NO20021395D0 - Kinazolinderivater - Google Patents
KinazolinderivaterInfo
- Publication number
- NO20021395D0 NO20021395D0 NO20021395A NO20021395A NO20021395D0 NO 20021395 D0 NO20021395 D0 NO 20021395D0 NO 20021395 A NO20021395 A NO 20021395A NO 20021395 A NO20021395 A NO 20021395A NO 20021395 D0 NO20021395 D0 NO 20021395D0
- Authority
- NO
- Norway
- Prior art keywords
- sup
- sub
- quinazoline
- aurora
- kinase
- Prior art date
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108090000461 Aurora Kinase A Proteins 0.000 abstract 1
- 102100032311 Aurora kinase A Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catching Or Destruction (AREA)
- Ropes Or Cables (AREA)
- Earth Drilling (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9922173.1A GB9922173D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
| PCT/GB2000/003562 WO2001021595A1 (en) | 1999-09-21 | 2000-09-18 | Quinazoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20021395D0 true NO20021395D0 (no) | 2002-03-20 |
| NO20021395L NO20021395L (no) | 2002-05-15 |
Family
ID=10861219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021395A NO20021395L (no) | 1999-09-21 | 2002-03-20 | Kinazolinderivater |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7105669B1 (no) |
| EP (1) | EP1218357B1 (no) |
| JP (1) | JP2003509498A (no) |
| KR (1) | KR20020029136A (no) |
| CN (1) | CN1391560A (no) |
| AT (1) | ATE292628T1 (no) |
| AU (1) | AU7433000A (no) |
| BG (1) | BG106535A (no) |
| BR (1) | BR0014136A (no) |
| CA (1) | CA2384284A1 (no) |
| CZ (1) | CZ20021007A3 (no) |
| DE (1) | DE60019317T2 (no) |
| EE (1) | EE200200148A (no) |
| GB (1) | GB9922173D0 (no) |
| HK (1) | HK1046687A1 (no) |
| HU (1) | HUP0204226A3 (no) |
| IL (1) | IL148498A0 (no) |
| IS (1) | IS6309A (no) |
| NO (1) | NO20021395L (no) |
| PL (1) | PL354972A1 (no) |
| SK (1) | SK3842002A3 (no) |
| WO (1) | WO2001021595A1 (no) |
| ZA (1) | ZA200201831B (no) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| AU2001278609B2 (en) | 2000-08-21 | 2005-04-14 | Astrazeneca Ab | Quinazoline derivatives |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| EP1330444B1 (en) | 2000-11-01 | 2011-03-23 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic compounds and process for making them |
| DE60233736D1 (de) * | 2001-06-22 | 2009-10-29 | Kirin Pharma K K | Chinolinderivat und chinazolinderivat, die die selbstphosphorylierung des hepatocytus-proliferator-rezeptors hemmen, und diese enthaltende medizinische zusammensetzung |
| CA2473796A1 (en) | 2002-01-17 | 2003-07-31 | Neurogen Corporation | Substituted quinazolin-4-ylamine analogues |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| WO2004006846A2 (en) | 2002-07-15 | 2004-01-22 | Exelixis, Inc. | Receptor-type kinase modulators and methods of use |
| WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| CN1984660B (zh) | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| US7329664B2 (en) | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
| GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| ATE395346T1 (de) | 2003-09-16 | 2008-05-15 | Astrazeneca Ab | Chinazolinderivate als tyrosinkinaseinhibitoren |
| GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| EP1694686A1 (en) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
