NO20051757L - Process for the preparation of 2-azadihydroxy-bicyclo [2.2.2] -heptane derivatives - Google Patents
Process for the preparation of 2-azadihydroxy-bicyclo [2.2.2] -heptane derivativesInfo
- Publication number
- NO20051757L NO20051757L NO20051757A NO20051757A NO20051757L NO 20051757 L NO20051757 L NO 20051757L NO 20051757 A NO20051757 A NO 20051757A NO 20051757 A NO20051757 A NO 20051757A NO 20051757 L NO20051757 L NO 20051757L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compound
- azadihydroxy
- bicyclo
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000006359 acetalization reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Abstract
Fremgangsmåte ved fremstilling av en forbindelse. Fremgangsmåte ved frenstilling av en forbindelse av formel i" VXD"-" hvor R er hydrogen eller henholdsvis en gruppe av formel R, Ri hvor Ri er alkyl og Ar er eventuelt substituert aryl, Rj. og Rj'. er hydrogen, alkyl eller fenyl eller Rv og Rb-' tatt sammen med karbonatomet til hvilket de er bundet danner cykloalkyl omfattende syreassistert acetaliserir.g eller ketalisering av en forbindelse av formel hvor alkoksy, eller tatt sammen .med karbon- atom.et til hvilket de er bundet danner karbonyl med (IR) diastereomeren av 2-azadlhydrcksybicyklo[2.2.1j heptanfor- bindc-lson ifølge formel HOk HO 1- V-N-f (1) elltjr salt derav i isopcopanol.Process for preparing a compound. A process for preparing a compound of formula in "VXD" - "wherein R is hydrogen or, respectively, a group of formula R, R 1 wherein R 1 is alkyl and Ar is optionally substituted aryl, R 1 and R 2 'are hydrogen, alkyl or phenyl. or Rv and Rb taken together with the carbon atom to which they are attached form cycloalkyl comprising acid-assisted acetalization or ketallization of a compound of formula wherein alkoxy, or taken together with the carbon atom to which they are attached forms carbonyl with (IR) the diastereomer of 2-azadylhydroxybicyclo [2.2.1] heptane compound-ccone of formula HOk HO 1- VNf (1) or its salt in isopcopanol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/732,024 US5684159A (en) | 1995-05-30 | 1996-10-16 | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
| PCT/US1997/018365 WO1998016510A1 (en) | 1996-10-16 | 1997-10-15 | Process for preparing 2-azadihydroxybicyclo[2.2.1]heptane compounds and the l-tartaric acid salt of the compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20051757L true NO20051757L (en) | 1999-06-15 |
| NO20051757D0 NO20051757D0 (en) | 2005-04-08 |
Family
ID=24941881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991800A NO320332B1 (en) | 1996-10-16 | 1999-04-15 | Process for Preparation of 2-Azadihydroxybicyclo [2.2.2] Heptane Compounds and L-Tartaric Acid Salts of the Compounds |
| NO20051757A NO20051757D0 (en) | 1996-10-16 | 2005-04-08 | Process for the preparation of 2-azadihydroxybicyclo [2.2.2] -heptane compounds and L-tartaric acid salts of the compounds |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991800A NO320332B1 (en) | 1996-10-16 | 1999-04-15 | Process for Preparation of 2-Azadihydroxybicyclo [2.2.2] Heptane Compounds and L-Tartaric Acid Salts of the Compounds |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US5684159A (en) |
| EP (1) | EP0934268A4 (en) |
| JP (1) | JP2001502329A (en) |
| KR (1) | KR20000049195A (en) |
| CN (2) | CN1094927C (en) |
| AP (1) | AP942A (en) |
| AU (1) | AU721965B2 (en) |
| BG (2) | BG64701B1 (en) |
| BR (1) | BR9711910A (en) |
| CA (1) | CA2268652A1 (en) |
| CZ (1) | CZ291387B6 (en) |
| EA (3) | EA200100660A1 (en) |
| HU (1) | HUP9903583A3 (en) |
| IL (1) | IL129231A (en) |
| NO (2) | NO320332B1 (en) |
| OA (1) | OA11112A (en) |
| PL (1) | PL332827A1 (en) |
| SK (1) | SK43799A3 (en) |
| UA (1) | UA52702C2 (en) |
| WO (1) | WO1998016510A1 (en) |
| ZA (1) | ZA979268B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
| ES2216252T3 (en) * | 1997-12-25 | 2004-10-16 | Kuraray Co., Ltd. | PREPARATION PROCEDURE AND METHOD OF CRYSTALLIZATION OF 2-AZABICICLO (2.2.1) HEPTA-5-EN-3-ONA. |
| TW396337B (en) * | 1998-02-13 | 2000-07-01 | Mediatek Inc | The automatic regulating device of cdrom optimum focusing spot and the method thereof |
| US5952339A (en) * | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| US6057446A (en) * | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
| US5986100A (en) * | 1998-04-02 | 1999-11-16 | Crooks; Peter Anthony | Pharmaceutical compositions and methods for use |
| DE69920045T2 (en) | 1998-12-31 | 2005-09-29 | Aventis Pharmaceuticals Inc. | METHOD FOR PRODUCING N6 SUBSTITUTED DEAZA ADENOSINE DERIVATIVES |
