[go: up one dir, main page]

NL300050I2 - Glycosileringsvarianten van weefselplasminogene activator met verbeterde therapeutische eigenschappen. - Google Patents

Glycosileringsvarianten van weefselplasminogene activator met verbeterde therapeutische eigenschappen.

Info

Publication number
NL300050I2
NL300050I2 NL300050C NL300050C NL300050I2 NL 300050 I2 NL300050 I2 NL 300050I2 NL 300050 C NL300050 C NL 300050C NL 300050 C NL300050 C NL 300050C NL 300050 I2 NL300050 I2 NL 300050I2
Authority
NL
Netherlands
Prior art keywords
plasminogen activator
tissue plasminogen
therapeutic properties
improved therapeutic
glycosylation variants
Prior art date
Application number
NL300050C
Other languages
English (en)
Other versions
NL300050I1 (nl
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NL300050I1 publication Critical patent/NL300050I1/nl
Publication of NL300050I2 publication Critical patent/NL300050I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NL300050C 1992-06-03 2001-07-24 Glycosileringsvarianten van weefselplasminogene activator met verbeterde therapeutische eigenschappen. NL300050I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89421392A 1992-06-03 1992-06-03
PCT/US1993/005109 WO1993024635A1 (en) 1992-06-03 1993-05-28 Tissue plasminogen activator glycosylation variants with improved therapeutic properties

Publications (2)

Publication Number Publication Date
NL300050I1 NL300050I1 (nl) 2001-10-01
NL300050I2 true NL300050I2 (nl) 2001-11-01

Family

ID=25402765

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300050C NL300050I2 (nl) 1992-06-03 2001-07-24 Glycosileringsvarianten van weefselplasminogene activator met verbeterde therapeutische eigenschappen.

Country Status (20)

