NO20050073L - Ring-substituted diphenyllazetidinones, their preparation, their use, and drugs containing the compounds - Google Patents
Ring-substituted diphenyllazetidinones, their preparation, their use, and drugs containing the compoundsInfo
- Publication number
- NO20050073L NO20050073L NO20050073A NO20050073A NO20050073L NO 20050073 L NO20050073 L NO 20050073L NO 20050073 A NO20050073 A NO 20050073A NO 20050073 A NO20050073 A NO 20050073A NO 20050073 L NO20050073 L NO 20050073L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- preparation
- substituted
- ring
- diphenyllazetidinones
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- VDOXIAUNJCHYRC-UHFFFAOYSA-N 1,3-diphenylazetidin-2-one Chemical class O=C1C(C=2C=CC=CC=2)CN1C1=CC=CC=C1 VDOXIAUNJCHYRC-UHFFFAOYSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Det beskrives ringsubstituerte difenylazetidinoner med formel 1, en fremgangsmåte for fremstilling derav, medikamenter inneholdende forbindelsene samt forbindelsenes anvendelse for behandling av hyperlipidemi, arteriosklerose og hyperkolesterolemi.There are disclosed ring-substituted diphenylazetidinones of formula 1, a process for their preparation, medicaments containing the compounds, and the use of the compounds for the treatment of hyperlipidemia, arteriosclerosis and hypercholesterolemia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10227506A DE10227506A1 (en) | 2002-06-19 | 2002-06-19 | Ring-substituted diphenylazetidinones, processes for their preparation, pharmaceutical compositions containing them and their use |
| PCT/EP2003/005815 WO2004000804A1 (en) | 2002-06-19 | 2003-06-04 | Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20050073L true NO20050073L (en) | 2005-01-06 |
Family
ID=29719281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20050073A NO20050073L (en) | 2002-06-19 | 2005-01-06 | Ring-substituted diphenyllazetidinones, their preparation, their use, and drugs containing the compounds |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1517892B1 (en) |
| JP (1) | JP2005533072A (en) |
| CN (1) | CN1662493A (en) |
| AR (1) | AR039689A1 (en) |
| AT (1) | ATE478842T1 (en) |
| AU (1) | AU2003242616B2 (en) |
| BR (1) | BR0311940A (en) |
| CA (1) | CA2490109A1 (en) |
| DE (2) | DE10227506A1 (en) |
| EC (1) | ECSP045498A (en) |
| HN (1) | HN2003000183A (en) |
| HR (1) | HRP20041203A2 (en) |
| IL (1) | IL165791A0 (en) |
| MA (1) | MA27252A1 (en) |
| MX (1) | MXPA04012236A (en) |
| MY (1) | MY135850A (en) |
| NO (1) | NO20050073L (en) |
| NZ (1) | NZ537304A (en) |
| OA (1) | OA12868A (en) |
| PA (1) | PA8576001A1 (en) |
| PE (1) | PE20040577A1 (en) |
| PL (1) | PL372690A1 (en) |
| RS (1) | RS108504A (en) |
| RU (1) | RU2315754C2 (en) |
| SV (1) | SV2004001549A (en) |
| TN (1) | TNSN04255A1 (en) |
| TW (1) | TW200404774A (en) |
| UY (1) | UY27851A1 (en) |
| WO (1) | WO2004000804A1 (en) |
| ZA (1) | ZA200409381B (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7447226B2 (en) * | 2003-10-31 | 2008-11-04 | International Business Machines Corporation | Methods and apparatus for continuous connectivity between mobile device and network using dynamic connection spreading |
| ATE485267T1 (en) | 2003-12-23 | 2010-11-15 | Astrazeneca Ab | DIPHENYLAZETIDINONE DERIVATIVES WITH CHOLESTERINE ABSORPTION INHIBITING EFFECT |
| WO2006060461A1 (en) | 2004-12-03 | 2006-06-08 | Schering Corporation | Substituted piperazines as cb1 antagonists |
| EP1865947A1 (en) | 2005-04-04 | 2007-12-19 | Pontificia Universidad Catolica de Chile | The use of ezetimibe in the prevention and treatment of cholesterol gallstones |
| ATE450526T1 (en) | 2005-06-20 | 2009-12-15 | Schering Corp | PIPERIDINE DERIVATIVES SUITABLE AS ANTAGONISTS OF HISTAMINE H3 |
| SA06270191B1 (en) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions |
| TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| EP2061767B1 (en) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
| EP2091915A1 (en) * | 2006-11-02 | 2009-08-26 | Sanofi-Aventis Deutschland GmbH | Novel diphenylazetidinone substituted by piperazine-1-sulfonic acid having improved pharmacological properties |
| DE102007002260A1 (en) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Use of substituted pyranonic acid derivatives for the preparation of medicaments for the treatment of the metabolic syndrome |
| EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
