists |
| AR117844A1 (es) * | 2019-01-22 | 2021-09-01 | Merck Patent Gmbh | Derivados de tiazolopiridina como antagonistas del receptor de adenosina |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI91859C (fi) * | 1987-06-17 | 1994-08-25 | Eisai Co Ltd | Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi |
| IL90337A0 (en) * | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
| CN1234358C (zh) * | 2000-06-21 | 2006-01-04 | 弗·哈夫曼-拉罗切有限公司 | 苯并噻唑衍生物 |
| WO2003045385A1 (en) * | 2001-11-27 | 2003-06-05 | F. Hoffmann-La Roche Ag | Benzothiazole derivatives |
| US6727247B2 (en) * | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
| US6734179B2 (en) * | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
| KR100699615B1 (ko) * | 2003-01-13 | 2007-03-23 | 에프. 호프만-라 로슈 아게 | 벤족사졸 유도체 및 아데노신 수용체 리간드로서의 이들의용도 |
-
2004
- 2004-05-14 AU AU2004251814A patent/AU2004251814B2/en not_active Ceased
- 2004-05-14 HR HR20080207T patent/HRP20080207T3/xx unknown
- 2004-05-14 RU RU2005139527/04A patent/RU2351597C2/ru not_active IP Right Cessation
- 2004-05-14 WO PCT/EP2004/005178 patent/WO2005000842A1/en not_active Ceased
- 2004-05-14 ES ES04732950T patent/ES2301991T3/es not_active Expired - Lifetime
- 2004-05-14 CN CNB2004800135624A patent/CN100528871C/zh not_active Expired - Fee Related
- 2004-05-14 CA CA2524366A patent/CA2524366C/en not_active Expired - Fee Related
- 2004-05-14 DK DK04732950T patent/DK1636223T3/da active
- 2004-05-14 TW TW093113590A patent/TW200505882A/zh unknown
- 2004-05-14 PT PT04732950T patent/PT1636223E/pt unknown
- 2004-05-14 DE DE602004012555T patent/DE602004012555T2/de not_active Expired - Lifetime
- 2004-05-14 JP JP2006529816A patent/JP4444290B2/ja not_active Expired - Fee Related
- 2004-05-14 SI SI200430668T patent/SI1636223T1/sl unknown
- 2004-05-14 PL PL04732950T patent/PL1636223T3/pl unknown
- 2004-05-14 AT AT04732950T patent/ATE389652T1/de active
- 2004-05-14 KR KR1020057021945A patent/KR100859886B1/ko not_active Expired - Fee Related
- 2004-05-14 NZ NZ543074A patent/NZ543074A/en unknown
- 2004-05-14 EP EP04732950A patent/EP1636223B1/en not_active Expired - Lifetime
- 2004-05-14 MX MXPA05012360A patent/MXPA05012360A/es active IP Right Grant
- 2004-05-14 BR BRPI0410440-4A patent/BRPI0410440A/pt not_active Application Discontinuation
- 2004-05-17 CL CL200401067A patent/CL2004001067A1/es unknown
- 2004-05-17 AR ARP040101684A patent/AR044362A1/es not_active Application Discontinuation
- 2004-05-17 US US10/847,558 patent/US7371748B2/en not_active Expired - Fee Related
-
2005
- 2005-10-31 IL IL171686A patent/IL171686A/en active IP Right Grant
- 2005-11-03 NO NO20055150A patent/NO20055150L/no not_active Application Discontinuation
- 2005-11-16 CO CO05116289A patent/CO5630031A2/es not_active Application Discontinuation
- 2005-11-16 ZA ZA200509294A patent/ZA200509294B/en unknown
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