NO20003511L - Lipase-inhiberende polymerer - Google Patents
Lipase-inhiberende polymererInfo
- Publication number
- NO20003511L NO20003511L NO20003511A NO20003511A NO20003511L NO 20003511 L NO20003511 L NO 20003511L NO 20003511 A NO20003511 A NO 20003511A NO 20003511 A NO20003511 A NO 20003511A NO 20003511 L NO20003511 L NO 20003511L
- Authority
- NO
- Norway
- Prior art keywords
- inhibiting polymers
- lipase inhibiting
- polymers
- patient
- methods
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 4
- 102000004882 Lipase Human genes 0.000 title abstract 2
- 108090001060 Lipase Proteins 0.000 title abstract 2
- 239000004367 Lipase Substances 0.000 title abstract 2
- 235000019421 lipase Nutrition 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Det er beskrevet en fremgangsmåte for å behandle fedme i en pasient ved administrering til pasienten en polymer som er blitt substituert med en eller flere grupper som inhiberer lipaser, som har enzymer ansvarlig for hydrolyse av fett. Det er videre beskrevet polymerer anvendt i metodene beskrevet heri samt nye mellom-produkter og fremgangsmåter for fremstilling av polymerene.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US537998A | 1998-01-09 | 1998-01-09 | |
| US09/166,510 US6267952B1 (en) | 1998-01-09 | 1998-10-05 | Lipase inhibiting polymers |
| PCT/US1999/000195 WO1999034786A2 (en) | 1998-01-09 | 1999-01-06 | Lipase inhibiting polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20003511D0 NO20003511D0 (no) | 2000-07-07 |
| NO20003511L true NO20003511L (no) | 2000-09-07 |
Family
ID=26674279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003511A NO20003511L (no) | 1998-01-09 | 2000-07-07 | Lipase-inhiberende polymerer |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US6267952B1 (no) |
| EP (1) | EP1043982B1 (no) |
| JP (1) | JP2002500182A (no) |
| KR (1) | KR100620634B1 (no) |
| CN (2) | CN1636574A (no) |
| AT (1) | ATE308979T1 (no) |
| AU (1) | AU747016B2 (no) |
| BR (1) | BR9907233A (no) |
| CA (1) | CA2318416A1 (no) |
| DE (1) | DE69928219T2 (no) |
| DK (1) | DK1043982T3 (no) |
| ES (1) | ES2253872T3 (no) |
| HK (1) | HK1079706A1 (no) |
| HU (1) | HUP0101128A3 (no) |
| IL (1) | IL137098A (no) |
| NO (1) | NO20003511L (no) |
| NZ (1) | NZ505296A (no) |
| PL (1) | PL193453B1 (no) |
| RU (1) | RU2207861C2 (no) |
| WO (1) | WO1999034786A2 (no) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| PE20010588A1 (es) * | 1999-09-10 | 2001-06-23 | Procter & Gamble | Conjugados polimericos inhibidores de enzimas proteoliticas y lipoliticas |
| PE20010586A1 (es) * | 1999-09-10 | 2001-06-23 | Procter & Gamble | Conjugados de polimeros funcionales que inhiben enzimas lipoliticas y/o proteoliticas |
| AR025609A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones lipidas solidas |
| AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| WO2002000201A2 (en) * | 2000-06-27 | 2002-01-03 | F. Hoffmann-La Roche Ag | Method for preparing a composition |
| KR100556324B1 (ko) | 2000-07-28 | 2006-03-03 | 에프. 호프만-라 로슈 아게 | 리파제 억제제 및 담즙산 격리제를 포함하는 약학 조성물 |
| PT1307264E (pt) | 2000-07-28 | 2005-02-28 | Hoffmann La Roche | Nova composicao farmaceutica |
| ATE390920T1 (de) | 2000-08-09 | 2008-04-15 | Hoffmann La Roche | Lipase inhibitoren zur behandlung von dyspepsia |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| EP1318814B1 (en) | 2000-09-15 | 2007-05-30 | Vertex Pharmaceuticals Incorporated | Triazole compounds useful as protein kinase inhibitors |
| AU2167002A (en) | 2000-10-16 | 2002-06-11 | Hoffmann La Roche | Indoline derivatives and their use as 5-ht2 receptor ligands |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| US7625913B2 (en) * | 2000-12-21 | 2009-12-01 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| JP4094950B2 (ja) | 2000-12-27 | 2008-06-04 | エフ.ホフマン−ラ ロシュ アーゲー | インドール誘導体および5−ht2bおよび5−ht2c受容体リガンドとしてのそれらの使用 |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| DE60225274T2 (de) | 2001-05-21 | 2009-03-26 | F. Hoffmann-La Roche Ag | Chinolinderivate als liganden für den neuropeptid-y-rezeptor |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| AU2003205679B2 (en) | 2002-02-04 | 2006-06-29 | F. Hoffmann-La Roche Ag | Quinoline derivatives as NPY antagonists |
