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NO20013709L - Nye N-triazolylmetyl-piperazinderivater som neurokininreseptor-antagonister - Google Patents

Nye N-triazolylmetyl-piperazinderivater som neurokininreseptor-antagonister

Info

Publication number
NO20013709L
NO20013709L NO20013709A NO20013709A NO20013709L NO 20013709 L NO20013709 L NO 20013709L NO 20013709 A NO20013709 A NO 20013709A NO 20013709 A NO20013709 A NO 20013709A NO 20013709 L NO20013709 L NO 20013709L
Authority
NO
Norway
Prior art keywords
triazolylmethyl
new
receptor antagonists
piperazine derivatives
neurokinin receptor
Prior art date
Application number
NO20013709A
Other languages
English (en)
Other versions
NO20013709D0 (no
NO323233B1 (no
Inventor
Daniel Jasserand
Uwe Schoen
Holger Sann
Reinhard Brueckner
Christian Eeckhout
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NO20013709D0 publication Critical patent/NO20013709D0/no
Publication of NO20013709L publication Critical patent/NO20013709L/no
Publication of NO323233B1 publication Critical patent/NO323233B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20013709A 2000-07-28 2001-07-27 Nye N-triazolylmetyl-piperazinderivater som neurokininreseptor-antagonister, legemidler som inneholder forbindelsene, fremgangsmater for fremstilling av forbindelsene, samt mellomprodukter i fremgangsmaten. NO323233B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10036818A DE10036818A1 (de) 2000-07-28 2000-07-28 Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (3)

Publication Number Publication Date
NO20013709D0 NO20013709D0 (no) 2001-07-27
NO20013709L true NO20013709L (no) 2002-01-29
NO323233B1 NO323233B1 (no) 2007-02-05

Family

ID=7650544

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013709A NO323233B1 (no) 2000-07-28 2001-07-27 Nye N-triazolylmetyl-piperazinderivater som neurokininreseptor-antagonister, legemidler som inneholder forbindelsene, fremgangsmater for fremstilling av forbindelsene, samt mellomprodukter i fremgangsmaten.

Country Status (27)

Country Link
US (1) US6407106B1 (no)
EP (1) EP1176144B1 (no)
JP (1) JP2002053577A (no)
KR (1) KR100924405B1 (no)
CN (1) CN1167698C (no)
AR (1) AR028743A1 (no)
AT (1) ATE244716T1 (no)
AU (1) AU779318B2 (no)
BR (1) BR0103048A (no)
CA (1) CA2354213C (no)
CZ (1) CZ301695B6 (no)
DE (2) DE10036818A1 (no)
DK (1) DK1176144T3 (no)
DZ (1) DZ3119A1 (no)
ES (1) ES2201007T3 (no)
HU (1) HU226687B1 (no)
IL (1) IL144299A (no)
IN (1) IN191021B (no)
NO (1) NO323233B1 (no)
NZ (1) NZ513041A (no)
PL (1) PL210436B1 (no)
PT (1) PT1176144E (no)
RU (1) RU2288918C2 (no)
SK (1) SK284802B6 (no)
TW (1) TWI304403B (no)
UA (1) UA73728C2 (no)
ZA (1) ZA200105737B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77515C2 (en) * 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
US7320994B2 (en) * 2002-04-26 2008-01-22 Eli Lilly And Company Triazole derivatives as tachykinin receptor antagonists
IL164787A0 (en) * 2002-04-26 2005-12-18 Lilly Co Eli Tachykinin receptor antagonists
US20060160794A1 (en) * 2003-06-12 2006-07-20 Amegadzie Albert K Tachykinin receptor antagonists
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
KR100978961B1 (ko) * 2005-07-25 2010-08-30 에프. 호프만-라 로슈 아게 치환된 트라이아졸 유도체 및 뉴로키닌 3 수용체길항물질로서의 상기 화합물의 용도
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
DK2729147T3 (en) 2011-07-04 2017-12-18 Irbm - Science Park S P A NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA
EP4371613A3 (en) 2018-02-26 2024-07-24 Ospedale San Raffaele S.r.l. Compounds for use in the treatment of ocular pain
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency
CN115184498B (zh) * 2022-07-15 2023-02-21 山东京卫制药有限公司 N-Boc-哌嗪中有关物质哌嗪的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883098A (en) 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
IL111730A (en) 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
NZ307625A (en) * 1995-05-25 1999-02-25 Fujisawa Pharmaceutical Co 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists
GB9513118D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
DE69621831T2 (de) * 1995-12-18 2003-01-02 Fujisawa Pharmaceutical Co., Ltd. Piperazinderivative als tachykinin antagonisten
KR100458346B1 (ko) * 1996-03-29 2005-06-21 듀파 인터내셔날 리서치 베 파우 피페라진및피페리딘화합물
AUPO735997A0 (en) * 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
DE59814233D1 (de) * 1997-08-27 2008-07-03 Solvay Pharm Gmbh Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Also Published As

Publication number Publication date
DZ3119A1 (fr) 2004-09-19
SK284802B6 (sk) 2005-11-03
NO20013709D0 (no) 2001-07-27
IL144299A0 (en) 2002-05-23
ES2201007T3 (es) 2004-03-16
KR100924405B1 (ko) 2009-10-29
AU5767501A (en) 2002-01-31
CN1167698C (zh) 2004-09-22
HUP0102931A2 (hu) 2002-11-28
ZA200105737B (en) 2002-01-22
IL144299A (en) 2004-08-31
US6407106B1 (en) 2002-06-18
KR20020010482A (ko) 2002-02-04
DE50100358D1 (de) 2003-08-14
ATE244716T1 (de) 2003-07-15
EP1176144A1 (de) 2002-01-30
PT1176144E (pt) 2003-11-28
NO323233B1 (no) 2007-02-05
HU226687B1 (en) 2009-06-29
CZ20011813A3 (cs) 2002-03-13
EP1176144B1 (de) 2003-07-09
US20020065276A1 (en) 2002-05-30
JP2002053577A (ja) 2002-02-19
CN1335316A (zh) 2002-02-13
DK1176144T3 (da) 2003-10-27
DE10036818A1 (de) 2002-02-07
CA2354213A1 (en) 2002-01-28
UA73728C2 (en) 2005-09-15
HUP0102931A3 (en) 2003-07-28
BR0103048A (pt) 2002-04-02
AR028743A1 (es) 2003-05-21
TWI304403B (en) 2008-12-21
AU779318B2 (en) 2005-01-13
HK1042699A1 (en) 2002-08-23
HU0102931D0 (en) 2001-09-28
IN191021B (no) 2003-09-13
RU2288918C2 (ru) 2006-12-10
PL348946A1 (en) 2002-02-11
SK7572001A3 (en) 2002-02-05
NZ513041A (en) 2002-12-20
CA2354213C (en) 2010-04-27
CZ301695B6 (cs) 2010-05-26
PL210436B1 (pl) 2012-01-31

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