NO20005301D0 - Pyrrolidiner som inhibitorer av neuraminidaser - Google Patents

Pyrrolidiner som inhibitorer av neuraminidaser

Info

Publication number: NO20005301D0
Authority: NO; Norway
Prior art keywords: neuraminidases; pyrrolidines; inhibitors
Prior art date: 1998-04-23

Application number

NO20005301A

Other languages

English (en)

Other versions

NO20005301L (no

Inventor

Clarence J Maring

Yu-Gui Gu

Hui-Ju Chen

Yuanwei Chen

David A Degoey

William J Flosi

Vincent L Giranda

David J Grampovnik

Warren M Kati

Dale J Kempf

Larry L Klein

Allan C Krueger

Zhen Lin

Darold L Madigan

Keith F Mcdaniel

Steven W Muchmore

Hing L Sham

Kent D Stewart

Vincent S Stoll

Minghua Sun

Gary T Wang

Sheldon Wang

Yibo Xu

Ming C Yeung

Chen Zhao

April Kennedy

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-23

Filing date

2000-10-20

Publication date

2000-10-20

2000-10-20 Application filed by Abbott Lab filed Critical Abbott Lab

2000-10-20 Publication of NO20005301D0 publication Critical patent/NO20005301D0/no

2000-12-08 Publication of NO20005301L publication Critical patent/NO20005301L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrrole Compounds (AREA)

NO20005301A 1998-04-23 2000-10-20 Pyrrolidiner som inhibitorer av neuraminidaser NO20005301L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6522598A	1998-04-23	1998-04-23
PCT/US1999/007945 WO1999054299A1 (en)	1998-04-23	1999-04-12	Pyrrolidines as inhibitors of neuraminidases

Publications (2)

Publication Number	Publication Date
NO20005301D0 true NO20005301D0 (no)	2000-10-20
NO20005301L NO20005301L (no)	2000-12-08

Family

ID=22061195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005301A NO20005301L (no)	1998-04-23	2000-10-20	Pyrrolidiner som inhibitorer av neuraminidaser

Country Status (17)

Country	Link
EP (1)	EP1315698A1 (no)
JP (1)	JP2002512224A (no)
CN (1)	CN1328546A (no)
AR (1)	AR018196A1 (no)
AU (1)	AU3554599A (no)
BG (1)	BG104962A (no)
BR (1)	BR9909870A (no)
CA (1)	CA2329422A1 (no)
CO (1)	CO5011122A1 (no)
HU (1)	HUP0101224A3 (no)
IL (1)	IL138601A0 (no)
NO (1)	NO20005301L (no)
PL (1)	PL343678A1 (no)
SK (1)	SK15092000A3 (no)
TR (1)	TR200003065T2 (no)
WO (1)	WO1999054299A1 (no)
ZA (1)	ZA200005238B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2263179T3 (es)	1996-06-14	2006-12-01	Biocryst Pharmaceuticals Inc.	Compuestos de clopentano sustituido como inhibidores de la neuraminidasa.
BR9813480A (pt)	1997-12-17	2000-10-10	Biocryst Pharm Inc	Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza-
US6455571B1 (en)	1998-04-23	2002-09-24	Abbott Laboratories	Inhibitors of neuraminidases
WO2000028328A1 (en)	1998-11-05	2000-05-18	Biocryst Pharmaceuticals, Inc.	New cyclopentane and cyclopentene compounds and use for detecting influenza virus
AU2001252578A1 (en) *	2000-04-25	2001-11-07	Sankyo Company Limited	Preventives for influenza
US6518299B1 (en)	2000-10-20	2003-02-11	Biocryst Pharmaceuticals, Inc.	Substituted pyrrolidine compounds useful as neuraminidase inhibitors
WO2002081441A1 (en) *	2001-04-03	2002-10-17	Abbott Laboratories	Process for the preparation of substituted pyrrolidine neuraminidase inhibitors
JP2005511573A (ja) *	2001-11-02	2005-04-28	グラクソ　グループ　リミテッド	Ｈｃｖ阻害剤としての４−（５−員）−ヘテロアリールアシルピロリジン誘導体
ATE370137T1 (de) *	2001-11-02	2007-09-15	Glaxo Group Ltd	4-(6-gliedriger)-heteroaryl-acyl-pyrrolidin derivate als hcv-inhibitoren
WO2004037818A1 (en) *	2002-10-24	2004-05-06	Glaxo Group Limited	1-acyl-pyrrolidine derivatives for the treatment of viral infections
CN104402754B (zh) *	2014-11-25	2016-03-02	广东东阳光药业有限公司	作为神经氨酸酶抑制剂的化合物及其在药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4035961A1 (de) *	1990-11-02	1992-05-07	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SI9620042A (sl) *	1995-02-27	1998-12-31	Gilead Sciences, Inc.	Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz
ES2263179T3 (es) *	1996-06-14	2006-12-01	Biocryst Pharmaceuticals Inc.	Compuestos de clopentano sustituido como inhibidores de la neuraminidasa.
ZA988469B (en) *	1997-09-17	1999-03-17	Biocryst Pharm Inc	Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors

1999
- 1999-04-12 PL PL99343678A patent/PL343678A1/xx unknown
- 1999-04-12 BR BR9909870-9A patent/BR9909870A/pt not_active IP Right Cessation
- 1999-04-12 IL IL13860199A patent/IL138601A0/xx unknown
- 1999-04-12 HU HU0101224A patent/HUP0101224A3/hu unknown
- 1999-04-12 CN CN99807610A patent/CN1328546A/zh active Pending
- 1999-04-12 EP EP99917414A patent/EP1315698A1/en not_active Withdrawn
- 1999-04-12 WO PCT/US1999/007945 patent/WO1999054299A1/en not_active Ceased
- 1999-04-12 JP JP2000544640A patent/JP2002512224A/ja not_active Withdrawn
- 1999-04-12 AU AU35545/99A patent/AU3554599A/en not_active Abandoned
- 1999-04-12 CA CA002329422A patent/CA2329422A1/en not_active Abandoned
- 1999-04-12 SK SK1509-2000A patent/SK15092000A3/sk unknown
- 1999-04-12 TR TR2000/03065T patent/TR200003065T2/xx unknown
- 1999-04-21 CO CO99024047A patent/CO5011122A1/es unknown
- 1999-04-23 AR ARP990101905A patent/AR018196A1/es not_active Application Discontinuation
2000
- 2000-09-28 ZA ZA200005238A patent/ZA200005238B/en unknown
- 2000-10-20 NO NO20005301A patent/NO20005301L/no not_active Application Discontinuation
- 2000-11-17 BG BG104962A patent/BG104962A/bg unknown

Also Published As

Publication number	Publication date
CA2329422A1 (en)	1999-10-28
HUP0101224A3 (en)	2002-12-28
SK15092000A3 (sk)	2001-05-10
EP1315698A1 (en)	2003-06-04
HUP0101224A2 (hu)	2001-08-28
AU3554599A (en)	1999-11-08
ZA200005238B (en)	2001-12-04
AR018196A1 (es)	2001-10-31
BG104962A (bg)	2001-07-31
TR200003065T2 (tr)	2001-02-21
IL138601A0 (en)	2001-10-31
PL343678A1 (en)	2001-08-27
JP2002512224A (ja)	2002-04-23
CO5011122A1 (es)	2001-02-28
NO20005301L (no)	2000-12-08
BR9909870A (pt)	2000-12-19
WO1999054299A1 (en)	1999-10-28
CN1328546A (zh)	2001-12-26

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Legal Events

Date	Code	Title	Description
2003-12-08	FC2A	Withdrawal, rejection or dismissal of laid open patent application