| WO2005072731A1 (en) * | 2004-01-29 | 2005-08-11 | X-Ceptor Therapeutics, Inc. | 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders |
| EP1778669A2 (en) | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
| TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
| MX2007004403A (es) | 2004-10-12 | 2007-04-27 | Astrazeneca Ab | Derivados de quinazolina. |
| ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1856053A1 (en) * | 2005-01-14 | 2007-11-21 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
| US7462639B2 (en) | 2005-04-14 | 2008-12-09 | Hoffmann-La Roche Inc. | Aminopyrazole derivatives |
| JP5075624B2 (ja) | 2005-04-28 | 2012-11-21 | 田辺三菱製薬株式会社 | シアノピリジン誘導体及びその医薬としての用途 |
| GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| UY30183A1 (es) * | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
| EP1994024A2 (en) * | 2006-03-02 | 2008-11-26 | AstraZeneca AB | Quinoline derivatives |
| US20080033000A1 (en) * | 2006-05-15 | 2008-02-07 | Senex Biotechnology, Inc. | Identification of CDKI pathway inhibitors |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| EA200901041A1 (ru) | 2007-02-06 | 2010-02-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения |
| ATE554076T1 (de) * | 2008-01-17 | 2012-05-15 | Bayer Pharma AG | Sulfoximinsubstituierte chinazolinderivate als immunmodulatoren, ihre herstellung und ihre verwendung als medikamente |
| PL2245026T3 (pl) | 2008-02-07 | 2013-01-31 | Boehringer Ingelheim Int | Spirocykliczne heterocykle, leki zawierające te związki, ich zastosowanie i sposób ich produkcji |
| ES2444128T3 (es) | 2008-05-13 | 2014-02-24 | Astrazeneca Ab | Nueva SAL-554 |
| JP5539351B2 (ja) | 2008-08-08 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法 |
| CN105777654B (zh) * | 2016-03-28 | 2018-03-27 | 贵州大学 | 一种含喹唑啉的阿魏酸酯类衍生物、其制备方法和用途 |
| US20210017174A1 (en) | 2018-03-07 | 2021-01-21 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitor |
| US20240246940A1 (en) * | 2021-04-22 | 2024-07-25 | Voronoi Inc. | Heteroaryl derivative compound and use thereof |
| CN119504613A (zh) * | 2024-09-29 | 2025-02-25 | 江苏海洋大学 | 含喹唑啉单元的新型香豆素衍生物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE205483T1 (de) | 1995-03-30 | 2001-09-15 | Pfizer | Chinazolinderivate |
| GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| AU2003247141A1 (en) * | 2002-08-01 | 2004-02-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases |
-
1999
- 1999-09-21 GB GBGB9922173.1A patent/GB9922173D0/en not_active Ceased
-
2000
- 2000-09-18 CZ CZ20021007A patent/CZ20021007A3/cs unknown
- 2000-09-18 CA CA002384284A patent/CA2384284A1/en not_active Abandoned
- 2000-09-18 HU HU0204226A patent/HUP0204226A3/hu unknown
- 2000-09-18 AU AU74330/00A patent/AU7433000A/en not_active Abandoned
- 2000-09-18 EE EEP200200148A patent/EE200200148A/xx unknown
- 2000-09-18 US US10/088,852 patent/US7105669B1/en not_active Expired - Fee Related
- 2000-09-18 BR BR0014136-4A patent/BR0014136A/pt not_active IP Right Cessation
- 2000-09-18 EP EP00962682A patent/EP1218357B1/en not_active Expired - Lifetime
- 2000-09-18 IL IL14849800A patent/IL148498A0/xx unknown
- 2000-09-18 AT AT00962682T patent/ATE292628T1/de not_active IP Right Cessation
- 2000-09-18 SK SK384-2002A patent/SK3842002A3/sk unknown
- 2000-09-18 JP JP2001524974A patent/JP2003509498A/ja active Pending