| RU2004126671A (ru) * | 2002-02-06 | 2005-04-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероарилсоединения, полезные в качестве ингибиторов gsk-3 |
| JP2005517435A (ja) * | 2002-02-19 | 2005-06-16 | ザ プロクター アンド ギャンブル カンパニー | 新規の真菌リパーゼ |
| CN100363362C (zh) | 2002-02-28 | 2008-01-23 | 霍夫曼-拉罗奇有限公司 | 用作npy受体拮抗剂的噻唑衍生物 |
| DE60332604D1 (de) * | 2002-03-15 | 2010-07-01 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
| AU2003223930A1 (en) * | 2002-06-14 | 2003-12-31 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
| MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| CN1665791A (zh) | 2002-07-05 | 2005-09-07 | 霍夫曼-拉罗奇有限公司 | 喹唑啉衍生物 |
| WO2004013140A1 (en) * | 2002-08-02 | 2004-02-12 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
| CN100381429C (zh) | 2002-08-07 | 2008-04-16 | 霍夫曼-拉罗奇有限公司 | 噻唑衍生物 |
| CA2546696A1 (en) * | 2002-11-19 | 2004-06-03 | Genzyme Corporation | Polymeric boronic acid derivatives as lipase inhibitors |
| WO2004072029A2 (en) * | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| DE602004019939D1 (de) | 2003-08-12 | 2009-04-23 | Hoffmann La Roche | Thiazolderivate als npy-antagonisten |
| JP2007501823A (ja) | 2003-08-12 | 2007-02-01 | エフ.ホフマン−ラ ロシュ アーゲー | 2−アミノ−5−ベンゾイルチアゾールなるnpyアンタゴニスト |
| US20050239859A2 (en) * | 2003-09-03 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity |
| US20050124660A1 (en) * | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
| US20050143441A1 (en) * | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
| CA2546727C (en) | 2003-11-20 | 2012-10-02 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use |
| WO2005056547A2 (en) * | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
| US7462394B2 (en) * | 2004-05-06 | 2008-12-09 | Ppg Industries Ohio, Inc. | Method of stabilizing metal pigments against gassing |
| US7943713B2 (en) * | 2004-07-30 | 2011-05-17 | Basf Aktiengesellschaft | Polymeric boronic acid derivatives and their use for papermaking |
| RU2007119315A (ru) * | 2004-10-25 | 2008-11-27 | Зольвай Фармасьютиклз Гмбх (De) | Фармацевтические композиции, содержащие антагонисты каннабиноидного рецептора св1 и открыватели калиевых каналов, предназначенные для лечения сахарного диабета типа i, ожирения и связанных с ними состояний |
| AU2006243243B2 (en) | 2005-05-03 | 2009-05-14 | F. Hoffmann-La Roche Ag | Tetracyclic azapyrazinoindolines as 5-HT2 ligands |
| WO2007016539A2 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
| WO2007022384A2 (en) * | 2005-08-18 | 2007-02-22 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
| CN101243078A (zh) | 2005-08-18 | 2008-08-13 | 霍夫曼-拉罗奇有限公司 | 噻唑基哌啶衍生物 |
| AR056499A1 (es) * | 2005-09-06 | 2007-10-10 | Serapis Farmaceuticals Ltd | Compuestos |
| NZ606259A (en) * | 2005-11-03 | 2014-06-27 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
| CN101316835A (zh) | 2005-11-30 | 2008-12-03 | 霍夫曼-拉罗奇有限公司 | 5-取代的吲哚-2-甲酰胺衍生物 |
| RU2008126391A (ru) | 2005-11-30 | 2010-01-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные 1,5-замещенного индол-2-иламида |
| ATE507222T1 (de) | 2005-11-30 | 2011-05-15 | Hoffmann La Roche | 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren |
| ES2333672T3 (es) | 2005-12-09 | 2010-02-25 | F. Hoffmann-La Roche Ag | Derivados de amida triciclica para tratamiento de obesidad. |
| CA2631694A1 (en) | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-c]pyridine derivatives |
