NO20040404L - 2- (3,5-bis-trifluorometyl-fenyl) - N - [6-(1,1-diokso-1lam bda6-tiomorfolin-4-yl) - 4 - (2-metyl- eller 4-fluor-2-metylsubstituert) fenyl-pyridin-3-yl] -N-metyl-isobutyrami. - Google Patents

2- (3,5-bis-trifluorometyl-fenyl) - N - [6-(1,1-diokso-1lam bda6-tiomorfolin-4-yl) - 4 - (2-metyl- eller 4-fluor-2-metylsubstituert) fenyl-pyridin-3-yl] -N-metyl-isobutyrami.

Info

Publication number: NO20040404L
Authority: NO; Norway
Prior art keywords: methyl; phenyl; bda6; isobutyramine; thiomorpholin
Prior art date: 2001-07-31

Application number

NO20040404A

Other languages

English (en)

Inventor

Andrew Sleight

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-31

Filing date

2004-01-29

Publication date

2004-01-29

2004-01-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-01-29 Publication of NO20040404L publication Critical patent/NO20040404L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Otolaryngology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Addiction (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

NO20040404A 2001-07-31 2004-01-29 2- (3,5-bis-trifluorometyl-fenyl) - N - [6-(1,1-diokso-1lam bda6-tiomorfolin-4-yl) - 4 - (2-metyl- eller 4-fluor-2-metylsubstituert) fenyl-pyridin-3-yl] -N-metyl-isobutyrami. NO20040404L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01118412		2001-07-31
PCT/EP2002/008311 WO2003011860A2 (en)	2001-07-31	2002-07-26	2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)-4-(2-METHYL OR 4-FLUORO-2-METHYL SUBSTITUTED)PHENYL-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE

Publications (1)

Publication Number	Publication Date
NO20040404L true NO20040404L (no)	2004-01-29

Family

ID=8178193

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20040404A NO20040404L (no)	2001-07-31	2004-01-29	2- (3,5-bis-trifluorometyl-fenyl) - N - [6-(1,1-diokso-1lam bda6-tiomorfolin-4-yl) - 4 - (2-metyl- eller 4-fluor-2-metylsubstituert) fenyl-pyridin-3-yl] -N-metyl-isobutyrami.

Country Status (29)

Country	Link
US (1)	US6849624B2 (no)
EP (1)	EP1414525B1 (no)
JP (1)	JP4700908B2 (no)
KR (1)	KR100577101B1 (no)
CN (1)	CN1289497C (no)
AR (1)	AR034921A1 (no)
AT (1)	ATE430600T1 (no)
BR (1)	BR0211523A (no)
CA (1)	CA2452502C (no)
DE (1)	DE60232246D1 (no)
EA (1)	EA006238B1 (no)
EC (1)	ECSP044963A (no)
ES (1)	ES2324209T3 (no)
GT (1)	GT200200159A (no)
HR (1)	HRP20040039A2 (no)
HU (1)	HUP0400398A3 (no)
MA (1)	MA27055A1 (no)
MX (1)	MXPA04000917A (no)
MY (1)	MY128464A (no)
NO (1)	NO20040404L (no)
NZ (1)	NZ530579A (no)
PA (1)	PA8551601A1 (no)
PE (1)	PE20030276A1 (no)
PL (1)	PL366986A1 (no)
UA (1)	UA77685C2 (no)
UY (1)	UY27403A1 (no)
WO (1)	WO2003011860A2 (no)
YU (1)	YU2704A (no)
ZA (1)	ZA200400652B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1385577T3 (da) *	2001-04-23	2006-08-21	Hoffmann La Roche	Anvendelse af NK-1-receptorantagonister mod godartet prostatahyperplasi
SE521512C2 (sv) *	2001-06-25	2003-11-11	Niconovum Ab	Anordning för administrering av en substans till främre delen av en individs munhåla
ATE359075T1 (de)	2002-12-20	2007-05-15	Niconovum Ab	Chemisch und physikalisch stabiles teilchenförmiges material enthaltend nikotin und microcrystalline cellulose
WO2004067007A1 (en) *	2003-01-31	2004-08-12	F. Hoffmann-La Roche Ag	NEW CRYSTALLINE MODIFICATION OF 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)-4(4-FLUORO-2-METHYL-PHENYL)-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE
CN1984891B (zh)	2004-07-06	2012-08-08	弗·哈夫曼-拉罗切有限公司	用作合成nk-1受体拮抗剂的中间体的甲酰胺吡啶衍生物的制备方法
US7176205B2 (en) *	2005-02-22	2007-02-13	Hoffmann-La Roche Inc.	Bi-pyridinyl derivatives as NK-1 antagonists
EP2281556A1 (en)	2005-02-25	2011-02-09	F. Hoffmann-La Roche AG	Tablets with improved drugs substance dispersibility
AU2007224584A1 (en)	2006-03-16	2007-09-20	Niconovum Ab	Improved snuff composition
GB0808747D0 (en)	2008-05-14	2008-06-18	Glaxo Wellcome Mfg Pte Ltd	Novel compounds
US10383894B2 (en) *	2010-03-17	2019-08-20	Lutran Industries, Inc.	Human medicinal treatment using salt of peroxymonosulfuric acid
RU2673084C2 (ru)	2013-11-08	2018-11-22	Киссеи Фармасьютикал Ко., Лтд.	Производное карбоксиметилпиперидина
TWI649307B (zh)	2014-05-07	2019-02-01	日商橘生藥品工業股份有限公司	Cyclohexylpyridine derivative
KR102860817B1 (ko)	2015-03-04	2025-09-16	반다 파마슈티칼즈, 인코퍼레이티드.	트라디피턴트에 의한 치료 방법
CA3101210A1 (en) *	2018-06-08	2019-12-12	Vanda Pharmaceuticals Inc.	Method of treatment with tradipitant

