[go: up one dir, main page]

NO20045240L - Transepicutaneous administration to treat restless legs syndrome - Google Patents

Transepicutaneous administration to treat restless legs syndrome

Info

Publication number
NO20045240L
NO20045240L NO20045240A NO20045240A NO20045240L NO 20045240 L NO20045240 L NO 20045240L NO 20045240 A NO20045240 A NO 20045240A NO 20045240 A NO20045240 A NO 20045240A NO 20045240 L NO20045240 L NO 20045240L
Authority
NO
Norway
Prior art keywords
restless leg
leg syndrome
administration
transepicutaneous
restless legs
Prior art date
Application number
NO20045240A
Other languages
Norwegian (no)
Other versions
NO333619B1 (en
Inventor
Thomas Lauterbach
Erwin Schollmayer
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29285132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20045240(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of NO20045240L publication Critical patent/NO20045240L/en
Publication of NO333619B1 publication Critical patent/NO333619B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a trans-epicutaneous pharmaceutical composition containing Rotigotin for effective treatment of Restless Leg Syndrome (RLS), especially in the form of a transdermal therapeutic system (TDS) based on acrylate or silicone having a surface of 2.5 - 20 cm<2> and containing 1.125 9.0 mg/cm<2> Rotigotin as an active component against Restless Leg Syndrome, which, according to the International Restless Leg Syndrome Study Group (IRLSSG) Rating Scale, results in an improvement in the conditions of human Restless Leg Syndrome patients in comparison with a placebo treatment of 2 units or more, after administration over a period of time of at least 8 days.
NO20045240A 2002-05-06 2004-11-30 Transepicutaneous administration to treat restless leg syndrome NO333619B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10220230A DE10220230A1 (en) 2002-05-06 2002-05-06 Use of Rotigotine to treat restless leg syndrome
PCT/EP2003/004685 WO2003092677A1 (en) 2002-05-06 2003-05-05 Trans-epicutaneous administration form for treating restless leg syndrome

Publications (2)

Publication Number Publication Date
NO20045240L true NO20045240L (en) 2004-11-30
NO333619B1 NO333619B1 (en) 2013-07-22

Family

ID=29285132

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045240A NO333619B1 (en) 2002-05-06 2004-11-30 Transepicutaneous administration to treat restless leg syndrome

Country Status (23)