| US6387033B1 (en) | 2000-11-22 | 2002-05-14 | Council Of Scientific And Industrial Research | Preparation of new layered double hydroxides exchanged with osmate for asymmetric dihydroxylation of olefins to vicinal diols |
| JP2005507371A (en) * | 2001-05-10 | 2005-03-17 | アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | NOVEL PROCESS FOR PRODUCING ADENOSINE COMPOUND AND INTERMEDIATE THEREOF |
| EP1574508A1 (en) * | 2004-01-30 | 2005-09-14 | Lonza AG | Process for the preparation of acetals and ketals of 3-amimo-5-(hydroxymethyl)-cyclopentane-1,2-diols and their derivatives and salts |
| WO2008044702A1 (en) * | 2006-10-11 | 2008-04-17 | Nippon Soda Co., Ltd. | Process for production of azabicycloalkanol derivative |
| CN102311440B (en) * | 2010-07-02 | 2015-01-07 | 无锡药明康德生物技术有限公司 | 1-methoxycarbonyl-3-benzyl-8-tertiarybutoxy carbonyl-3,8-diazabicyclo [3.2.1] octane and preparation method |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK532575A (en) * | 1974-12-13 | 1976-06-14 | Merck & Co Inc | PROCEDURE FOR RACEMATIC DECOMPOSITION OF ORGANIC COMPOUNDS |
| US4508911A (en) * | 1982-06-21 | 1985-04-02 | The Upjohn Company | Amine intermediates for analgesic compounds |
| US5284769A (en) * | 1989-10-16 | 1994-02-08 | Chiros Ltd. | Process for preparing a single enantiomer of a lactam using lactamase |
| CA2032124A1 (en) * | 1989-12-13 | 1991-06-14 | Theunis G. Fourie | Polycyclic nitrile compounds and pharmaceutical compositions thereof |
| JP2891740B2 (en) * | 1990-03-30 | 1999-05-17 | 塩野義製薬株式会社 | Method for producing optically active norbornane-based amine derivative |
| EP0550631B1 (en) * | 1990-09-25 | 1997-01-02 | Rhone-Poulenc Rorer International (Holdings) Inc. | Compounds having antihypertensive and anti-ischemic properties |
| US5700895A (en) * | 1993-08-23 | 1997-12-23 | Sumitomo Chemical Company, Limited | Ethylene-α-olefin copolymer and molded article thereof |
| US5670649A (en) * | 1995-05-30 | 1997-09-23 | Rhone-Poulenc Rorer S.A. | Derivatives of 2-azabicyclo 2.2.1!heptane, their preparation and their application |
| US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
| FR2734822B1 (en) * | 1995-05-30 | 1997-07-04 | Rhone Poulenc Rorer Sa | NEW 2-AZABICYCLO (2.2.1) HEPTANE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION |
| US5856497A (en) * | 1995-12-11 | 1999-01-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines |
-
1996
- 1996-10-16 US US08/732,024 patent/US5684159A/en not_active Expired - Fee Related
-
1997
- 1997-06-10 US US08/873,096 patent/US5886192A/en not_active Expired - Fee Related
- 1997-06-10 US US08/873,284 patent/US5831096A/en not_active Expired - Fee Related
- 1997-06-10 US US08/873,285 patent/US5808093A/en not_active Expired - Fee Related
- 1997-10-15 CN CN97198783A patent/CN1094927C/en not_active Expired - Fee Related
- 1997-10-15 BR BR9711910A patent/BR9711910A/en not_active Application Discontinuation
- 1997-10-15 PL PL97332827A patent/PL332827A1/en not_active IP Right Cessation
- 1997-10-15 AP APAP/P/1999/001486A patent/AP942A/en active
- 1997-10-15 IL IL12923197A patent/IL129231A/en unknown
- 1997-10-15 EA EA200100660A patent/EA200100660A1/en unknown
- 1997-10-15 KR KR1019990703293A patent/KR20000049195A/en not_active Abandoned
- 1997-10-15 EA EA199900382A patent/EA002438B1/en not_active IP Right Cessation
- 1997-10-15 SK SK437-99A patent/SK43799A3/en unknown
- 1997-10-15 JP JP10518472A patent/JP2001502329A/en not_active Ceased
- 1997-10-15 UA UA99052680A patent/UA52702C2/en unknown
- 1997-10-15 CA CA002268652A patent/CA2268652A1/en not_active Abandoned
- 1997-10-15 EP EP97910894A patent/EP0934268A4/en not_active Withdrawn
- 1997-10-15 AU AU48160/97A patent/AU721965B2/en not_active Ceased
- 1997-10-15 EA EA200100661A patent/EA200100661A1/en unknown
- 1997-10-15 CZ CZ19991312A patent/CZ291387B6/en not_active IP Right Cessation
- 1997-10-15 WO PCT/US1997/018365 patent/WO1998016510A1/en not_active Ceased
- 1997-10-15 HU HU9903583A patent/HUP9903583A3/en unknown
- 1997-10-16 ZA ZA979268A patent/ZA979268B/en unknown
-
1999
- 1999-03-30 BG BG103296A patent/BG64701B1/en unknown
- 1999-03-30 BG BG108906A patent/BG64733B1/en unknown
- 1999-04-09 OA OA9900080A patent/OA11112A/en unknown
- 1999-04-15 NO NO19991800A patent/NO320332B1/en unknown
-
2002
- 2002-06-05 CN CN02122409A patent/CN1385422A/en active Pending
-
2005
- 2005-04-08 NO NO20051757A patent/NO20051757D0/en unknown
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