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NO20050244L - Epimeriserte derivater av K5-polysakkarid med en meget hoy grad av sulfatering - Google Patents

Epimeriserte derivater av K5-polysakkarid med en meget hoy grad av sulfatering

Info

Publication number
NO20050244L
NO20050244L NO20050244A NO20050244A NO20050244L NO 20050244 L NO20050244 L NO 20050244L NO 20050244 A NO20050244 A NO 20050244A NO 20050244 A NO20050244 A NO 20050244A NO 20050244 L NO20050244 L NO 20050244L
Authority
NO
Norway
Prior art keywords
epik5
sulfation
oversulfate
epimerized
high degree
Prior art date
Application number
NO20050244A
Other languages
English (en)
Inventor
Giorgio Zoppetti
Pasqua Anna Oreste
Original Assignee
Glycores 2000 Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT2002MI001346A external-priority patent/ITMI20021346A1/it
Priority claimed from IT2002MI001345A external-priority patent/ITMI20021345A1/it
Priority claimed from ITMI20021854 external-priority patent/ITMI20021854A1/it
Application filed by Glycores 2000 Srl filed Critical Glycores 2000 Srl
Publication of NO20050244L publication Critical patent/NO20050244L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Det beskrives en ny fremgangsmåte for oversulfatering av et epiK5-N-sulfat for å danne et epiK5-amin-O-oversulfat med en meget høy grad av sulfatering, hvilket etter påfølgende N-sulfatering gir nye epiK5-N,O-oversulfat-derivater med en grad av sulfatering på minst 4, som er hovedsakelig frie for aktivitet overfor koaguleringsparametrene, og som er anvendelige på det kosmetiske eller farmasøytiske område. Beskrevet er også nye lavmolekylære epiK5-N-sulfater som er anvendelige som mellomprodukter ved fremstilling av de tilsvarende LMW-epiK5-N,O-oversulfat-derivater.
NO20050244A 2002-06-18 2005-01-17 Epimeriserte derivater av K5-polysakkarid med en meget hoy grad av sulfatering NO20050244L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT2002MI001346A ITMI20021346A1 (it) 2002-06-18 2002-06-18 Polisaccaridi a basso peso molecolare e procedimento per la loro preparazione
IT2002MI001345A ITMI20021345A1 (it) 2002-06-18 2002-06-18 Derivati epimerizzati del polissacaride k5 a elevatissimo grado di solfatazione
ITMI20021854 ITMI20021854A1 (it) 2002-08-27 2002-08-27 Polisaccaride supersolfatato a basso peso molecolare.
PCT/IB2003/002338 WO2003106504A1 (en) 2002-06-18 2003-06-17 Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation

Publications (1)

Publication Number Publication Date
NO20050244L true NO20050244L (no) 2005-03-16

Family

ID=29740492

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20050247A NO20050247L (no) 2002-06-18 2005-01-17 Lavmolekylaert oversulfatert polysakkarid
NO20050244A NO20050244L (no) 2002-06-18 2005-01-17 Epimeriserte derivater av K5-polysakkarid med en meget hoy grad av sulfatering
NO20050245A NO20050245L (no) 2002-06-18 2005-01-17 Fremgangsmate for fremstilling av N-acyl-(epi)K5-amin-o-sulfat-derivater og de derved oppnadde produkter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20050247A NO20050247L (no) 2002-06-18 2005-01-17 Lavmolekylaert oversulfatert polysakkarid

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20050245A NO20050245L (no) 2002-06-18 2005-01-17 Fremgangsmate for fremstilling av N-acyl-(epi)K5-amin-o-sulfat-derivater og de derved oppnadde produkter

Country Status (15)

Country Link
US (4) US20050245736A1 (no)
EP (3) EP1513880B1 (no)
JP (3) JP2005530877A (no)
CN (3) CN1675249A (no)
AT (1) ATE485308T1 (no)
AU (3) AU2003240191A1 (no)
BR (3) BR0312197A (no)
CA (3) CA2489866A1 (no)
DE (1) DE60334617D1 (no)
IL (2) IL165807A (no)
MX (3) MXPA04012721A (no)
NO (3) NO20050247L (no)
NZ (3) NZ537216A (no)
PL (3) PL375088A1 (no)
WO (3) WO2003106506A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
CN1675249A (zh) * 2002-06-18 2005-09-28 格利考斯2000有限公司 N－酰基－(表)k5－胺－o－硫酸盐衍生物及其产品的制备方法
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
FR2871379B1 (fr) * 2004-06-14 2006-09-29 Ifremer Utilisation de derives polysaccharidiques hautement sulfates et de faible masse molaire pour moduler l'angiogenese
FR2871476B1 (fr) * 2004-06-14 2011-04-01 Ifremer Derives depolymerises sulfates d'exopolysaccharides (eps) provenant de bacteries marines mesophiles, leur procede de preparation et leurs utilisations en regeneration tissulaire
EP1951260A4 (en) * 2005-10-21 2009-11-11 Bezwada Biomedical Llc FUNCTIONALIZED PHENOLIC COMPOUNDS AND POURABLE ARTICLES THEREOF
BR112022027064A2 (pt) * 2020-07-02 2023-03-07 Institut Francais De Rech Pour Lexploitation De La Mer Ifremer Derivados de exopolissacarídeos de bactérias marinhas e usos dos mesmos no tratamento de mucopolissacaridoses