Country Link
EP (1) EP1501499B1 (en)
JP (2) JP5253707B2 (en)
KR (1) KR20040104697A (en)
CN (1) CN100396281C (en)
AT (1) ATE387912T1 (en)
AU (1) AU2003233233B2 (en)
BR (1) BR0309837A (en)
CA (2) CA2483120C (en)
CY (1) CY1107452T1 (en)
DE (2) DE10220230A1 (en)
DK (1) DK1501499T3 (en)
ES (1) ES2301795T3 (en)
IL (2) IL164861A0 (en)
MX (1) MXPA04010687A (en)
NO (1) NO333619B1 (en)
NZ (1) NZ536533A (en)
PL (1) PL218549B1 (en)
PT (1) PT1501499E (en)
RU (1) RU2301063C9 (en)
SI (1) SI1501499T1 (en)
UA (1) UA81625C2 (en)
WO (1) WO2003092677A1 (en)
ZA (1) ZA200408862B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041478A1 (en) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh New pharmaceutical composition
DE10359528A1 (en) * 2003-12-18 2005-07-28 Schwarz Pharma Ag (S) -2-N-propylamino-5-hydroxytetralin as a D3 agonist therapeutic
ES2466647T3 (en) * 2006-05-08 2014-06-10 Teikoku Seiyaku Co., Ltd. Absorbable preparation transdermally comprising an agent against dementia
TWI392670B (en) * 2006-06-22 2013-04-11 Ucb Pharma Gmbh Use of substituted 2-aminotetralines for the manufacture of a medicament for the prevention, alleviation and/or treatment of various types of pain
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
MY165575A (en) 2007-11-28 2018-04-05 Ucb Pharma Gmbh Polymorphic form of rotigotine
US20110028880A1 (en) 2008-02-27 2011-02-03 Hisamitsu Pharmaceutical Co., Inc. Patch
JP5546013B2 (en) 2008-02-27 2014-07-09 久光製薬株式会社 Patches and packaging
EP2201941A1 (en) 2008-12-29 2010-06-30 UCB Pharma GmbH Plaster production technology
EP2281559A1 (en) 2009-06-26 2011-02-09 UCB Pharma GmbH Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
CN102665699A (en) 2009-12-22 2012-09-12 优时比制药有限公司 Polyvinylpyrrolidone for stabilizing solid dispersions of rotigotine in non-crystalline form
US8729306B2 (en) 2010-02-05 2014-05-20 Ucb Pharma Gmbh Process for the preparation of nitrogen substituted aminotetralins derivatives
BR112012029944A2 (en) 2010-06-25 2019-09-24 Ucb Pharma Gmbh process for preparing nitrogen substituted aminotetralines derivatives
EP2559435A1 (en) 2011-08-19 2013-02-20 UCB Pharma GmbH Rotigotine in the treatment of hemispatial neglect, stroke and deficits following stroke
DE102012013439A1 (en) 2012-07-03 2014-01-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermal therapeutic system useful for treatment, alleviation and/or prophylaxis of e.g. Parkinson disease, depression and restless syndrome, comprises backing layer, matrix layer comprising rotigotin and protective film
WO2013075823A1 (en) 2011-11-22 2013-05-30 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermal therapeutic system comprising rotigotine and crystallization inhibitor
DE102012013421A1 (en) 2012-07-03 2014-01-09 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermal therapeutic system useful for treating, alleviating and/or preventing e.g. Parkinson's disease, depression, comprises backing layer, matrix layer comprising rotigotine, and protection film applied to part of matrix layer surface
KR101558042B1 (en) * 2012-07-05 2015-10-07 에스케이케미칼주식회사 Transdermal composition comprising rotigotine
EP2870963A4 (en) * 2012-07-06 2016-03-09 Sk Chemicals Co Ltd Preparation for percutaneous absorption containing rotigotine
TW201431570A (en) 2012-11-22 2014-08-16 Ucb Pharma Gmbh Multi-day patch for the transdermal administration of rotigotine
CA2916183C (en) 2013-07-03 2022-03-29 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with electronic component
MX2016011152A (en) 2014-02-27 2016-12-09 Medrx Co Ltd Pramipexole-containing transdermal patch for treatment of neurodegenerative disease.
US11752110B2 (en) 2014-05-20 2023-09-12 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an interface mediator
JP6573913B2 (en) 2014-05-20 2019-09-11 エルテーエス ローマン テラピー−ジステーメ アーゲー Transdermal delivery system containing rotigotine
CA2948219C (en) 2014-05-20 2023-04-04 Lts Lohmann Therapie-Systeme Ag Method for adjusting the release of active agent in a transdermal delivery system
KR102401412B1 (en) 2019-06-14 2022-05-23 히사미쓰 세이야꾸 가부시키가이샤 Rotigotine-containing patch
FI3854388T3 (en) 2020-01-24 2023-11-27 Luye Pharma Switzerland Ag A transdermal treatment system with the active ingredient rotigotine and at least one non-amine-resistant silicone adhesive

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5232702A (en) * 1991-07-22 1993-08-03 Dow Corning Corporation Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices
DE4238223C1 (en) * 1992-11-12 1994-05-26 Lohmann Therapie Syst Lts Transdermal therapeutic system for the administration of physostigmine to the skin and method for its production
US5482988A (en) * 1994-01-14 1996-01-09 Dow Corning Corporation Hot-melt silicone pressure sensitive adhesive with siloxylated polyether waxes as additives
IL116539A (en) * 1995-01-06 2002-02-10 Noven Pharma Compositions for transdermal delivery of acid-labile drugs
FR2749514B1 (en) * 1996-06-11 1998-08-07 Hoechst Marion Roussel TRANSDERMAL SYSTEMS CONTAINING 2 ACTIVE INGREDIENTS IN SEPARATE COMPARTMENTS, THEIR PREPARATION METHOD AND THEIR APPLICATION AS A MEDICAMENT
DE19701619B4 (en) * 1997-01-17 2007-10-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of pramipexole for the treatment of restless legs syndrome
DE19814084B4 (en) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2 agonist-containing transdermal therapeutic system for the treatment of Parkinson's syndrome and process for its preparation
DE19938825A1 (en) * 1999-08-19 2001-04-26 Boehringer Ingelheim Pharma Active ingredient combination with clonidine
DE19938823A1 (en) * 1999-08-19 2001-02-22 Boehringer Ingelheim Pharma Treatment of restless leg syndrome symptoms, using synergistic combination of alpha-2 agonist, preferably clonidine, and another neuro-psychic drug, e.g. pramipexol
DE10041479A1 (en) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh New pharmaceutical composition for the administration of N-0923
ES2203563T3 (en) * 2001-05-08 2004-04-16 Schwarz Pharma Ag IMPROVED TRANSDERMAL THERAPEUTIC SYSTEM FOR THE TREATMENT OF PARKINSON'S DISEASE.
DK1256339T3 (en) * 2001-05-08 2004-02-09 Sanol Arznei Schwarz Gmbh Transdermal therapeutic system for obtaining high plasma levels of rotigotine in the treatment of Parkinson's disease

