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NO20042198L - Tetrahydrocarbazole derivatives as ligands for G protein-coupled receptors (GPCR). - Google Patents

Tetrahydrocarbazole derivatives as ligands for G protein-coupled receptors (GPCR).

Info

Publication number
NO20042198L
NO20042198L NO20042198A NO20042198A NO20042198L NO 20042198 L NO20042198 L NO 20042198L NO 20042198 A NO20042198 A NO 20042198A NO 20042198 A NO20042198 A NO 20042198A NO 20042198 L NO20042198 L NO 20042198L
Authority
NO
Norway
Prior art keywords
gpcr
ligands
protein
coupled receptors
tetrahydrocarbazole derivatives
Prior art date
Application number
NO20042198A
Other languages
Norwegian (no)
Other versions
NO326692B1 (en
Inventor
Holger Hess-Stumpp
Kenneth J Shaw
Marcus Koppitz
Hans-Peter Muhn
Klaus Paulini
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10164564A external-priority patent/DE10164564B4/en
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of NO20042198L publication Critical patent/NO20042198L/en
Publication of NO326692B1 publication Critical patent/NO326692B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20042198A 2001-12-14 2004-05-26 Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCRs), their use and pharmaceutical preparations containing these NO326692B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10164564A DE10164564B4 (en) 2001-12-14 2001-12-14 Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCR)
US34187801P 2001-12-21 2001-12-21
PCT/EP2002/014344 WO2003051837A2 (en) 2001-12-14 2002-12-16 Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr)

Publications (2)

Publication Number Publication Date
NO20042198L true NO20042198L (en) 2004-07-09
NO326692B1 NO326692B1 (en) 2009-02-02

Family

ID=26010882

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042198A NO326692B1 (en) 2001-12-14 2004-05-26 Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCRs), their use and pharmaceutical preparations containing these

Country Status (17)

Country Link
EP (1) EP1453803A2 (en)
JP (1) JP2005518375A (en)
CN (1) CN100500654C (en)
AR (1) AR037863A1 (en)
AU (1) AU2002361430B2 (en)
BR (1) BR0214958A (en)
CA (1) CA2468880A1 (en)
HR (1) HRP20040609A2 (en)
HU (1) HUP0500014A3 (en)
IL (2) IL161626A0 (en)
MX (1) MXPA04005768A (en)
NO (1) NO326692B1 (en)
NZ (1) NZ533430A (en)
PL (1) PL373400A1 (en)
RU (1) RU2319692C2 (en)
TW (1) TWI246423B (en)
WO (1) WO2003051837A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE537825T1 (en) * 2003-05-19 2012-01-15 Irm Llc IMMUNOSUPPRESSIVE COMPOUNDS AND COMPOSITIONS
US7351733B2 (en) * 2003-06-10 2008-04-01 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives and their pharmaceutical use
CA2538759C (en) * 2003-09-12 2015-11-03 Elixir Pharmaceuticals, Inc. Substituted heterocyclic compounds as sirtuin inhitibitors
US20060074124A1 (en) * 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
PL1732892T3 (en) * 2004-03-26 2009-03-31 Hoffmann La Roche Tetrahydrocarbazoles and derivatives
DE102004033902A1 (en) 2004-07-14 2006-02-16 Zentaris Gmbh New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease
RU2430088C2 (en) * 2004-07-14 2011-09-27 Центарис Гмбх Tetrahydrocarbazole derivatives and pharmaceutical composition based on said derivatives
NZ556657A (en) * 2004-12-27 2010-10-29 Actelion Pharmaceuticals Ltd 2,3,4,9-tetrahydro-1H-carbazole derivatives as CRTH2 receptor antagonists
BRPI0611705A2 (en) * 2005-06-24 2016-11-16 Lilly Co Eli compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and use of compound
CN101500996B (en) * 2006-08-07 2012-07-04 埃科特莱茵药品有限公司 (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
EP1967202A1 (en) * 2007-03-05 2008-09-10 AEterna Zentaris GmbH Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
EP2095818A1 (en) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
MX2012010820A (en) 2010-03-22 2012-10-10 Actelion Pharmaceuticals Ltd DERIVATIVES OF 3- (HETEROARIL-AMINO) -1, 2, 3, 4-TETRAHIDRO-9H-CARBAZO L AND ITS USE AS MODULATORS OF THE PROSTAGLANDINE RECEIVER D2.
WO2012140612A1 (en) 2011-04-14 2012-10-18 Actelion Pharmaceuticals Ltd 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
UA117780C2 (en) 2014-03-17 2018-09-25 Ідорсія Фармасьютікалз Лтд AZAINDOLACETIC ACID DERIVATIVES AND THEIR APPLICATIONS AS MODULATORS OF PROSTAGLANDIN D2 RECEPTORS
RU2016140708A (en) 2014-03-18 2018-04-18 Идорсиа Фармасьютиклз Лтд Acetic acid derivatives of azaindole and their use as modulators of the prostaglandin receptor D2
UA123156C2 (en) 2015-09-15 2021-02-24 Ідорсія Фармасьютікалз Лтд Crystalline forms

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1418703A (en) * 1973-06-02 1975-12-24 Pfizer Ltd 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles
BG25793A3 (en) * 1973-07-18 1978-12-12 Schering Aktiengesellschaft METHOD FOR OBTAINING CARBAZOLE DERIVATIVES
DE3786030T2 (en) * 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole esters.
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
JP2002502427A (en) * 1997-06-05 2002-01-22 メルク エンド カンパニー インコーポレーテッド Gonadotropin-releasing hormone antagonist

Also Published As

Publication number Publication date
CN1599720A (en) 2005-03-23
MXPA04005768A (en) 2004-09-10
WO2003051837A3 (en) 2004-02-26
AU2002361430A1 (en) 2003-06-30
JP2005518375A (en) 2005-06-23
AU2002361430B2 (en) 2007-09-13
IL161626A0 (en) 2004-09-27
EP1453803A2 (en) 2004-09-08
HUP0500014A2 (en) 2005-04-28
PL373400A1 (en) 2005-08-22
RU2004121776A (en) 2005-05-10
WO2003051837A2 (en) 2003-06-26
RU2319692C2 (en) 2008-03-20
NZ533430A (en) 2005-12-23
CA2468880A1 (en) 2003-06-26
CN100500654C (en) 2009-06-17
HUP0500014A3 (en) 2010-06-28
NO326692B1 (en) 2009-02-02
TWI246423B (en) 2006-01-01
IL192991A0 (en) 2011-08-01
TW200305405A (en) 2003-11-01
HRP20040609A2 (en) 2005-06-30
WO2003051837A8 (en) 2004-05-06
BR0214958A (en) 2004-12-28
AR037863A1 (en) 2004-12-09

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