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NO20052124L - Nye 1,4-diazabisykloalkanderivater, deres fremstilling og anvendelse - Google Patents

Nye 1,4-diazabisykloalkanderivater, deres fremstilling og anvendelse

Info

Publication number
NO20052124L
NO20052124L NO20052124A NO20052124A NO20052124L NO 20052124 L NO20052124 L NO 20052124L NO 20052124 A NO20052124 A NO 20052124A NO 20052124 A NO20052124 A NO 20052124A NO 20052124 L NO20052124 L NO 20052124L
Authority
NO
Norway
Prior art keywords
disorders
enantiomers
compounds
nervous system
disease
Prior art date
Application number
NO20052124A
Other languages
English (en)
Other versions
NO20052124D0 (no
Inventor
Gunnar M Olsen
Dan Peters
Elsebet Ostergaard Nielsen
Philip K Ahring
Tino Dyhring Jorgensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2003/000639 external-priority patent/WO2004029053A1/en
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO20052124D0 publication Critical patent/NO20052124D0/no
Publication of NO20052124L publication Critical patent/NO20052124L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Denne oppfinnelsen vedrører nye 1,l-diazabisykloalkanderivater med formel (I) a:K (I) hvilken som helst av dets enantio- merer eller hvilken som helst blanding av dets enantiomerer, eller et farmaseytisk akseptabelt addisjonssalt derav, eller et M- oksid derav, og deres anvendelse ved fremstillingen av farmasøytiske preparater. Forbindelsene ifølge oppfinnelsen er funnet å være kol- inerge ligander i nikocinacetyl- kolinreseptorene oq modulatorene for monoaminreseptorene og -trans- portørene. På grunn av deres farma- kologiske profil kan forbindelsene ifolge oppfinnelsen være anvendbare til behandlingen av så forskjellige sykdorraner eller forstyrrelser som de som er relatert til det kolin- erge system i sentralnervesystemet (CNS), det perifere nervesystem (PMS), sykdcm.mer eller forstyrr- elser relatert til glattratisk^ilkon- traksjon, endokrine sykdommer eller forstyrrelser, sykdommer eller for- styrrelser relatert til nevro-
NO20052124A 2002-09-30 2005-04-29 Nye 1,4-diazabisykloalkanderivater, deres fremstilling og anvendelse NO20052124L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
PCT/DK2003/000639 WO2004029053A1 (en) 2002-09-30 2003-09-29 Novel 1,4-diazabicycloalkane derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
NO20052124D0 NO20052124D0 (no) 2005-04-29
NO20052124L true NO20052124L (no) 2005-06-29

Family

ID=34828377

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052124A NO20052124L (no) 2002-09-30 2005-04-29 Nye 1,4-diazabisykloalkanderivater, deres fremstilling og anvendelse

Country Status (11)

Country Link
JP (1) JP4711391B2 (no)
KR (1) KR20050062575A (no)
CN (1) CN1326857C (no)
BR (1) BR0314183A (no)
IL (1) IL166821A (no)
IS (1) IS7829A (no)
MX (1) MXPA05003344A (no)
NO (1) NO20052124L (no)
PT (1) PT1551835E (no)
RU (1) RU2323218C2 (no)
SI (1) SI1551835T1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2368614C2 (ru) * 2004-02-04 2009-09-27 НьюроСёрч А/С Диазабициклические арильные производные в качестве модуляторов холинергических рецепторов
JO3019B1 (ar) * 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
CN101432286A (zh) * 2006-05-30 2009-05-13 神经研究公司 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途
WO2008016123A1 (en) * 2006-08-03 2008-02-07 Takeda Pharmaceutical Company Limited GSK-3β INHIBITOR
JP2010519193A (ja) * 2007-02-15 2010-06-03 アージェンタ ディスカバリー リミテッド Ｍ３ムスカリン受容体としての複素環式誘導体
EP2780015B1 (en) 2011-11-18 2017-01-04 Heptares Therapeutics Limited Muscarinic m1 receptor agonists
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
MX391850B (es) * 2015-12-10 2025-03-19 Ptc Therapeutics Inc Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington
CN108752286B (zh) * 2016-09-18 2021-05-11 广西师范大学 1，2，8-氧代二氮杂环壬烷衍生物及其合成方法和应用
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
WO1995018129A1 (en) * 1993-12-29 1995-07-06 Pfizer Inc. Diazabicyclic neurokinin antagonists
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
EP1202990A2 (en) * 1999-07-09 2002-05-08 Ortho-McNeil Pharmaceutical, Inc. Neurotrophic pyrrolidines and piperidines, and related compositions containing them
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
FR2809731B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
FR2832713B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
NO20052124D0 (no) 2005-04-29
JP2006503062A (ja) 2006-01-26
IL166821A (en) 2009-06-15
IL166821A0 (en) 2006-01-15
KR20050062575A (ko) 2005-06-23
SI1551835T1 (sl) 2007-06-30
IS7829A (is) 2005-04-28
CN1326857C (zh) 2007-07-18
BR0314183A (pt) 2005-08-09
CN1684965A (zh) 2005-10-19
JP4711391B2 (ja) 2011-06-29
RU2005105048A (ru) 2005-11-20
RU2323218C2 (ru) 2008-04-27
HK1081954A1 (en) 2006-05-26
PT1551835E (pt) 2007-03-30
MXPA05003344A (es) 2005-11-23

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