Also Published As

Publication number Publication date
PL373276A1 (en) 2005-08-22
NO333619B1 (en) 2013-07-22
CA2483120A1 (en) 2003-11-13
MXPA04010687A (en) 2005-06-08
RU2004131866A (en) 2005-06-10
RU2301063C9 (en) 2007-11-27
RU2301063C2 (en) 2007-06-20
PL218549B1 (en) 2014-12-31
CA2483120C (en) 2013-07-16
KR20040104697A (en) 2004-12-10
ES2301795T3 (en) 2008-07-01
SI1501499T1 (en) 2008-06-30
AU2003233233A1 (en) 2003-11-17
BR0309837A (en) 2005-03-01
CA2787384A1 (en) 2003-11-13
JP5253707B2 (en) 2013-07-31
ZA200408862B (en) 2005-09-28
NZ536533A (en) 2010-02-26
UA81625C2 (en) 2008-01-25
HK1072541A1 (en) 2005-09-02
DK1501499T3 (en) 2008-06-23
IL164861A0 (en) 2005-12-18
CY1107452T1 (en) 2012-12-19
AU2003233233B2 (en) 2008-03-06
JP2005528413A (en) 2005-09-22
DE50309318D1 (en) 2008-04-17
JP2010159302A (en) 2010-07-22
CN1665497A (en) 2005-09-07
DE10220230A1 (en) 2003-11-27
EP1501499A1 (en) 2005-02-02
EP1501499B1 (en) 2008-03-05
IL164861A (en) 2011-06-30
WO2003092677A1 (en) 2003-11-13
ATE387912T1 (en) 2008-03-15
PT1501499E (en) 2008-05-20
CN100396281C (en) 2008-06-25

Similar Documents

Publication Publication Date Title
NO20045240L (en) Transepicutaneous administration to treat restless legs syndrome
SG146643A1 (en) Treating or preventing restless legs syndrome using prodrugs of gaba analogs
EP1587506A4 (en) ADMINISTRATION OF CAPSAICINOIDES
DK1346041T3 (en) Therapeutic agents and methods for their use in the treatment of an amyloidogenic disease
DE60316779D1 (en) THIADIAZOLYLPIPERAZINE DERIVATIVES SUITABLE FOR THE TREATMENT OF BZW. PREVENTION OF PAIN
NO20024586L (en) Method and Preparation for the Prevention of Hormone Induced Adverse Effects
RU2003128642A (en) IMPROVED TRANSMISSION THERAPEUTIC SYSTEM FOR TREATMENT OF PARKINSON&#39;S DISEASE
RU2003133217A (en) PERCUTANEAL THERAPEUTIC SYSTEM FOR THE TREATMENT OF PARKINSON&#39;S DISEASE, INDUCING HIGH LEVELS OF ROTIGOTINE IN PLASMA
BRPI0415953A (en) oral controlled release dosage formulation, method of treating a disorder, set of controlled release dosage forms and method for administering the formulation
DK1299130T3 (en) Method of treating and preventing infectious diseases
TW200517107A (en) Novel formulation
DE60323765D1 (en) INHIBITORS OF 17-BETA-HYDROXYSTEROIDDEHYDROGENASE OF TYPE 3 FOR THE TREATMENT OF ANDROGEN-DEPENDENT DISEASES
DE602004018944D1 (en) USE OF SUPPLEMENT FOR TREATMENT OF IRRITATION SYNDROME
ES2570401T3 (en) Methods of treatment using single doses of oritavancin
HK1082660A1 (en) Anti-microbial compositions and methods of using same
EE9900428A (en) Anti-cough formulations
DE50114474D1 (en) COMBINATION OF A TRANSDERMAL THERAPEUTIC SYSTEM AND ORAL AND / OR PARENTERAL PREPARATION CONTAINING DOPAMINAGONISTS FOR THE TREATMENT OF DOPAMINERGER ILLNESSES
DK1677806T3 (en) Compositions for the treatment of acute and congestion-induced sprains and stretching using hyaluronic acid
DE602005024571D1 (en) OPIOIDES FOR THE TREATMENT OF RESTLESSNESS IN THE LOWER LIMBS
EA200801731A1 (en) COMPOSITIONS AND METHODS OF TREATMENT OF TROBMOCYTHEMIA
TW200511999A (en) Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone
UA92498C2 (en) Cannabinoid active pharmaceutical ingredient for improved dosage forms
NZ594154A (en) Transdermal administration of buprenorphine for preoperative treatment of post operative pain
SE0102887D0 (en) New formulation
EP1603595A4 (en) Pharmaceutical composition for treatment of drug dependence

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees