NO20015477D0 - 4,5,6,7-tetrahydroindazol-derivater som anti-tumor midler - Google Patents

4,5,6,7-tetrahydroindazol-derivater som anti-tumor midler

Info

Publication number: NO20015477D0
Authority: NO; Norway
Prior art keywords: tumor agents; tetrahydroindazole derivatives; tetrahydroindazole; derivatives; tumor
Prior art date: 1999-05-12

Application number

NO20015477A

Other languages

English (en)

Other versions

NO20015477L (no

Inventor

Paolo Pevarello

Manuela Villa

Mario Varasi

Antonella Isacchi

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-12

Filing date

2001-11-08

Publication date

2001-11-08

2001-11-08 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

2001-11-08 Publication of NO20015477D0 publication Critical patent/NO20015477D0/no

2002-01-11 Publication of NO20015477L publication Critical patent/NO20015477L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20015477A 1999-05-12 2001-11-08 4,5,6,7-tetrahydroindazolderivater som antitumormidler NO20015477L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9911053.8A GB9911053D0 (en)	1999-05-12	1999-05-12	4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
PCT/EP2000/004208 WO2000069846A1 (en)	1999-05-12	2000-05-04	4,5,6,7-tetrahydroindazole derivatives as antitumor agents

Publications (2)

Publication Number	Publication Date
NO20015477D0 true NO20015477D0 (no)	2001-11-08
NO20015477L NO20015477L (no)	2002-01-11

Family

ID=10853343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20015477A NO20015477L (no)	1999-05-12	2001-11-08	4,5,6,7-tetrahydroindazolderivater som antitumormidler

Country Status (26)

Country	Link
US (1)	US6716856B1 (no)
EP (1)	EP1177185B1 (no)
JP (1)	JP2002544271A (no)
KR (1)	KR20010113926A (no)
CN (1)	CN1350528A (no)
AR (1)	AR023971A1 (no)
AT (1)	ATE293618T1 (no)
AU (1)	AU4564500A (no)
BR (1)	BR0010476A (no)
CA (1)	CA2372429A1 (no)
CZ (1)	CZ20013970A3 (no)
DE (1)	DE60019577T2 (no)
EA (1)	EA200101194A1 (no)
ES (1)	ES2239595T3 (no)
GB (1)	GB9911053D0 (no)
HK (1)	HK1045687A1 (no)
HU (1)	HUP0201225A3 (no)
IL (1)	IL146100A0 (no)
MX (1)	MXPA01011441A (no)
NO (1)	NO20015477L (no)
NZ (1)	NZ514873A (no)
PL (1)	PL351611A1 (no)
PT (1)	PT1177185E (no)
SK (1)	SK15712001A3 (no)
WO (1)	WO2000069846A1 (no)
ZA (1)	ZA200108530B (no)