| CA2631695A1 (en) | 2005-12-16 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-b]pyridine derivatives as h3 receptor modulators |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| JP2009538859A (ja) | 2006-05-30 | 2009-11-12 | エフ.ホフマン−ラ ロシュ アーゲー | ピペリジニルピリミジン誘導体 |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| EP2086965B1 (en) * | 2006-11-02 | 2010-02-10 | Vertex Pharmaceuticals, Inc. | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| JP2010513567A (ja) * | 2006-12-19 | 2010-04-30 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼの阻害剤として有用なアミノピリミジン |
| JP5520057B2 (ja) * | 2007-03-09 | 2014-06-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | 蛋白キナーゼの阻害剤として有用なアミノピリミジン |
| AU2008226461A1 (en) | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyridines useful as inhibitors of protein kinases |
| NZ579485A (en) * | 2007-03-09 | 2012-02-24 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
| NZ580343A (en) | 2007-04-13 | 2012-03-30 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
| MX2009011811A (es) * | 2007-05-02 | 2010-01-14 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasa. |
| EP2152694A2 (en) * | 2007-05-02 | 2010-02-17 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
| EP2152696B1 (en) * | 2007-05-02 | 2014-09-24 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| EP2164842A2 (en) * | 2007-05-24 | 2010-03-24 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
| EP2183237A1 (en) | 2007-07-25 | 2010-05-12 | F. Hoffmann-Roche AG | Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators |
| CA2694499A1 (en) * | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
| US8185398B2 (en) * | 2007-12-31 | 2012-05-22 | Intel-Ge Care Innovations Llc | Reading device with shortcut read function |
| KR20110050549A (ko) * | 2008-09-03 | 2011-05-13 | 버텍스 파마슈티칼스 인코포레이티드 | 공-결정 및 이를 포함하는 제약 제제 |
| CA2792733C (en) * | 2010-03-13 | 2015-06-02 | Eastpond Laboratories Limited | Fat-binding compositions comprising .alpha.- or .beta.-cyclodextrin |
| CN102199172A (zh) * | 2010-03-24 | 2011-09-28 | 金凯美(大连)医药科技有限公司 | 一种1-取代亚磷酰二氯的制备方法 |
| US9980942B2 (en) | 2012-05-02 | 2018-05-29 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| CN114450027A (zh) | 2019-08-16 | 2022-05-06 | 儿童医院医疗中心 | 用cdc42特异性抑制剂治疗受试者的方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7017227A (no) | 1969-12-27 | 1971-06-29 | ||
| US4211765A (en) * | 1971-10-12 | 1980-07-08 | Monsanto Company | Method for controlling obesity |
| US3923972A (en) | 1971-10-12 | 1975-12-02 | Monsanto Co | Method of lowering blood cholesterol level |
| IT1052819B (it) | 1975-12-12 | 1981-07-20 | Fargal Pharmasint Lab Biochim | Preparato inibitore dell assorbimento dei lipidi a base di dietilamminoetildestrano |
| US4265879A (en) | 1977-09-13 | 1981-05-05 | Monsanto Company | Method for controlling blood triglycerides |
| US4302450A (en) | 1979-01-15 | 1981-11-24 | Hoffmann-La Roche Inc. | Polyether ionophores as antiobesity and hypotriglyceridemic agents |
| US4218443A (en) | 1979-01-15 | 1980-08-19 | Hoffmann-La Roche Inc. | Polyether ionophores as antiobesity and hypotriglyceridemic agents |
| US4432968A (en) | 1980-10-20 | 1984-02-21 | The Dow Chemical Company | Weight control with fat imbibing polymers |
| AU7653081A (en) | 1980-10-20 | 1982-04-29 | Dow Chemical Company, The | T-butylstyrene copolymers for controlling body weight of animals |
| US5597810A (en) | 1984-12-27 | 1997-01-28 | Hoffman; Allan S. | Method for reducing absorption of undesired lipids in the gastrointestinal tract |
| US5200183A (en) | 1987-11-19 | 1993-04-06 | Oklahoma Medical Research Foundation | Recombinant bile salt activated lipases |
| US5089163A (en) | 1989-01-30 | 1992-02-18 | Lever Brothers Company, Division Of Conopco, Inc. | Enzymatic liquid detergent composition |
| US4959179A (en) | 1989-01-30 | 1990-09-25 | Lever Brothers Company | Stabilized enzymes liquid detergent composition containing lipase and protease |
