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NO20043851L - Derivater av 4-(imidazol-5-yl)-2-(4-sulfoanilino) pyrimidin med CDK inhibitorisk aktivitet - Google Patents

Derivater av 4-(imidazol-5-yl)-2-(4-sulfoanilino) pyrimidin med CDK inhibitorisk aktivitet

Info

Publication number
NO20043851L
NO20043851L NO20043851A NO20043851A NO20043851L NO 20043851 L NO20043851 L NO 20043851L NO 20043851 A NO20043851 A NO 20043851A NO 20043851 A NO20043851 A NO 20043851A NO 20043851 L NO20043851 L NO 20043851L
Authority
NO
Norway
Prior art keywords
sulfoanilino
imidazol
pyrimidine
derivatives
inhibitory activity
Prior art date
Application number
NO20043851A
Other languages
English (en)
Inventor
Andrew Peter Thomas
Nicholas John Newcombe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20043851L publication Critical patent/NO20043851L/no

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med formel (I) hvor R, R, R,,5 og p er som definert i beskrivelsen og et farmasøytisk akseptabelt salt og in vivo hydrolyserbare estere er beskrevet. Også beskrevet er fremgangsmåter for deres fremstilling og anvendelse av dem som medikamenter, spesielt medikamenter for å produsere en cellecyklus-hemmende (anti-celleproliferasjon) effekt hos et varmblodig dyr, så som mennesker.
NO20043851A 2002-03-09 2004-09-14 Derivater av 4-(imidazol-5-yl)-2-(4-sulfoanilino) pyrimidin med CDK inhibitorisk aktivitet NO20043851L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0205693.5A GB0205693D0 (en) 2002-03-09 2002-03-09 Chemical compounds
PCT/GB2003/000983 WO2003076436A1 (en) 2002-03-09 2003-03-06 Derivatives of 4- (imidazol-5-yl)-2-(4-sulfoanilino) pyrimidine with cdk inhibitory activity

Publications (1)

Publication Number Publication Date
NO20043851L true NO20043851L (no) 2004-09-14

Family

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NO20043851A NO20043851L (no) 2002-03-09 2004-09-14 Derivater av 4-(imidazol-5-yl)-2-(4-sulfoanilino) pyrimidin med CDK inhibitorisk aktivitet

Country Status (21)

Country Link
US (1) US7465728B2 (no)
EP (1) EP1487823A1 (no)
JP (2) JP3569524B1 (no)
KR (1) KR20040091114A (no)
CN (1) CN1649863A (no)
AR (1) AR039563A1 (no)
AU (1) AU2003214394A1 (no)
BR (1) BR0308212A (no)
CA (1) CA2478701A1 (no)
GB (1) GB0205693D0 (no)
IL (1) IL163910A0 (no)
IS (1) IS7439A (no)
MX (1) MXPA04008807A (no)
NO (1) NO20043851L (no)
PL (1) PL372703A1 (no)
RU (1) RU2004130440A (no)
TW (1) TW200306838A (no)
UA (1) UA78292C2 (no)
UY (1) UY27705A1 (no)
WO (1) WO2003076436A1 (no)
ZA (1) ZA200406937B (no)

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IL163910A0 (en) 2005-12-18
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AU2003214394A1 (en) 2003-09-22
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AR039563A1 (es) 2005-02-23
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