| DE102007054497B3 (en) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Novel crystalline diphenylazetidinone hydrates and process for their preparation |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (en) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | Azetidinone compound and medical applications thereof |
| CN102482312A (en) | 2009-08-26 | 2012-05-30 | 赛诺菲 | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| EP2582709B1 (en) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| EP2683699B1 (en) | 2011-03-08 | 2015-06-24 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683705B1 (en) | 2011-03-08 | 2015-04-22 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120053A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| WO2012120056A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| CZ293957B6 (en) * | 1995-10-31 | 2004-08-18 | Scheringácorporation | Hypocholesterolemic sugar-substituted 2-azetidinones, pharmaceutical composition and a kit containing thereof |
| DE10042447A1 (en) * | 2000-08-29 | 2002-03-28 | Aventis Pharma Gmbh | Vertebrate intestinal protein that absorbs cholesterol and use of this protein to identify inhibitors of intestinal cholesterol transport |
-
2002
- 2002-06-19 DE DE10227506A patent/DE10227506A1/en not_active Withdrawn
-
2003
- 2003-01-17 HN HN2003000183A patent/HN2003000183A/en unknown
- 2003-06-02 SV SV2003001549A patent/SV2004001549A/en not_active Application Discontinuation
- 2003-06-04 AU AU2003242616A patent/AU2003242616B2/en not_active Ceased
- 2003-06-04 AT AT03760591T patent/ATE478842T1/en active
- 2003-06-04 BR BR0311940-8A patent/BR0311940A/en not_active IP Right Cessation
- 2003-06-04 MX MXPA04012236A patent/MXPA04012236A/en active IP Right Grant
- 2003-06-04 JP JP2004514660A patent/JP2005533072A/en not_active Abandoned
- 2003-06-04 RU RU2005101091/04A patent/RU2315754C2/en not_active IP Right Cessation
- 2003-06-04 OA OA1200400330A patent/OA12868A/en unknown
- 2003-06-04 DE DE50313017T patent/DE50313017D1/en not_active Expired - Lifetime
- 2003-06-04 WO PCT/EP2003/005815 patent/WO2004000804A1/en not_active Ceased
- 2003-06-04 EP EP03760591A patent/EP1517892B1/en not_active Expired - Lifetime
- 2003-06-04 CN CN03814087XA patent/CN1662493A/en active Pending
- 2003-06-04 NZ NZ537304A patent/NZ537304A/en unknown
- 2003-06-04 HR HR20041203A patent/HRP20041203A2/en not_active Application Discontinuation
- 2003-06-04 RS YUP-1085/04A patent/RS108504A/en unknown
- 2003-06-04 CA CA002490109A patent/CA2490109A1/en not_active Abandoned
- 2003-06-04 PL PL03372690A patent/PL372690A1/en not_active Application Discontinuation
- 2003-06-16 UY UY27851A patent/UY27851A1/en unknown
- 2003-06-17 TW TW092116319A patent/TW200404774A/en unknown
- 2003-06-17 AR ARP030102142A patent/AR039689A1/en unknown
- 2003-06-18 MY MYPI20032289A patent/MY135850A/en unknown
- 2003-06-18 PA PA20038576001A patent/PA8576001A1/en unknown
- 2003-06-18 PE PE2003000613A patent/PE20040577A1/en not_active Application Discontinuation
-
2004
- 2004-11-22 ZA ZA200409381A patent/ZA200409381B/en unknown
- 2004-12-08 MA MA27990A patent/MA27252A1/en unknown
- 2004-12-15 IL IL16579104A patent/IL165791A0/en unknown
- 2004-12-16 EC EC2004005498A patent/ECSP045498A/en unknown
- 2004-12-17 TN TNP2004000255A patent/TNSN04255A1/en unknown
-
2005
- 2005-01-06 NO NO20050073A patent/NO20050073L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE10227506A1 (en) | 2004-01-08 |
| PA8576001A1 (en) | 2004-02-07 |
| TW200404774A (en) | 2004-04-01 |
| ECSP045498A (en) | 2005-03-10 |
| WO2004000804A1 (en) | 2003-12-31 |
| RS108504A (en) | 2007-02-05 |
| ZA200409381B (en) | 2006-05-31 |
| RU2315754C2 (en) | 2008-01-27 |
| HRP20041203A2 (en) | 2005-06-30 |
| EP1517892B1 (en) | 2010-08-25 |
| OA12868A (en) | 2006-09-15 |
| EP1517892A1 (en) | 2005-03-30 |
| AU2003242616A1 (en) | 2004-01-06 |
| CN1662493A (en) | 2005-08-31 |
| AU2003242616B2 (en) | 2008-12-11 |
| NZ537304A (en) | 2005-10-28 |
| DE50313017D1 (en) | 2010-10-07 |
| MA27252A1 (en) | 2005-03-01 |
| MXPA04012236A (en) | 2005-02-25 |
| TNSN04255A1 (en) | 2007-03-12 |
| AR039689A1 (en) | 2005-03-09 |
| UY27851A1 (en) | 2003-12-31 |
| IL165791A0 (en) | 2006-01-15 |
| ATE478842T1 (en) | 2010-09-15 |
| PE20040577A1 (en) | 2004-10-11 |
| MY135850A (en) | 2008-07-31 |
| RU2005101091A (en) | 2005-07-10 |
| SV2004001549A (en) | 2004-03-19 |
| JP2005533072A (en) | 2005-11-04 |
| PL372690A1 (en) | 2005-07-25 |
| CA2490109A1 (en) | 2003-12-31 |
| HN2003000183A (en) | 2003-08-01 |
| BR0311940A (en) | 2005-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |