NO20034473L - Anvendelse av selektive cox-2-inhibitorer ved behandling av urininkontinens - Google Patents
Anvendelse av selektive cox-2-inhibitorer ved behandling av urininkontinensInfo
- Publication number
- NO20034473L NO20034473L NO20034473A NO20034473A NO20034473L NO 20034473 L NO20034473 L NO 20034473L NO 20034473 A NO20034473 A NO 20034473A NO 20034473 A NO20034473 A NO 20034473A NO 20034473 L NO20034473 L NO 20034473L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- treatment
- urinary incontinence
- selective cox
- cox
- Prior art date
Links
- 206010046543 Urinary incontinence Diseases 0.000 title 1
- 229940111134 coxibs Drugs 0.000 title 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000733A ITMI20010733A1 (it) | 2001-04-05 | 2001-04-05 | Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria |
| PCT/EP2002/003850 WO2002080927A1 (fr) | 2001-04-05 | 2002-04-05 | Utilisation d'inhibiteurs selectifs de la cox-2 pour le traitement de l'incontinence urinaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20034473D0 NO20034473D0 (no) | 2003-10-06 |
| NO20034473L true NO20034473L (no) | 2003-12-05 |
Family
ID=11447449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20034473A NO20034473L (no) | 2001-04-05 | 2003-10-06 | Anvendelse av selektive cox-2-inhibitorer ved behandling av urininkontinens |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6440963B1 (fr) |
| EP (1) | EP1381369A1 (fr) |
| JP (1) | JP2004531514A (fr) |
| KR (1) | KR20030087046A (fr) |
| CN (1) | CN1688315A (fr) |
| AU (1) | AU2002253181B2 (fr) |
| BR (1) | BR0208694A (fr) |
| CA (1) | CA2443031A1 (fr) |
| HU (1) | HUP0303908A2 (fr) |
| IL (1) | IL158050A0 (fr) |
| IT (1) | ITMI20010733A1 (fr) |
| MX (1) | MXPA03008966A (fr) |
| NO (1) | NO20034473L (fr) |
| PL (1) | PL364465A1 (fr) |
| RU (1) | RU2003132445A (fr) |
| WO (1) | WO2002080927A1 (fr) |
| ZA (1) | ZA200307731B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005526040A (ja) * | 2002-02-19 | 2005-09-02 | ファルマシア・コーポレーション | 失禁の治療のためのシクロオキシゲナーゼ阻害剤及び抗ムスカリン剤の使用 |
| EP1915992A1 (fr) * | 2002-02-19 | 2008-04-30 | Pharmacia Corporation | Utilisation d'inhibiteurs de la cyclooxygenase et d'agents anti-muscariniques destinée au traitement de l'incontinence |
| EP1492757A1 (fr) * | 2002-04-08 | 2005-01-05 | Glaxo Group Limited | Acide (2-((2-alcoxy) -phenyl) -cyclopent-1-enyl) aromatique carbocyclique and heterocyclique et ses derives |
| EP1400243A1 (fr) * | 2002-09-19 | 2004-03-24 | Tanabe Seiyaku Co., Ltd. | Activateur de canaux potassiques dependants du calcium |
| GB0225548D0 (en) * | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| WO2004069158A2 (fr) * | 2003-01-27 | 2004-08-19 | Merck & Co., Inc. | Pyrazoles substitues, compositions contenant de tels composes et procedes d'utilisation |
| US20050075359A1 (en) * | 2003-03-14 | 2005-04-07 | Rikako Kono | Large conductance calcium-activated K channel opener |
| GB0323585D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
| GB0323584D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
| GB0323581D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Novel compounds |
| US20070060629A1 (en) * | 2003-10-17 | 2007-03-15 | Yasuhiro Imanishi | Large conductance calcium-activated k channel opener |
| GB0410121D0 (en) * | 2004-05-06 | 2004-06-09 | Glaxo Group Ltd | Compounds |
| ES2306165T3 (es) * | 2004-06-04 | 2008-11-01 | MERCK & CO., INC. | Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso. |
| US20070281927A1 (en) * | 2006-06-06 | 2007-12-06 | Shanthakumar Tyavanagimatt | Anti-inflammatory and analgesic compositions and related methods |
| MX2009006575A (es) * | 2006-12-22 | 2009-07-02 | Recordati Ireland Ltd | Terapia de combinacion de trastornos del tracto urinario inferior con ligandos a2d y farmacos anti-inflamatorios no esteroidales (nsaids). |
| JP5277256B2 (ja) | 2008-04-09 | 2013-08-28 | 田辺三菱製薬株式会社 | maxi−Kチャネル開口薬としてのピリミジン、ピリジン及びトリアジン誘導体 |
