NO20023817L - Amider anvendelige for inhibering av IL-8-indusert kjemotakse av neutrofiler - Google Patents

Amider anvendelige for inhibering av IL-8-indusert kjemotakse av neutrofiler

Info

Publication number: NO20023817L
Authority: NO; Norway
Prior art keywords: amides; neutrophils; inhibiting; propionyl; aryl
Prior art date: 2000-02-11

Application number

NO20023817A

Other languages

English (en)

Other versions

NO331460B1 (no

NO20023817D0 (no

Inventor

Marcello Allegretti

Riccardo Bertini

Cinzia Bizzarri

Vilma Sabbatini

Gianfranco Caselli

Maria Candida Cesta

Carmelo A Gandolfi

Francesco Colotta

Original Assignee

Dompe Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-11

Filing date

2002-08-12

Publication date

2002-08-12

2002-08-12 Application filed by Dompe Spa filed Critical Dompe Spa

2002-08-12 Publication of NO20023817L publication Critical patent/NO20023817L/no

2002-08-12 Publication of NO20023817D0 publication Critical patent/NO20023817D0/no

2012-01-09 Publication of NO331460B1 publication Critical patent/NO331460B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Neurology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Hydrogenated Pyridines (AREA)

NO20023817A 2000-02-11 2002-08-12 (R)-enantiomerer av 2-arylpropylamider, fremgangsmate for fremstilling av samme, anvendelse av samme, anvendelse av dem i fremstilling av medikamenter, farmasoytisk preparat inneholdende de samme og (R)-enantiomerer av 2-arylpropionsyrer NO331460B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI000227A IT1317826B1 (it)	2000-02-11	2000-02-11	Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
PCT/EP2001/001285 WO2001058852A2 (en)	2000-02-11	2001-02-06	(r)-2-aryl-propionamides, useful in the inhibition of il-8-induced chemiotaxis of neutrophils

Publications (3)

Publication Number	Publication Date
NO20023817L true NO20023817L (no)	2002-08-12
NO20023817D0 NO20023817D0 (no)	2002-08-12
NO331460B1 NO331460B1 (no)	2012-01-09

Family

ID=11443980

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20023817A NO331460B1 (no)	2000-02-11	2002-08-12	(R)-enantiomerer av 2-arylpropylamider, fremgangsmate for fremstilling av samme, anvendelse av samme, anvendelse av dem i fremstilling av medikamenter, farmasoytisk preparat inneholdende de samme og (R)-enantiomerer av 2-arylpropionsyrer

Country Status (27)

Country	Link
US (1)	US7705050B2 (no)
EP (1)	EP1255726B1 (no)
JP (1)	JP4937479B2 (no)
KR (1)	KR100884417B1 (no)
CN (1)	CN100513386C (no)
AT (1)	ATE448195T1 (no)
AU (2)	AU2001244125B2 (no)
BR (2)	BRPI0108152B1 (no)
CA (1)	CA2396937C (no)
CY (1)	CY1109780T1 (no)
CZ (1)	CZ302945B6 (no)
DE (1)	DE60140429D1 (no)
DK (1)	DK1255726T3 (no)
EE (1)	EE05284B1 (no)
ES (1)	ES2336301T3 (no)
HU (1)	HU229447B1 (no)
IL (1)	IL150523A0 (no)
IT (1)	IT1317826B1 (no)
MX (1)	MXPA02007714A (no)
NO (1)	NO331460B1 (no)
NZ (1)	NZ519925A (no)
PL (1)	PL207126B1 (no)
PT (1)	PT1255726E (no)
RU (1)	RU2273630C2 (no)
SI (1)	SI1255726T1 (no)
SK (1)	SK287224B6 (no)
WO (1)	WO2001058852A2 (no)

