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NO20052728L - Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister - Google Patents

Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister

Info

Publication number
NO20052728L
NO20052728L NO20052728A NO20052728A NO20052728L NO 20052728 L NO20052728 L NO 20052728L NO 20052728 A NO20052728 A NO 20052728A NO 20052728 A NO20052728 A NO 20052728A NO 20052728 L NO20052728 L NO 20052728L
Authority
NO
Norway
Prior art keywords
sup
antagonists
receptor agonists
serotonin receptor
novel compounds
Prior art date
Application number
NO20052728A
Other languages
English (en)
Other versions
NO20052728D0 (no
Inventor
Taekyu Lee
Wenting Chen
Wei Deng
Albert Robichaud
Ruth Wexler
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20052728D0 publication Critical patent/NO20052728D0/no
Publication of NO20052728L publication Critical patent/NO20052728L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår nye forbindelser representert ved strukturell Formel (I): R eller et farmasøytisk akseptabelt salt derav, hvor R1, R4a, R5, R6, R7, R8, R9,og m, er definert her. Oppfinnelsen vedrører videre farmasøytiske formuleringer omfattende disse nye forbindelser som aktive bestanddeler og anvendelse av de nye forbindelsene og deres formuleringer ved behandling av visse sentralnervesystem lidelser. Forbindelsene ifølge foreliggende oppfinnelse er serotonin reseptor-modulatorer, spesielt 5HT2C reseptor-agonister og antagonister og er anvendelige for kontroll eller forebygging av sentralnervesystem lidelser omfattende fedme, anoreksi, bulemi, depresjon, angst, psykose, schizofreni, migrene, vanedannende adferd, obsessiv tvangslidelse og seksuelle lidelser.
NO20052728A 2002-12-19 2005-06-07 Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister NO20052728L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43476002P 2002-12-19 2002-12-19
PCT/US2003/041447 WO2004056324A2 (en) 2002-12-19 2003-12-19 Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists

Publications (2)

Publication Number Publication Date
NO20052728D0 NO20052728D0 (no) 2005-06-07
NO20052728L true NO20052728L (no) 2005-08-23

Family

ID=32682101

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052728A NO20052728L (no) 2002-12-19 2005-06-07 Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister

Country Status (10)

Country Link
US (1) US7109339B2 (no)
EP (1) EP1581221B1 (no)
JP (1) JP4486505B2 (no)
AT (1) ATE509929T1 (no)
AU (1) AU2003303210A1 (no)
ES (1) ES2364046T3 (no)
IS (1) IS7891A (no)
NO (1) NO20052728L (no)
PL (1) PL377426A1 (no)
WO (1) WO2004056324A2 (no)

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Also Published As

Publication number Publication date
WO2004056324A2 (en) 2004-07-08
US20040180875A1 (en) 2004-09-16
IS7891A (is) 2005-06-10
EP1581221A2 (en) 2005-10-05
JP2006511568A (ja) 2006-04-06
EP1581221B1 (en) 2011-05-18
AU2003303210A8 (en) 2004-07-14
EP1581221A4 (en) 2008-11-26
PL377426A1 (pl) 2006-02-06
AU2003303210A1 (en) 2004-07-14
US7109339B2 (en) 2006-09-19
ATE509929T1 (de) 2011-06-15
WO2004056324A3 (en) 2004-09-02
JP4486505B2 (ja) 2010-06-23
NO20052728D0 (no) 2005-06-07
ES2364046T3 (es) 2011-08-23

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