Country Link
US (1) US5612029A (nl)
EP (2) EP0643772B1 (nl)
JP (1) JP3559559B2 (nl)
AT (2) ATE155816T1 (nl)
AU (1) AU664469B2 (nl)
CA (1) CA2129660C (nl)
DE (3) DE69333127T2 (nl)
DK (2) DK0643772T3 (nl)
EE (1) EE03128B1 (nl)
ES (2) ES2107041T3 (nl)
FI (1) FI117940B (nl)
GE (1) GEP20012448B (nl)
GR (1) GR3024806T3 (nl)
HK (1) HK1000449A1 (nl)
IL (1) IL105883A (nl)
LU (1) LU90800I2 (nl)
NL (1) NL300050I2 (nl)
NZ (1) NZ253556A (nl)
PT (1) PT786257E (nl)
WO (1) WO1993024635A1 (nl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060484B1 (en) 1993-11-12 2006-06-13 Gilead Sciences, Inc. Polypeptides and coagulation therapy
AU1096595A (en) * 1993-11-12 1995-05-29 Gilead Sciences, Inc. Thrombin mutants
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5510330A (en) † 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
DE4423574A1 (de) * 1994-07-05 1996-01-11 Boehringer Mannheim Gmbh Nicht-glykosylierte Plasminogenaktivator-Derivate und ihre Verwendung bei erhöhtem Blutungsrisiko
US5945432A (en) * 1995-12-22 1999-08-31 The University Of Vermont And State Agricultural College Thrombolytic agents and thienopyridine derivatives in acute stroke
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
AU1208599A (en) * 1997-10-31 1999-05-24 Eli Lilly And Company Glycosylated obesity protein analogs
US6242473B1 (en) 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
SI1226269T1 (en) 1999-11-04 2003-12-31 Genentech, Inc. Assay
US20030036181A1 (en) * 2000-06-30 2003-02-20 Okkels Jens Sigurd Peptide extended glycosylated polypeptides
CA2466083A1 (en) * 2001-11-06 2003-05-15 Maxim Pharmaceuticals, Inc. Compositions for the treatment of infectious diseases
BR0215098A (pt) * 2001-11-26 2004-12-14 Genentech Inc Composição útil para remoção de coágulos de sangue, método para a remoção de coágulos de sangue, catéter e embalagens de múltiplos compartimentos
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
US20060105387A1 (en) * 2002-08-30 2006-05-18 Prior Christopher P Transferrin fusion proteins libraries
US20070014779A1 (en) * 2002-11-14 2007-01-18 Genentech, Inc. Plasminogen activator variant formulations
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US20060104969A1 (en) * 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
AP2007004251A0 (en) * 2005-06-02 2007-12-31 Avestha Gengraine Tech Pvt Ltd A method for production of a bioengineered form oftissue plasminogen activator
US7932084B2 (en) * 2005-09-08 2011-04-26 University Of Virginia Patent Foundation Methods and compositions for growing adipose stem cells
WO2007120818A2 (en) * 2006-04-12 2007-10-25 Massachusetts Institute Of Technology Compositions and methods for inhibiting adhesions
EP2012815A4 (en) * 2006-04-14 2009-12-09 Massachusetts Inst Technology IDENTIFICATION AND MODULATION OF MOLECULAR PATHS FOR PROCESSING NEURONAL PLASTICITY
SG10201804944XA (en) 2006-08-29 2018-07-30 Genentech Inc Use of tenecteplase for treating acute ischemic stroke
WO2008060374A2 (en) * 2006-10-06 2008-05-22 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
EP2086571A2 (en) 2006-11-07 2009-08-12 Genentech, Inc. Tissue plasminogen activator variant uses
KR100834561B1 (ko) 2006-12-08 2008-06-02 가톨릭대학교 산학협력단 크링글 도메인 1 및 2로 이루어진 비-글리코실화 재조합단백질, 그 제조 방법 및 이를 포함하는 조성물
EP2289541A1 (en) 2009-08-31 2011-03-02 PAION Deutschland GmbH Treatment of neurological or neurodegenerative disorders
EP2289542A1 (en) 2009-08-31 2011-03-02 PAION Deutschland GmbH Treatment of neurological or neurodegenerative disorders
US20130122076A1 (en) * 2011-11-11 2013-05-16 Mathew Gelfand Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease
CN104602701B (zh) * 2012-07-05 2019-04-16 哈达斯特医疗研究服务和开发有限公司 作为抗纤维蛋白溶解剂的纤维蛋白溶酶原活化剂的突变体
CA2931172C (en) 2012-12-05 2022-11-15 National Jewish Health Treatment for airway cast obstruction
CN103623396B (zh) * 2013-04-07 2016-03-02 安源生物科技(上海)有限公司 包含重组组织型纤溶酶原激活剂的药物组合物
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders
EP3708226A1 (en) * 2014-11-03 2020-09-16 Thrombolytic Science, LLC Methods and compositions for safe and effective thrombolysis
TWI810173B (zh) 2017-02-03 2023-08-01 法商艾提寇生物技術公司 使用抗人類ｇｐｖｉ抗體抑制血小板凝集
EP3624832B1 (en) 2017-05-16 2025-08-20 Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for the treatment of acute ischemic stroke
WO2018232305A1 (en) 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis
US12123000B2 (en) 2018-06-15 2024-10-22 Inserm (Institut National De La Sante Et De La Recherche Medicale) Use of PI3KC2B inhibitors for the preservation of vascular endothelial cell barrier integrity
WO2021148439A1 (en) 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stimulating cerebrovascular function
WO2021249974A1 (en) 2020-06-09 2021-12-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidan-functionalized polysaccharide particles with t-pa for targeted thrombolytic therapy
US20250154252A1 (en) 2022-02-21 2025-05-15 Acticor Biotech Treatment of cardiovascular diseases using anti-human gpvi antibodies
WO2024229429A1 (en) 2023-05-04 2024-11-07 Genentech, Inc. Use of tenecteplase for treating late-window stroke patients
WO2025064654A1 (en) * 2023-09-19 2025-03-27 The Research Foundation For The State University Of New York Truncated tissue plasminogen activator proteins and use thereof
EP4556492A1 (en) 2023-11-14 2025-05-21 Acticor Biotech Treatment of cardiovascular diseases using anti-human gpvi antibodies in subpopulations of subjects