| US5063210A (en) | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5484777A (en) | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| US5674482A (en) | 1989-08-14 | 1997-10-07 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Polymers with alkyl- or heteroalkyl -aryl backbone and pharmaceutical compositions incorporating same |
| CA2064793C (en) | 1989-08-29 | 2001-11-13 | Edward A. Dennis | Hydrolytic enzyme inhibitors and substrates and assays, methods and kits embodying same |
| US5308766A (en) | 1989-08-29 | 1994-05-03 | The Regents Of The University Of California | Hydrolytic enzyme inhibitors/inactivators and methods for using same |
| US5376640A (en) * | 1989-12-25 | 1994-12-27 | Nisshin Flour Milling Co., Ltd. | Lipolytic enzyme inhibitors |
| US5260310A (en) | 1990-02-26 | 1993-11-09 | Hoffmann-La Roche Inc. | Oxetanone compounds and pharmaceutical compositions containing them |
| DK244090D0 (da) | 1990-10-09 | 1990-10-09 | Novo Nordisk As | Kemiske forbindelser |
| US5137716A (en) | 1990-11-15 | 1992-08-11 | Weisenfeld Michael S | Method of reducing weight in mammals |
| ATE183924T1 (de) | 1992-01-14 | 1999-09-15 | Hisamitsu Pharmaceutical Co | Cholesterinspiegelsenkendes mittel |
| CA2063499C (en) | 1992-03-19 | 1996-06-18 | Leon Edward St. Pierre | Ingestible polymeric phosphonium salts for the lowering of blood cholesterol |
| JP2667351B2 (ja) | 1992-03-24 | 1997-10-27 | 麒麟麦酒株式会社 | 食餌脂質消化吸収阻害剤および飲食品 |
| ATE130193T1 (de) | 1992-03-28 | 1995-12-15 | Hoechst Ag | Arzneimittel aus polyhydroxymethylenderivaten, verfahren zu deren herstellung und verwendung. |
| RU2066185C1 (ru) * | 1993-01-11 | 1996-09-10 | Институт пищевых веществ РАН | Гиполипидемический энтеросорбент |
| US5618530A (en) | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5624963A (en) | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5607669A (en) | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5703188A (en) | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5569452A (en) | 1993-08-31 | 1996-10-29 | Tsrl, Inc. | Pharmaceutical formulation having enhanced bile acid binding affinity |
| US5414068A (en) | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| US5474993A (en) | 1994-06-14 | 1995-12-12 | Sterling Winthrop, Inc. | Lactam inhibitors of cholesterol esterase |
| JPH0859458A (ja) | 1994-08-25 | 1996-03-05 | Zeria Pharmaceut Co Ltd | インダン誘導体を含有する高脂血症治療剤 |
| JP3532999B2 (ja) | 1995-03-24 | 2004-05-31 | 株式会社ロッテ | 新規なタンニン類およびこれを有効成分とするリパーゼ阻害剤 |
| US5993675A (en) * | 1997-12-31 | 1999-11-30 | Hagerthy; Albert P. | Fuel-water separator for marine and diesel engines |
| HUP0100890A3 (en) * | 1998-01-09 | 2001-12-28 | Genzyme Corp Cambridge | Fat-binding polymers |
| US6299868B1 (en) * | 1999-07-14 | 2001-10-09 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| US5942500A (en) * | 1998-04-27 | 1999-08-24 | Perry; Stephen C. | Dietary composition to reduce dietary fats |
-
1998
- 1998-10-05 US US09/166,510 patent/US6267952B1/en not_active Expired - Fee Related
-
1999
- 1999-01-06 CN CNA2004100879814A patent/CN1636574A/zh active Pending
- 1999-01-06 JP JP2000527237A patent/JP2002500182A/ja active Pending
- 1999-01-06 AT AT99901332T patent/ATE308979T1/de not_active IP Right Cessation
- 1999-01-06 RU RU2000120917/14A patent/RU2207861C2/ru not_active IP Right Cessation
- 1999-01-06 ES ES99901332T patent/ES2253872T3/es not_active Expired - Lifetime
- 1999-01-06 PL PL99344022A patent/PL193453B1/pl not_active IP Right Cessation
- 1999-01-06 EP EP99901332A patent/EP1043982B1/en not_active Expired - Lifetime
- 1999-01-06 NZ NZ505296A patent/NZ505296A/xx unknown
- 1999-01-06 BR BR9907233-5A patent/BR9907233A/pt not_active Application Discontinuation
- 1999-01-06 DE DE69928219T patent/DE69928219T2/de not_active Expired - Fee Related
- 1999-01-06 WO PCT/US1999/000195 patent/WO1999034786A2/en not_active Ceased
