NO177673C - Analogous Process for the Preparation of Therapeutically Active N7-Substituted Mitomycin Derivatives - Google Patents

Analogous Process for the Preparation of Therapeutically Active N7-Substituted Mitomycin Derivatives

Info

Publication number: NO177673C
Authority: NO; Norway
Prior art keywords: preparation; therapeutically active; analogous process; mitomycin derivatives; substituted mitomycin
Prior art date: 1988-08-23

Application number

NO910662A

Other languages

Norwegian (no)

Other versions

NO910662L (en

NO910662D0 (en

NO177673B (en

Inventor

Abdolhossen Talebian

Diana Green

Charles Hammer

Philip S Schein

Original Assignee

Univ Georgetown

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-23

Filing date

1991-02-19

Publication date

1995-11-01

1991-02-19 Application filed by Univ Georgetown filed Critical Univ Georgetown

1991-02-19 Publication of NO910662D0 publication Critical patent/NO910662D0/en

1991-03-21 Publication of NO910662L publication Critical patent/NO910662L/en

1995-07-24 Publication of NO177673B publication Critical patent/NO177673B/en

1995-11-01 Publication of NO177673C publication Critical patent/NO177673C/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO910662A 1988-08-23 1991-02-19 Analogous Process for the Preparation of Therapeutically Active N7-Substituted Mitomycin Derivatives NO177673C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23522488A	1988-08-23	1988-08-23
PCT/US1989/003180 WO1990001931A1 (en)	1988-08-23	1989-07-25	Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Publications (4)

Publication Number	Publication Date
NO910662D0 NO910662D0 (en)	1991-02-19
NO910662L NO910662L (en)	1991-03-21
NO177673B NO177673B (en)	1995-07-24
NO177673C true NO177673C (en)	1995-11-01

Family

ID=22884628

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO910662A NO177673C (en)	1988-08-23	1991-02-19	Analogous Process for the Preparation of Therapeutically Active N7-Substituted Mitomycin Derivatives

Country Status (16)

Country	Link
EP (1)	EP0431008A4 (en)
JP (1)	JPH04500513A (en)
KR (1)	KR900701269A (en)
CN (1)	CN1040593A (en)
AU (1)	AU628846B2 (en)
CA (1)	CA1327037C (en)
DK (1)	DK29691A (en)
ES (1)	ES2018726A6 (en)
GR (1)	GR1000785B (en)
IE (1)	IE63036B1 (en)
IL (1)	IL91332A0 (en)
NO (1)	NO177673C (en)
NZ (1)	NZ230343A (en)
PT (1)	PT91499B (en)
WO (1)	WO1990001931A1 (en)
ZA (1)	ZA896025B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5091523A (en) *	1990-04-25	1992-02-25	Georgetown University	Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
DE69127345D1 (en) *	1990-11-13	1997-09-25	Kyowa Hakko Kogyo Kk	Mitomycin derivatives
GB2282384B8 (en) *	1993-08-18	1997-09-04	Europ Economic Community	Drug delivery agents incorporating mitomycin
AU2015306574B2 (en)	2014-08-22	2020-07-23	Yafei Shanghai Biology Medicine Science & Technology Co. Ltd.	Specifically activated micromolecular target coupling body in tumor microenvironment and use thereof
CN104231045B (en) *	2014-08-22	2017-10-31	亚飞（上海）生物医药科技有限公司	A kind of E09 of targeted activation release and application thereof
US9801909B2 (en)	2015-04-06	2017-10-31	The Penn State Research Foundation	Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US479130A (en) *		1892-07-19		Rudolf allert
US3226393A (en) *	1962-06-07	1965-12-28	American Cyanamid Co	N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (en) *	1964-07-09	1970-04-09	Kyowa Hakko Kogyo Kk	Process for the production of mitosan compounds
US3367945A (en) *	1965-05-18	1968-02-06	Kyowa Hakko Kogyo Kk	Thiourea derivatives of mitomycin
JPS5240B2 (en) *	1973-12-17	1977-01-05
JPS5630978A (en) *	1979-08-24	1981-03-28	Kyowa Hakko Kogyo Co Ltd	Novel mitomycin and its preparation
US4268676A (en) *	1979-12-05	1981-05-19	University Patents, Inc.	Mitomycin analogs
US4746746A (en) *	1983-02-07	1988-05-24	University Patents, Inc.	Mitomycin analogs
JPS601197A (en) *	1983-06-17	1985-01-07	Kyowa Hakko Kogyo Co Ltd	mitomycin derivative
US4814445A (en) *	1984-09-04	1989-03-21	Bristol-Myers Company	Process for preparing mitomycin analogs
EP0197799B1 (en) *	1985-04-10	1990-09-12	Kyowa Hakko Kogyo Kabushiki Kaisha	Pharmacologically active mitomycin derivatives
US4720543A (en) *	1985-06-06	1988-01-19	Georgetown University	1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (en) *	1986-08-26	1988-03-08	Kyowa Hakko Kogyo Co Ltd	mitomycin derivative
JPS63246336A (en) *	1986-11-10	1988-10-13	Kyowa Hakko Kogyo Co Ltd	Composition containing mitomycin-antibody complex
JPH06335575A (en) *	1993-05-28	1994-12-06	Tokyo Electric Co Ltd	Shaver

1989
- 1989-07-25 EP EP19890909473 patent/EP0431008A4/en not_active Withdrawn
- 1989-07-25 AU AU40650/89A patent/AU628846B2/en not_active Ceased
- 1989-07-25 WO PCT/US1989/003180 patent/WO1990001931A1/en not_active Ceased
- 1989-07-25 JP JP1508792A patent/JPH04500513A/en active Pending
- 1989-07-25 KR KR1019900700816A patent/KR900701269A/en not_active Ceased
- 1989-08-08 ZA ZA896025A patent/ZA896025B/en unknown
- 1989-08-16 IL IL91332A patent/IL91332A0/en unknown
- 1989-08-17 NZ NZ230343A patent/NZ230343A/en unknown
- 1989-08-18 GR GR890100514A patent/GR1000785B/en unknown
- 1989-08-21 PT PT91499A patent/PT91499B/en not_active IP Right Cessation
- 1989-08-22 ES ES8902910A patent/ES2018726A6/en not_active Expired - Lifetime
- 1989-08-22 CA CA000608960A patent/CA1327037C/en not_active Expired - Fee Related
- 1989-08-22 CN CN89106432A patent/CN1040593A/en active Pending
- 1989-08-22 IE IE269189A patent/IE63036B1/en not_active IP Right Cessation
1991
- 1991-02-19 NO NO910662A patent/NO177673C/en unknown
- 1991-02-20 DK DK029691A patent/DK29691A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1040593A (en)	1990-03-21
NO910662L (en)	1991-03-21
AU4065089A (en)	1990-03-23
GR890100514A (en)	1991-12-30
DK29691A (en)	1991-04-23
NO910662D0 (en)	1991-02-19
PT91499B (en)	1995-07-06
PT91499A (en)	1990-03-08
IE892691L (en)	1990-02-23
CA1327037C (en)	1994-02-15
KR900701269A (en)	1990-12-01
JPH04500513A (en)	1992-01-30
IL91332A0 (en)	1990-03-19
ZA896025B (en)	1990-05-30
EP0431008A1 (en)	1991-06-12
EP0431008A4 (en)	1992-03-11
NZ230343A (en)	1992-01-29
DK29691D0 (en)	1991-02-20
ES2018726A6 (en)	1991-05-01
NO177673B (en)	1995-07-24
AU628846B2 (en)	1992-09-24
GR1000785B (en)	1992-12-30
IE63036B1 (en)	1995-03-22
WO1990001931A1 (en)	1990-03-08

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