[go: up one dir, main page]

NO20054208L - Nitrogen-substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, methods of preparation and use thereof as medicaments - Google Patents

Nitrogen-substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, methods of preparation and use thereof as medicaments

Info

Publication number
NO20054208L
NO20054208L NO20054208A NO20054208A NO20054208L NO 20054208 L NO20054208 L NO 20054208L NO 20054208 A NO20054208 A NO 20054208A NO 20054208 A NO20054208 A NO 20054208A NO 20054208 L NO20054208 L NO 20054208L
Authority
NO
Norway
Prior art keywords
pyrimidine
preparation
medicaments
nitrogen
methods
Prior art date
Application number
NO20054208A
Other languages
Norwegian (no)
Inventor
Pavel Safar
Gregory Harold Merriman
Kenneth J Bordeau
Matthias Gossel
Thomas Klabunde
Stefanie Flohr
Petra Stahl
James Spoonamore
Martin Smrcina
Joseph T Klein
Brian Whiteley
Carolina Lanter
Zhaoxia Yang
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10305885A external-priority patent/DE10305885A1/en
Priority claimed from DE10349671A external-priority patent/DE10349671A1/en
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20054208L publication Critical patent/NO20054208L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Forbindelsen angår nittogen-substituerte heksahydropyrazino[l,2-a]pyrimidin-4,7-dion derivater, i tillegg til fysiologisk kompatible salter derav og fysiologisk funksjonelle derivater. Oppfinnelsen angår også forbindelser med formel I, hvor radikalene har angitte betydninger, fysiologisk kompatible salter derav og fremgangsmåte for fremstilling derav. Nevnte forbindelser kan anvendes for eksempel som anorektiske midler.The compound relates to nitogenesubstituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, in addition to physiologically compatible salts thereof and physiologically functional derivatives. The invention also relates to compounds of formula I wherein the radicals have meanings, physiologically compatible salts thereof and process for their preparation. Said compounds can be used, for example, as anorectic agents.

NO20054208A 2003-02-13 2005-09-09 Nitrogen-substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, methods of preparation and use thereof as medicaments NO20054208L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10305885A DE10305885A1 (en) 2003-02-13 2003-02-13 New pyrazinopyrimidine or pyrazinoimidazole derivatives useful for weight reduction in mammals, for preventing or treating obesity, type II diabetes or metabolic syndrome and for treating sexual disorders
DE10349671A DE10349671A1 (en) 2003-10-24 2003-10-24 New pyrazinopyrimidine or pyrazinoimidazole derivatives useful for weight reduction in mammals, for preventing or treating obesity, type II diabetes or metabolic syndrome and for treating sexual disorders
PCT/EP2004/000770 WO2004072077A1 (en) 2003-02-13 2004-01-29 Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, method for the production and use thereof as medicaments

Publications (1)

Publication Number Publication Date
NO20054208L true NO20054208L (en) 2005-09-09

Family

ID=32870333

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054208A NO20054208L (en) 2003-02-13 2005-09-09 Nitrogen-substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, methods of preparation and use thereof as medicaments

Country Status (20)

