NO20014529L - Tetrahydropyranderivater og deres anvendelse som terapautiske midler - Google Patents
Tetrahydropyranderivater og deres anvendelse som terapautiske midlerInfo
- Publication number
- NO20014529L NO20014529L NO20014529A NO20014529A NO20014529L NO 20014529 L NO20014529 L NO 20014529L NO 20014529 A NO20014529 A NO 20014529A NO 20014529 A NO20014529 A NO 20014529A NO 20014529 L NO20014529 L NO 20014529L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydroxy
- alkoxy
- fluoro
- group
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 150000003527 tetrahydropyrans Chemical class 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Foreliggende oppfinnelse angår forbindelser av formel (I) (D hvori R1, R2, R3, R4, R5, R9 og R10 betegner et utall av substituenter; R6 betegner hydrogen eller en d.4-alkylgruppe eventu- elt substituert med en hydroksygruppe; R7 betegner halogen, hydroksy, C2_4-alkenyl, N3, -NR^R12, -NRaCORb, -OSO2Ra, - (CH2)pNRa(CH2)qCOORb, CORa, COORa eller en femleddet eller seksleddet, nitrogenholdig, heteroaromatisk ring eventuelt inneholdende l, 2 eller 3 ytterligere heteroatomer valgt fra N, O og S, hvilken heteroaromatisk ring eventuelt er substituert ved enhver substi- tuerbar stilling med en substituent valgt fra =O, =S, halogen, hydroksy, -SH, CORa, C02Ra, -ZNR^R12, d-4-alkyl, hydroksy-Ci-4- alkyl, f luor-C1.4-alkyl, Ci_4-alkoksy, fluor-Ci-4-alkoksy eller Ci_4-alkoksy substi- tuert med en d_4-alkoksy- eller hydroksyl- gruppe; R8 betegner hydrogen, Ci_6-alkyl, f luor-Ci-s-alkyl, hydroksy, Ci-6-alkoksy eller hydroksy-d-6-alkyl; og n er O, l eller 2; eller et farmasøytisk aksept- abelt salt derav. Forbindelsene er av særlig anvendelse ved behandling eller forhindring av depresjon, angst, smerte, inflammasjon, migrene, emesis eller postherpetisk neuralgi.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9906480.0A GB9906480D0 (en) | 1999-03-19 | 1999-03-19 | Therapeutic agents |
| GBGB9924616.7A GB9924616D0 (en) | 1999-10-18 | 1999-10-18 | Therapeutic agents |
| PCT/GB2000/000977 WO2000056728A1 (en) | 1999-03-19 | 2000-03-16 | Tetrahydropyran derivatives and their use as therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20014529D0 NO20014529D0 (no) | 2001-09-18 |
| NO20014529L true NO20014529L (no) | 2001-11-13 |
Family
ID=26315315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014529A NO20014529L (no) | 1999-03-19 | 2001-09-18 | Tetrahydropyranderivater og deres anvendelse som terapautiske midler |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6458830B1 (no) |
| EP (1) | EP1165540B1 (no) |
| JP (1) | JP2002540107A (no) |
| KR (1) | KR20010113773A (no) |
| CN (1) | CN1344264A (no) |
| AT (1) | ATE247096T1 (no) |
| AU (2) | AU746251B2 (no) |
| BG (1) | BG105859A (no) |
| BR (1) | BR0009127A (no) |
| CA (1) | CA2367985A1 (no) |
| CO (1) | CO5150225A1 (no) |
| CZ (1) | CZ20013377A3 (no) |
| DE (1) | DE60004504T2 (no) |
| EA (1) | EA200100902A1 (no) |
| EE (1) | EE200100491A (no) |
| ES (1) | ES2203434T3 (no) |
| HU (1) | HUP0200441A3 (no) |
| IL (1) | IL144236A0 (no) |
| NO (1) | NO20014529L (no) |
| PE (1) | PE20001556A1 (no) |
| PL (1) | PL350123A1 (no) |
| SK (1) | SK13322001A3 (no) |
| WO (2) | WO2000056727A1 (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10001785A1 (de) * | 2000-01-18 | 2001-07-19 | Boehringer Ingelheim Pharma | NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms |
| GB0017256D0 (en) | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| GB0020721D0 (en) | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
| PE20020444A1 (es) | 2000-09-22 | 2002-06-14 | Merck & Co Inc | Antagonistas de receptores de taquiquinina zwitterionica |
| CA2433835A1 (en) | 2001-01-17 | 2002-07-25 | Merck Sharp & Dohme Limited | Tetrahydropyran derivatives as neurokinin receptor antagonists |
| GB0121874D0 (en) * | 2001-09-10 | 2001-10-31 | Merck Sharp & Dohme | Therapeutic agents |
| GB0217068D0 (en) * | 2002-07-23 | 2002-08-28 | Merck Sharp & Dohme | Therapeutic agents |
| US20060247216A1 (en) * | 2002-10-25 | 2006-11-02 | Haj-Yehia Abdullah I | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
| EP1578413A2 (en) * | 2002-11-29 | 2005-09-28 | Yissum Research Development Company of The Hebrew University of Jerusalem | Ace-inhibitors having antioxidant and no-donor activity |
| ATE411311T1 (de) | 2003-03-07 | 2008-10-15 | Merck Sharp & Dohme | Tetrahydropyranverbindungen als tachykininantagonisten |
