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NL301057I1 - Glasdegib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, met inbegrip van het maleaatzout - Google Patents

Glasdegib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, met inbegrip van het maleaatzout

Info

Publication number
NL301057I1
NL301057I1 NL301057C NL301057C NL301057I1 NL 301057 I1 NL301057 I1 NL 301057I1 NL 301057 C NL301057 C NL 301057C NL 301057 C NL301057 C NL 301057C NL 301057 I1 NL301057 I1 NL 301057I1
Authority
NL
Netherlands
Prior art keywords
degib
optionally
glass
pharmaceutically acceptable
salt
Prior art date
Application number
NL301057C
Other languages
English (en)
Other versions
NL301057I2 (nl
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NL301057I1 publication Critical patent/NL301057I1/nl
Publication of NL301057I2 publication Critical patent/NL301057I2/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL301057C 2007-06-29 2020-07-15 Glasdegib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, met inbegrip van het maleaatzout NL301057I2 (nl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94728707P 2007-06-29 2007-06-29
US4164508P 2008-04-02 2008-04-02
PCT/IB2008/001575 WO2009004427A2 (en) 2007-06-29 2008-06-16 Benzimidazole derivatives

Publications (2)

Publication Number Publication Date
NL301057I1 true NL301057I1 (nl) 2020-07-22
NL301057I2 NL301057I2 (nl) 2020-09-10

Family

ID=40161351

Family Applications (1)

Application Number Title Priority Date Filing Date
NL301057C NL301057I2 (nl) 2007-06-29 2020-07-15 Glasdegib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, met inbegrip van het maleaatzout

Country Status (45)

Country Link
US (2) US8148401B2 (nl)
EP (1) EP2170860B9 (nl)
JP (2) JP4567099B2 (nl)
KR (1) KR101143246B1 (nl)
CN (1) CN101687841B (nl)
AP (1) AP2377A (nl)
AR (1) AR067346A1 (nl)
AU (1) AU2008272641B2 (nl)
BR (1) BRPI0813412B8 (nl)
CA (1) CA2690953C (nl)
CL (1) CL2008001922A1 (nl)
CO (1) CO6160232A2 (nl)
CR (1) CR11150A (nl)
CU (1) CU23847B1 (nl)
CY (2) CY1118650T1 (nl)
DK (1) DK2170860T5 (nl)
DO (1) DOP2009000278A (nl)
EA (1) EA016888B1 (nl)
EC (1) ECSP099803A (nl)
ES (1) ES2609258T3 (nl)
FR (1) FR20C1038I2 (nl)
GE (1) GEP20125702B (nl)
GT (1) GT200900328A (nl)
HN (1) HN2008000974A (nl)
HR (1) HRP20161562T2 (nl)
HU (2) HUE030052T4 (nl)
IL (1) IL202420A (nl)
LT (2) LT2170860T (nl)
MA (1) MA31466B1 (nl)
ME (1) ME00962B (nl)
MY (1) MY148636A (nl)
NI (1) NI200900219A (nl)
NL (1) NL301057I2 (nl)
NO (1) NO2020027I1 (nl)
NZ (1) NZ581889A (nl)
PA (1) PA8785401A1 (nl)
PE (2) PE20121010A1 (nl)
PL (1) PL2170860T3 (nl)
PT (1) PT2170860T (nl)
RS (1) RS55395B9 (nl)
SI (1) SI2170860T1 (nl)
TN (1) TN2009000544A1 (nl)
TW (1) TWI371451B (nl)
UY (1) UY31164A1 (nl)
WO (1) WO2009004427A2 (nl)

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CN101687841B (zh) * 2007-06-29 2013-07-10 辉瑞大药厂 苯并咪唑衍生物
CA2735593C (en) 2008-09-03 2017-08-15 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
MX2011013294A (es) * 2009-06-11 2012-01-12 Siena Biotech Spa Antagonistas de la trayectoria de hedgehog y aplicaciones terapeuticas de los mismos.
GEP20146075B (en) 2009-08-26 2014-04-10 Takeda Pharmaceuticals Co Fused heterocyclic ring derivative and usage thereof
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
EP2630134B9 (en) 2010-10-20 2018-04-18 Pfizer Inc Pyridine-2- derivatives as smoothened receptor modulators
JP5452459B2 (ja) 2010-12-16 2014-03-26 株式会社Nttドコモ ホーム基地局及びハンドオーバ方法
JP6250403B2 (ja) 2011-02-28 2017-12-20 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US9051305B2 (en) 2011-03-08 2015-06-09 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
FR2980477B1 (fr) 2011-09-23 2013-10-18 Centre Nat Rech Scient Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications
ES2612934T3 (es) * 2011-09-26 2017-05-19 Merck Patent Gmbh Compuestos de piperidin bencilo como antagonista del receptor del ácido lisofosfatídico (LPA)
US20150133450A1 (en) 2012-06-20 2015-05-14 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
EP2922544B1 (en) 2012-11-21 2018-08-01 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
BR112015023399A8 (pt) 2013-03-15 2019-12-03 Biomarin Pharm Inc inibidores de hdac, seu uso e composição farmacêutica
EP2996689A1 (en) * 2013-04-17 2016-03-23 Albert-Ludwigs-Universität Freiburg Compounds for use as bromodomain inhibitors
US10732182B2 (en) 2013-08-01 2020-08-04 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
GB2519344A (en) * 2013-10-18 2015-04-22 Redx Pharma Ltd Compounds
AU2014342269B2 (en) 2013-10-30 2020-02-27 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
SG11201707863QA (en) * 2015-04-24 2017-11-29 Pfizer Crystalline forms of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
ES2973822T3 (es) 2020-01-28 2024-06-24 Assia Chem Ind Ltd Procesos para la preparación de Glasdegib y su sal, y formas en estado sólido de maleato de Glasdegib y proceso para la preparación del mismo
CN113248475B (zh) * 2020-02-11 2023-03-17 中国科学院上海药物研究所 一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途
WO2021191278A1 (en) 2020-03-26 2021-09-30 Lek Pharmaceuticals D.D. Dimaleate form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
US20230301950A1 (en) 2020-06-26 2023-09-28 Raqualia Pharma Inc. Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent
WO2023002362A1 (en) 2021-07-22 2023-01-26 Pfizer Inc. Treatment of hematological malignancy

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NZ530580A (en) 2001-07-27 2007-02-23 Curis Inc Mediators of hedgehog signaling pathways, compositions and uses related thereto
SI1499607T1 (sl) * 2001-12-04 2006-06-30 Actelion Pharmaceuticals Ltd 4-(piperidil- in pirolidil-alkil-ureido)-kinolinikot antagonisti receptorja urotensina II
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
WO2004035549A1 (en) 2002-10-17 2004-04-29 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
WO2005042495A1 (en) 2003-10-21 2005-05-12 Imclone Systems Incorporated (benzimidazol-2-yl)-phenyl-phenyl-urea compounds and methods for inhibiting heparanase activity
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EP2121626A1 (en) 2006-12-15 2009-11-25 Pfizer Products Inc. Benzimidazole derivatives
CN101687841B (zh) 2007-06-29 2013-07-10 辉瑞大药厂 苯并咪唑衍生物
EP2303275A4 (en) 2008-06-17 2012-05-09 Univ Duke STANDARD RECEPTOR MODULATORS
JP5555236B2 (ja) 2008-08-25 2014-07-23 アイアールエム・リミテッド・ライアビリティ・カンパニー ヘッジホッグ経路モジュレーター

Also Published As

Publication number Publication date
GEP20125702B (en) 2012-12-10
LTC2170860I2 (lt) 2022-03-10
MA31466B1 (fr) 2010-06-01
BRPI0813412A2 (pt) 2014-12-30
ME00962B (me) 2012-06-20
US20090005416A1 (en) 2009-01-01
IL202420A0 (en) 2010-06-30
AP2377A (en) 2012-03-07
BRPI0813412B8 (pt) 2021-05-25
NO2020027I1 (no) 2020-08-11
PT2170860T (pt) 2017-01-04
BRPI0813412B1 (pt) 2020-01-21
CY2020028I2 (el) 2020-11-25
GT200900328A (es) 2011-08-29
US8148401B2 (en) 2012-04-03
ECSP099803A (es) 2010-01-29
CA2690953A1 (en) 2009-01-08
JP2010280693A (ja) 2010-12-16
CO6160232A2 (es) 2010-05-20
FR20C1038I2 (fr) 2021-08-13
HK1139658A1 (en) 2010-09-24
EA200971104A1 (ru) 2010-06-30
DK2170860T3 (en) 2017-01-09
PL2170860T3 (pl) 2017-05-31
KR20100028120A (ko) 2010-03-11
AU2008272641B2 (en) 2013-08-29
ES2609258T3 (es) 2017-04-19
WO2009004427A3 (en) 2009-06-04
TW200911792A (en) 2009-03-16
EP2170860A2 (en) 2010-04-07
UY31164A1 (es) 2009-01-30
HRP20161562T1 (hr) 2016-12-30
TN2009000544A1 (fr) 2011-03-31
NI200900219A (es) 2010-03-11
PE20090772A1 (es) 2009-06-24
US8431597B2 (en) 2013-04-30
HRP20161562T2 (hr) 2017-04-21
KR101143246B1 (ko) 2012-05-18
PA8785401A1 (es) 2009-01-23
MY148636A (en) 2013-05-15
RS55395B9 (sr) 2020-01-31
LT2170860T (lt) 2017-01-10
AU2008272641A1 (en) 2009-01-08
CR11150A (es) 2010-02-08
EP2170860B1 (en) 2016-11-02
IL202420A (en) 2014-05-28
EA016888B1 (ru) 2012-08-30
NZ581889A (en) 2011-05-27
AP2009005089A0 (en) 2009-12-31
JP4567099B2 (ja) 2010-10-20
HUE030052T4 (en) 2017-06-28
CY2020028I1 (el) 2020-11-25
FR20C1038I1 (nl) 2020-10-02
PE20121010A1 (es) 2012-08-06
HN2008000974A (es) 2011-01-24
AR067346A1 (es) 2009-10-07
DK2170860T5 (en) 2017-03-20
US20120157495A1 (en) 2012-06-21
CN101687841B (zh) 2013-07-10
HUE030052T2 (hu) 2017-04-28
WO2009004427A2 (en) 2009-01-08
RS55395B1 (sr) 2017-04-28
DOP2009000278A (es) 2009-12-31
TWI371451B (en) 2012-09-01
HUS2000031I1 (hu) 2020-09-28
EP2170860B9 (en) 2017-02-22
SI2170860T1 (sl) 2017-01-31
CN101687841A (zh) 2010-03-31
CL2008001922A1 (es) 2009-01-02
JP2010531869A (ja) 2010-09-30
CA2690953C (en) 2012-10-02
NL301057I2 (nl) 2020-09-10
CU23847B1 (es) 2012-10-15
LTPA2020528I1 (lt) 2020-09-25
CU20090225A7 (es) 2012-02-15
CY1118650T1 (el) 2017-07-12

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