NO177349C - Fremgangsmåte for fremstilling av isepamicin - Google Patents
Fremgangsmåte for fremstilling av isepamicinInfo
- Publication number
- NO177349C NO177349C NO915071A NO915071A NO177349C NO 177349 C NO177349 C NO 177349C NO 915071 A NO915071 A NO 915071A NO 915071 A NO915071 A NO 915071A NO 177349 C NO177349 C NO 177349C
- Authority
- NO
- Norway
- Prior art keywords
- isoserine
- isepamicin
- preparation
- compounds
- diformyl
- Prior art date
Links
- UDIIBEDMEYAVNG-ZKFPOVNWSA-N isepamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1NC(=O)[C@@H](O)CN UDIIBEDMEYAVNG-ZKFPOVNWSA-N 0.000 title abstract 2
- 229960000798 isepamicin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical class NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 2
- MGZKLMXORRUSMO-VKHMYHEASA-N (2s)-3-formamido-2-hydroxypropanoic acid Chemical compound OC(=O)[C@@H](O)CNC=O MGZKLMXORRUSMO-VKHMYHEASA-N 0.000 abstract 1
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 abstract 1
- CFMZSMGAMPBRBE-UHFFFAOYSA-N 2-hydroxyisoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(O)C(=O)C2=C1 CFMZSMGAMPBRBE-UHFFFAOYSA-N 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 abstract 1
- RHRAMPXHWHSKQB-GGEUKFTFSA-N betamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1N RHRAMPXHWHSKQB-GGEUKFTFSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- RHRAMPXHWHSKQB-UHFFFAOYSA-N gentamicin B Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CN)O2)O)C(N)CC1N RHRAMPXHWHSKQB-UHFFFAOYSA-N 0.000 abstract 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 abstract 1
- ZUSSTQCWRDLYJA-UHFFFAOYSA-N n-hydroxy-5-norbornene-2,3-dicarboximide Chemical compound C1=CC2CC1C1C2C(=O)N(O)C1=O ZUSSTQCWRDLYJA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36957889A | 1989-06-21 | 1989-06-21 | |
| PCT/US1990/003328 WO1990015810A2 (en) | 1989-06-21 | 1990-06-19 | Improved process for preparing isepamicin |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO915071L NO915071L (no) | 1991-12-20 |
| NO915071D0 NO915071D0 (no) | 1991-12-20 |
| NO177349B NO177349B (no) | 1995-05-22 |
| NO177349C true NO177349C (no) | 1995-08-30 |
Family
ID=23456036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO915071A NO177349C (no) | 1989-06-21 | 1991-12-20 | Fremgangsmåte for fremstilling av isepamicin |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP0405820B1 (no) |
| JP (2) | JPH0692433B2 (no) |
| KR (1) | KR940003496B1 (no) |
| AT (2) | ATE152094T1 (no) |
| AU (1) | AU629960B2 (no) |
| CA (2) | CA2062788C (no) |
| DE (2) | DE69008052T2 (no) |
| DK (2) | DK0547031T3 (no) |
| ES (2) | ES2063274T3 (no) |
| FI (1) | FI96955C (no) |
| GR (1) | GR3023942T3 (no) |
| HK (1) | HK185096A (no) |
| HU (1) | HU207338B (no) |
| NO (1) | NO177349C (no) |
| RU (1) | RU2120444C1 (no) |
| WO (1) | WO1990015810A2 (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100927626B1 (ko) * | 2002-09-18 | 2009-11-20 | 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 | 이세파마이신의 제조 방법 |
| CN101928310B (zh) * | 2010-03-26 | 2012-09-05 | 常州方圆制药有限公司 | 3,2’,6’-三-N-乙酰基庆大霉素C1a的制备方法 |
| CN102190690B (zh) * | 2011-04-01 | 2015-01-21 | 福州博立医药科技有限公司 | 一种简便且高收率阿贝卡星合成方法 |
| CN105524129B (zh) * | 2015-12-25 | 2018-06-26 | 无锡济民可信山禾药业股份有限公司 | 一种硫酸依替米星的制备方法 |
| RU2659032C1 (ru) * | 2017-04-26 | 2018-06-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Удмуртский государственный университет" | Способ модификации гентамицина сополимером винилпирролидона с диацеталем акролеина |
| CN108586313B (zh) * | 2018-03-31 | 2019-12-27 | 海正药业南通有限公司 | 一种新型合成n-取代苯酐-(s)-异丝氨酸的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230847A (en) * | 1976-06-17 | 1980-10-28 | Schering Corporation | Aminoglycoside antibiotic compounds |
| US4136254A (en) * | 1976-06-17 | 1979-01-23 | Schering Corporation | Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby |
| IE48972B1 (en) * | 1978-11-11 | 1985-06-26 | Microbial Chem Res Found | The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic |
| EP0156771A3 (en) * | 1984-03-29 | 1986-03-19 | Biochemie Gesellschaft M.B.H. | Cephalosporins |
-
1990
- 1990-06-19 HU HU906641A patent/HU207338B/hu not_active IP Right Cessation
- 1990-06-19 ES ES90306657T patent/ES2063274T3/es not_active Expired - Lifetime
- 1990-06-19 ES ES93102033T patent/ES2100380T3/es not_active Expired - Lifetime
- 1990-06-19 EP EP90306657A patent/EP0405820B1/en not_active Expired - Lifetime
- 1990-06-19 CA CA002062788A patent/CA2062788C/en not_active Expired - Fee Related
- 1990-06-19 CA CA002325082A patent/CA2325082A1/en not_active Abandoned
- 1990-06-19 DK DK93102033.3T patent/DK0547031T3/da active
- 1990-06-19 EP EP90917766A patent/EP0478707A1/en active Pending
- 1990-06-19 DK DK90306657.9T patent/DK0405820T3/da active
- 1990-06-19 AT AT93102033T patent/ATE152094T1/de not_active IP Right Cessation
- 1990-06-19 DE DE69008052T patent/DE69008052T2/de not_active Expired - Fee Related
- 1990-06-19 RU SU5010871A patent/RU2120444C1/ru active
- 1990-06-19 JP JP2509550A patent/JPH0692433B2/ja not_active Expired - Lifetime
- 1990-06-19 AU AU59463/90A patent/AU629960B2/en not_active Ceased
- 1990-06-19 AT AT90306657T patent/ATE104310T1/de not_active IP Right Cessation
- 1990-06-19 KR KR1019910700196A patent/KR940003496B1/ko not_active Expired - Fee Related
- 1990-06-19 DE DE69030590T patent/DE69030590T2/de not_active Expired - Fee Related
- 1990-06-19 EP EP93102033A patent/EP0547031B1/en not_active Expired - Lifetime
- 1990-06-19 WO PCT/US1990/003328 patent/WO1990015810A2/en not_active Ceased
-
1991
- 1991-12-18 FI FI915953A patent/FI96955C/fi active
- 1991-12-20 NO NO915071A patent/NO177349C/no not_active IP Right Cessation
-
1994
- 1994-05-09 JP JP6095303A patent/JP2500059B2/ja not_active Expired - Lifetime
-
1996
- 1996-10-03 HK HK185096A patent/HK185096A/en not_active IP Right Cessation
-
1997
- 1997-06-30 GR GR970401590T patent/GR3023942T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN DECEMBER 2003 |