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NO20015008L - eNOS-mutasjoner anvendbare for genterapi og terapeutiske sök - Google Patents

eNOS-mutasjoner anvendbare for genterapi og terapeutiske sök

Info

Publication number
NO20015008L
NO20015008L NO20015008A NO20015008A NO20015008L NO 20015008 L NO20015008 L NO 20015008L NO 20015008 A NO20015008 A NO 20015008A NO 20015008 A NO20015008 A NO 20015008A NO 20015008 L NO20015008 L NO 20015008L
Authority
NO
Norway
Prior art keywords
searches
therapeutic
gene therapy
mutations useful
enos
Prior art date
Application number
NO20015008A
Other languages
English (en)
Norwegian (no)
Other versions
NO20015008D0 (no
Inventor
William C Sessa
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Publication of NO20015008D0 publication Critical patent/NO20015008D0/no
Publication of NO20015008L publication Critical patent/NO20015008L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075—Nitric-oxide synthase (1.14.13.39)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20015008A 1999-04-16 2001-10-15 eNOS-mutasjoner anvendbare for genterapi og terapeutiske sök NO20015008L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12955099P 1999-04-16 1999-04-16
PCT/US2000/009913 WO2000062605A1 (fr) 1999-04-16 2000-04-14 Mutations enos utiles en therapie genique et pour le criblage d'agents therapeutiques

Publications (2)

Publication Number Publication Date
NO20015008D0 NO20015008D0 (no) 2001-10-15
NO20015008L true NO20015008L (no) 2001-12-07

Family

ID=22440541

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20015008A NO20015008L (no) 1999-04-16 2001-10-15 eNOS-mutasjoner anvendbare for genterapi og terapeutiske sök

Country Status (25)

Country Link
US (4) US6900038B2 (fr)
EP (1) EP1178722A4 (fr)
JP (1) JP2002541829A (fr)
KR (1) KR100737945B1 (fr)
CN (1) CN100357433C (fr)
AU (2) AU774010B2 (fr)
BG (1) BG106051A (fr)
BR (1) BR0009805A (fr)
CA (1) CA2369764A1 (fr)
CZ (1) CZ20013427A3 (fr)
EE (1) EE200100538A (fr)
HK (1) HK1046081B (fr)
HR (1) HRP20010797A2 (fr)
HU (1) HUP0200799A3 (fr)
IL (1) IL145760A0 (fr)
MX (1) MXPA01010459A (fr)
NO (1) NO20015008L (fr)
NZ (1) NZ514305A (fr)
PL (1) PL351087A1 (fr)
RU (1) RU2257226C2 (fr)
SK (1) SK14692001A3 (fr)
UA (1) UA76939C2 (fr)
WO (1) WO2000062605A1 (fr)
YU (1) YU73301A (fr)
ZA (1) ZA200108463B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0200799A3 (en) * 1999-04-16 2004-11-29 Univ Yale New Haven Enos mutations useful for gene therapy and therapeutic screening
US7098016B2 (en) 2002-06-14 2006-08-29 Wisconsin Alumni Research Foundation Ribonuclease zymogen design
CN1691958A (zh) * 2002-08-16 2005-11-02 舍林股份公司 用于基因治疗的eNOS突变体
WO2004016761A2 (fr) * 2002-08-16 2004-02-26 Schering Aktiengesellschaft Therapie genique pour l'ischemie aigue des membres avec enos de type sauvage ou mutant
GB0226463D0 (en) * 2002-11-13 2002-12-18 Isis Innovation Mimicking the athletic heart
US7259149B2 (en) * 2002-12-02 2007-08-21 Anges Mg, Inc. Methods for treating or preventing angiogenesis-dependent symptoms
US7531318B2 (en) 2004-08-20 2009-05-12 Board Of Regents, The University Of Texas System Screening of agents for activity against ischemic myocardial insults
US7740849B2 (en) * 2004-09-24 2010-06-22 Beth Israel Deaconess Medical Center Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
JP5270161B2 (ja) * 2004-09-24 2013-08-21 ベス イスラエル デアコネス メディカル センター 妊娠合併症を診断および処置する方法
CA2654283A1 (fr) * 2006-05-31 2008-03-13 Beth Israel Deaconess Medical Center, Inc. Methodes pour le diagnostic et le traitement de complications associees a une grossesse
US20090286271A1 (en) * 2006-05-31 2009-11-19 Karumanchi Ananth S Methods of Diagnosing and Treating Complications of Pregnancy
US8183007B2 (en) * 2008-07-22 2012-05-22 Promega Corporation ADP detection based methods using adenylate cyclase and bioluminescence
RU2520748C2 (ru) * 2008-12-04 2014-06-27 Санофи Способы и применения, включающие гемсвязывающий белок 1
RU2526575C2 (ru) * 2012-11-02 2014-08-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ повышения иммуносупрессивных свойств мезенхимальных стромальных клеток жировой ткани
JP6510041B2 (ja) 2014-10-08 2019-05-08 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 生物発光サクシネート検出アッセイ
CN107802826B (zh) * 2017-10-26 2020-02-18 首都医科大学宣武医院 eNOS突变体在促进血管生成中的应用
CN116790603B (zh) * 2023-08-18 2023-10-31 成都中科奥格生物科技有限公司 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498539A (en) * 1992-07-02 1996-03-12 Daiichi Pharmaceutical Co., Ltd. Bovine endothelial nitric oxide synthase nucleic acids
US5658565A (en) * 1994-06-24 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Inducible nitric oxide synthase gene for treatment of disease
DE4411402A1 (de) * 1994-03-31 1995-10-05 Juergen Schrader DNA-Expressionsvektoren zur Verwendung in der gentherapeutischen Behandlung von Gefäßerkrankungen
FR2722507B1 (fr) * 1994-07-12 1996-08-14 Rhone Poulenc Rorer Sa Adenovirus comportant un gene codant pour une no synthase
US5968983A (en) * 1994-10-05 1999-10-19 Nitrosystems, Inc Method and formulation for treating vascular disease
US5837534A (en) * 1995-11-14 1998-11-17 The Board Of Regents Of The University Of Texas System Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells
CA2335391A1 (fr) * 1998-10-02 2000-04-13 Kenneth Walsh Compositions akt augmentant la survie de cellules
SI1144600T1 (sl) * 1999-03-19 2008-12-31 Aventis Pharma Inc AKT-3-nukleinske kisline, polipeptidi in njihove uporabe
HUP0200799A3 (en) * 1999-04-16 2004-11-29 Univ Yale New Haven Enos mutations useful for gene therapy and therapeutic screening
JP2003530818A (ja) * 1999-06-11 2003-10-21 アベンティス・ファーマスーティカルズ・インコーポレイテツド セリン／トレオニンプロテインキナーゼＡｋｔによる血管内皮成長因子（ＶＥＧＦ）の導入