| KR102027663B1 (ko) | 2013-05-06 | 2019-10-01 | 가오슝 창 궁 메모리얼 하스피털 | 약학적 조성물 및 이의 용도 |
| CN108690078A (zh) * | 2017-03-29 | 2018-10-23 | 江苏恒瑞医药股份有限公司 | 一种苯并塞嗪磷酸酯衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| DE2756113A1 (de) | 1977-12-16 | 1979-06-21 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4318791A (en) | 1977-12-22 | 1982-03-09 | Ciba-Geigy Corporation | Use of aromatic-aliphatic ketones as photo sensitizers |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| DE3103372A1 (de) | 1981-01-27 | 1982-09-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue indanyl-derivate, ihre herstellung und verwendung |
| US5474994A (en) | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
| US5604260A (en) | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
| ATE233245T1 (de) | 1993-11-30 | 2003-03-15 | Searle & Co | Substituierte pyrazolyl-benzolsulfonamide und ihre verwendung als cyclooxygenaseii inhibitoren |
| US5547975A (en) | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5552422A (en) | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
| US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| EP0889878B1 (fr) | 1996-03-29 | 2002-09-04 | Merck Frosst Canada & Co. | Derives bisarylcyclobutene comme inhibiteurs de la cyclo-oxygenase |
| BR9708574A (pt) | 1996-04-12 | 1999-08-03 | Searle & Co | Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2 |
| IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| EP1007515A1 (fr) | 1997-08-22 | 2000-06-14 | Abbott Laboratories | Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase |
| US20020035139A1 (en) * | 2000-06-20 | 2002-03-21 | Herbst Arthur L. | COX-2 inhibitors and the prevention of the side effects of radiation therapy |
| AU2001286557A1 (en) * | 2000-08-23 | 2002-03-04 | Merck Frosst Canada And Co. | Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists |
-
2001
- 2001-04-05 IT IT2001MI000733A patent/ITMI20010733A1/it unknown
- 2001-10-01 US US09/969,538 patent/US6440963B1/en not_active Expired - Fee Related
-
2002
- 2002-04-05 WO PCT/EP2002/003850 patent/WO2002080927A1/fr not_active Ceased
- 2002-04-05 HU HU0303908A patent/HUP0303908A2/hu unknown
- 2002-04-05 KR KR10-2003-7012891A patent/KR20030087046A/ko not_active Withdrawn
- 2002-04-05 BR BR0208694-8A patent/BR0208694A/pt not_active Application Discontinuation
- 2002-04-05 AU AU2002253181A patent/AU2002253181B2/en not_active Expired - Fee Related
- 2002-04-05 CA CA002443031A patent/CA2443031A1/fr not_active Abandoned
- 2002-04-05 JP JP2002578966A patent/JP2004531514A/ja active Pending
- 2002-04-05 CN CNA028078101A patent/CN1688315A/zh active Pending
- 2002-04-05 IL IL15805002A patent/IL158050A0/xx unknown
- 2002-04-05 EP EP02722290A patent/EP1381369A1/fr not_active Withdrawn
- 2002-04-05 RU RU2003132445/15A patent/RU2003132445A/ru not_active Application Discontinuation
- 2002-04-05 PL PL02364465A patent/PL364465A1/xx not_active Application Discontinuation
- 2002-04-05 MX MXPA03008966A patent/MXPA03008966A/es unknown
-
2003
- 2003-10-03 ZA ZA200307731A patent/ZA200307731B/xx unknown
- 2003-10-06 NO NO20034473A patent/NO20034473L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002253181B2 (en) | 2005-02-17 |
| MXPA03008966A (es) | 2004-10-15 |
| JP2004531514A (ja) | 2004-10-14 |
| US6440963B1 (en) | 2002-08-27 |
| PL364465A1 (en) | 2004-12-13 |
| EP1381369A1 (fr) | 2004-01-21 |
| IL158050A0 (en) | 2004-03-28 |
| WO2002080927A1 (fr) | 2002-10-17 |
| RU2003132445A (ru) | 2005-03-10 |
| ITMI20010733A1 (it) | 2002-10-05 |
| KR20030087046A (ko) | 2003-11-12 |
| ITMI20010733A0 (it) | 2001-04-05 |
| ZA200307731B (en) | 2004-09-13 |
| BR0208694A (pt) | 2004-03-30 |
| CN1688315A (zh) | 2005-10-26 |
| CA2443031A1 (fr) | 2002-10-17 |
| HUP0303908A2 (hu) | 2004-04-28 |
| NO20034473D0 (no) | 2003-10-06 |
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