- 1999-01-06 US US09/226,585 patent/US6352692B1/en not_active Expired - Fee Related
- 1999-01-06 HU HU0101128A patent/HUP0101128A3/hu unknown
- 1999-01-06 AU AU21056/99A patent/AU747016B2/en not_active Ceased
- 1999-01-06 KR KR1020007007607A patent/KR100620634B1/ko not_active Expired - Fee Related
- 1999-01-06 CN CN99802023A patent/CN1287489A/zh active Pending
- 1999-01-06 DK DK99901332T patent/DK1043982T3/da active
- 1999-01-06 IL IL137098A patent/IL137098A/en active IP Right Grant
- 1999-01-06 CA CA002318416A patent/CA2318416A1/en not_active Abandoned
-
2000
- 2000-07-07 NO NO20003511A patent/NO20003511L/no not_active Application Discontinuation
- 2000-11-16 US US09/714,541 patent/US6558657B1/en not_active Expired - Fee Related
- 2000-11-16 US US09/714,327 patent/US6572850B1/en not_active Expired - Fee Related
-
2003
- 2003-02-05 US US10/359,458 patent/US6875428B2/en not_active Expired - Fee Related
-
2004
- 2004-10-07 US US10/960,579 patent/US20050085535A1/en not_active Abandoned
-
2005
- 2005-12-29 HK HK05112104.3A patent/HK1079706A1/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20003511L (no) | Lipase-inhiberende polymerer | |
| ES2195993T3 (es) | Metodo para inhibir la produccion de etileno en plantas. | |
| DE69408993D1 (de) | Verfahren zur Bestimmung von Mikroorganismen mittels mindestens zwei Chromogene | |
| DE68925002D1 (de) | Verfahren zur Herstellung von optisch-aktiven alpha-substituierten organischen Säuren und Mikroorganismen und Enzyme, die dafür verwendet werden. | |
| BRPI0411874A (pt) | potencial de staygreen controlado em plantas por gene simples obtido por engenharia genética | |
| ATE329047T1 (de) | Stimulierung der homologen rekombination in pflanzlichen organismen mittels rekombinations fördernder enzyme | |
| HUP9701652A2 (hu) | Eljárás L-aminosav előállítására fermentáció útján | |
| ES511504A0 (es) | "procedimiento para preparar un producto de enzima, para eliminacion de ramificaciones, capaz de hidrolizar enlaces alfa-1,6-glicosidicos". | |
| DE69634699D1 (de) | Methode zur regulation der ligninzusammensetzung in pflanzen | |
| EP0644889A4 (en) | COMPOSITIONS AND METHODS FOR MODULATION OF -g (b) -AMYLOID. | |
| BR0003943A (pt) | Sequências de nucleotìdeo que codificam para o gene thre e processo para a produção enzimática de l-treonina usando bactérias corineforma | |
| BRPI0411182A (pt) | método para aumentar a toleráncia de uma planta ao estresse abiótico, método para aumentar a biomassa de uma planta, construto de ácido nucléico, polipeptìdio isolado e célula de planta | |
| HUP9901198A2 (hu) | Eljárás L-aminosavak előállítására | |
| CA2256758A1 (en) | Method of producing l-serine by fermentation | |
| WO1998002550A3 (de) | Mikrobielle erzeugung von isopren | |
| IL112061A0 (en) | Methods for the preparation of taxanes | |
| EP1672061A3 (en) | Nucleotide sequences encoding ACC synthase enzymes | |
| Suzuki et al. | A cold-active esterase with a substrate preference for vinyl esters from a psychrotroph, Acinetobacter sp. strain no. 6: gene cloning, purification, and characterization | |
| DE69322974D1 (de) | Enzymatisches triglycerid-umsetzverfahren | |
| DK0759981T3 (da) | Fremgangsmåde til dyrkning af bakterier, der producerer proteiner, som udtrykkes på en temperaturreguleret måde | |
| BR0005307A (pt) | Processo para a produção fermentativa de l-lisina usando bactérias coryneform | |
| ATE153067T1 (de) | Molekulare klonierung und expression von genen, die für lipolytische enzyme kodieren | |
| SE9201006D0 (sv) | Delignifying preparation exhibiting alpha-l-arabino -furanosidase activity, production and application thereof | |
| WO1999006579A3 (en) | Inhibition of unwanted hormone action in plants | |
| WO2025099076A3 (en) | Sble mutants with altered activity and sble homologues |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |