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NO20026014L - Vitamin D-derivater - Google Patents

Vitamin D-derivater

Info

Publication number
NO20026014L
NO20026014L NO20026014A NO20026014A NO20026014L NO 20026014 L NO20026014 L NO 20026014L NO 20026014 A NO20026014 A NO 20026014A NO 20026014 A NO20026014 A NO 20026014A NO 20026014 L NO20026014 L NO 20026014L
Authority
NO
Norway
Prior art keywords
hydrogen atom
vitamin
derivatives
represent
atom
Prior art date
Application number
NO20026014A
Other languages
English (en)
Other versions
NO20026014D0 (no
NO328868B1 (no
Inventor
Kazumi Morikawa
Masayuki Ohmori
Kazuki Shimizu
Akira Kawase
Takashi Emura
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of NO20026014D0 publication Critical patent/NO20026014D0/no
Publication of NO20026014L publication Critical patent/NO20026014L/no
Publication of NO328868B1 publication Critical patent/NO328868B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20026014A 2000-06-15 2002-12-13 Vitamin D-derivat, anvendelse derav, og farmasoytisk preparat og terapeutisk middel for hudsykdommer omfattende et slikt derivat NO328868B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000179251 2000-06-15
JP2000351412 2000-11-17
JP2000375024 2000-12-08
PCT/JP2001/005062 WO2001096293A1 (en) 2000-06-15 2001-06-14 Vitamin d derivatives

Publications (3)

Publication Number Publication Date
NO20026014D0 NO20026014D0 (no) 2002-12-13
NO20026014L true NO20026014L (no) 2003-02-17
NO328868B1 NO328868B1 (no) 2010-06-07

Family

ID=27343730

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20026014A NO328868B1 (no) 2000-06-15 2002-12-13 Vitamin D-derivat, anvendelse derav, og farmasoytisk preparat og terapeutisk middel for hudsykdommer omfattende et slikt derivat
NO20092832A NO332310B1 (no) 2000-06-15 2009-08-13 Fremgangsmate for karbonylering av en forbindelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20092832A NO332310B1 (no) 2000-06-15 2009-08-13 Fremgangsmate for karbonylering av en forbindelse

Country Status (15)