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TWI243164B (en)	2001-02-13	2005-11-11	Aventis Pharma Gmbh	Acylated indanyl amines and their use as pharmaceuticals
ITMI20010395A1 (it)	2001-02-27	2002-08-27	Dompe Spa	Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
ITMI20012025A1 (it) *	2001-09-28	2003-03-28	Dompe Spa	Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
ITMI20012434A1 (it)	2001-11-20	2003-05-20	Dompe Spa	Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
CN100383110C (zh) *	2002-12-10	2008-04-23	冬姆佩制药股份公司	治疗嗜中性白细胞依赖性炎症疾病的手性芳香酮
EP1590314B1 (en) *	2003-02-06	2015-08-05	Dompé farmaceutici s.p.a.	2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them
EP1457485A1 (en) *	2003-03-14	2004-09-15	Dompé S.P.A.	Sulfonic acids, their derivatives and pharmaceutical compositions containing them
RU2375346C2 (ru)	2003-09-25	2009-12-10	ДОМПЕ ФА.Р.МА С.п.А.	Амидины и их производные и содержащие их фармацевтические композиции
PL1776336T3 (pl) *	2004-03-23	2010-06-30	Dompe Farm Spa	Pochodne kwasu 2-fenylopropionowego i zawierające je kompozycje farmaceutyczne
AU2005315591B2 (en) *	2004-12-15	2011-03-17	Dompe' Farmaceutici S.P.A.	2-arylpropionic acid derivatives and pharmaceutical compositions containing them
EP1676834A1 (en)	2004-12-30	2006-07-05	Sanofi-Aventis Deutschland GmbH	Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
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CN103772259B (zh) *	2006-08-08	2016-08-31	于崇曦	具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
EP2990402A1 (en) *	2006-08-08	2016-03-02	Techfields Biochem Co. Ltd	Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate
CN103772258B (zh) *	2006-08-08	2016-09-28	于崇曦	具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
WO2008149181A1 (en)	2007-06-04	2008-12-11	Techfields Inc	Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
AU2008310898B2 (en) *	2007-10-08	2014-05-08	National Science and Technology Development Agency acting through National Center for Genetic Engineering and Biotechnology	Antimalarial compounds with flexible side-chains
AU2008345573B2 (en)	2007-12-20	2013-12-19	Envivo Pharmaceuticals, Inc.	Tetrasubstituted benzenes
EP2166006A1 (en)	2008-09-18	2010-03-24	Dompe' S.P.A.	2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
WO2010065936A1 (en)	2008-12-04	2010-06-10	Chongxi Yu	High penetration compositions and their applications
UA113501C2 (xx) *	2010-11-03	2017-02-10		Пестицидні композиції і пов'язані з ними способи
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2000
- 2000-02-11 IT IT2000MI000227A patent/IT1317826B1/it active
2001
- 2001-02-06 AU AU2001244125A patent/AU2001244125B2/en not_active Ceased
- 2001-02-06 ES ES01916976T patent/ES2336301T3/es not_active Expired - Lifetime
- 2001-02-06 SI SI200130957T patent/SI1255726T1/sl unknown
- 2001-02-06 PT PT01916976T patent/PT1255726E/pt unknown
- 2001-02-06 AT AT01916976T patent/ATE448195T1/de active
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- 2001-02-06 IL IL15052301A patent/IL150523A0/xx not_active IP Right Cessation
- 2001-02-06 RU RU2002124136/04A patent/RU2273630C2/ru not_active IP Right Cessation
- 2001-02-06 MX MXPA02007714A patent/MXPA02007714A/es active IP Right Grant
- 2001-02-06 PL PL362506A patent/PL207126B1/pl unknown
- 2001-02-06 WO PCT/EP2001/001285 patent/WO2001058852A2/en not_active Ceased
- 2001-02-06 AU AU4412501A patent/AU4412501A/xx active Pending
- 2001-02-06 BR BRPI0108152-7A patent/BRPI0108152B1/pt unknown
- 2001-02-06 KR KR1020027009836A patent/KR100884417B1/ko not_active Expired - Fee Related
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- 2001-02-06 CN CNB018047866A patent/CN100513386C/zh not_active Expired - Fee Related
- 2001-02-06 CZ CZ20022728A patent/CZ302945B6/cs not_active IP Right Cessation
- 2001-02-06 EP EP01916976A patent/EP1255726B1/en not_active Expired - Lifetime
- 2001-02-06 DE DE60140429T patent/DE60140429D1/de not_active Expired - Lifetime
- 2001-02-06 BR BR0108152-7A patent/BR0108152A/pt not_active IP Right Cessation
- 2001-02-06 SK SK1141-2002A patent/SK287224B6/sk not_active IP Right Cessation
- 2001-02-06 DK DK01916976.2T patent/DK1255726T3/da active
2002
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Also Published As

