[go: up one dir, main page]

NO20051665L - Antibiotiske mikrosfaerer for behandling av infeksjoner og osteomyelitt - Google Patents

Antibiotiske mikrosfaerer for behandling av infeksjoner og osteomyelitt

Info

Publication number
NO20051665L
NO20051665L NO20051665A NO20051665A NO20051665L NO 20051665 L NO20051665 L NO 20051665L NO 20051665 A NO20051665 A NO 20051665A NO 20051665 A NO20051665 A NO 20051665A NO 20051665 L NO20051665 L NO 20051665L
Authority
NO
Norway
Prior art keywords
antibiotic
infections
microspheres
treatment
osteomyelitis
Prior art date
Application number
NO20051665A
Other languages
English (en)
Inventor
Catherine G Ambrose
Antonios G Mikos
Terry A Clyburn
Original Assignee
Clyburn Terry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clyburn Terry filed Critical Clyburn Terry
Publication of NO20051665L publication Critical patent/NO20051665L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Bionedbrytbare mikrosfærer implantert, injisert, eller på annen måte plassert helt eller delvis inne i kroppen er i stand til nesten-lineær kontrollert frigjøring av et antibiotikum for en forhåndsbestemt tidsperiode for behandling og forebygging av infeksjoner som involverer kroppen. Mikrosfærene er dannet av polymelkesyre-ko-glykolsyre (PLGA) og en effektiv mengde av et antibiotikum som er tilstrekkelig til å produsere baktericide nivåer i kroppsvev, og kan innbefatte polyetylenglykol (PEG), eller ikke. Mikrosfærene oppviser nesten-lineær levering av antibiotikumet i minst 4 uker på nivåer som overskrider minste hemmende konsentrasjon (MIC) for bakterier som det er vanlig å finne som årsak til infeksjoner.
NO20051665A 2002-09-05 2005-04-04 Antibiotiske mikrosfaerer for behandling av infeksjoner og osteomyelitt NO20051665L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40850202P 2002-09-05 2002-09-05
US40849602P 2002-09-05 2002-09-05
PCT/US2003/028010 WO2004022000A2 (en) 2002-09-05 2003-09-05 Antibiotic microspheres for treatment of infections and osteomyelitis

Publications (1)

Publication Number Publication Date
NO20051665L true NO20051665L (no) 2005-05-31

Family

ID=31981593

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051665A NO20051665L (no) 2002-09-05 2005-04-04 Antibiotiske mikrosfaerer for behandling av infeksjoner og osteomyelitt

Country Status (11)

Country Link
US (1) US20040131681A1 (no)
EP (1) EP1549246B1 (no)
AT (1) ATE555748T1 (no)
AU (1) AU2003272284B2 (no)
CA (1) CA2497973C (no)
CR (1) CR7777A (no)
ES (1) ES2388623T3 (no)
MX (1) MXPA05002589A (no)
NO (1) NO20051665L (no)
NZ (1) NZ539166A (no)
WO (1) WO2004022000A2 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1596765A2 (en) * 2003-02-10 2005-11-23 Smith & Nephew, Inc. Resorbable devices
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
WO2007020432A2 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc High strength devices and composites
DE102005040429A1 (de) * 2005-08-25 2007-03-01 Heraeus Kulzer Gmbh Wirkstofffreisetzungssystem und seine Verwendung
CA2679365C (en) 2006-11-30 2016-05-03 Smith & Nephew, Inc. Fiber reinforced composite material
WO2008129245A1 (en) 2007-04-18 2008-10-30 Smith & Nephew Plc Expansion moulding of shape memory polymers
WO2008131197A1 (en) 2007-04-19 2008-10-30 Smith & Nephew, Inc. Multi-modal shape memory polymers
AU2008243035B2 (en) 2007-04-19 2013-09-12 Smith & Nephew, Inc. Graft fixation
GB0814302D0 (en) * 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
WO2011088296A1 (en) * 2010-01-15 2011-07-21 William Marsh Rice University Combined space maintenance and bone regeneration system for the reconstruction of large osseous defects
EP2908870B1 (en) 2012-10-16 2018-05-23 SurModics, Inc. Wound packing device and methods
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
US10029031B2 (en) * 2015-10-28 2018-07-24 Warsaw Orthopedic, Inc. Bone void filler having sustained therapeutic agent release

