NO20043696L - Gamma-sekretaseinhibitorer - Google Patents
Gamma-sekretaseinhibitorerInfo
- Publication number
- NO20043696L NO20043696L NO20043696A NO20043696A NO20043696L NO 20043696 L NO20043696 L NO 20043696L NO 20043696 A NO20043696 A NO 20043696A NO 20043696 A NO20043696 A NO 20043696A NO 20043696 L NO20043696 L NO 20043696L
- Authority
- NO
- Norway
- Prior art keywords
- secretase
- gamma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35561802P | 2002-02-06 | 2002-02-06 | |
| PCT/US2003/003471 WO2003066592A1 (en) | 2002-02-06 | 2003-02-05 | Gamma secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20043696L true NO20043696L (no) | 2004-11-05 |
| NO329067B1 NO329067B1 (no) | 2010-08-16 |
Family
ID=27734543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20043696A NO329067B1 (no) | 2002-02-06 | 2004-09-03 | Gamma-sekretaseinhibitorer, farmasoytiske preparater som omfatter forbindelsene, samt anvendelser av forbindelsene til fremstilling av medikamenter |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7208602B2 (no) |
| EP (1) | EP1472223A1 (no) |
| JP (1) | JP4758609B2 (no) |
| KR (1) | KR20040081489A (no) |
| CN (1) | CN1628100A (no) |
| AR (1) | AR038482A1 (no) |
| AU (1) | AU2003210865B2 (no) |
| BR (1) | BR0307492A (no) |
| CA (1) | CA2478423A1 (no) |
| CO (1) | CO5611195A2 (no) |
| EC (1) | ECSP045218A (no) |
| MX (1) | MXPA04007659A (no) |
| MY (1) | MY141504A (no) |
| NO (1) | NO329067B1 (no) |
| NZ (1) | NZ534223A (no) |
| PE (1) | PE20030977A1 (no) |
| PL (1) | PL371735A1 (no) |
| RU (1) | RU2004126864A (no) |
| TW (1) | TW200302717A (no) |
| WO (1) | WO2003066592A1 (no) |
| ZA (1) | ZA200406237B (no) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2304140C2 (ru) | 2001-12-27 | 2007-08-10 | Дайити Фармасьютикал Ко., Лтд. | ИНГИБИТОРЫ ПРОДУЦИРОВАНИЯ / СЕКРЕЦИИ β-АМИЛОИДНОГО БЕЛКА |
| US7256186B2 (en) | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
| US20040171614A1 (en) * | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| NZ542304A (en) | 2003-03-14 | 2009-07-31 | Ono Pharmaceutical Co | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
| CA2526487A1 (en) | 2003-06-30 | 2005-01-06 | Daiichi Pharmaceutical Co., Ltd. | Heterocyclic methyl sulfone derivative |
| ATE424383T1 (de) | 2003-08-08 | 2009-03-15 | Schering Corp | Cyclische amine mit benzamidsubstituent als bace- 1-inhibitoren |
| AR045219A1 (es) | 2003-08-08 | 2005-10-19 | Pharmacopeia Inc | Aminas ciclicas inhibidoras de base - 1 que poseen un sustiuyente heterociclico |
| EP1680406A1 (en) * | 2003-10-29 | 2006-07-19 | Elan Pharmaceuticals, Inc. | N-substituted benzene sulfonamides |
| EP1740570A2 (en) * | 2004-04-05 | 2007-01-10 | Schering Corporation | Novel gamma secretase inhibitors |
| EP1758884A2 (en) * | 2004-05-20 | 2007-03-07 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| US7763613B2 (en) * | 2004-06-30 | 2010-07-27 | Schering Corporation | Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors |
| JP4845883B2 (ja) * | 2004-07-13 | 2011-12-28 | エフ．ホフマン−ラ ロシュ アーゲー | スルホンアミド誘導体 |
| AR049726A1 (es) | 2004-07-22 | 2006-08-30 | Schering Corp | Amidas sustituidas inhibidoras de beta secretasa |
| ES2457041T3 (es) | 2004-09-13 | 2014-04-24 | Ono Pharmaceutical Co., Ltd. | Derivados de N-4-piperidilurea y medicamentos que los contienen como principio activo |
| GB0423356D0 (en) * | 2004-10-21 | 2004-11-24 | Merck Sharp & Dohme | Therapeutic agents |
| EP1916985A4 (en) * | 2005-08-19 | 2010-06-09 | Elan Pharm Inc | BRIDGED N-CYCLIC SULPHONAMIDE INHIBITORS OF THE GAMMED CRYSTETRY |
| BRPI0708731A2 (pt) | 2006-03-10 | 2011-06-07 | Ono Pharmaceutical Co | derivado heterocìclico nitrogenado, e agente farmacêutico compreendendo o derivado como ingrediente ativo |
| US20100226922A1 (en) * | 2006-06-08 | 2010-09-09 | Dorothea Maetzel | Specific protease inhibitors and their use in cancer therapy |
| CN101553481A (zh) * | 2006-09-29 | 2009-10-07 | 格吕伦塔尔有限公司 | 取代的磺酰胺衍生物 |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| JP2010510224A (ja) * | 2006-11-17 | 2010-04-02 | アボット・ラボラトリーズ | ケモカイン受容体拮抗薬としてのアミノピロリジン類 |
