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NO20053955L - Pyrazolo [1,5-A] pyrimidinderivater - Google Patents

Pyrazolo [1,5-A] pyrimidinderivater Download PDF

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Publication number
NO20053955L
NO20053955L NO20053955A NO20053955A NO20053955L NO 20053955 L NO20053955 L NO 20053955L NO 20053955 A NO20053955 A NO 20053955A NO 20053955 A NO20053955 A NO 20053955A NO 20053955 L NO20053955 L NO 20053955L
Authority
NO
Norway
Prior art keywords
tokyo
pyrazolo
pyrimidine derivatives
kinase
chome
Prior art date
Application number
NO20053955A
Other languages
English (en)
Other versions
NO20053955D0 (no
Inventor
Kenichiro Kataoka
Minoru Imai
Satoshi Sugiura
Tomomi Kosugi
Yasuhiro Oue
Dale Robert Mitchell
Gen Unoki
Naotaka Suzuki
Hiroaki Makino
Mika Takakuwa
Aiko Fujino
Yuko Yamakoshi
Donald James Simpson
Clifford James Harris
Joelle Le
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0304665A external-priority patent/GB0304665D0/en
Priority claimed from GB0329446A external-priority patent/GB0329446D0/en
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of NO20053955D0 publication Critical patent/NO20053955D0/no
Publication of NO20053955L publication Critical patent/NO20053955L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
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  • Cardiology (AREA)
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Abstract

Pyrazolo[l,5-a]pyrimidinderivater representert ved formel I og deres farmasøytisk akseptable salter viser utmerket kinasehemmende aktivitet. Medikamenter omfattende forbindelsene som effektive bestanddeler er derfor forventet å være anvendelige som terapeutiske eller profylaktiske midler for en proteinkinase-mediert lidelse hvor kinase er implisert, så som inflammatorisk sykdom, autoimmun sykdom, destruktiv benlidelse, kreft og/eller rumorvekst.

Description

Minoru Imai, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 ILINO-SHI, TOKYO, JP Satoshi Sugiura, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Tomomi Kosugi, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Yasuhiro Oue, c/o Teijin Ltd, Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Dale Robert Mitchell, c/o BioFocus Plc, Chesterford Park, CB101XL SAF FRON WALDEN, ESSEX, GB
Gen Unoki, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Naotaka Suzuki, c/o Teijin Pharma Ltd., 1-1 Uchisaiwaicho 2-chome, Chiyoda-ku, 1000011 TOKYO, JP
Hiroaki Makino, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Mika Takakuwa, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Aiko Fujino, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Yuko Yamakoshi, c/o Teijin Ltd., Tokyo Research Center, 3-2, Asahigaoka 4-chome, 191-0065 HINO-SHI, TOKYO, JP Donald James Simpson, c/o BioFocus Plc, Chesterford Park, CB101XL SAFFRON WALDEN, ESSEX, GB
Clifford James Harris, c/o BioFocus Plc, Chesterford Park, CB101XL SAFFRON WALDEN, ESSEX, GB
Joelle Le, c/o BioFocus Plc, Chesterford Park, CB101XL SAFFRON WALDEN, ESSEX, GB
NO20053955A 2003-02-28 2005-08-25 Pyrazolo [1,5-A] pyrimidinderivater NO20053955L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0304665A GB0304665D0 (en) 2003-02-28 2003-02-28 Compounds
US50069503P 2003-09-08 2003-09-08
GB0329446A GB0329446D0 (en) 2003-12-19 2003-12-19 Compounds
PCT/JP2004/002522 WO2004076458A1 (en) 2003-02-28 2004-03-01 Pyrazolo[1,5-a]pyrimidine derivatives

Publications (2)

Publication Number Publication Date
NO20053955D0 NO20053955D0 (no) 2005-08-25
NO20053955L true NO20053955L (no) 2005-09-22

Family

ID=32931047

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053955A NO20053955L (no) 2003-02-28 2005-08-25 Pyrazolo [1,5-A] pyrimidinderivater

Country Status (12)

Country Link
US (1) US7557110B2 (no)
EP (1) EP1599482A4 (no)
JP (1) JP4564485B2 (no)
KR (1) KR20050115252A (no)
AU (1) AU2004215481B2 (no)
BR (1) BRPI0407834A (no)
CA (1) CA2516824A1 (no)
CO (1) CO5650257A2 (no)
MA (1) MA27711A1 (no)
MX (1) MXPA05008955A (no)
NO (1) NO20053955L (no)
WO (1) WO2004076458A1 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO337520B1 (no) * 2004-02-11 2016-05-02 Pharmacopeia Drug Discovery Inc Pyrazolopyrimidinderivater som syklinavhengige kinaseinhibitorer, anvendelse derav for fremstilling av et medikament og farmasøytiske preparater som inneholder én eller flere slike forbindelser.

Families Citing this family (94)

* Cited by examiner, † Cited by third party
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US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
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JPWO2005035516A1 (ja) * 2003-10-10 2006-12-21 小野薬品工業株式会社 新規縮合複素環化合物およびその用途
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WO2006033796A1 (en) * 2004-09-17 2006-03-30 Wyeth SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME
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EP1900739A1 (en) * 2006-08-30 2008-03-19 Cellzome Ag Diazolodiazine derivatives as kinase inhibitors
JP5274805B2 (ja) * 2006-09-20 2013-08-28 三菱化学株式会社 フッ素化芳香族化合物の製造方法
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CA2675669C (en) * 2007-02-23 2015-05-26 High Point Pharmaceuticals, Llc Novel compounds
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