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NO20033828L - Peptiddeformylaseinhibitorer - Google Patents

Peptiddeformylaseinhibitorer

Info

Publication number
NO20033828L
NO20033828L NO20033828A NO20033828A NO20033828L NO 20033828 L NO20033828 L NO 20033828L NO 20033828 A NO20033828 A NO 20033828A NO 20033828 A NO20033828 A NO 20033828A NO 20033828 L NO20033828 L NO 20033828L
Authority
NO
Norway
Prior art keywords
peptiddeformylaseinhibitorer
Prior art date
Application number
NO20033828A
Other languages
English (en)
Norwegian (no)
Other versions
NO20033828D0 (no
Inventor
Jia-Ning Xiang
Siegfried B Christensen
Jinhwa Lee
Daniel J Mercer
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20033828D0 publication Critical patent/NO20033828D0/no
Publication of NO20033828L publication Critical patent/NO20033828L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/34Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/192Radicals derived from carboxylic acids from aromatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/30Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C243/32Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02Compounds containing any of the groups, e.g. carbazates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06Compounds containing any of the groups, e.g. semicarbazides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215Radicals derived from nitrogen analogues of carbonic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
NO20033828A 2001-03-01 2003-08-28 Peptiddeformylaseinhibitorer NO20033828L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27257001P 2001-03-01 2001-03-01
PCT/US2002/006275 WO2002070541A2 (fr) 2001-03-01 2002-03-01 Inhibiteurs de la peptide deformylase

Publications (2)

Publication Number Publication Date
NO20033828D0 NO20033828D0 (no) 2003-08-28
NO20033828L true NO20033828L (no) 2003-10-06

Family

ID=23040368

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033828A NO20033828L (no) 2001-03-01 2003-08-28 Peptiddeformylaseinhibitorer

Country Status (20)

Country Link
US (1) US7019003B2 (fr)
EP (1) EP1363873B1 (fr)
JP (1) JP4266638B2 (fr)
KR (1) KR20030092008A (fr)
CN (1) CN1505607A (fr)
AR (1) AR032920A1 (fr)
AU (1) AU2002335490B2 (fr)
BR (1) BR0207810A (fr)
CA (1) CA2439827A1 (fr)
CZ (1) CZ20032342A3 (fr)
EG (1) EG24516A (fr)
HU (1) HUP0303308A2 (fr)
IL (1) IL157643A0 (fr)
MX (1) MXPA03007869A (fr)
NO (1) NO20033828L (fr)
NZ (1) NZ527728A (fr)
PE (1) PE20020906A1 (fr)
PL (1) PL364563A1 (fr)
UY (1) UY27192A1 (fr)
WO (1) WO2002070541A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27813A1 (es) 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
JP2005532358A (ja) * 2002-06-06 2005-10-27 スミスクライン・ビーチャム・コーポレイション ペプチドデホルミラーゼ阻害剤
ES2321504T3 (es) * 2002-09-19 2009-06-08 Novartis Ag Proceso para la preparacion de productos intermedios.
GB0229673D0 (en) * 2002-12-19 2003-01-29 British Biotech Pharm Antibacterial agents
US7332485B2 (en) * 2003-07-08 2008-02-19 Smithkline Beecham Corp Peptide deformylase inhibitors
EP1654239A4 (fr) * 2003-08-15 2008-10-01 Smithkline Beecham Corp Inhibiteurs de la deformylase de peptides
WO2006055663A2 (fr) 2004-11-17 2006-05-26 Smithkline Beecham Corporation Nouvelle utilisation
US7982053B2 (en) * 2005-07-29 2011-07-19 Glaxosmithkline Llc Peptide deformylase inhibitors
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
WO2007081597A2 (fr) * 2005-10-21 2007-07-19 Glaxo Group Limited Composés
KR100753796B1 (ko) * 2006-07-28 2007-08-31 주식회사 프로메디텍 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물
GB0707706D0 (en) * 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
UA108596C2 (xx) * 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
CA2710039C (fr) 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarnazones et composes associes, et methodes de traitement du cancer
EP2318406B1 (fr) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Composés inhibiteurs et procédés de traitement du cancer
CA2999435A1 (fr) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Composes et methodes pour le traitement du vih
JP2015500238A (ja) * 2011-12-02 2015-01-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッドGlaxosmithkline Intellectual Property No.2 Limited ペプチドデホルミラーゼ阻害剤
CN116375698B (zh) * 2023-06-05 2023-08-01 中国林业科学研究院林产化学工业研究所 具有靶向抗肿瘤活性的漆酚基异羟肟酸型hdac抑制剂及其制备方法和应用
CN119462779A (zh) * 2024-11-06 2025-02-18 中国船舶集团有限公司第七一八研究所 一种光引发剂fmt的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK77487A (da) 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
US6013792A (en) 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
JPH10500986A (ja) 1994-05-28 1998-01-27 ブリテッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
GB9827805D0 (en) * 1998-12-16 1999-02-10 British Biotech Pharm Antibacterial agents
WO2001042431A2 (fr) 1999-12-08 2001-06-14 Bayer Aktiengesellschaft Regulation de la deformylase des mitochondries humaines

Also Published As

Publication number Publication date
JP4266638B2 (ja) 2009-05-20
AR032920A1 (es) 2003-12-03
AU2002335490B2 (en) 2005-10-20
KR20030092008A (ko) 2003-12-03
US20040087585A1 (en) 2004-05-06
NO20033828D0 (no) 2003-08-28
EP1363873A4 (fr) 2006-01-04
EP1363873B1 (fr) 2016-04-20
WO2002070541A3 (fr) 2002-12-19
HUP0303308A2 (hu) 2004-01-28
EP1363873A2 (fr) 2003-11-26
UY27192A1 (es) 2002-09-30
CZ20032342A3 (cs) 2004-04-14
EG24516A (en) 2009-08-19
BR0207810A (pt) 2008-04-15
MXPA03007869A (es) 2003-12-04
PE20020906A1 (es) 2002-12-08
US7019003B2 (en) 2006-03-28
NZ527728A (en) 2004-09-24
CN1505607A (zh) 2004-06-16
JP2004537507A (ja) 2004-12-16
WO2002070541A2 (fr) 2002-09-12
CA2439827A1 (fr) 2002-09-12
IL157643A0 (en) 2004-03-28
PL364563A1 (en) 2004-12-13

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