Also Published As

Publication number Publication date
WO2000062605A1 (fr) 2000-10-26
ZA200108463B (en) 2003-01-15
HUP0200799A3 (en) 2004-11-29
BR0009805A (pt) 2002-01-15
US7888089B2 (en) 2011-02-15
BG106051A (en) 2002-06-28
NZ514305A (en) 2004-01-30
HK1046081B (zh) 2008-09-05
AU2004210533A1 (en) 2004-11-04
HUP0200799A2 (en) 2002-06-29
CN1347283A (zh) 2002-05-01
MXPA01010459A (es) 2003-08-20
JP2002541829A (ja) 2002-12-10
US20090246183A1 (en) 2009-10-01
EP1178722A4 (fr) 2003-03-05
US6900038B2 (en) 2005-05-31
UA76939C2 (en) 2006-10-16
KR20010110770A (ko) 2001-12-13
CZ20013427A3 (cs) 2002-03-13
YU73301A (sh) 2004-07-15
EP1178722A1 (fr) 2002-02-13
RU2257226C2 (ru) 2005-07-27
IL145760A0 (en) 2002-07-25
AU774010B2 (en) 2004-06-10
HRP20010797A2 (en) 2003-02-28
NO20015008D0 (no) 2001-10-15
US20110173711A1 (en) 2011-07-14
PL351087A1 (en) 2003-03-24
HK1046081A1 (zh) 2002-12-27
AU4237800A (en) 2000-11-02
CN100357433C (zh) 2007-12-26
US20040253685A1 (en) 2004-12-16
EE200100538A (et) 2002-12-16
SK14692001A3 (sk) 2002-09-10
CA2369764A1 (fr) 2000-10-26
US20030049823A1 (en) 2003-03-13
KR100737945B1 (ko) 2007-07-13

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Legal Events

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