Country Link
US (1) US7985744B2 (no)
EP (1) EP1295871B1 (no)
JP (2) JP3706104B2 (no)
KR (2) KR100734799B1 (no)
CN (2) CN100469764C (no)
AT (1) ATE509910T1 (no)
AU (2) AU6428001A (no)
CA (2) CA2411409C (no)
DK (1) DK1295871T3 (no)
HK (1) HK1054373B (no)
IL (3) IL153395A0 (no)
NO (2) NO328868B1 (no)
NZ (1) NZ528622A (no)
TW (1) TWI288131B (no)
WO (1) WO2001096293A1 (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
EP2070911A2 (en) 2000-07-18 2009-06-17 Bone Care International, Inc. Stabilized 1Alpha-Hydroxy vitamin D
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
KR20070086727A (ko) * 2004-12-03 2007-08-27 니뽄 신야쿠 가부시키가이샤 9,10-세코프레그난 유도체 및 의약
JP4961562B2 (ja) * 2005-03-04 2012-06-27 国立大学法人 東京医科歯科大学 19−ノルビタミンd誘導体
DK1961740T3 (da) 2005-11-30 2013-05-27 Chugai Pharmaceutical Co Ltd Fremgangsmåde til at fremstille vitamin D derivate ved at udnytte fotoreaktion
WO2007064011A1 (ja) 2005-12-02 2007-06-07 Chugai Seiyaku Kabushiki Kaisha コンバージェント法を用いるビタミンd誘導体の製造方法
EP2025667B1 (en) * 2006-06-02 2016-08-10 Nippon Shinyaku Co., Ltd. 9,10-secopregnane derivative and pharmaceutical
US9481646B2 (en) * 2007-04-18 2016-11-01 The Johns Hopkins University Low calcemic, highly antiproliferative, analogs of calcitriol
US8551463B2 (en) 2007-10-22 2013-10-08 Living Proof, Inc. Hair care compositions and methods of treating hair
DE102009028939A1 (de) * 2009-08-27 2011-03-03 Ludwig-Maximilians-Universität München Verfahren zur Herstellung von Arylaluminiumhalogeniden und deren Verwendung
JP5652723B2 (ja) * 2012-08-17 2015-01-14 フォーモサ・ラボラトリーズ・インコーポレーテッド マキサカルシトールの新しい結晶形態
CN106279239B (zh) 2015-05-29 2019-06-28 上海彩迩文生化科技有限公司 多烯化合物、制备方法及其应用
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
CN113105517B (zh) * 2021-04-10 2022-03-01 台州仙琚药业有限公司 雄甾-1,4,9-三烯-3,17-二酮的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
DE69208478T2 (de) * 1991-11-07 1996-09-05 Research Institute For Medicine And Chemistry Inc., Cambridge, Mass. Amid derivate von vitamin d
JP3493037B2 (ja) * 1991-12-18 2004-02-03 中外製薬株式会社 22−オキサコレカルシフェロール誘導体とその製造方法
GB9226877D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
GB9309422D0 (en) * 1993-05-07 1993-06-23 Res Inst Medicine Chem Chemical compounds
US5361722A (en) 1993-06-16 1994-11-08 Universal Dairy Equipment Inc. Milking facility with service alley
JP3759639B2 (ja) 1994-04-11 2006-03-29 中外製薬株式会社 22−チアビタミン▲d3▼誘導体
DE69518410T2 (de) 1994-04-11 2000-12-14 Chugai Seiyaku K.K., Tokio/Tokyo 22-thiavitamin-d3-derivate
PE28297A1 (es) * 1995-01-26 1997-08-20 Hoffmann La Roche Empleo dermatologico de derivados de vitamina d
KR100573234B1 (ko) * 1996-12-20 2006-04-24 쥬가이 세이야쿠 가부시키가이샤 16-엔-비타민 d 유도체
US6184398B1 (en) 1996-12-20 2001-02-06 Chugai Seiyaku Kabushiki Kaisha 16-ene-vitamin D derivatives
JP4012293B2 (ja) 1996-12-20 2007-11-21 中外製薬株式会社 16−エン−ビタミンd誘導体
DE69832699T2 (de) * 1997-05-16 2006-08-24 Woman & Infants Hospital Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen
JP4803939B2 (ja) * 2000-04-19 2011-10-26 中外製薬株式会社 ビタミンd誘導体
DK1961740T3 (da) * 2005-11-30 2013-05-27 Chugai Pharmaceutical Co Ltd Fremgangsmåde til at fremstille vitamin D derivate ved at udnytte fotoreaktion
WO2007064011A1 (ja) * 2005-12-02 2007-06-07 Chugai Seiyaku Kabushiki Kaisha コンバージェント法を用いるビタミンd誘導体の製造方法

Also Published As

Publication number Publication date
EP1295871B1 (en) 2011-05-18
JP4233504B2 (ja) 2009-03-04
IL178350A (en) 2010-11-30
AU6428001A (en) 2001-12-24
IL178350A0 (en) 2007-02-11
KR100786053B1 (ko) 2007-12-17
EP1295871A4 (en) 2009-02-25
KR100734799B1 (ko) 2007-07-03
US7985744B2 (en) 2011-07-26
AU2001264280C1 (en) 2001-12-24
NO20092832L (no) 2003-02-17
CN102617690A (zh) 2012-08-01
JP3706104B2 (ja) 2005-10-12
CA2664720C (en) 2011-11-22
IL153395A (en) 2010-06-30
CA2411409C (en) 2011-05-17
HK1054373A1 (en) 2003-11-28
NZ528622A (en) 2005-05-27
US20040019023A1 (en) 2004-01-29
CN100469764C (zh) 2009-03-18
HK1054373B (en) 2011-11-18
HK1056163A1 (zh) 2004-02-06
NO20026014D0 (no) 2002-12-13
KR20060070581A (ko) 2006-06-23
CA2411409A1 (en) 2002-12-04
TWI288131B (en) 2007-10-11
JP2005060402A (ja) 2005-03-10
WO2001096293A1 (en) 2001-12-20
NO328868B1 (no) 2010-06-07
EP1295871A1 (en) 2003-03-26
CA2664720A1 (en) 2002-12-04
IL153395A0 (en) 2003-07-06
ATE509910T1 (de) 2011-06-15
CN102617690B (zh) 2015-07-08
NO332310B1 (no) 2012-08-20
CN1436170A (zh) 2003-08-13
KR20030029058A (ko) 2003-04-11
DK1295871T3 (da) 2011-07-11
AU2001264280B2 (en) 2005-08-25

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