Country Link
EP (1) EP1597259B1 (en)
JP (1) JP2006517551A (en)
KR (1) KR20050100686A (en)
AR (1) AR043154A1 (en)
AT (1) ATE393769T1 (en)
AU (1) AU2004212043A1 (en)
BR (1) BRPI0407387A (en)
CA (1) CA2514791A1 (en)
CO (1) CO5690596A2 (en)
DE (1) DE502004007000D1 (en)
HR (1) HRP20050711A2 (en)
MA (1) MA27734A1 (en)
MX (1) MXPA05008288A (en)
NO (1) NO20054208L (en)
PE (1) PE20040949A1 (en)
PL (1) PL377660A1 (en)
RS (1) RS20050572A (en)
RU (1) RU2005128499A (en)
TW (1) TW200510417A (en)
WO (1) WO2004072077A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072831A1 (en) * 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7671054B1 (en) 2001-10-12 2010-03-02 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7576084B2 (en) 2001-10-12 2009-08-18 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7566711B2 (en) 2001-10-12 2009-07-28 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7232822B2 (en) 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US8080657B2 (en) 2001-10-12 2011-12-20 Choongwae Pharma Corporation Compounds of reverse turn mimetics and the use thereof
KR20050111588A (en) * 2003-02-13 2005-11-25 사노피-아벤티스 도이칠란트 게엠베하 Substituted hexahydropyrazino[1,2-a]pyrimidin-4,7-dion derivatives, method for the production and use thereof as medicaments
DE102004042441A1 (en) * 2004-08-31 2006-04-06 Sanofi-Aventis Deutschland Gmbh Amino acid substituted hexahydro-pyrazino (1,2-a) pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments
JP2008545009A (en) 2005-06-30 2008-12-11 プロシディオン・リミテッド GPCR agonist
JP5102985B2 (en) * 2006-07-18 2012-12-19 東ソ−・エフテック株式会社 Method for producing fluorine-containing secondary amine compound
EP2061767B1 (en) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
GB0700122D0 (en) 2007-01-04 2007-02-14 Prosidion Ltd GPCR agonists
ATE523507T1 (en) 2007-01-04 2011-09-15 Prosidion Ltd PIPERIDINE GPCR AGONISTS
PE20081659A1 (en) 2007-01-04 2008-10-24 Prosidion Ltd GPCR AGONISTS
EA016507B1 (en) 2007-01-04 2012-05-30 Прозидион Лимитед Piperidine gpcr agonists
CL2008000017A1 (en) 2007-01-04 2008-08-01 Prosidion Ltd COMPOUNDS DERIVED FROM NITROGEN AND OXYGEN HETEROCICLES, GPCR AGONISTS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF OBESITY, DIABETES, METABOLIC SYNDROME, HYPERLIPIDEMIA, TOLERANCE
JP5204438B2 (en) * 2007-07-31 2013-06-05 東ソ−・エフテック株式会社 Method for producing fluorine-containing amine compound
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
US8470841B2 (en) 2008-07-09 2013-06-25 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
CN102186853A (en) 2008-10-14 2011-09-14 株式会社棱镜生物实验室 Alpha helix mimetics in the treatment of cancer
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US9040531B2 (en) 2009-05-07 2015-05-26 Prism BioLab Co., Ltd. Alpha helix mimetics and methods relating thereto
CN102482312A (en) 2009-08-26 2012-05-30 赛诺菲 Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
EP2683702B1 (en) 2011-03-08 2014-12-24 Sanofi New substituted phenyl oxathiazine derivatives, method for their manufacture, medicines containing these compounds and their application
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120056A1 (en) 2011-03-08 2012-09-13 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120053A1 (en) 2011-03-08 2012-09-13 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8846666B2 (en) 2011-03-08 2014-09-30 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683705B1 (en) 2011-03-08 2015-04-22 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683703B1 (en) 2011-03-08 2015-05-27 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120051A1 (en) 2011-03-08 2012-09-13 Sanofi Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof
EP3474835B1 (en) 2016-06-23 2023-07-05 University of Maryland, Baltimore Non-catalytic substrate-selective p38 -specific mapk inhibitors with endothelial-stabilizing and anti-inflammatory activity, and methods of use thereof
EP3890733B1 (en) 2018-12-07 2025-04-16 University of Maryland, Baltimore Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors
WO2021236449A1 (en) * 2020-05-18 2021-11-25 Gen1E Lifesciences Inc. P38alpha mitogen-activated protein kinase inhibitors
IL302235A (en) 2020-10-29 2023-06-01 Gen1E Lifesciences Inc Crystalline 5-(dimethylamino)-n-(4-(morpholinomethyl)phenyl) naphthalene-1-sulfonmide di-hydrochloride di-hydrate
JP7659650B2 (en) 2021-03-23 2025-04-09 ジーニー ライフサイエンシズ インコーポレイテッド Substituted naphthyl P38 alpha mitogen-activated protein kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184223B1 (en) * 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
ATE356139T1 (en) * 1997-06-25 2007-03-15 Pfizer DIPEPTIDE DERIVATIVES FOR PROMOTING GROWTH HORMONE SECRETION
US6294525B1 (en) * 1999-09-01 2001-09-25 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
KR20050111588A (en) * 2003-02-13 2005-11-25 사노피-아벤티스 도이칠란트 게엠베하 Substituted hexahydropyrazino[1,2-a]pyrimidin-4,7-dion derivatives, method for the production and use thereof as medicaments

Also Published As

Publication number Publication date
WO2004072077A1 (en) 2004-08-26
AR043154A1 (en) 2005-07-20
RS20050572A (en) 2007-09-21
PL377660A1 (en) 2006-02-06
TW200510417A (en) 2005-03-16
DE502004007000D1 (en) 2008-06-12
CO5690596A2 (en) 2006-10-31
MXPA05008288A (en) 2006-03-21
JP2006517551A (en) 2006-07-27
ATE393769T1 (en) 2008-05-15
BRPI0407387A (en) 2006-02-07
PE20040949A1 (en) 2005-01-12
RU2005128499A (en) 2006-01-27
MA27734A1 (en) 2006-02-01
EP1597259A1 (en) 2005-11-23
CA2514791A1 (en) 2004-08-26
KR20050100686A (en) 2005-10-19
EP1597259B1 (en) 2008-04-30
HRP20050711A2 (en) 2006-09-30
AU2004212043A1 (en) 2004-08-26

Similar Documents

Publication Publication Date Title
NO20054208L (en) Nitrogen-substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, methods of preparation and use thereof as medicaments
NO20054085L (en) Substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, methods of preparation and use thereof as medicaments
MX337817B (en) PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES.
TW200510297A (en) Substituted n-aryl heterocycles, process for their preparation and their use as medicaments
MX2010006748A (en) PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS.
GEP20135780B (en) Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer agents
BRPI0510560A (en) substituted pyrido [2,3-d] pyrimidin-7-ones and their derivatives as therapeutic agents
TW200613305A (en) Polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
TW200606162A (en) Pyrazolopyridine derivatives
GEP20094720B (en) Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors
TW200504062A (en) Novel pyridopyrazines and the use thereof as kinase inhibitors
NO20056032L (en) Novel pyridopyrazines and their use as kinase modulators
CY1109366T1 (en) Substituted Compounds 1,4,8-Triazazepiro [4.5] Decan-2-One
NO20072089L (en) Benzimidazole derivatives, compositions containing them, their preparation and their use
MY140630A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
NO20080418L (en) Pyrido [2,3-D] pyrimidiride derivatives, process for their preparation and therapeutic use of the same
TW200504029A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
TW200504030A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
PT1869038E (en) Substituted 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-ylamine compounds and their use for producing drugs
BRPI0513287A (en) pyrido pyrimidine derivatives, their preparation, their application in therapeutic
NO20063619L (en) Diarylmethylpiperazine derivatives, preparation and use thereof
WO2006071564A3 (en) Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
NO20053805L (en) Diarylmethylindenepiperidine derivatives, processes for their preparation, and use thereof
BRPI0507811A (en) 7h-pyrrolopyrimidine derivatives
NO20053876L (en) Carbonylamino-substituted acylphenylurea derivatives, process for their preparation and use thereof

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application