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NO20055893L - Nye linkomycinderivativer med antimikrobiell aktivitet - Google Patents

Nye linkomycinderivativer med antimikrobiell aktivitet

Info

Publication number
NO20055893L
NO20055893L NO20055893A NO20055893A NO20055893L NO 20055893 L NO20055893 L NO 20055893L NO 20055893 A NO20055893 A NO 20055893A NO 20055893 A NO20055893 A NO 20055893A NO 20055893 L NO20055893 L NO 20055893L
Authority
NO
Norway
Prior art keywords
linkomycin
derivatives
new
antimicrobial activity
compounds
Prior art date
Application number
NO20055893A
Other languages
English (en)
Inventor
Mikhail F Gordeev
Sampath K Anandan
Jason Gustaf Lewis
Hardwin O'dowd
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/642,807 external-priority patent/US7164011B2/en
Priority claimed from US10/777,455 external-priority patent/US7199105B2/en
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of NO20055893L publication Critical patent/NO20055893L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nye linkomycin-derivater er beskrevet. Disse linkomycin-derivater viser antibakteriell aktivitet. Forbindelsene ifølge foreliggende oppfinnelse kan vise kraftig aktivitet mot bakterier, omfattende gram-positive organismer og kan være nyttige, antimikrobielle midler. Metoder for syntese og anvendelige forbindelser er også beskrevet.
NO20055893A 2003-06-17 2005-12-12 Nye linkomycinderivativer med antimikrobiell aktivitet NO20055893L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47929603P 2003-06-17 2003-06-17
US47950203P 2003-06-17 2003-06-17
US10/642,807 US7164011B2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/777,455 US7199105B2 (en) 2002-08-15 2004-02-11 Lincomycin derivatives possessing antibacterial activity
PCT/US2004/019689 WO2005012320A2 (en) 2003-06-17 2004-06-17 Novel lincomycin derivatives possessing antimicrobial activity

Publications (1)

Publication Number Publication Date
NO20055893L true NO20055893L (no) 2006-03-14

Family

ID=40203032

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055893A NO20055893L (no) 2003-06-17 2005-12-12 Nye linkomycinderivativer med antimikrobiell aktivitet

Country Status (16)

Country Link
EP (1) EP1644393A2 (no)
JP (1) JP2007516172A (no)
KR (1) KR20060091050A (no)
AU (1) AU2004261550A1 (no)
BR (1) BRPI0411534A (no)
CA (1) CA2528592A1 (no)
EC (1) ECSP056233A (no)
GE (1) GEP20084437B (no)
IL (1) IL172183A0 (no)
IS (1) IS8147A (no)
MA (1) MA27860A1 (no)
MX (1) MXPA05013915A (no)
NO (1) NO20055893L (no)
OA (1) OA13179A (no)
RS (1) RS20050931A (no)
WO (1) WO2005012320A2 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199105B2 (en) 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
WO2004016632A2 (en) 2002-08-15 2004-02-26 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
CA2528596A1 (en) * 2003-06-17 2005-01-27 Vicuron Pharmaceuticals Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7361743B2 (en) 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
KR20080041722A (ko) * 2005-08-31 2008-05-13 와이어쓰 글리실사이클린의 9-아미노카르보닐 치환된 유도체
JP5064237B2 (ja) 2005-12-09 2012-10-31 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 リンコマイシン誘導体およびこれを有効成分とする抗菌剤
JP5356223B2 (ja) * 2007-05-31 2013-12-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 リンコマイシン誘導体及びこれを有効成分とする抗菌剤
US7867980B2 (en) 2007-05-31 2011-01-11 Meiji Seika Kaisha, Ltd. Lincosamide derivatives and antimicrobial agents comprising the same as active ingredient
US20130267699A1 (en) 2011-06-24 2013-10-10 California Institute Of Technology Quaternary heteroatom containing compounds
US8822679B2 (en) * 2011-06-24 2014-09-02 California Institute Of Technology Quaternary heteroatom containing compounds
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
EP3274342B1 (en) 2015-03-27 2022-05-04 California Institute of Technology Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
EP3426391A4 (en) 2016-03-11 2019-08-28 California Institute of Technology COMPOSITIONS AND METHODS FOR ACYLATING LACTAMEN
US10358422B2 (en) 2017-11-01 2019-07-23 California Institute Of Technology Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
EP3699173A1 (en) 2018-10-18 2020-08-26 California Institute of Technology Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
CN110357839A (zh) * 2019-08-29 2019-10-22 重庆经致制药技术开发有限公司 布瓦西坦手性中间体的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128232C (no) * 1964-04-13
US3268556A (en) * 1964-04-13 1966-08-23 Upjohn Co Novel lincomycin derivatives
NL146501C (no) * 1964-07-01
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
NL140527B (nl) * 1965-02-08 1973-12-17 Upjohn Co Werkwijze ter bereiding van aan lincomycine verwante verbindingen.
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
US3549615A (en) * 1968-10-17 1970-12-22 Upjohn Co Lincomycin derivatives and process for producing the same
DE2118636A1 (de) * 1970-04-20 1971-11-04 The Upjohn Co., Kalamazoo, Mich. (V.StA.) 3-Nucleotide von Lincomycin und deren Analogen, Verfahren zu ihrer Herstellung und ihre Verwendung in therapeutischen Präparaten
US3787390A (en) * 1971-06-23 1974-01-22 Upjohn Co Analogs of lincomycin and process
US3849396A (en) * 1973-01-08 1974-11-19 Upjohn Co Lincomycin and clindamycin 1-o-ethers
US3923602A (en) * 1973-10-25 1975-12-02 Upjohn Co Composition of matter and process
JPS5641239A (en) * 1979-09-13 1981-04-17 Hitachi Cable Ltd Flame-retardant composition
US4278789A (en) * 1979-11-23 1981-07-14 The Upjohn Company Lincomycin compounds
WO2004016632A2 (en) * 2002-08-15 2004-02-26 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
BRPI0411537A (pt) * 2003-06-17 2006-08-01 Vicuron Pharm Inc derivados de lincomicina que possuem atividade antibacteriana

Also Published As

Publication number Publication date
IL172183A0 (en) 2011-08-01
MA27860A1 (fr) 2006-04-03
RS20050931A (sr) 2008-04-04
MXPA05013915A (es) 2006-07-03
AU2004261550A1 (en) 2005-02-10
OA13179A (en) 2006-12-13
EP1644393A2 (en) 2006-04-12
WO2005012320A2 (en) 2005-02-10
GEP20084437B (en) 2008-07-25
WO2005012320A3 (en) 2005-10-20
IS8147A (is) 2005-11-24
KR20060091050A (ko) 2006-08-17
ECSP056233A (es) 2006-04-19
HK1090061A1 (zh) 2006-12-15
BRPI0411534A (pt) 2006-08-22
CA2528592A1 (en) 2005-02-10
JP2007516172A (ja) 2007-06-21

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