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NL8003402A (nl) 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
IL68561A (en) 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4943529A (en) 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
EP0112122B1 (en) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogen activator
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
AU3145184A (en) 1983-08-16 1985-02-21 Zymogenetics Inc. High expression of foreign genes in schizosaccharomyces pombe
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4658830A (en) * 1984-08-08 1987-04-21 Survival Technology, Inc. Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
DE3588149T2 (de) * 1984-10-01 1997-10-09 Genzyme Corp Rekombinante DNS-Verfahren und dadurch hergestellte Produkte
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
PT82326B (pt) * 1985-04-04 1988-10-14 Beecham Group Plc Processo para a preparacao de activador de plasminogenio de tipo tissular fibrinoliticamente activo
HU206520B (en) * 1985-04-22 1992-11-30 Genentech Inc Process for producing new human tissue plasminogen activator /tpa/ mutants and pharmaceutical compositions containing them
DE3617753A1 (de) * 1985-05-28 1986-12-04 The Wellcome Foundation Ltd., London Gewebe-plasminogenaktivator, diesen enthaltende pharmazeutische formulierungen sowie ihre herstellung und ihre verwendung in der human- und veterinaermedizin
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
EP0218112B1 (en) * 1985-09-10 1992-12-09 Eisai Co., Ltd. Composition containing tissue plasminogen activator
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
KR880700856A (ko) * 1985-12-20 1988-04-12 로버어트 에이 아미테이지 조직 플라스미노겐 활성화인자(tpa)상사체
ES2031826T3 (es) 1985-12-23 1993-01-01 Chiron Corporation Procedimiento para producir nuevos peptidos activadores del plasminogeno.
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
AU612974B2 (en) * 1986-01-31 1991-07-25 Genetics Institute, Llc Novel thrombolytic proteins
IE81073B1 (en) 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
PT84588B (en) 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
AU7090687A (en) 1986-04-02 1987-10-08 Beecham Group Plc Modified tissue-type plasminogen activators
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
EP0266032A1 (en) * 1986-08-29 1988-05-04 Beecham Group Plc Modified fibrinolytic enzyme
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
EP0292009A1 (en) * 1987-05-22 1988-11-23 Zymogenetics, Inc. Fibrinolytic proteins
IE64782B1 (en) * 1987-06-04 1995-09-06 Eisai Co Ltd Mutant t-PA with kringle replacement
EP0293936B1 (en) * 1987-06-04 1995-02-22 Zymogenetics, Inc. Tissue plasminogen activator analogs having modified growth factor domains
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
KR960015610B1 (ko) * 1987-06-22 1996-11-18 제네틱스 인스티튜트, 인코포레이티드 신규의 혈전붕괴 단백질의 제조방법
US4935237A (en) 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
EP0365597B2 (en) * 1987-06-30 2005-02-09 Genentech, Inc. Improved processes for the treatment of vascular disease
JPH03500002A (ja) * 1987-07-06 1991-01-10 ジェネティックス・インスチチュート・インコーポレーテッド 新規な血栓崩壊蛋白
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
CA1308377C (en) 1987-08-21 1992-10-06 Henry Berger, Jr. Complex of polyethyleneglycol and tissue plasminogen activator
IL88247A0 (en) 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
US5225540A (en) 1988-04-26 1993-07-06 Du Pont Merck Pharmaceutical Company Monoclonal antibodies to tissue plasminogen activator (t-pa) which prolong its functional half-life
IL90146A (en) 1988-05-20 1994-10-07 Genentech Inc Glycosylation derivatives of tissue plasminogen activator
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
EP0435911B1 (en) 1988-09-23 1996-03-13 Cetus Oncology Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
US5041376A (en) * 1988-12-09 1991-08-20 The Board Of Regents Of The University Of Texas System Method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells, the mutant proteins so produced and genes encoding said mutant proteins
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
ES2154629T3 (es) * 1989-03-06 2001-04-16 Univ Texas Mutantes t-pa resistentes a la inhibicion por sus inhibidores similares.
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
ES2038579T3 (es) 1989-04-28 1997-02-16 Rhein Biotech Proz & Prod Gmbh Celulas de levadura del genero schwanniomyces.
FR2649120B1 (fr) 1989-06-30 1994-01-28 Cayla Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
US5087572A (en) 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
US5366730A (en) * 1989-12-20 1994-11-22 Boehringer Mannheim Gmbh Stabilized compositions having human tissue type plasminogen activator enzymatic activity
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
EP0542869B1 (en) 1990-07-31 1995-09-13 Genentech, Inc. Tissue plasminogen activator variants with decreased clearance
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants

Also Published As

Publication number Publication date
ES2203668T3 (es) 2004-04-16
FI943632L (fi) 1994-10-04
AU664469B2 (en) 1995-11-16
GR3024806T3 (en) 1998-01-30
DE69333127D1 (de) 2003-09-04
JP3559559B2 (ja) 2004-09-02
US5612029A (en) 1997-03-18
DE69333127T2 (de) 2004-05-06
NZ253556A (en) 1995-11-27
HK1001190A1 (en) 1998-05-29
HK1000449A1 (en) 2004-03-05
DK0643772T3 (da) 1998-02-02
AU4397393A (en) 1993-12-30
DE69312493T2 (de) 1998-01-15
FI943632A0 (fi) 1994-08-04
IL105883A (en) 2003-04-10
IL105883A0 (en) 1993-10-20
EP0643772B1 (en) 1997-07-23
GEP20012448B (en) 2001-05-25
NL300050I1 (nl) 2001-10-01
EP0643772A1 (en) 1995-03-22
FI117940B (fi) 2007-04-30
JPH07507448A (ja) 1995-08-24
CA2129660A1 (en) 1993-12-09
PT786257E (pt) 2003-12-31
EE03128B1 (et) 1998-10-15
CA2129660C (en) 2005-06-28
WO1993024635A1 (en) 1993-12-09
DK0786257T3 (da) 2003-10-06
DE10199044I1 (de) 2002-02-21
EP0786257B1 (en) 2003-07-30
ES2107041T3 (es) 1997-11-16
EP0786257A1 (en) 1997-07-30
DE10199044I2 (de) 2006-02-09
LU90800I2 (fr) 2001-10-08
DE69312493D1 (de) 1997-09-04
ATE155816T1 (de) 1997-08-15
ATE246000T1 (de) 2003-08-15

Similar Documents

Publication Publication Date Title
NL300050I1 (nl) Glycosileringsvarianten van weefselplasminogene activator met verbeterde therapeutische eigenschappen.
IL147293A0 (en) Peptides that lower blood glucose levels
IL80659A (en) Modified tissue plasminogen activators,their preparation and pharmaceutical compositions containing them
ES2018367A6 (es) Un metodo para proporcionar variantes de t-pa humano.
DK0383417T3 (da) Flagmusespyt-plasminogenaktivator v-PAalfa1
DK0542869T3 (da) Vævsplasminogenaktivatorvarianter med nedsat udskillelse
FI880891A7 (fi) Humaanikudoksen plasminogeenin rekombinanttiaktivaattorin koostumus.
GR3015094T3 (en) Tissue plasminogen activator substitution variant.
NO880831D0 (no) Rekombinant human vevsplasminogen-aktivatorblanding.