NL8001842A - Nieuwe antibiotica die istamycinen zijn genoemd, werk- wijzen voor de bereiding van deze antibiotica, alsmede farmaceutische preparaten met werkzaamheid tegen bacterien die deze antibiotica bevatten en werkwijze voor het remmen van de groei van bacterien. - Google Patents

Nieuwe antibiotica die istamycinen zijn genoemd, werk- wijzen voor de bereiding van deze antibiotica, alsmede farmaceutische preparaten met werkzaamheid tegen bacterien die deze antibiotica bevatten en werkwijze voor het remmen van de groei van bacterien. Download PDF

Info

Publication number: NL8001842A
Authority: NL; Netherlands
Prior art keywords: istamycin; culture medium; streptomyces; antibiotics; preparation
Prior art date: 1979-05-01

Application number

NL8001842A

Other languages

English (en)

Dutch (nl)

Original Assignee

Microbial Chem Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-01

Filing date

1980-03-28

Publication date

1980-11-04

1979-05-01 Priority claimed from JP5251779A external-priority patent/JPS55145697A/ja

1979-09-17 Priority claimed from JP11791279A external-priority patent/JPS5643295A/ja

1980-03-28 Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found

1980-11-04 Publication of NL8001842A publication Critical patent/NL8001842A/nl

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238000000034 method Methods 0.000 title claims description 35
239000003242 anti bacterial agent Substances 0.000 title claims description 27
229940088710 antibiotic agent Drugs 0.000 title claims description 25
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239000000825 pharmaceutical preparation Substances 0.000 title description 2
229930190043 istamycin Natural products 0.000 claims description 199
NEFDRWXEVITQMN-UHFFFAOYSA-N istamycin B Natural products O1C(CNC)CCC(N)C1OC1C(O)C(N(C)C(=O)CN)C(OC)CC1N NEFDRWXEVITQMN-UHFFFAOYSA-N 0.000 claims description 143
NEFDRWXEVITQMN-JWYRXTSNSA-N Sannamycin A Chemical compound O1[C@H](CNC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@H](N(C)C(=O)CN)[C@@H](OC)C[C@@H]1N NEFDRWXEVITQMN-JWYRXTSNSA-N 0.000 claims description 75
NEFDRWXEVITQMN-MKRRRRENSA-N Istamycin B Chemical compound O1[C@H](CNC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@H](N(C)C(=O)CN)[C@@H](OC)C[C@H]1N NEFDRWXEVITQMN-MKRRRRENSA-N 0.000 claims description 68
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
GKYYNFPFPFRFFN-FWCUKHODSA-N Istamycin B0 Chemical compound O1[C@H](CNC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@H](NC)[C@@H](OC)C[C@H]1N GKYYNFPFPFRFFN-FWCUKHODSA-N 0.000 description 1
241000588747 Klebsiella pneumoniae Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
229910021380 Manganese Chloride Inorganic materials 0.000 description 1
GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 1
241000515012 Micrococcus flavus Species 0.000 description 1
241000191938 Micrococcus luteus Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
241000187480 Mycobacterium smegmatis Species 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
241000588767 Proteus vulgaris Species 0.000 description 1
241000588777 Providencia rettgeri Species 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
108010006183 R388 Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
GKYYNFPFPFRFFN-UHFFFAOYSA-N Sannamyicin C Natural products O1C(CNC)CCC(N)C1OC1C(O)C(NC)C(OC)CC1N GKYYNFPFPFRFFN-UHFFFAOYSA-N 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
241000607715 Serratia marcescens Species 0.000 description 1
241000607764 Shigella dysenteriae Species 0.000 description 1
241000607762 Shigella flexneri Species 0.000 description 1
241000607760 Shigella sonnei Species 0.000 description 1
229930191041 Sporaricin Natural products 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
241000191963 Staphylococcus epidermidis Species 0.000 description 1
241000231756 Streptomyces viridifaciens Species 0.000 description 1
241000187191 Streptomyces viridochromogenes Species 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
229960000583 acetic acid Drugs 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
ZMZINYUKVRMNTG-UHFFFAOYSA-N acetic acid;formic acid Chemical compound OC=O.CC(O)=O ZMZINYUKVRMNTG-UHFFFAOYSA-N 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
229940024606 amino acid Drugs 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
238000003556 assay Methods 0.000 description 1
BIDUPMYXGFNAEJ-APGVDKLISA-N astromicin Chemical compound O[C@@H]1[C@H](N(C)C(=O)CN)[C@@H](OC)[C@@H](O)[C@H](N)[C@H]1O[C@@H]1[C@H](N)CC[C@@H]([C@H](C)N)O1 BIDUPMYXGFNAEJ-APGVDKLISA-N 0.000 description 1
229940065181 bacillus anthracis Drugs 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
ZUPQZJYQJUUILJ-UHFFFAOYSA-N butan-1-ol;pyridin-1-ium;acetate Chemical compound CC(O)=O.CCCCO.C1=CC=NC=C1 ZUPQZJYQJUUILJ-UHFFFAOYSA-N 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
229940023913 cation exchange resins Drugs 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
230000015271 coagulation Effects 0.000 description 1
238000005345 coagulation Methods 0.000 description 1
229940125758 compound 15 Drugs 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
229940127089 cytotoxic agent Drugs 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000000890 drug combination Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
230000029142 excretion Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000003925 fat Substances 0.000 description 1
210000003495 flagella Anatomy 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000000499 gel Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
125000001841 imino group Chemical group [H]N=* 0.000 description 1
229910017053 inorganic salt Inorganic materials 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229940099690 malic acid Drugs 0.000 description 1
239000011565 manganese chloride Substances 0.000 description 1
235000002867 manganese chloride Nutrition 0.000 description 1
229940099607 manganese chloride Drugs 0.000 description 1
235000012054 meals Nutrition 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
239000012046 mixed solvent Substances 0.000 description 1
230000035772 mutation Effects 0.000 description 1
239000006837 my medium Substances 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
231100000926 not very toxic Toxicity 0.000 description 1
239000006877 oatmeal agar Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
229940007042 proteus vulgaris Drugs 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229940007046 shigella dysenteriae Drugs 0.000 description 1
229940115939 shigella sonnei Drugs 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000020183 skimmed milk Nutrition 0.000 description 1
238000002791 soaking Methods 0.000 description 1
239000004317 sodium nitrate Substances 0.000 description 1
235000010344 sodium nitrate Nutrition 0.000 description 1
229940045870 sodium palmitate Drugs 0.000 description 1
GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
239000000758 substrate Substances 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002211 ultraviolet spectrum Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
- C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NL8001842A 1979-05-01 1980-03-28 Nieuwe antibiotica die istamycinen zijn genoemd, werk- wijzen voor de bereiding van deze antibiotica, alsmede farmaceutische preparaten met werkzaamheid tegen bacterien die deze antibiotica bevatten en werkwijze voor het remmen van de groei van bacterien. NL8001842A (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP5251779		1979-05-01
JP5251779A JPS55145697A (en)	1979-05-01	1979-05-01	Istamycins a or/and b, and their preparation
JP11791279A JPS5643295A (en)	1979-09-17	1979-09-17	Istamycin ao and/or istamycin bo, and their preparation
JP11791279		1979-09-17

