NO20021846D0 - Imidazole derivatives as phosphodiesterase VII inhibitors - Google Patents

Imidazole derivatives as phosphodiesterase VII inhibitors

Info

Publication number: NO20021846D0
Authority: NO; Norway
Prior art keywords: imidazole derivatives; phosphodiesterase vii; vii inhibitors; inhibitors; phosphodiesterase
Prior art date: 1999-10-21

Application number

NO20021846A

Other languages

Norwegian (no)

Other versions

NO20021846L (en

Inventor

Hans-Michael Eggenweiler

Jonas Rochus

Michael Wolf

Michael Gassen

Oliver Poeschke

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-21

Filing date

2002-04-19

Publication date

2002-04-19

2002-04-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2002-04-19 Publication of NO20021846D0 publication Critical patent/NO20021846D0/en

2002-04-19 Publication of NO20021846L publication Critical patent/NO20021846L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)

NO20021846A 1999-10-21 2002-04-19 Imidazole derivatives as phosphodiesterase VII inhibitors NO20021846L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19950647A DE19950647A1 (en)	1999-10-21	1999-10-21	Benzopyranoimidazolone and benzothiopyranoimidazolone derivatives as phosphodiesterase-VII inhibitors useful for treatment of e.g. asthma, psoriasis, osteoporosis, cachexia, sepsis, tumors and AIDS
PCT/EP2000/009926 WO2001029049A2 (en)	1999-10-21	2000-10-10	Imidazole derivatives as phosphodiesterase vii inhibitors

Publications (2)

Publication Number	Publication Date
NO20021846D0 true NO20021846D0 (en)	2002-04-19
NO20021846L NO20021846L (en)	2002-04-19

Family

ID=7926352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20021846A NO20021846L (en)	1999-10-21	2002-04-19	Imidazole derivatives as phosphodiesterase VII inhibitors

Country Status (22)

Country	Link
EP (1)	EP1222193B1 (en)
JP (1)	JP2003512381A (en)
KR (1)	KR20020060201A (en)
CN (1)	CN1382146A (en)
AR (1)	AR026198A1 (en)
AT (1)	ATE247121T1 (en)
AU (1)	AU780788B2 (en)
BR (1)	BR0014922A (en)
CA (1)	CA2388314C (en)
CZ (1)	CZ293751B6 (en)
DE (2)	DE19950647A1 (en)
DK (1)	DK1222193T3 (en)
ES (1)	ES2200957T3 (en)
HU (1)	HUP0203139A3 (en)
MX (1)	MXPA02003952A (en)
NO (1)	NO20021846L (en)
PL (1)	PL355020A1 (en)
PT (1)	PT1222193E (en)
RU (1)	RU2259199C2 (en)
SK (1)	SK4922002A3 (en)
WO (1)	WO2001029049A2 (en)
ZA (1)	ZA200203995B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE375347T1 (en)	2001-12-13	2007-10-15	Asubio Pharma Co Ltd	PYRAZOLOPYRIMIDINONE DERIVATIVES WITH PDE7 INHIBITING EFFECT
DE10163991A1 (en) *	2001-12-24	2003-07-03	Merck Patent Gmbh	Pyrrolo-pyrimidine
JP2006219373A (en)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Pyridinylpyrazolopyrimidinone derivatives having PDE7 inhibitory action
JP2006219374A (en)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Imidazotriazinone derivatives having PDE7 inhibitory action
EP2433943B1 (en)	2004-07-01	2013-09-11	Daiichi Sankyo Company, Limited	Intermediates for thienopyrazole derivatives having PDE7 inhibitory activity
CN101917992A (en)	2007-03-27	2010-12-15	奥默罗斯公司	Use of PDE7 inhibitors for the treatment of movement disorders
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
EP4275752A3 (en)	2010-11-08	2024-02-21	Omeros Corporation	Treatment of addiction and impulse-control disorders using pde7 inhibitors
CN119768172A (en)	2022-08-18	2025-04-04	米托迪治愈有限责任公司	Use of therapeutic agents having phosphodiesterase-7 inhibitory activity in the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertion intolerance

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4305954A (en) *	1981-02-11	1981-12-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 3,4-dihydro(or 1,4-dihydro)-2-[(substituted)thio]-[1]benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones
DE69417560T2 (en) *	1993-08-19	1999-11-11	Janssen Pharmaceutica N.V., Beerse	VASCARIATING SUBTITUATED DIHYDROPYRANOPYRIDINE
DE19632423A1 (en) *	1996-08-12	1998-02-19	Merck Patent Gmbh	Thienopyrimidines
TW591030B (en) *	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
WO2000023091A2 (en) *	1998-10-15	2000-04-27	Bioimage A/S	Specific therapeutic interventions obtained by interference with redistribution and/or targeting of cyclic nucleotide phosphodiesterases of i-kappa-b kinases
AU4589800A (en) *	1999-05-05	2000-11-21	Darwin Discovery Limited	9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7inhibitors