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FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
DE3787996T2 (de) * 1986-05-16 1994-03-03 Italfarmaco Spa Heparine, frei von E.D.T.A., Fraktionen und Fragmente von Heparin, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, welche diese enthalten.
EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
GB2286193A (en) 1991-03-28 1995-08-09 Italfarmaco Spa Anticoagulants and processes for preparing such
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IT1289613B1 (it) * 1997-02-07 1998-10-15 Inalco Spa Polisaccaridi batterici o-solfatati
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US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US20050027117A1 (en) * 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
ITMI20032498A1 (it) * 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20010779A1 (it) * 2001-04-12 2002-10-12 Giorgio Zoppetti Uso di polisaccaridi batterici solfati atti all'inibizione dell'angiogenesi
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
ITMI20012200A1 (it) * 2001-10-22 2003-04-22 Ibsa Inst Biochimique Sa Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti
ITMI20021294A1 (it) * 2002-06-12 2003-12-12 Inalco Spa Polisaccaridi batterici o-solfatati e loro uso
CN1675249A (zh) * 2002-06-18 2005-09-28 格利考斯2000有限公司 N－酰基－(表)k5－胺－o－硫酸盐衍生物及其产品的制备方法
ITMI20032614A1 (it) * 2003-12-30 2005-06-30 Altergon Sa Nuova composizione comprendente cs

Also Published As

Publication number Publication date
AU2003240191A1 (en) 2003-12-31
EP1513880A1 (en) 2005-03-16
US7838644B2 (en) 2010-11-23
EP1513880B1 (en) 2010-10-20
US20050256079A1 (en) 2005-11-17
IL165807A (en) 2011-10-31
US20050245736A1 (en) 2005-11-03
JP2005533878A (ja) 2005-11-10
PL375087A1 (en) 2005-11-14
MXPA04012721A (es) 2005-08-15
CA2489870A1 (en) 2003-12-24
IL165807A0 (en) 2006-01-15
CN1675249A (zh) 2005-09-28
ATE485308T1 (de) 2010-11-15
EP1519961A1 (en) 2005-04-06
US20060014718A1 (en) 2006-01-19
NO20050245L (no) 2005-03-16
PL375088A1 (en) 2005-11-14
CN1671744A (zh) 2005-09-21
BR0312197A (pt) 2005-04-05
AU2003240190A1 (en) 2003-12-31
WO2003106505A9 (en) 2004-02-26
AU2003240190B2 (en) 2009-07-09
JP2005536577A (ja) 2005-12-02
JP5053512B2 (ja) 2012-10-17
CA2489866A1 (en) 2003-12-24
PL373004A1 (en) 2005-08-08
CA2489862C (en) 2012-03-27
CN1675250A (zh) 2005-09-28
NO20050247L (no) 2005-03-16
DE60334617D1 (de) 2010-12-02
NZ537217A (en) 2005-09-30
EP1517924A1 (en) 2005-03-30
BR0312179A (pt) 2005-04-05
US8193166B2 (en) 2012-06-05
IL165808A0 (en) 2006-01-15
CA2489862A1 (en) 2003-12-24
MXPA04012714A (es) 2005-08-15
MXPA04012805A (es) 2005-08-19
WO2003106504A1 (en) 2003-12-24
NZ537215A (en) 2006-11-30
US20110021766A1 (en) 2011-01-27
AU2003242881A1 (en) 2003-12-31
CN1675250B (zh) 2012-11-14
WO2003106505A1 (en) 2003-12-24
BR0312182A (pt) 2005-04-05
WO2003106506A1 (en) 2003-12-24
NZ537216A (en) 2005-05-27
JP2005530877A (ja) 2005-10-13

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