Publication number	Publication date
KR20020073194A (ko)	2002-09-19
DK1255726T3 (da)	2010-03-22
CA2396937C (en)	2011-09-13
JP4937479B2 (ja)	2012-05-23
SI1255726T1 (sl)	2010-03-31
US20040181073A1 (en)	2004-09-16
AU2001244125B2 (en)	2006-11-09
PL207126B1 (pl)	2010-11-30
ATE448195T1 (de)	2009-11-15
EP1255726A2 (en)	2002-11-13
EE200200441A (et)	2003-12-15
SK287224B6 (sk)	2010-03-08
KR100884417B1 (ko)	2009-02-19
CY1109780T1 (el)	2014-09-10
RU2002124136A (ru)	2004-01-10
HK1062675A1 (zh)	2004-11-19
BR0108152A (pt)	2003-03-25
IL150523A0 (en)	2003-02-12
AU4412501A (en)	2001-08-20
SK11412002A3 (sk)	2003-01-09
PT1255726E (pt)	2010-02-11
EE05284B1 (et)	2010-04-15
NO331460B1 (no)	2012-01-09
ITMI20000227A0 (it)	2000-02-11
EP1255726B1 (en)	2009-11-11
JP2003522750A (ja)	2003-07-29
CA2396937A1 (en)	2001-08-16
BRPI0108152B1 (pt)	2017-09-26
NZ519925A (en)	2004-12-24
MXPA02007714A (es)	2002-10-23
IT1317826B1 (it)	2003-07-15
DE60140429D1 (de)	2009-12-24
HU229447B1 (en)	2013-12-30
CZ20022728A3 (cs)	2003-01-15
ES2336301T3 (es)	2010-04-12
CN1479715A (zh)	2004-03-03
HUP0301576A3 (en)	2004-10-28
WO2001058852A3 (en)	2002-03-14
PL362506A1 (en)	2004-11-02
CN100513386C (zh)	2009-07-15
RU2273630C2 (ru)	2006-04-10
US7705050B2 (en)	2010-04-27
ITMI20000227A1 (it)	2001-08-11
CZ302945B6 (cs)	2012-01-25
NO20023817D0 (no)	2002-08-12
HUP0301576A2 (hu)	2003-11-28
WO2001058852A2 (en)	2001-08-16

Publication	Publication Date	Title
NO20023817L (no)	2002-08-12	Amider anvendelige for inhibering av IL-8-indusert kjemotakse av neutrofiler
MXPA03006786A (es)	2004-05-31	Omega-aminoalquilamidas de los acidos r-2-aril-propionicos como inhibidores de la quimiotaxis de las celulas mononucleadas y polimorfonucleadas.
IT1303249B1 (it)	2000-11-06	Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
MXPA04000278A (es)	2004-05-04	Uso de antagonistas del receptor nk-1 con estructura piridinica para tratamiento de lesiones cerebrales, espinales o neuronales.
MY147780A (en)	2013-01-31	Carboxamide compounds and their use as calpain inhibitors
NO20053627L (no)	2005-08-10	Malonamidderivater som gamma-sekretase inhibitorer
KR970703172A (ko)	1997-07-03	모노아민, 디아민, 티올-함유 금속 킬레이터(monoamine, diamide, thiol-containing metal chelating agents)
CA2458035A1 (en)	2003-04-10	Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them
CY1107078T1 (el)	2012-10-24	Αμιδια του r-2-(αμινοαρυλ)-προπιονικου οξεος για χρηση στην προληψη της ενεργοποιησης των λευκοκυτταρων
JP2019535814A5 (no)	2021-04-30
WO2005028425A3 (en)	2005-06-09	Amidines and derivatives thereof and pharmaceutical compositions containing them
NO20063012L (no)	2006-06-28	Fremgangsmaten for syntesen av perindopril og farmasoytisk akseptable salter derav
EA200501083A1 (ru)	2006-02-24	Соединения, активные в ингибировании пролилолигопептидазы
DK1370526T3 (da)	2006-07-31	Diamider som inhiberer tryptase og faktor Xa-virkning

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Date	Code	Title	Description
2015-09-14	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: DOMPE FARMACEUTICI S.P.A., IT
2019-09-23	MM1K	Lapsed by not paying the annual fees