- 2000-09-18 DE DE60019317T patent/DE60019317T2/de not_active Expired - Fee Related
- 2000-09-18 CN CN00816000A patent/CN1391560A/zh active Pending
- 2000-09-18 PL PL00354972A patent/PL354972A1/xx not_active Application Discontinuation
- 2000-09-18 HK HK02108373.8A patent/HK1046687A1/zh unknown
- 2000-09-18 KR KR1020027003679A patent/KR20020029136A/ko not_active Withdrawn
- 2000-09-18 WO PCT/GB2000/003562 patent/WO2001021595A1/en not_active Ceased
-
2002
- 2002-03-05 ZA ZA200201831A patent/ZA200201831B/xx unknown
- 2002-03-19 IS IS6309A patent/IS6309A/is unknown
- 2002-03-20 BG BG106535A patent/BG106535A/bg unknown
- 2002-03-20 NO NO20021395A patent/NO20021395L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL148498A0 (en) | 2002-09-12 |
| PL354972A1 (en) | 2004-03-22 |
| DE60019317T2 (de) | 2006-03-09 |
| HUP0204226A2 (en) | 2003-05-28 |
| JP2003509498A (ja) | 2003-03-11 |
| EP1218357A1 (en) | 2002-07-03 |
| HK1046687A1 (zh) | 2003-01-24 |
| IS6309A (is) | 2002-03-19 |
| US7105669B1 (en) | 2006-09-12 |
| KR20020029136A (ko) | 2002-04-17 |
| EE200200148A (et) | 2003-04-15 |
| SK3842002A3 (en) | 2002-10-08 |
| AU7433000A (en) | 2001-04-24 |
| DE60019317D1 (de) | 2005-05-12 |
| ATE292628T1 (de) | 2005-04-15 |
| EP1218357B1 (en) | 2005-04-06 |
| HUP0204226A3 (en) | 2003-07-28 |
| WO2001021595A1 (en) | 2001-03-29 |
| NO20021395L (no) | 2002-05-15 |
| BG106535A (bg) | 2002-12-29 |
| GB9922173D0 (en) | 1999-11-17 |
| BR0014136A (pt) | 2002-05-21 |
| ZA200201831B (en) | 2003-08-27 |
| CN1391560A (zh) | 2003-01-15 |
| CZ20021007A3 (cs) | 2002-06-12 |
| CA2384284A1 (en) | 2001-03-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20021395D0 (no) | Kinazolinderivater | |
| HK1046688A1 (zh) | 喹唑啉化合物和含有喹唑啉化合物的藥物組合物 | |
| NO20004090L (no) | Kjemiske forbindelser | |
| MXPA02011974A (es) | Derivados de quinazolina sustituidos y su uso como inhibidores. | |
| ATE227570T1 (de) | Bizyklische pyrrolderivate als mcp-1 inhibitoren | |
| EA199900591A1 (ru) | АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха | |
| ID29452A (id) | 4-okso-1,4-dihidro-3-quinolinkarboksamida sebagai agen-agen antivirus | |
| ATE449099T1 (de) | Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren | |
| DE602004024988D1 (de) | 2-aminopyrimidin-derivate als raf-kinase-hemmer | |
| ES2189968T3 (es) | Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS. | |
| ES2196396T3 (es) | Compuestos heteroaromaticos de 5 miembros conteniendo oxigeno o azufre como inhibidores del factor xa. | |
| DK0931788T3 (da) | Metalloproteasehæmmere | |
| DE60127845D1 (de) | Benzylidenthiazolidindione und ihre verwendung als antimykotische mittel | |
| TR200001950T2 (tr) | İkameli 2-benzilamino-2-fenil-asetamid bileşikler. | |
| DE69808099D1 (de) | Substituierte 6-alkylphenanthridine | |
| DE60036558D1 (de) | Phthalazinon-derivate als pde 4 hemmer | |
| ATE247660T1 (de) | Furopyridinderivate und ihre therapeutische verwendung | |
| DE60105028D1 (de) | Ruthenium (ii) verbindungen in der krebsbehandlung | |
| HRP20010885B1 (en) | Ethanesulfonyl-piperidine derivatives | |
| TR200003877T2 (tr) | İnsan CD23 üretiminin ve TNF salınmasının ihhibitörleri olan hiydroxamic acid türevleri | |
| DE60319743D1 (de) | Phthalazinderivate als phosphodiesterase-4-hemmer |