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DE10148617A1 (de) *	2001-09-25	2003-04-24	Schering Ag	Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel
UA81790C2 (uk)	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази
EA010904B1 (ru)	2003-05-22	2008-12-30	НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.	Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
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KR101617774B1 (ko) *	2005-02-25	2016-05-04	에사넥스, 인코포레이티드	테트라히드로인돌론 및 테트라히드로인다졸론 유도체
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US20080119457A1 (en) *	2006-08-24	2008-05-22	Serenex, Inc.	Benzene, Pyridine, and Pyridazine Derivatives
US20080070933A1 (en) *	2006-08-24	2008-03-20	Huang Kenneth H	Purine, Pyrimidine, and Azaindole Derivatives
US20080076813A1 (en) *	2006-08-24	2008-03-27	Huang Kenneth H	Benzene, Pyridine, and Pyridazine Derivatives
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DE102006060598A1 (de) *	2006-12-21	2008-06-26	Merck Patent Gmbh	Tetrahydrobenzoisoxazole
EP2120933B1 (en)	2007-02-27	2015-07-08	Nerviano Medical Sciences S.r.l.	Isoquinolinopyrrolopyridinones active as kinase inhibitors
EP2003129B1 (en)	2007-06-11	2017-08-09	Nerviano Medical Sciences S.r.l.	1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives
US20110129467A1 (en)	2008-07-24	2011-06-02	Nerviano Medical Sciences S.R.L.	Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents
KR101787116B1 (ko)	2009-01-28	2017-10-18	케러 테라퓨틱스, 인코포레이티드	바이시클릭 피라졸로-헤테로사이클
US7741350B1 (en)	2009-01-28	2010-06-22	Cara Therapeutics, Inc.	Bicyclic pyrazolo-heterocycles
CN102311389A (zh) *	2010-06-29	2012-01-11	王小龙	一种氮芳香取代吡唑衍生物、及其合成和抗癌应用
RU2652638C2 (ru)	2010-12-17	2018-04-28	НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.	Замещенные пиразолхиназолиновые производные в качестве ингибиторов киназы
AU2012204232A1 (en)	2011-01-07	2013-06-27	Corcept Therapeutics, Inc.	Combination steroid and glucocorticoid receptor antagonist therapy
ES2620316T3 (es) *	2012-05-11	2017-06-28	Bayer Pharma Aktiengesellschaft	Cicloalquenopirazoles sustituidos como inhibidores de BUB1 para el tratamiento del cáncer
US12226412B2 (en)	2012-05-25	2025-02-18	Corcept Therapeutics, Inc.	Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
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ES2743620T3 (es)	2013-11-25	2020-02-20	Corcept Therapeutics Inc	Moduladores del receptor de glucocorticoides de azadecalina condensada con octahidro
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CN113490496A (zh)	2019-02-22	2021-10-08	科赛普特治疗学股份有限公司	一种杂芳基-酮稠合氮杂萘烷糖皮质激素受体调节剂瑞拉可兰的治疗用途
KR20220113767A (ko)	2019-12-11	2022-08-16	코어셉트 쎄라퓨틱스 인코포레이티드	미리코릴란트로 항정신병약-유도 체중 증가를 치료하는 방법
CR20220299A (es)	2019-12-20	2022-08-05	Pfizer	Derivados de becimidazol
WO2022134033A1 (en)	2020-12-25	2022-06-30	Corcept Therapeutics Incorporated	Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
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1999
- 1999-05-12 GB GBGB9911053.8A patent/GB9911053D0/en not_active Ceased
2000
- 2000-05-04 PL PL00351611A patent/PL351611A1/xx not_active Application Discontinuation
- 2000-05-04 AU AU45645/00A patent/AU4564500A/en not_active Abandoned
- 2000-05-04 JP JP2000618263A patent/JP2002544271A/ja not_active Withdrawn
- 2000-05-04 HU HU0201225A patent/HUP0201225A3/hu unknown
- 2000-05-04 MX MXPA01011441A patent/MXPA01011441A/es active IP Right Grant
- 2000-05-04 WO PCT/EP2000/004208 patent/WO2000069846A1/en not_active Ceased
- 2000-05-04 ES ES00927184T patent/ES2239595T3/es not_active Expired - Lifetime
- 2000-05-04 NZ NZ514873A patent/NZ514873A/xx unknown
- 2000-05-04 BR BR0010476-0A patent/BR0010476A/pt not_active Application Discontinuation
- 2000-05-04 CZ CZ20013970A patent/CZ20013970A3/cs unknown
- 2000-05-04 KR KR1020017014383A patent/KR20010113926A/ko not_active Withdrawn
- 2000-05-04 CA CA002372429A patent/CA2372429A1/en not_active Abandoned
- 2000-05-04 US US09/926,478 patent/US6716856B1/en not_active Expired - Fee Related
- 2000-05-04 CN CN00807465A patent/CN1350528A/zh active Pending
- 2000-05-04 DE DE60019577T patent/DE60019577T2/de not_active Expired - Fee Related
- 2000-05-04 SK SK1571-2001A patent/SK15712001A3/sk not_active Application Discontinuation
- 2000-05-04 EP EP00927184A patent/EP1177185B1/en not_active Expired - Lifetime
- 2000-05-04 IL IL14610000A patent/IL146100A0/xx unknown
- 2000-05-04 PT PT00927184T patent/PT1177185E/pt unknown
- 2000-05-04 HK HK02107036.9A patent/HK1045687A1/zh unknown
- 2000-05-04 EA EA200101194A patent/EA200101194A1/ru unknown
- 2000-05-04 AT AT00927184T patent/ATE293618T1/de not_active IP Right Cessation
- 2000-05-12 AR ARP000102286A patent/AR023971A1/es unknown
2001
- 2001-10-17 ZA ZA200108530A patent/ZA200108530B/xx unknown
- 2001-11-08 NO NO20015477A patent/NO20015477L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE293618T1 (de)	2005-05-15
HUP0201225A2 (en)	2002-08-28
US6716856B1 (en)	2004-04-06
AR023971A1 (es)	2002-09-04
WO2000069846A1 (en)	2000-11-23
NO20015477L (no)	2002-01-11
SK15712001A3 (sk)	2002-06-04
EA200101194A1 (ru)	2002-06-27
ES2239595T3 (es)	2005-10-01
ZA200108530B (en)	2003-02-03
CN1350528A (zh)	2002-05-22
HK1045687A1 (zh)	2002-12-06
PL351611A1 (en)	2003-05-05
MXPA01011441A (es)	2002-10-21
NZ514873A (en)	2004-05-28
HUP0201225A3 (en)	2003-11-28
KR20010113926A (ko)	2001-12-28
EP1177185B1 (en)	2005-04-20
EP1177185A1 (en)	2002-02-06
CZ20013970A3 (cs)	2002-04-17
DE60019577D1 (de)	2005-05-25
BR0010476A (pt)	2003-07-01
AU4564500A (en)	2000-12-05
PT1177185E (pt)	2005-08-31
IL146100A0 (en)	2002-07-25
JP2002544271A (ja)	2002-12-24
CA2372429A1 (en)	2000-11-23
DE60019577T2 (de)	2006-03-09
GB9911053D0 (en)	1999-07-14

Publication	Publication Date	Title
NO20015477D0 (no)	2001-11-08	4,5,6,7-tetrahydroindazol-derivater som anti-tumor midler
NO20013671L (no)	2001-09-26	Substituerte bisycliske derivater nyttige som anticancer midler
NO20020684L (no)	2002-04-03	3(5)-aminopyrazolderivater, fremgangsmåtet for deres fremstilling og deres anvendelse som antitumormidler
DE69933287D1 (de)	2006-11-02	12,13-modifizierte epothilon-derivate
TR200000520A3 (tr)	2001-06-21	4-Fenil-piridin türevleri.
PT1218378E (pt)	2003-09-30	Derivados de terc-butil-(7-metil-imidazo-¬1,2-a\|-piridin-3-il)-amina
DK1930330T3 (da)	2011-12-12	Pleuromutilinderivater som antimikrobielle midler
DE60214428D1 (de)	2006-10-12	1, 4-dihydro-1, 4-diphenylpyridin-derivate
NO20013909L (no)	2001-10-08	Heteroaryl-substituerte kinolin-2-on derivater nyttige som anticancer midler
ATE293104T1 (de)	2005-04-15	Thiazolylamid-derivate
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