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NO20040511L - Aminoisoxazolderivater som kinaseinhibitorer - Google Patents

Aminoisoxazolderivater som kinaseinhibitorer

Info

Publication number
NO20040511L
NO20040511L NO20040511A NO20040511A NO20040511L NO 20040511 L NO20040511 L NO 20040511L NO 20040511 A NO20040511 A NO 20040511A NO 20040511 A NO20040511 A NO 20040511A NO 20040511 L NO20040511 L NO 20040511L
Authority
NO
Norway
Prior art keywords
compounds
kinase inhibitors
aminoisoxazole derivatives
aminoisoxazole
derivatives
Prior art date
Application number
NO20040511A
Other languages
English (en)
Norwegian (no)
Inventor
Paolo Pevarello
Barbara Salom
Anna Vulpetti
Marcello Cavicchioli
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of NO20040511L publication Critical patent/NO20040511L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20040511A 2001-08-06 2004-02-03 Aminoisoxazolderivater som kinaseinhibitorer NO20040511L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92175101A 2001-08-06 2001-08-06
PCT/EP2002/008634 WO2003013517A1 (fr) 2001-08-06 2002-07-29 Dérivés d'aminoisoxazole agissant comme inhibiteurs de la kinase

Publications (1)

Publication Number Publication Date
NO20040511L true NO20040511L (no) 2004-03-23

Family

ID=25445927

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040511A NO20040511L (no) 2001-08-06 2004-02-03 Aminoisoxazolderivater som kinaseinhibitorer

Country Status (18)

