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NO20050068L - New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing them - Google Patents

New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing them

Info

Publication number
NO20050068L
NO20050068L NO20050068A NO20050068A NO20050068L NO 20050068 L NO20050068 L NO 20050068L NO 20050068 A NO20050068 A NO 20050068A NO 20050068 A NO20050068 A NO 20050068A NO 20050068 L NO20050068 L NO 20050068L
Authority
NO
Norway
Prior art keywords
compounds
preparing
methods
drugs containing
antagonist effect
Prior art date
Application number
NO20050068A
Other languages
Norwegian (no)
Inventor
Heike-Andrea Wieland
Martin Lenter
Klaus Rudolf
Thorsten Lehmann-Lintz
Stephan Georg Mueller
Ralf Richard Hermann Lotz
Dirk Stenkamp
Philipp Lustenberger
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20050068L publication Critical patent/NO20050068L/en

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
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    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

Foreliggende oppfinnelse angår karboksamid-forbindelser med den generelle formel I a r'¿n'' v n a-^w^itB ' hvor gruppene og restene A, B, W, X, Y, Z, R', R^, R' og k har betydningene som er oppgitt i krav 1. Videre angår oppfinnelsen en fremgangsmåte for fremstilling av de ovennevnte karboksamider, så vel som farmasøytiske preparater som inneholder minst ett karboksamid ifølge oppfinnelsen. På bakgrunn av deies MCH-reseptorantagonistiske virkning er de farmasøytiske preparater ifølge oppfinnelsen egnet for behandling av metabolske lidelser og/eller spiseforstyrrelser, spesielt fedme, bulimi, anoreksi, hyperfagi og diabetes.BACKGROUND OF THE INVENTION The present invention relates to carboxamide compounds of the general formula I in which the groups and residues A, B, W, X, Y, Z, R ', R and k has the meanings given in claim 1. Furthermore, the invention relates to a process for the preparation of the above carboxamides, as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of these MCH receptor antagonistic effects, the pharmaceutical compositions of the invention are suitable for the treatment of metabolic disorders and / or eating disorders, especially obesity, bulimia, anorexia, hyperphagia and diabetes.

NO20050068A 2002-08-24 2005-01-06 New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing them NO20050068L (en)

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DE10238865A DE10238865A1 (en) 2002-08-24 2002-08-24 New carboxamides are melanin-concentrating hormone receptor antagonists, useful for treating e.g. metabolic diseases, diabetes, eating disorders, cardiovascular disease, emotional disorders, reproductive and memory disorders
PCT/EP2003/009099 WO2004024702A1 (en) 2002-08-24 2003-08-16 Novel carboxamide compounds having an mch-antagonistic effect, medicaments containing said compounds, and methods for the production thereof

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EP1534689A1 (en) 2005-06-01
CA2496563A1 (en) 2004-03-25
RS20050173A (en) 2007-09-21
MXPA05002158A (en) 2005-05-23
UA82853C2 (en) 2008-05-26
AU2003258620A1 (en) 2004-04-30
ZA200500086B (en) 2006-07-26

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