| DK2091948T3 (da) | 2006-11-30 | 2012-07-23 | Probiodrug Ag | Nye inhibitorer af glutaminylcyclase |
| US8080549B2 (en) * | 2007-01-12 | 2011-12-20 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2008147800A1 (en) * | 2007-05-25 | 2008-12-04 | Elan Pharmaceuticals, Inc. | Pyrazolopyrrolidines as inhibitors of gamma secretase |
| US20110251220A1 (en) * | 2008-06-03 | 2011-10-13 | Acikgoez Oezlem | Pharmaceutical compositions comprising gamma secretase modulators |
| EP2475428B1 (en) | 2009-09-11 | 2015-07-01 | Probiodrug AG | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| EA022420B1 (ru) | 2010-03-10 | 2015-12-30 | Пробиодруг Аг | Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
| EP2953940B1 (en) | 2013-02-07 | 2018-08-22 | Heptares Therapeutics Limited | Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic m4 receptor agonists |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2687146B1 (fr) * | 1992-02-12 | 1994-04-01 | Adir Cie | Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US6166037A (en) * | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
| GB9800750D0 (en) * | 1998-01-14 | 1998-03-11 | Lilly Co Eli | Pharmaceutical compound |
| GB9804426D0 (en) | 1998-03-02 | 1998-04-29 | Pfizer Ltd | Heterocycles |
| TW575561B (en) * | 1999-03-25 | 2004-02-11 | Hoffmann La Roche | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives |
| US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
-
2003
- 2003-01-30 TW TW092102236A patent/TW200302717A/zh unknown
- 2003-02-04 PE PE2003000130A patent/PE20030977A1/es not_active Application Discontinuation
- 2003-02-04 AR ARP030100346A patent/AR038482A1/es unknown
- 2003-02-05 PL PL03371735A patent/PL371735A1/xx not_active Application Discontinuation
- 2003-02-05 BR BR0307492-7A patent/BR0307492A/pt not_active IP Right Cessation
- 2003-02-05 JP JP2003565966A patent/JP4758609B2/ja not_active Expired - Fee Related
- 2003-02-05 WO PCT/US2003/003471 patent/WO2003066592A1/en not_active Ceased
- 2003-02-05 RU RU2004126864/04A patent/RU2004126864A/ru not_active Application Discontinuation
- 2003-02-05 CA CA002478423A patent/CA2478423A1/en not_active Abandoned
- 2003-02-05 MY MYPI20030381A patent/MY141504A/en unknown
- 2003-02-05 NZ NZ534223A patent/NZ534223A/en unknown
- 2003-02-05 KR KR10-2004-7012102A patent/KR20040081489A/ko not_active Ceased
- 2003-02-05 EP EP03737650A patent/EP1472223A1/en not_active Withdrawn
- 2003-02-05 US US10/358,898 patent/US7208602B2/en not_active Expired - Fee Related
- 2003-02-05 AU AU2003210865A patent/AU2003210865B2/en not_active Ceased
- 2003-02-05 CN CNA038032686A patent/CN1628100A/zh active Pending
- 2003-02-05 MX MXPA04007659A patent/MXPA04007659A/es active IP Right Grant
-
2004
- 2004-08-03 EC EC2004005218A patent/ECSP045218A/es unknown
- 2004-08-04 ZA ZA200406237A patent/ZA200406237B/en unknown
- 2004-08-06 CO CO04076759A patent/CO5611195A2/es not_active Application Discontinuation
- 2004-09-03 NO NO20043696A patent/NO329067B1/no not_active IP Right Cessation
-
2005
- 2005-10-03 US US11/242,337 patent/US20060100427A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO329067B1 (no) | 2010-08-16 |
| US20040048848A1 (en) | 2004-03-11 |
| ECSP045218A (es) | 2004-09-28 |
| JP4758609B2 (ja) | 2011-08-31 |
| RU2004126864A (ru) | 2005-07-10 |
| AU2003210865B2 (en) | 2008-01-31 |
| BR0307492A (pt) | 2004-11-23 |
| MY141504A (en) | 2010-05-14 |
| TW200302717A (en) | 2003-08-16 |
| US7208602B2 (en) | 2007-04-24 |
| US20060100427A1 (en) | 2006-05-11 |
| PE20030977A1 (es) | 2003-12-04 |
| AR038482A1 (es) | 2005-01-19 |
| MXPA04007659A (es) | 2005-06-08 |
| JP2005522437A (ja) | 2005-07-28 |
| NZ534223A (en) | 2007-05-31 |
| CA2478423A1 (en) | 2003-08-14 |
| ZA200406237B (en) | 2005-09-22 |
| KR20040081489A (ko) | 2004-09-21 |
| CN1628100A (zh) | 2005-06-15 |
| WO2003066592A1 (en) | 2003-08-14 |
| EP1472223A1 (en) | 2004-11-03 |
| CO5611195A2 (es) | 2006-02-28 |
| PL371735A1 (en) | 2005-06-27 |
| AU2003210865A1 (en) | 2003-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |