NO20013462L - Serinproteaseinhibitorer - Google Patents
SerinproteaseinhibitorerInfo
- Publication number
- NO20013462L NO20013462L NO20013462A NO20013462A NO20013462L NO 20013462 L NO20013462 L NO 20013462L NO 20013462 A NO20013462 A NO 20013462A NO 20013462 A NO20013462 A NO 20013462A NO 20013462 L NO20013462 L NO 20013462L
- Authority
- NO
- Norway
- Prior art keywords
- serine protease
- protease inhibitors
- compounds
- factor
- kallikrein
- Prior art date
Links
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 108010054265 Factor VIIa Proteins 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 108060005987 Kallikrein Proteins 0.000 abstract 1
- 102000001399 Kallikrein Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 229940012414 factor viia Drugs 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11577299P | 1999-01-13 | 1999-01-13 | |
| US15202999P | 1999-09-01 | 1999-09-01 | |
| PCT/US2000/000673 WO2000041531A2 (fr) | 1999-01-13 | 2000-01-11 | Inhibiteurs de la serine protease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20013462D0 NO20013462D0 (no) | 2001-07-12 |
| NO20013462L true NO20013462L (no) | 2001-09-12 |
Family
ID=26813550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013462A NO20013462L (no) | 1999-01-13 | 2001-07-12 | Serinproteaseinhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6472393B1 (fr) |
| EP (1) | EP1144373B1 (fr) |
| JP (1) | JP2002534449A (fr) |
| KR (1) | KR100838418B1 (fr) |
| CN (1) | CN100488947C (fr) |
| AT (1) | ATE307111T1 (fr) |
| AU (1) | AU771776B2 (fr) |
| BR (1) | BR0008755A (fr) |
| CA (1) | CA2356934A1 (fr) |
| CZ (1) | CZ20012508A3 (fr) |
| DE (1) | DE60023266T2 (fr) |
| ES (1) | ES2251363T3 (fr) |
| HU (1) | HUP0105077A3 (fr) |
| IL (2) | IL144032A0 (fr) |
| MX (1) | MXPA01007038A (fr) |
| NO (1) | NO20013462L (fr) |
| NZ (1) | NZ512736A (fr) |
| PL (1) | PL350042A1 (fr) |
| WO (1) | WO2000041531A2 (fr) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100838418B1 (ko) * | 1999-01-13 | 2008-06-13 | 제넨테크, 인크. | 세린 프로테아제 억제제 |
| JP4556371B2 (ja) * | 1999-09-30 | 2010-10-06 | 三菱化学株式会社 | アシルスルホンアミド誘導体 |
| MXPA03009130A (es) | 2000-10-20 | 2004-02-26 | Biocryst Pharm Inc | Compuestos de biarilo que funcionan como inhibidores de proteasa serina. |
| JP4179878B2 (ja) * | 2001-02-02 | 2008-11-12 | 中外製薬株式会社 | ペプチド誘導体 |
| DE10130374A1 (de) * | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| DK1485345T3 (da) * | 2002-03-11 | 2008-11-03 | Curacyte Ag | Urokinaseinhibitorer, deres fremstilling og anvendelse |
| GB0207637D0 (en) * | 2002-04-02 | 2002-05-15 | Karobio Ab | Novel compound |
| AU2003231865A1 (en) * | 2002-05-31 | 2003-12-19 | Genzyme Corporation | Alpha acyloxyacetamides for kallikrein and urokinase inhibition |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| US7144895B2 (en) * | 2003-02-11 | 2006-12-05 | Bristol-Myers Squibb Co. | Benzene acetamide compounds useful as serine protease inhibitors |
| EP1594505A4 (fr) * | 2003-02-11 | 2008-08-13 | Bristol Myers Squibb Co | Derives de phenylglycine utiles en tant qu'inhibiteurs de serine protease |
| EP1628954A2 (fr) * | 2003-05-20 | 2006-03-01 | Genentech, Inc. | Inhibiteurs d'acylsulfamide de facteur viia |
| US7273886B2 (en) * | 2003-05-20 | 2007-09-25 | Genentech, Inc. | Benzofuran inhibitors of factor VIIa |
| DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| TW200637843A (en) * | 2005-01-10 | 2006-11-01 | Bristol Myers Squibb Co | Phenylglycinamide derivatives useful as anticoagulants |
| CA2602533A1 (fr) | 2005-03-29 | 2006-10-05 | Biocryst Pharmaceuticals, Inc. | Therapies contre l'hepatite c |
| AU2006202083A1 (en) * | 2005-06-03 | 2006-12-21 | Reto Brun | Linear dicationic terphenyls and their aza analogues as antiparasitic agents |
| US7964619B2 (en) * | 2005-06-03 | 2011-06-21 | The University Of North Carolina At Chapel Hill | Teraryl components as antiparasitic agents |
| ATE455103T1 (de) * | 2005-06-24 | 2010-01-15 | Bristol Myers Squibb Co | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
| DE602007011231D1 (de) * | 2006-03-24 | 2011-01-27 | Eisai R&D Man Co Ltd | Triazolonderivat |
| US7776832B2 (en) | 2006-04-21 | 2010-08-17 | Gem Pharmaceuticals, Llc | Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| TW200831080A (en) * | 2006-12-15 | 2008-08-01 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
| SI2114980T1 (sl) | 2007-01-12 | 2012-11-30 | Biocryst Pharm Inc | Protivirusni nukleozidni analogi |
| EA200970948A1 (ru) | 2007-04-13 | 2010-08-30 | Саузерн Рисерч Инститьют | Антиангиогенные агенты и способы их применения |
| WO2009018405A1 (fr) * | 2007-07-31 | 2009-02-05 | Mallinckrodt Inc. | Agents photoactifs intégrés et leurs utilisations |
| WO2009038157A1 (fr) | 2007-09-21 | 2009-03-26 | Eisai R & D Management Co., Ltd. | Dérivé de 2,3-dihydroiminoisoindole |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| WO2010036407A2 (fr) | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Analogues nucléosidiques antiviraux |
| ES2534832T3 (es) | 2009-03-10 | 2015-04-29 | Med Discovery Sa | Uso de inhibidores de serina proteasa en el tratamiento de la neutropenia |
| TW201206905A (en) | 2010-05-20 | 2012-02-16 | Eisai R & Amp D Man Co Ltd | Prodrug of triazolone compound |
| WO2012004678A2 (fr) | 2010-07-07 | 2012-01-12 | The Medicines Company (Leipzig) Gmbh | Inhibiteurs de la sérine protéase |
| US9187484B2 (en) | 2012-05-02 | 2015-11-17 | Southern Research Institute | Triazolopyridazine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof |
| AU2015217152A1 (en) | 2014-02-11 | 2016-08-11 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| US10023579B2 (en) | 2015-12-16 | 2018-07-17 | Southern Research Institute | Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof |
| WO2018094227A1 (fr) | 2016-11-17 | 2018-05-24 | The University Of North Carolina At Chapel Hill | Analogues d'alkyle pyrrolopyrimidine et leurs procédés de préparation et d'utilisation |
| US10450263B2 (en) | 2017-02-10 | 2019-10-22 | Southern Research Institute | Benzo annulenes as antiviral agents |
| US11160826B1 (en) | 2017-03-03 | 2021-11-02 | United States Government As Represented By The Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
| AU2018290225A1 (en) | 2017-06-21 | 2020-01-23 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| EP3700545A4 (fr) | 2017-10-26 | 2021-11-17 | Southern Research Institute | Analogues dipeptidiques utilisés comme inhibiteurs du tgf-bêta |
| AU2018357933B2 (en) | 2017-10-31 | 2019-11-21 | Southern Research Institute | Substituted quinazoline sulfonamides as thioredoxin interacting protein (TXNIP) inhibitors |
| TW202535858A (zh) | 2018-04-06 | 2025-09-16 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| KR102810546B1 (ko) | 2018-04-19 | 2025-05-20 | 써던 리서취 인스티튜트 | 암의 치료를 위한 4'-티오-뉴클레오타이드 및 -뉴클레오사이드 전구약물 |
| WO2020072386A1 (fr) | 2018-10-02 | 2020-04-09 | The United States Government As Represented By The Department Of Veterans Affairs | Inhibiteurs de la kinase spak en tant qu'agents neuroprotecteurs |
| US20220251134A1 (en) | 2019-06-14 | 2022-08-11 | Southern Research Institute | 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof |
| MX2022003160A (es) | 2019-09-17 | 2022-09-19 | Univ Utah Res Found | Benzimidazoles y métodos para usarlos. |
| UY38912A (es) | 2019-10-09 | 2021-05-31 | Biocryst Pharm Inc | Inhibidores del factor d del complemento para administración oral |
| AU2020396100A1 (en) | 2019-12-04 | 2022-06-16 | Southern Research Institute | Modulators of Programmed Death-Ligand-1 and/or Programmed Death-Ligand-2 |
| CN115916175A (zh) | 2020-04-02 | 2023-04-04 | 南方研究院 | 作为针对甲病毒属的有效抗病毒剂的新型2-嘧啶酮类似物 |
| AR121715A1 (es) | 2020-04-03 | 2022-06-29 | Biocryst Pharm Inc | Pirrolopirimidinaminas como inhibidores del sistema del complemento |
| WO2021222637A1 (fr) | 2020-04-30 | 2021-11-04 | United States Government As Represented By The Department Of Veterans Affairs | Agonistes de petites molécules du facteur 15 de type krüppel (klf15) dans une maladie rénale |
| CN116963740A (zh) | 2020-10-02 | 2023-10-27 | 麦托吉宁公司 | 治疗肾脏疾病和纤维化的组合物和方法 |
| WO2022109066A1 (fr) | 2020-11-18 | 2022-05-27 | Southern Research Institute | Composés pour le traitement d'une néphropathie aiguë et chronique |
| US11623918B2 (en) | 2020-11-18 | 2023-04-11 | Southern Research Institute | Compounds for the treatment of acute and chronic kidney disease |
| EP4422643A4 (fr) | 2021-10-26 | 2025-11-26 | Southern Res Inst | Développement de nouveaux analogues de la clofarabine pour cancérothérapie |
| US11905306B2 (en) | 2021-12-21 | 2024-02-20 | Southern Research Institute | Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus |
| CA3243387A1 (fr) | 2022-01-27 | 2023-08-03 | Trilink Biotechnologies, Llc | Analogues de coiffe trinucléotidique et leurs méthodes d'utilisation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| DE4342154A1 (de) | 1993-12-10 | 1995-06-14 | Behringwerke Ag | Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien |
| DE69529770T2 (de) | 1994-12-02 | 2003-12-24 | Yamanouchi Pharmaceutical Co., Ltd. | Neues amidinonaphthylderivat oder dessen salz |
| ES2208737T3 (es) * | 1995-03-10 | 2004-06-16 | Berlex Laboratories, Inc. | Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes. |
| JP2000514788A (ja) * | 1996-06-25 | 2000-11-07 | イーライ・リリー・アンド・カンパニー | 抗凝固剤 |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| TW542822B (en) * | 1997-01-17 | 2003-07-21 | Ajinomoto Kk | Benzamidine derivatives |
| EP0977773A1 (fr) * | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | INHIBITEURS SELECTIFS DU FACTEUR Xa |
| NZ500351A (en) * | 1997-04-14 | 2001-10-26 | Cor Therapeutics Inc | Cyclic diaza compounds as selective factor Xa inhibitors |
| NZ500353A (en) * | 1997-04-14 | 2002-02-01 | Cor Therapeutics Inc | Cyclic diaza compounds that are selective inhibitors of factor Xa |
| EP0975625A1 (fr) | 1997-04-14 | 2000-02-02 | Cor Therapeutics, Inc. | INHIBITEURS SELECTIFS DU FACTEUR Xa |