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
JPS6435115A (en) *	1987-07-31	1989-02-06	Nippon Seiko Kk	Bearing device
IL111960A (en)	1993-12-17	1999-12-22	Merck & Co Inc	Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
KR100286412B1 (ko)	1993-12-29	2001-04-16	더블유. 지. 콜	치환된 모르폴린 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
IL112778A0 (en)	1994-03-04	1995-05-26	Merck & Co Inc	Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US5972938A (en)	1997-12-01	1999-10-26	Merck & Co., Inc.	Method for treating or preventing psychoimmunological disorders
ES2226622T3 (es) *	1999-02-24	2005-04-01	F. Hoffmann-La Roche Ag	Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1.
DK1385577T3 (da)	2001-04-23	2006-08-21	Hoffmann La Roche	Anvendelse af NK-1-receptorantagonister mod godartet prostatahyperplasi

2002
- 2002-07-17 US US10/196,795 patent/US6849624B2/en not_active Expired - Fee Related
- 2002-07-25 PE PE2002000667A patent/PE20030276A1/es not_active Application Discontinuation
- 2002-07-26 NZ NZ530579A patent/NZ530579A/en unknown
- 2002-07-26 EA EA200400109A patent/EA006238B1/ru not_active IP Right Cessation
- 2002-07-26 KR KR1020047001322A patent/KR100577101B1/ko not_active Expired - Fee Related
- 2002-07-26 HU HU0400398A patent/HUP0400398A3/hu unknown
- 2002-07-26 EP EP02791471A patent/EP1414525B1/en not_active Expired - Lifetime
- 2002-07-26 JP JP2003517052A patent/JP4700908B2/ja not_active Expired - Fee Related
- 2002-07-26 AT AT02791471T patent/ATE430600T1/de active
- 2002-07-26 WO PCT/EP2002/008311 patent/WO2003011860A2/en not_active Ceased
- 2002-07-26 BR BR0211523-9A patent/BR0211523A/pt not_active Application Discontinuation
- 2002-07-26 PA PA20028551601A patent/PA8551601A1/es unknown
- 2002-07-26 ES ES02791471T patent/ES2324209T3/es not_active Expired - Lifetime
- 2002-07-26 CA CA2452502A patent/CA2452502C/en not_active Expired - Fee Related
- 2002-07-26 CN CNB028151100A patent/CN1289497C/zh not_active Expired - Fee Related
- 2002-07-26 PL PL02366986A patent/PL366986A1/xx not_active Application Discontinuation
- 2002-07-26 UA UA2004021462A patent/UA77685C2/uk unknown
- 2002-07-26 YU YU2704A patent/YU2704A/sh unknown
- 2002-07-26 DE DE60232246T patent/DE60232246D1/de not_active Expired - Lifetime
- 2002-07-26 MX MXPA04000917A patent/MXPA04000917A/es active IP Right Grant
- 2002-07-26 HR HR20040039A patent/HRP20040039A2/hr not_active Application Discontinuation
- 2002-07-29 AR ARP020102847A patent/AR034921A1/es not_active Application Discontinuation
- 2002-07-29 MY MYPI20022848A patent/MY128464A/en unknown
- 2002-07-30 UY UY27403A patent/UY27403A1/es not_active Application Discontinuation
- 2002-07-31 GT GT200200159A patent/GT200200159A/es unknown
2004
- 2004-01-27 ZA ZA200400652A patent/ZA200400652B/xx unknown
- 2004-01-29 EC EC2004004963A patent/ECSP044963A/es unknown
- 2004-01-29 NO NO20040404A patent/NO20040404L/no unknown
- 2004-01-30 MA MA27507A patent/MA27055A1/fr unknown