| EP1791847A2 (en) | 2004-09-08 | 2007-06-06 | Altana Pharma AG | Novel 3-thia-10-aza-phenanthrene derivatives |
| DE602005014138D1 (de) * | 2004-11-30 | 2009-06-04 | Mallinckrodt Inc | Verfahren zur kristallisierung von benzphetamin |
| CA2605594A1 (en) * | 2005-04-22 | 2006-11-02 | Daiichi Sankyo Company, Limited | Heterocyclic compound |
| CN100395242C (zh) * | 2006-06-08 | 2008-06-18 | 华东理工大学 | 烷氧基萘和萘醌类吡喃碳糖苷化合物及其制备方法 |
| DE102007010077B4 (de) * | 2007-02-28 | 2010-04-08 | RUHR-UNIVERSITäT BOCHUM | [1,3]-Dioxane zur Modulation von GABAa-Rezeptoren |
| EP2729147B1 (en) | 2011-07-04 | 2017-09-06 | IRBM - Science Park S.p.A. | Nk-1 receptor antagonists for treating corneal neovascularisation |
| EP2892509B1 (en) * | 2012-09-04 | 2024-12-11 | Lauren Sciences LLC | Bolaamphiphilic compounds, compositions and uses thereof |
| CA2951259A1 (en) | 2014-06-06 | 2015-12-10 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| WO2016073738A2 (en) * | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| HU231150B1 (hu) | 2017-03-13 | 2021-03-29 | Richter Gedeon Nyrt | Eljárás racém 3-alkilpiperidin-3-karbonsav-etil-észterek optikai izomerjeinek elválasztására |
| US11440896B2 (en) * | 2018-02-06 | 2022-09-13 | Daiichi Sankyo Company, Limited | Aminoalkyl compound |
| WO2019162519A1 (en) | 2018-02-26 | 2019-08-29 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
| US20230134843A1 (en) | 2020-03-11 | 2023-05-04 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301920D0 (en) * | 1993-02-01 | 1993-03-17 | Foundation For Ethnobiology Th | Polycetylenes |
-
2000
- 2000-03-10 CO CO00017612A patent/CO5150225A1/es unknown
- 2000-03-13 PE PE2000000218A patent/PE20001556A1/es not_active Application Discontinuation
- 2000-03-16 CN CN00805114A patent/CN1344264A/zh active Pending
- 2000-03-16 EP EP00911045A patent/EP1165540B1/en not_active Expired - Lifetime
- 2000-03-16 ES ES00911045T patent/ES2203434T3/es not_active Expired - Lifetime
- 2000-03-16 EE EEP200100491A patent/EE200100491A/xx unknown
- 2000-03-16 AT AT00911045T patent/ATE247096T1/de not_active IP Right Cessation
- 2000-03-16 BR BR0009127-8A patent/BR0009127A/pt not_active Application Discontinuation
- 2000-03-16 SK SK1332-2001A patent/SK13322001A3/sk unknown
- 2000-03-16 CZ CZ20013377A patent/CZ20013377A3/cs unknown
- 2000-03-16 JP JP2000606588A patent/JP2002540107A/ja not_active Withdrawn
- 2000-03-16 WO PCT/GB2000/000974 patent/WO2000056727A1/en not_active Ceased
- 2000-03-16 HU HU0200441A patent/HUP0200441A3/hu unknown
- 2000-03-16 US US09/936,343 patent/US6458830B1/en not_active Expired - Fee Related
- 2000-03-16 DE DE60004504T patent/DE60004504T2/de not_active Expired - Fee Related
- 2000-03-16 PL PL00350123A patent/PL350123A1/xx not_active Application Discontinuation
- 2000-03-16 KR KR1020017011885A patent/KR20010113773A/ko not_active Withdrawn
- 2000-03-16 CA CA002367985A patent/CA2367985A1/en not_active Abandoned
- 2000-03-16 WO PCT/GB2000/000977 patent/WO2000056728A1/en not_active Ceased
- 2000-03-16 IL IL14423600A patent/IL144236A0/xx unknown
- 2000-03-16 AU AU33042/00A patent/AU746251B2/en not_active Ceased
- 2000-03-16 AU AU33044/00A patent/AU3304400A/en not_active Abandoned
- 2000-03-16 EA EA200100902A patent/EA200100902A1/ru unknown
-
2001
- 2001-08-30 BG BG105859A patent/BG105859A/bg unknown
- 2001-09-18 NO NO20014529A patent/NO20014529L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3304200A (en) | 2000-10-09 |
| NO20014529D0 (no) | 2001-09-18 |
| DE60004504D1 (de) | 2003-09-18 |
| ATE247096T1 (de) | 2003-08-15 |
| CN1344264A (zh) | 2002-04-10 |
| CZ20013377A3 (cs) | 2002-02-13 |
| BG105859A (bg) | 2002-04-30 |
| AU746251B2 (en) | 2002-04-18 |
| US6458830B1 (en) | 2002-10-01 |
| EP1165540B1 (en) | 2003-08-13 |
| PE20001556A1 (es) | 2001-01-13 |
| JP2002540107A (ja) | 2002-11-26 |
| KR20010113773A (ko) | 2001-12-28 |
| DE60004504T2 (de) | 2004-06-24 |
| HUP0200441A3 (en) | 2002-09-30 |
| PL350123A1 (en) | 2002-11-04 |
| EA200100902A1 (ru) | 2002-02-28 |
| CO5150225A1 (es) | 2002-04-29 |
| EE200100491A (et) | 2002-12-16 |
| AU3304400A (en) | 2000-10-09 |
| WO2000056728A1 (en) | 2000-09-28 |
| IL144236A0 (en) | 2002-05-23 |
| CA2367985A1 (en) | 2000-09-28 |
| BR0009127A (pt) | 2001-12-26 |
| WO2000056727A1 (en) | 2000-09-28 |
| HUP0200441A2 (hu) | 2002-07-29 |
| SK13322001A3 (sk) | 2002-02-05 |
| EP1165540A1 (en) | 2002-01-02 |
| ES2203434T3 (es) | 2004-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |