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NO20050841L - Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer - Google Patents

Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer

Info

Publication number
NO20050841L
NO20050841L NO20050841A NO20050841A NO20050841L NO 20050841 L NO20050841 L NO 20050841L NO 20050841 A NO20050841 A NO 20050841A NO 20050841 A NO20050841 A NO 20050841A NO 20050841 L NO20050841 L NO 20050841L
Authority
NO
Norway
Prior art keywords
sub
sup
optionally substituted
formula
inhibitors
Prior art date
Application number
NO20050841A
Other languages
English (en)
Inventor
Martin Redpath Johnson
Michael Dennis Dowle
Richard Graham Knowles
Alison Judith Redgrave
Peter Ward
Paul Spencer Jones
Caroline Mary Cook
Diane Mary Coe
Julie Nicole Hamblin
David George Allen
Christopher David Edlin
Mika Kristian Lindvall
Charlotte Jane Mitchell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0221455A external-priority patent/GB0221455D0/en
Priority claimed from GBGB0230045.7A external-priority patent/GB0230045D0/en
Priority claimed from GB0306595A external-priority patent/GB0306595D0/en
Priority claimed from GB0308017A external-priority patent/GB0308017D0/en
Priority claimed from GB0319708A external-priority patent/GB0319708D0/en
Priority claimed from GB0321074A external-priority patent/GB0321074D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20050841L publication Critical patent/NO20050841L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen angår en forbindelse med formel (I) eller et salt derav:hvor: RerC.alkyl,Ci.fluoralkyl, -CHCHOH eller -CHCHC0Ci.alkyl;. R 2 er et hydrogenatom (H), melyl eller Cjfluoralkyl;. Rer eventuelt substituert C3. gcykloalkyl eller eventuelt substituert mono-umettet C_cykloalkenyl eller en. eventuelt substituert. heterocyklisk gruppe med underformel (aa), (bb) eller (cc); hvor n' og n^ uavhengig er 1 eller 2; og hvor Y er O. S, S0eller NR; eller Rer en bicyklisk gruppe (dd) eller (ee); og hvor X er NRReller OR^ a. Forbindelsene er fosfodiesterase- (PDE) inhibitorer, spesielt PDE4-inhibitorer. Også 1 i 1 veiebragt er anvendelse av en forbindelse med formel (I) eller et farmasøytisk akseptabelt salt derav, ved fremstilling av et medikament for behandling og/eller forebygging av en inflammatorisk og/eller allergisk sykdom hos et pattedyr så som el menneske, foreksempel kronisk obstruktiv lungesykdom (KOLS), astma eller allergisk 1 h i nitt.
NO20050841A 2002-09-16 2005-02-16 Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer NO20050841L (no)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0221455A GB0221455D0 (en) 2002-09-16 2002-09-16 Compounds
GBGB0230045.7A GB0230045D0 (en) 2002-12-23 2002-12-23 Compounds
GB0306595A GB0306595D0 (en) 2003-03-21 2003-03-21 Compounds
GB0308017A GB0308017D0 (en) 2003-04-07 2003-04-07 Compounds
GB0319708A GB0319708D0 (en) 2003-08-21 2003-08-21 Compounds
GB0321074A GB0321074D0 (en) 2003-09-09 2003-09-09 Compounds
PCT/EP2003/011814 WO2004024728A2 (en) 2002-09-16 2003-09-12 Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
NO20050841L true NO20050841L (no) 2005-06-15

Family

ID=31999797

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050841A NO20050841L (no) 2002-09-16 2005-02-16 Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer

Country Status (23)

Country Link
US (2) US20060089375A1 (no)
EP (1) EP1539753B1 (no)
JP (1) JP2006503108A (no)
KR (1) KR20050052501A (no)
CN (1) CN100387598C (no)
AT (1) ATE442367T1 (no)
AU (1) AU2010201417A1 (no)
BR (1) BR0314392A (no)
CA (1) CA2497550A1 (no)
CY (1) CY1109619T1 (no)
DE (1) DE60329193D1 (no)
DK (1) DK1539753T3 (no)
ES (1) ES2331119T3 (no)
IL (1) IL166898A (no)
IS (1) IS7709A (no)
MA (1) MA27475A1 (no)
MX (1) MXPA05002887A (no)
NO (1) NO20050841L (no)
NZ (1) NZ538515A (no)
PL (1) PL375993A1 (no)
PT (1) PT1539753E (no)
SI (1) SI1539753T1 (no)
WO (1) WO2004024728A2 (no)

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PT1539753E (pt) 2009-12-10
CN100387598C (zh) 2008-05-14
MXPA05002887A (es) 2005-05-27
SI1539753T1 (sl) 2009-12-31
DK1539753T3 (da) 2010-01-04
EP1539753A2 (en) 2005-06-15
PL375993A1 (en) 2005-12-12
ES2331119T3 (es) 2009-12-22
CA2497550A1 (en) 2004-03-25
IS7709A (is) 2005-02-24
US20060089375A1 (en) 2006-04-27
NZ538515A (en) 2007-04-27
CY1109619T1 (el) 2014-08-13
US20080175914A1 (en) 2008-07-24
ATE442367T1 (de) 2009-09-15
KR20050052501A (ko) 2005-06-02
EP1539753B1 (en) 2009-09-09
BR0314392A (pt) 2005-07-12
IL166898A (en) 2010-06-30
AU2010201417A1 (en) 2010-04-29
AU2003285300A1 (en) 2004-04-30
WO2004024728A3 (en) 2004-10-21
CN1694882A (zh) 2005-11-09
JP2006503108A (ja) 2006-01-26
MA27475A1 (fr) 2005-08-01
WO2004024728A2 (en) 2004-03-25
DE60329193D1 (de) 2009-10-22

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