Also Published As

Publication number	Publication date
KR100577101B1 (ko)	2006-05-10
NZ530579A (en)	2006-02-24
MY128464A (en)	2007-02-28
UY27403A1 (es)	2003-04-30
PL366986A1 (en)	2005-02-07
JP2005500354A (ja)	2005-01-06
HRP20040039A2 (en)	2004-06-30
US20030064983A1 (en)	2003-04-03
BR0211523A (pt)	2004-09-14
WO2003011860A3 (en)	2003-09-04
CN1537025A (zh)	2004-10-13
MXPA04000917A (es)	2004-04-02
AR034921A1 (es)	2004-03-24
US6849624B2 (en)	2005-02-01
PE20030276A1 (es)	2003-03-29
ECSP044963A (es)	2004-03-23
ES2324209T3 (es)	2009-08-03
ZA200400652B (en)	2005-04-28
EA006238B1 (ru)	2005-10-27
CA2452502C (en)	2011-02-15
PA8551601A1 (es)	2003-06-30
CN1289497C (zh)	2006-12-13
EP1414525B1 (en)	2009-05-06
MA27055A1 (fr)	2004-12-20
CA2452502A1 (en)	2003-02-13
JP4700908B2 (ja)	2011-06-15
EP1414525A2 (en)	2004-05-06
YU2704A (sh)	2006-08-17
ATE430600T1 (de)	2009-05-15
EA200400109A1 (ru)	2004-08-26
GT200200159A (es)	2003-05-16
HK1069136A1 (en)	2005-05-13
DE60232246D1 (de)	2009-06-18
KR20040029386A (ko)	2004-04-06
WO2003011860A2 (en)	2003-02-13
HUP0400398A2 (hu)	2004-09-28
AU2002355652B2 (en)	2007-07-05
UA77685C2 (en)	2007-01-15
HUP0400398A3 (en)	2010-06-28

Publication	Publication Date	Title
NO20040632L (no)	2004-03-11	2-amino-4,5-trisubstituerte tiazolylderivater.
EE05386B1 (et)	2011-02-15	Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim
FR2806720B1 (fr)	2006-12-08	Derives de 2,2,6,6-diethyl-dimethyl-1-alcoxypiperidines et 1-oxydes correspondants
DK1321025T3 (da)	2007-06-11	Höstmaskine med afgrödetekeringsindretning
ATE303388T1 (de)	2005-09-15	Substituierte 2-pyridinyl-6,7,8,9- tetrahydropyrimidoc1,2-aöpyrimidin-4-on- und 7- pyridinyl-2,3-dihydroimidazo-c1,2-aöpyrimidin- 5(1h)onderivate
NO20040404L (no)	2004-01-29	2- (3,5-bis-trifluorometyl-fenyl) - N - [6-(1,1-diokso-1lam bda6-tiomorfolin-4-yl) - 4 - (2-metyl- eller 4-fluor-2-metylsubstituert) fenyl-pyridin-3-yl] -N-metyl-isobutyrami.
ATE253561T1 (de)	2003-11-15	2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-( - morpholin-4-yl-4-o-tolyl-pyridin-3-yl)- isobutyramid
EP1426370A4 (en)	2009-12-23	PROPANOLAMINE DERIVATIVE WITH 1,4-BENZODIOXANE CORE
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