[go: up one dir, main page]

NO20030431L - Acetamidderivater og anvendelse derav som inhibitorer for koagulasjonsfaktorene Xa og VIIa - Google Patents

Acetamidderivater og anvendelse derav som inhibitorer for koagulasjonsfaktorene Xa og VIIa

Info

Publication number
NO20030431L
NO20030431L NO20030431A NO20030431A NO20030431L NO 20030431 L NO20030431 L NO 20030431L NO 20030431 A NO20030431 A NO 20030431A NO 20030431 A NO20030431 A NO 20030431A NO 20030431 L NO20030431 L NO 20030431L
Authority
NO
Norway
Prior art keywords
viia
inhibitors
coagulation factors
acetamide derivatives
tumor
Prior art date
Application number
NO20030431A
Other languages
English (en)
Other versions
NO20030431D0 (no
Inventor
Werner Mederski
Horst Juraszyk
Dieter Dorsch
Christos Tsaklakidis
Johannes Gleitz
Christopher Barnes
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20030431D0 publication Critical patent/NO20030431D0/no
Publication of NO20030431L publication Critical patent/NO20030431L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Nye forbindelser med formel I. hvor R, R 1 og R 2 er som definert i patentkrav 1, er inhibitorer for koagulasjonsfaktorene Xa og Vila, og kan anvendes til behandling av tromboser, hjerteinfarkt, arteriosklerose, betennelse, apopleksi, angina pectoris, restenose etter angioplastikk, claudiocatio intermittens, tumorer, tumorsykdommer og/eller tumormetastaser.
NO20030431A 2000-07-29 2003-01-28 Acetamidderivater og anvendelse derav som inhibitorer for koagulasjonsfaktorene Xa og VIIa NO20030431L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10037146A DE10037146A1 (de) 2000-07-29 2000-07-29 Acetamidderivate
PCT/EP2001/007594 WO2002010127A1 (de) 2000-07-29 2001-07-03 Acetamidderivate und ihre verwendung als inhibitoren des koagulationsfaktors xa und viia

Publications (2)

Publication Number Publication Date
NO20030431D0 NO20030431D0 (no) 2003-01-28
NO20030431L true NO20030431L (no) 2003-01-28

Family

ID=7650757

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030431A NO20030431L (no) 2000-07-29 2003-01-28 Acetamidderivater og anvendelse derav som inhibitorer for koagulasjonsfaktorene Xa og VIIa

Country Status (18)

Country Link
US (1) US20030187037A1 (no)
EP (1) EP1309549A1 (no)
JP (1) JP2004505106A (no)
KR (1) KR20030029531A (no)
CN (1) CN1444561A (no)
AR (1) AR029999A1 (no)
AU (1) AU2001281941A1 (no)
BR (1) BR0112813A (no)
CA (1) CA2417427A1 (no)
CZ (1) CZ2003465A3 (no)
DE (1) DE10037146A1 (no)
HU (1) HUP0301502A2 (no)
MX (1) MXPA03000780A (no)
NO (1) NO20030431L (no)
PL (1) PL358756A1 (no)
SK (1) SK1972003A3 (no)
WO (1) WO2002010127A1 (no)
ZA (1) ZA200301633B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200410921A (en) * 2002-11-25 2004-07-01 Hoffmann La Roche Mandelic acid derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819548A1 (de) * 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenylderivate
JP2003500383A (ja) * 1999-05-24 2003-01-07 コア・セラピューティクス，インコーポレイテッド 第Ｘａ因子阻害剤
JP2003500384A (ja) * 1999-05-24 2003-01-07 コア・セラピューティクス，インコーポレイテッド Ｘａ因子阻害剤
WO2001068605A1 (en) * 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade

Also Published As

Publication number Publication date
AU2001281941A1 (en) 2002-02-13
NO20030431D0 (no) 2003-01-28
CN1444561A (zh) 2003-09-24
WO2002010127A1 (de) 2002-02-07
CA2417427A1 (en) 2003-01-27
PL358756A1 (en) 2004-08-23
EP1309549A1 (de) 2003-05-14
MXPA03000780A (es) 2003-06-04
US20030187037A1 (en) 2003-10-02
DE10037146A1 (de) 2002-02-07
JP2004505106A (ja) 2004-02-19
KR20030029531A (ko) 2003-04-14
HUP0301502A2 (hu) 2003-08-28
BR0112813A (pt) 2003-07-01
ZA200301633B (en) 2004-06-22
CZ2003465A3 (cs) 2003-05-14
SK1972003A3 (en) 2003-06-03
AR029999A1 (es) 2003-07-23

Similar Documents

Publication Publication Date Title
DE60127863D1 (de) Phenylderivate
CY1107149T1 (el) Νεα παραγωγα αμιδινοβενζυλαμινης και χρηση τους ως αναστολεων θρομβινης
MY133897A (en) N-(4-carb-amimidophenyl) glycineamide derivatives
NO20031192D0 (no) Isoksazoler og deres anvendelse som inhibitorer av ERK
TR200200649T2 (tr) Farmasötik özelliklere sahip olan yeni aminodikarboksilik asit türevleri
ATE405266T1 (de) Monozyklische oder bizyklische carbozyklen und heterozyklen als hemmer von factor xa
NO996316L (no) Faktor Xa-inhibitorer med en noeytral P1-spesifisitetsgruppe
EA200300017A1 (ru) Ингибиторы серинпротеазы
ATE411288T1 (de) Aryl-, aryloxy- und alkyloxysubstituierte 1h- indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
TW200504012A (en) Ethynylproline derivatives
ATE491701T1 (de) Von pyrazol abgeleitete kinaseinhibitoren und deren verwendung
WO2000071516A3 (en) INHIBITORS OF FACTOR Xa
DE60105418D1 (de) Serinprotease-inhibitoren
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
DE60115466D1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
ATE325135T1 (de) 2-alkylierte cyclodextrinderivate : umkehrungsmittel von medikament-induzierter neuromuskulärer blockierung
NO20015892L (no) Inhibitorer av metallproteinaser
BR0109512A (pt) Imidazopiridinas tricìclicas
NO20030431L (no) Acetamidderivater og anvendelse derav som inhibitorer for koagulasjonsfaktorene Xa og VIIa
EA200301101A1 (ru) Производные пиперазина и их применение в качестве ингибиторов pde4
MXPA04004307A (es) Derivados de fenoxi-n-`4-(1,1-dioxoisotiazolidin-2-il)fenil-valeramida y otros compuestos como inhibidores del factor de coagulacion xa para el tratamiento de enfermedades tromboembolicas y tumores.
DE60118914D1 (de) Pharmazeutische zusammensetzungen die acryloyl-substituierte distamycin-derivate und topoisomerase i und ii inhibitoren enthalten
BR0112771A (pt) Derivados de ácido 1-amino-1,1-dialquil-carboxilico n-substituìdo
NO20052994L (no) Nye fosforamidderivater.
DE602004008247D1 (de) Zusammensetzung die tamsulosin und ein nichtsteroides entzündungshemmendes mittel enthält

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application