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236355A (en) * 1961-12-21 1966-02-22 Pitney Bowes Inc Mail handling device
US6217911B1 (en) * 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US6410056B1 (en) * 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5718921A (en) * 1987-03-13 1998-02-17 Massachusetts Institute Of Technology Microspheres comprising polymer and drug dispersed there within
US5690954A (en) * 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US5236355A (en) * 1988-12-22 1993-08-17 American Cyanamid Company Apparatus for the treatment of periodontal disease
JP3116311B2 (ja) * 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
US6197346B1 (en) * 1992-04-24 2001-03-06 Brown Universtiy Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
FR2692147B1 (fr) * 1992-06-15 1995-02-24 Centre Nat Rech Scient Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament.
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5569468A (en) * 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
GB9406094D0 (en) * 1994-03-28 1994-05-18 Univ Nottingham And University Polymer microspheres and a method of production thereof
FR2718642B1 (fr) * 1994-04-15 1996-07-12 Pf Medicament Microsphères biodégradables à libération contrôlée et leur procédé de préparation.
GB9412273D0 (en) * 1994-06-18 1994-08-10 Univ Nottingham Administration means
US5599889A (en) * 1994-08-16 1997-02-04 Stoever; Harald D. H. Method of forming polymer microspheres
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
JP2909418B2 (ja) * 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5578650A (en) * 1995-12-01 1996-11-26 Minnesota Mining And Manufacturing Company Methods of preparing hollow acrylate polymer microspheres
KR0162872B1 (ko) * 1996-04-01 1998-12-01 김은영 용매추출법을 이용한 생분해성 고분자 미립구의 개선된 제조방법 및 이를 이용한 국소염증 질환 치료용 미립구의 제조방법
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
GB9710699D0 (en) * 1997-05-24 1997-07-16 Danbiosyst Uk Gastro-retentive controlled release system
US6248345B1 (en) * 1997-07-02 2001-06-19 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
US6153210A (en) * 1997-08-14 2000-11-28 Periodontix, Inc. Use of locally delivered metal ions for treatment of periodontal disease
US6841617B2 (en) * 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
AU779277B2 (en) * 1999-06-04 2005-01-13 Alza Corporation Implantable gel compositions and method of manufacture
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100446101B1 (ko) * 2000-12-07 2004-08-30 주식회사 삼양사 수난용성 약물의 서방성 제형 조성물

Also Published As

Publication number Publication date
EP1549246A2 (en) 2005-07-06
MXPA05002589A (es) 2005-09-20
WO2004022000A3 (en) 2004-06-10
EP1549246A4 (en) 2008-11-05
AU2003272284B2 (en) 2009-03-05
CR7777A (es) 2008-10-08
CA2497973C (en) 2012-11-06
EP1549246B1 (en) 2012-05-02
US20040131681A1 (en) 2004-07-08
AU2003272284A1 (en) 2004-03-29
ES2388623T3 (es) 2012-10-17
CA2497973A1 (en) 2004-03-18
ATE555748T1 (de) 2012-05-15
NZ539166A (en) 2008-03-28
WO2004022000A2 (en) 2004-03-18

Similar Documents

Publication Publication Date Title
NO20051665L (no) Antibiotiske mikrosfaerer for behandling av infeksjoner og osteomyelitt
CO5700767A2 (es) Procedimiento de tratamiento de rechazo de transplantes
AR023130A1 (es) Composiciones para promover el crecimiento
FIC20190031I1 (fi) Rifamysiini SV
NO20073529L (no) Preparater og fremgangsmater for behandling av tilstander i negleenheten
JO2373B1 (en) W-carboxy-aryl diphenyl urease substitutes used as RAV inhibitors
BRPI0514420A (pt) peptìdeo, variante do mesmo, ou um sal farmaceuticamente aceitável do mesmo, composição, uso de um peptìdeo ou de uma variante de peptìdeo, substrato, e, métodos de tratamento ou prevenção de um infecção microbiana, e de tratamento de uma ferida em um indivìduo
WO2000015202A3 (de) Topisch anwendbare mittel
ATE531419T1 (de) Vorrichtung zur verabreichung von therapeutischen mitteln
MXPA03007881A (es) Bacterias productoras de acido lactico para tratar y prevenir la alergia.
DE69932939D1 (de) Fulvinsäure und dessen verwendung zur behandlung von diversen krankheitszuständen
AU2002211536A1 (en) Compositions for injection or intravenous administration for the treatment of internal infection or inflammation in humans and animals
HK1047707A1 (zh) (+)-曲马朵、o-去甲曲马朵或(+)-o-去甲曲马朵、o-去甲-n-单-去甲-曲马朵或(+)-o-去甲-n-单-去甲-曲马朵治疗尿失禁的用途
BR0111989A (pt) Peptìdeos, composições e processos para o tratamento de burkholderia cepacia
WO2005054234A8 (en) Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy
PT1001775E (pt) Medicamento contendo ioimbina e arginina para tratamento de disfuncao erectil
NZ509105A (en) Cyclic 24-membered depsipeptides for controlling ectoparasites
WO2004009773A3 (en) Methods and compositions for activating or inhibiting vegf-d and vegf-c
DE60138629D1 (de) Laspartomycin-derivate, sowie ihre herstellung und verwendung
TW200635616A (en) Organic compounds
GB0623258D0 (en) Thiadiazole derivatives for the treatment of neuro-degenerative diseases
GB2413764A (en) Anthelmintic composition
GB9505082D0 (en) Medicament
WO2007076053A8 (en) Stable s-nitrosothiol formulations
GB2377638B (en) Treatment of infection in animals

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application