Publications (1)

Publication Number	Publication Date
NL8001842A true NL8001842A (nl)	1980-11-04

Family

ID=26393116

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8001842A NL8001842A (nl)	1979-05-01	1980-03-28	Nieuwe antibiotica die istamycinen zijn genoemd, werk- wijzen voor de bereiding van deze antibiotica, alsmede farmaceutische preparaten met werkzaamheid tegen bacterien die deze antibiotica bevatten en werkwijze voor het remmen van de groei van bacterien.

Country Status (9)

Country	Link
US (1)	US4296106A (de)
CA (1)	CA1158999A (de)
CH (1)	CH646712A5 (de)
DE (1)	DE3012014C2 (de)
ES (1)	ES491077A0 (de)
FR (1)	FR2455596A1 (de)
GB (1)	GB2048855B (de)
IT (1)	IT1153794B (de)
NL (1)	NL8001842A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4382926A (en) *	1980-04-01	1983-05-10	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics
DE3162169D1 (en) *	1980-07-15	1984-03-15	Kowa Co	Process for production of antibiotics, and novel antibiotics produced thereby
JPS5740496A (en) *	1980-08-22	1982-03-06	Microbial Chem Res Found	Low toxic derivative of istamycin antibiotic
JPS5750996A (en) *	1980-09-11	1982-03-25	Microbial Chem Res Found	3-o-demthylistamycin b derivative
JPS58128395A (ja) *	1982-01-27	1983-07-30	Microbial Chem Res Found	３−０−デメチルイスタマイシンｂの低毒性誘導体
US4567165A (en) *	1984-05-08	1986-01-28	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B
JPH0631295B2 (ja) *	1986-03-11	1994-04-27	財団法人微生物化学研究会	低毒性の２′−デアミノ−２′−ヒドロキシイスタマイシンＢｏ誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR66054B (de) *	1976-10-28	1981-01-14	Abbott Lab
US4205070A (en) *	1977-12-21	1980-05-27	Abbott Laboratories	6'N-Alkyl- and 6',6'-di-N-alkyl derivatives of fortimicins A and B

1980
- 1980-03-28 NL NL8001842A patent/NL8001842A/nl not_active Application Discontinuation
- 1980-03-28 DE DE3012014A patent/DE3012014C2/de not_active Expired
- 1980-03-28 GB GB8010642A patent/GB2048855B/en not_active Expired
- 1980-03-28 IT IT09394/80A patent/IT1153794B/it active
- 1980-03-28 CH CH247080A patent/CH646712A5/de not_active IP Right Cessation
- 1980-04-18 US US06/141,492 patent/US4296106A/en not_active Expired - Lifetime
- 1980-04-30 FR FR8010136A patent/FR2455596A1/fr active Granted
- 1980-04-30 CA CA000351007A patent/CA1158999A/en not_active Expired
- 1980-04-30 ES ES491077A patent/ES491077A0/es active Granted

Also Published As

Publication number	Publication date
ES8105034A1 (es)	1981-05-16
IT8009394A0 (it)	1980-03-28
GB2048855A (en)	1980-12-17
DE3012014C2 (de)	1986-11-13
US4296106A (en)	1981-10-20
IT1153794B (it)	1987-01-21
FR2455596A1 (fr)	1980-11-28
CH646712A5 (de)	1984-12-14
DE3012014A1 (de)	1980-11-13
CA1158999A (en)	1983-12-20
ES491077A0 (es)	1981-05-16
FR2455596B1 (de)	1983-05-20
GB2048855B (en)	1983-06-15

Publication	Publication Date	Title
Weinstein et al.	1970	Antibiotic 6640, a new micromonospora-producbd aminoglycoside antibiotic
HU188077B (en)	1986-03-28	Process for producing new bmg162-af2 of anibiotic activity
NL8001842A (nl)	1980-11-04	Nieuwe antibiotica die istamycinen zijn genoemd, werk- wijzen voor de bereiding van deze antibiotica, alsmede farmaceutische preparaten met werkzaamheid tegen bacterien die deze antibiotica bevatten en werkwijze voor het remmen van de groei van bacterien.
US4359583A (en)	1982-11-16	Antibiotics TM-531 B and TM-531 C
US4425430A (en)	1984-01-10	Process for production of antibiotics and novel antibiotics produced thereby
US3849398A (en)	1974-11-19	Antibiotic having parasiticidal activity
RU2099349C1 (ru)	1997-12-20	Гликопептиды и лекарственный препарат, обладающий антибиоцидным действием
US4495358A (en)	1985-01-22	Antibiotic pyrrolomycin E
JPS58140053A (ja)	1983-08-19	抗生物質化合物
DK146342B (da)	1983-09-12	Fremgangsmaade til fremstilling af anthracyclinglycosidantibiotika betegnet ma 144-m1 og ma 144-m2 eller ikke toksiske syreadditionssalte eller komplekser deraf med desoxyribonucleinsyre
US4376778A (en)	1983-03-15	Antibiotic substances and processes for production thereof
US4209511A (en)	1980-06-24	Aminoglycoside antibiotics and process for production thereof
US3856938A (en)	1974-12-24	Antibiotic em{14 49
US3953293A (en)	1976-04-27	Process for the preparation of xylostasin
GB1572530A (en)	1980-07-30	Fortimicin antbiotics and the preparation thereof
DK141372B (da)	1980-03-03	Fremgangsmåde til fremstilling af et antibiotisk kompleks, kaldet Bu2231, eller bestanddele og syreadditionssalte deraf.
US4380581A (en)	1983-04-19	Istamycins and streptomyces culture for the production thereof
USRE29903E (en)	1979-02-06	Antibacterial antibiotics AM31α, AM31β and AM31γ
CA2351222A1 (en)	2000-05-18	Vancoresmycin, a process for its production and its use as a pharmaceutical
JP2594167B2 (ja)	1997-03-26	新規抗生物質ｓｆ２６９８物質およびその製造法
CA1129796A (en)	1982-08-17	Fortimicin factors kg.sub.1, kg.sub.2 and kg.sub.3 and processes for production thereof
EP0253413B1 (de)	1993-10-13	Antibiotika "Mureidomycine A,B,C und D" genannt, deren Verfahren zur Herstellung und deren Verwendung
US3941762A (en)	1976-03-02	O-acyl derivatives of antibiotic EM-49
US5665779A (en)	1997-09-09	Pharmaceutical composition for inhibiting the infection with AIDS virus
SU440847A1 (ru)	1974-08-25	Способ получения антибиотика

Legal Events

Date	Code	Title
1980-11-25	A1A	A request for search or an international-type search has been filed
1981-10-01	BB	A search report has been drawn up
1985-01-01	A85	Still pending on 85-01-01
1987-04-01	BC	A request for examination has been filed
1996-12-02	BV	The patent application has lapsed