Country Link
US (1) US20050059657A1 (fr)
EP (1) EP1435948A1 (fr)
JP (1) JP2005501073A (fr)
KR (1) KR20040030941A (fr)
CN (1) CN1549714A (fr)
AU (1) AU2002342607B2 (fr)
BR (1) BR0211742A (fr)
CA (1) CA2455631A1 (fr)
CO (1) CO5640104A2 (fr)
CZ (1) CZ2004168A3 (fr)
EA (1) EA006769B1 (fr)
IL (1) IL159926A0 (fr)
MX (1) MXPA04000920A (fr)
NO (1) NO20040511L (fr)
NZ (1) NZ530782A (fr)
PL (1) PL368403A1 (fr)
WO (1) WO2003013517A1 (fr)
ZA (1) ZA200400347B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027068A2 (fr) * 2001-09-24 2003-04-03 Elan Pharmaceuticals, Inc. Amines substituees pour le traitement de la maladie d'alzheimer
BRPI0413347A (pt) 2003-08-06 2006-10-10 Senomyx Inc novos sabores, modificadores de sabor, agentes de sabor, realçadores de sabor, agentes de sabor e/ou realçadores umami ou doces, e utilização correspondente
US7750160B2 (en) 2003-11-13 2010-07-06 Ambit Biosciences Corporation Isoxazolyl urea derivatives as kinase modulators
US7572914B2 (en) * 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20050250829A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Kinase inhibitors
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
AU2005245389A1 (en) 2004-05-12 2005-12-01 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
JP2008510734A (ja) * 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
ATE479687T1 (de) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinaseinhibitoren
US7645778B2 (en) 2005-01-19 2010-01-12 Bristol-Myers Squibb Company Heteroaryl compounds as P2Y1 receptor inhibitors
EP1850681B1 (fr) 2005-02-04 2019-12-18 Firmenich Incorporated Composes comportant des groupes fonctionnels d'heteroaryle lies et leur utilisation en tant que nouveaux modificateurs de saveur, agents gustatifs et exhausteurs de gout umami pour des compositions alimentaires
US8952176B2 (en) 2005-06-07 2015-02-10 Shionogi & Co., Ltd. Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity
TW200715993A (en) 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
WO2007002634A1 (fr) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Antagonistes carbocycliques et heherocycliques du recepteur p2y1, utiles pour traiter des etats pathologiques thrombotiques
ATE485269T1 (de) 2005-06-27 2010-11-15 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden
WO2007002584A1 (fr) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Mimetiques lineaires de l’uree antagonistes du recepteur p2y1, utilises dans le traitement des troubles thrombotiques
DE602006021306D1 (fr) 2005-06-27 2011-05-26 Bristol Myers Squibb Co
EP1772449A1 (fr) * 2005-10-05 2007-04-11 Bayer CropScience S.A. Derives de carboxamides N-alkyl-heterocycliques
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
CN101277952B (zh) * 2005-10-11 2011-09-28 弗·哈夫曼-拉罗切有限公司 异*唑衍生物
BRPI0618383A2 (pt) * 2005-11-09 2011-08-30 Hoffmann La Roche derivados de 3-aril-isoxazol-4-carbonil-benzofurano
KR101394245B1 (ko) * 2005-12-30 2014-05-14 에스케이바이오팜 주식회사 아이속사졸 유도체 및 이의 용도
JP5240775B2 (ja) 2006-03-30 2013-07-17 塩野義製薬株式会社 Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するイソキサゾール誘導体およびイソチアゾール誘導体
EP2010009B1 (fr) 2006-04-21 2017-06-14 Senomyx, Inc. Procédés de préparation de compositions aromatisantes solides
UA95480C2 (uk) * 2006-06-08 2011-08-10 Елі Ліллі Енд Компані Заміщені карбоксаміди
SG175609A1 (en) 2006-10-09 2011-11-28 Takeda Pharmaceutical Kinase inhibitors
EP2223925A1 (fr) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase
US8193225B2 (en) 2006-10-13 2012-06-05 The Board Of Regents Of The University Of Texas System Isoxazole amides, derivatives and methods of chemical induction of neurogenesis
WO2008046072A2 (fr) * 2006-10-13 2008-04-17 The Board Of Regents Of The University Of Texas System Inducteurs chimiques de la neurogénèse
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2009005269A2 (fr) * 2007-06-29 2009-01-08 Sk Holdings Co., Ltd. Composition pharmaceutique contenant des dérivés d'isoxazole destinée à prévenir et à traiter la resténose
AU2008299220B2 (en) 2007-09-10 2011-07-21 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2009076454A2 (fr) * 2007-12-12 2009-06-18 Calcimedica, Inc. Compositions qui modulant le calcium intracellulaire
WO2010027875A2 (fr) 2008-08-27 2010-03-11 Calcimedica Inc. Composés qui modulent le calcium intracellulaire
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
WO2011034962A2 (fr) 2009-09-16 2011-03-24 Calcimedica Inc. Composés qui modulent le calcium intracellulaire
CN103242256A (zh) * 2013-05-21 2013-08-14 苏州科捷生物医药有限公司 一种3-胺甲基-异噁唑盐酸盐的合成方法
KR101646180B1 (ko) * 2014-09-22 2016-08-05 한양대학교 에리카산학협력단 N-(5-아릴아미도-2-메틸페닐)-5-메틸이소옥사졸-4-카복스아미드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 fms 키나아제 저해제
JP2022508953A (ja) 2018-10-22 2022-01-19 アッセンブリー バイオサイエンシズ，インコーポレイテッド Ｈｂｖの処置のための５員のヘテロアリールカルボキサミド化合物
EP3995494B1 (fr) * 2020-11-06 2025-06-18 Eberhard Karls Universität Tübingen Modulateurs d'interactions protéine-protéine de l'aurora kinase a et leur utilisation dans la prévention et/ou le traitement du cancer
CN113069451B (zh) * 2021-04-02 2022-08-09 苏州大学 一种吡咯-2-磺酰胺化合物的制备方法及其在制备抗肿瘤药物中的应用
CN116283946B (zh) * 2023-03-27 2024-05-07 武汉工程大学 5-(n-取代吲哚-5-基)异噁唑-3-甲酸衍生物及其合成方法和应用
WO2024236054A1 (fr) * 2023-05-15 2024-11-21 Stichting Amsterdam UMC Nouveau traceur pour la détection in vivo de l'agrégation d'alpha-synucléine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1108397A (en) * 1965-08-18 1968-04-03 Geigy Ag J R 5-nitro-2-furyl-isoxazoles
GB1162257A (en) * 1965-09-22 1969-08-20 Danippon Pharmaceutical Co Ltd 3-(5-Nitro-2-Furyl) Isoxazole Derivatives and methods of preparation thereof
US3631169A (en) * 1966-09-22 1971-12-28 Dainippon Pharmaceutical Co 3-(5-nitro-2-furyl)isoxazoline derivatives
US3522252A (en) * 1968-04-03 1970-07-28 R & L Molecular Research Ltd Basic esters of 5-alkanoylamino-3-(5'-nitrofur - 2' - yl)isoxazole - 4 - carboxylic acid
GB1250219A (fr) * 1968-12-06 1971-10-20
US5968737A (en) * 1996-11-12 1999-10-19 The University Of Mississippi Method of identifying inhibitors of glutathione S-transferase (GST) gene expression
HUP0300340A3 (en) * 1999-08-13 2005-04-28 Vertex Pharmaceuticals Inc Cam Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases, pharmaceutical compositions containing them and their use
AU2001290940A1 (en) * 2000-09-15 2002-03-26 Vertex Pharmaceuticals Incorporated Isoxazoles and their use as inhibitors of erk

Also Published As

Publication number Publication date
CN1549714A (zh) 2004-11-24
CO5640104A2 (es) 2006-05-31
EA006769B1 (ru) 2006-04-28
IL159926A0 (en) 2004-06-20
CZ2004168A3 (cs) 2004-05-12
EP1435948A1 (fr) 2004-07-14
AU2002342607B2 (en) 2006-10-19
EA200400289A1 (ru) 2004-06-24
WO2003013517A1 (fr) 2003-02-20
BR0211742A (pt) 2004-08-24
PL368403A1 (en) 2005-03-21
JP2005501073A (ja) 2005-01-13
US20050059657A1 (en) 2005-03-17
KR20040030941A (ko) 2004-04-09
MXPA04000920A (es) 2004-04-02
ZA200400347B (en) 2005-03-30
NZ530782A (en) 2005-11-25
CA2455631A1 (fr) 2003-02-20

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