| DE19718181A1 (de) * | 1997-04-30 | 1998-11-05 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US5998424A (en) * | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
| EP0987274A1 (fr) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Inhibiteurs du facteur VIIa |
| KR100838418B1 (ko) * | 1999-01-13 | 2008-06-13 | 제넨테크, 인크. | 세린 프로테아제 억제제 |
-
2000
- 2000-01-11 KR KR1020017008804A patent/KR100838418B1/ko not_active Expired - Fee Related
- 2000-01-11 CA CA002356934A patent/CA2356934A1/fr not_active Abandoned
- 2000-01-11 PL PL00350042A patent/PL350042A1/xx not_active Application Discontinuation
- 2000-01-11 EP EP00911572A patent/EP1144373B1/fr not_active Expired - Lifetime
- 2000-01-11 DE DE60023266T patent/DE60023266T2/de not_active Expired - Lifetime
- 2000-01-11 CN CNB008044228A patent/CN100488947C/zh not_active Expired - Fee Related
- 2000-01-11 MX MXPA01007038A patent/MXPA01007038A/es active IP Right Grant
- 2000-01-11 ES ES00911572T patent/ES2251363T3/es not_active Expired - Lifetime
- 2000-01-11 IL IL14403200A patent/IL144032A0/xx active IP Right Grant
- 2000-01-11 BR BRPI0008755-6A patent/BR0008755A/pt not_active Application Discontinuation
- 2000-01-11 NZ NZ512736A patent/NZ512736A/en not_active IP Right Cessation
- 2000-01-11 CZ CZ20012508A patent/CZ20012508A3/cs unknown
- 2000-01-11 WO PCT/US2000/000673 patent/WO2000041531A2/fr not_active Ceased
- 2000-01-11 JP JP2000593153A patent/JP2002534449A/ja active Pending
- 2000-01-11 AU AU33451/00A patent/AU771776B2/en not_active Ceased
- 2000-01-11 AT AT00911572T patent/ATE307111T1/de not_active IP Right Cessation
- 2000-01-11 HU HU0105077A patent/HUP0105077A3/hu not_active Application Discontinuation
- 2000-01-11 US US09/509,104 patent/US6472393B1/en not_active Expired - Fee Related
-
2001
- 2001-06-27 IL IL144032A patent/IL144032A/en not_active IP Right Cessation
- 2001-07-12 NO NO20013462A patent/NO20013462L/no not_active Application Discontinuation
-
2002
- 2002-08-19 US US10/224,114 patent/US6919369B2/en not_active Expired - Fee Related
-
2005
- 2005-03-24 US US11/088,511 patent/US20050186198A1/en not_active Abandoned
-
2006
- 2006-09-29 US US11/537,482 patent/US20070037813A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2356934A1 (fr) | 2000-07-20 |
| IL144032A0 (en) | 2002-04-21 |
| HUP0105077A2 (hu) | 2002-05-29 |
| WO2000041531A2 (fr) | 2000-07-20 |
| JP2002534449A (ja) | 2002-10-15 |
| AU771776B2 (en) | 2004-04-01 |
| DE60023266D1 (de) | 2005-11-24 |
| PL350042A1 (en) | 2002-10-21 |
| KR20010101852A (ko) | 2001-11-15 |
| DE60023266T2 (de) | 2006-07-13 |
| EP1144373B1 (fr) | 2005-10-19 |
| AU3345100A (en) | 2000-08-01 |
| NZ512736A (en) | 2003-11-28 |
| US20070037813A1 (en) | 2007-02-15 |
| CZ20012508A3 (cs) | 2002-02-13 |
| HUP0105077A3 (en) | 2005-04-28 |
| KR100838418B1 (ko) | 2008-06-13 |
| ES2251363T3 (es) | 2006-05-01 |
| US20030212071A1 (en) | 2003-11-13 |
| BR0008755A (pt) | 2007-05-29 |
| NO20013462D0 (no) | 2001-07-12 |
| US20050186198A1 (en) | 2005-08-25 |
| US6472393B1 (en) | 2002-10-29 |
| EP1144373A3 (fr) | 2002-01-02 |
| CN100488947C (zh) | 2009-05-20 |
| CN1342139A (zh) | 2002-03-27 |
| ATE307111T1 (de) | 2005-11-15 |
| MXPA01007038A (es) | 2002-07-30 |
| US6919369B2 (en) | 2005-07-19 |
| IL144032A (en) | 2006-06-11 |
| EP1144373A2 (fr) | 2001-10-17 |
| WO2000041531A3 (fr) | 2001-08-16 |
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