NO20042266L - Kombinasjoner av antistoffer selektive for en tumor nekrose faktor-relatert apoptose-induserende ligandreseptor og andre terapeutiske midler - Google Patents
Kombinasjoner av antistoffer selektive for en tumor nekrose faktor-relatert apoptose-induserende ligandreseptor og andre terapeutiske midlerInfo
- Publication number
- NO20042266L NO20042266L NO20042266A NO20042266A NO20042266L NO 20042266 L NO20042266 L NO 20042266L NO 20042266 A NO20042266 A NO 20042266A NO 20042266 A NO20042266 A NO 20042266A NO 20042266 L NO20042266 L NO 20042266L
- Authority
- NO
- Norway
- Prior art keywords
- therapeutic agents
- combinations
- necrosis factor
- tumor necrosis
- ligand receptor
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 108040000066 TRAIL receptor activity proteins Proteins 0.000 title 1
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 208000034615 apoptosis-related disease Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 102000053594 human TNFRSF10B Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000006654 negative regulation of apoptotic process Effects 0.000 abstract 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Mycology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34640201P | 2001-11-01 | 2001-11-01 | |
| US39147802P | 2002-06-24 | 2002-06-24 | |
| PCT/US2002/034420 WO2003038043A2 (en) | 2001-11-01 | 2002-10-25 | Combinations of dr5 antibody and other therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20042266L true NO20042266L (no) | 2004-07-23 |
| NO333828B1 NO333828B1 (no) | 2013-09-23 |
Family
ID=26994839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20042266A NO333828B1 (no) | 2001-11-01 | 2004-06-01 | In-vitro metode for selektivt å indusere apoptose i målceller som uttrykker DR5 og sammensetning |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1506285B1 (no) |
| JP (1) | JP4663232B2 (no) |
| KR (1) | KR20040081422A (no) |
| CN (1) | CN100506277C (no) |
| AT (1) | ATE491019T1 (no) |
| AU (1) | AU2002360307B2 (no) |
| BR (1) | BRPI0213846B8 (no) |
| CA (1) | CA2465314C (no) |
| CO (1) | CO5650175A2 (no) |
| DE (1) | DE60238560D1 (no) |
| HU (1) | HU230378B1 (no) |
| IL (2) | IL161686A0 (no) |
| MX (1) | MXPA04004184A (no) |
| NO (1) | NO333828B1 (no) |
| NZ (2) | NZ533164A (no) |
| PL (1) | PL216750B1 (no) |
| RO (1) | RO123525B1 (no) |
| RU (1) | RU2313368C2 (no) |
| WO (1) | WO2003038043A2 (no) |
| ZA (1) | ZA200403573B (no) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| JP3665316B2 (ja) | 2001-05-18 | 2005-06-29 | 麒麟麦酒株式会社 | 抗trail−r抗体 |
| US7361341B2 (en) | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| EP1409544B1 (en) | 2001-07-03 | 2009-06-17 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
| CA2463816C (en) | 2001-10-19 | 2014-07-08 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
| AU2008201431B2 (en) * | 2002-11-27 | 2011-11-24 | Irm, Llc | Methods and compositions for inducing Apoptosis in cancer cells |
| DE60334247D1 (de) * | 2002-11-27 | 2010-10-28 | Irm Llc | Verfahren und zusammensetzungen zur apoptoseinduktion in krebszellen |
| US20060228331A1 (en) | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
| WO2005037306A1 (en) * | 2003-10-17 | 2005-04-28 | Novo Nordisk A/S | Combination therapy |
| KR20070010046A (ko) * | 2004-04-06 | 2007-01-19 | 제넨테크, 인크. | Dr5 항체 및 그의 용도 |
| CA2575152A1 (en) | 2004-08-06 | 2006-02-16 | Genentech, Inc. | Method for predicting sensitivity of mammalian cells to apo2l/trail comprising deletion of biomarker expression |
| BRPI0513639A (pt) | 2004-08-06 | 2008-05-13 | Genentech Inc | métodos de previsão da sensibilidade, métodos de indução da apoptose e métodos de tratamento de disfunção em mamìferos e de cáncer |
| NZ553174A (en) * | 2004-09-08 | 2010-03-26 | Genentech Inc | Methods of using death receptor ligands Apo2L/Trail and CD20 antibodies |
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| US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
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| PT1192185E (pt) * | 1999-06-09 | 2006-11-30 | Genentech Inc | Sinergismo de agonista do receptor de apo-2l e cpt-11 |
| US6294546B1 (en) * | 1999-08-30 | 2001-09-25 | The Broad Of Trustees Of The Leland Stanford Junior University | Uses of diterpenoid triepoxides as an anti-proliferative agent |
| EP1226161A2 (en) * | 1999-09-15 | 2002-07-31 | Genentech, Inc. | Apo-2 receptor antibodies |
| DK1272647T3 (en) * | 2000-04-11 | 2014-12-15 | Genentech Inc | Multivalent antibodies and uses thereof |
| TWI318983B (en) * | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
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