1999
- 1999-10-21 DE DE19950647A patent/DE19950647A1/en not_active Withdrawn
2000
- 2000-10-10 CA CA002388314A patent/CA2388314C/en not_active Expired - Fee Related
- 2000-10-10 DK DK00972714T patent/DK1222193T3/en active
- 2000-10-10 RU RU2002111413/15A patent/RU2259199C2/en not_active IP Right Cessation
- 2000-10-10 KR KR1020027004903A patent/KR20020060201A/en not_active Withdrawn
- 2000-10-10 WO PCT/EP2000/009926 patent/WO2001029049A2/en not_active Ceased
- 2000-10-10 ES ES00972714T patent/ES2200957T3/en not_active Expired - Lifetime
- 2000-10-10 HU HU0203139A patent/HUP0203139A3/en unknown
- 2000-10-10 PT PT00972714T patent/PT1222193E/en unknown
- 2000-10-10 CN CN00814402A patent/CN1382146A/en active Pending
- 2000-10-10 EP EP00972714A patent/EP1222193B1/en not_active Expired - Lifetime
- 2000-10-10 MX MXPA02003952A patent/MXPA02003952A/en unknown
- 2000-10-10 DE DE50003309T patent/DE50003309D1/en not_active Expired - Lifetime
- 2000-10-10 BR BR0014922-5A patent/BR0014922A/en not_active IP Right Cessation
- 2000-10-10 PL PL00355020A patent/PL355020A1/en unknown
- 2000-10-10 JP JP2001531847A patent/JP2003512381A/en active Pending
- 2000-10-10 AU AU11356/01A patent/AU780788B2/en not_active Ceased
- 2000-10-10 AT AT00972714T patent/ATE247121T1/en not_active IP Right Cessation
- 2000-10-10 CZ CZ20021251A patent/CZ293751B6/en not_active IP Right Cessation
- 2000-10-10 SK SK492-2002A patent/SK4922002A3/en unknown
- 2000-10-20 AR ARP000105542A patent/AR026198A1/en unknown
2002
- 2002-04-19 NO NO20021846A patent/NO20021846L/en not_active Application Discontinuation
- 2002-05-20 ZA ZA200203995A patent/ZA200203995B/en unknown

Also Published As

Publication number	Publication date
ES2200957T3 (en)	2004-03-16
WO2001029049A3 (en)	2001-11-01
CN1382146A (en)	2002-11-27
HUP0203139A2 (en)	2003-01-28
JP2003512381A (en)	2003-04-02
CA2388314C (en)	2009-06-16
DE50003309D1 (en)	2003-09-18
BR0014922A (en)	2002-06-11
AR026198A1 (en)	2003-01-29
AU1135601A (en)	2001-04-30
AU780788B2 (en)	2005-04-14
CA2388314A1 (en)	2001-04-26
SK4922002A3 (en)	2002-09-10
DE19950647A1 (en)	2001-04-26
RU2259199C2 (en)	2005-08-27
HUP0203139A3 (en)	2004-12-28
EP1222193B1 (en)	2003-08-13
NO20021846L (en)	2002-04-19
EP1222193A2 (en)	2002-07-17
ATE247121T1 (en)	2003-08-15
MXPA02003952A (en)	2004-09-06
WO2001029049A2 (en)	2001-04-26
DK1222193T3 (en)	2003-12-01
PT1222193E (en)	2003-12-31
ZA200203995B (en)	2003-10-29
KR20020060201A (en)	2002-07-16
PL355020A1 (en)	2004-03-22
CZ293751B6 (en)	2004-07-14
CZ20021251A3 (en)	2002-07-17

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ATE256127T1 (en)	2003-12-15	BETACARBOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
EE200300049A (en)	2004-10-15	Imidazole derivatives
DK1244647T3 (en)	2006-09-25	Quinzoline derivatives as VIGF inhibitors
ATE360620T1 (en)	2007-05-15	IMIDAZOLE DERIVATIVES
ATE278690T1 (en)	2004-10-15	SUBSTITUTED PYPROLOPYRIDINONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
DK1185529T3 (en)	2005-02-07	Pyrazole benzodiazepines as CDK2 inhibitors
ATE425147T1 (en)	2009-03-15	IMIDAZOLE DERIVATIVES
NL300242I1 (en)	2006-12-01	Mega-carboxyaryl substituted diphenylureas as well as kinase inhibitors.
NO20022125D0 (en)	2002-05-03	Pyrrole derivatives as inhibitors of phosphodiesterase VII
DK1226143T3 (en)	2003-06-30	Imidazopyridine derivatives as phosphodiesterase VII inhibitors
DK1228073T3 (en)	2003-11-03	Imidazole Compounds as Phosphodiesterase VII Inhibitors
NO20016201D0 (en)	2001-12-18	Tienopyrimidines as phosphodiesterase inhibitors
NO20021959L (en)	2002-05-29	Tetrahydrotiopyranephthalazinone derivatives as PDE4 inhibitors
NO20022123D0 (en)	2002-05-03	Oxoxazole derivatives for use as inhibitors of phosphodiesterase VII
DK1222193T3 (en)	2003-12-01	Imidazole derivatives as phosphodiesterase VII inhibitors
DE60009296D1 (en)	2004-04-29	SUBSTITUTED PURINE DERIVATIVES AS CELL ADHESION INHIBITORS
ATE262517T1 (en)	2004-04-15	THIOPYRANE DERIVATIVES AS MMP INHIBITORS
EE200200389A (en)	2003-10-15	Novel derivatives of imidazole
ATE264308T1 (en)	2004-04-15	AMINOALKYL-3,4-DIHYDROCINOLINE DERIVATIVES AS NO SYNTHASE INHIBITORS
NO20020592D0 (en)	2002-02-06	Fluorine derivatives as integrin inhibitors
DK1296981T3 (en)	2005-07-25	Substituted pyrrolopyridinone derivatives as phosphodiesterase inhibitors

Legal Events

Date	Code	Title	Description
2004-10-18	FC2A	Withdrawal, rejection or dismissal of laid open patent application