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NL2035771B1 - Precise dosing method for magnetic capsules - Google Patents

Precise dosing method for magnetic capsules Download PDF

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Publication number
NL2035771B1
NL2035771B1 NL2035771A NL2035771A NL2035771B1 NL 2035771 B1 NL2035771 B1 NL 2035771B1 NL 2035771 A NL2035771 A NL 2035771A NL 2035771 A NL2035771 A NL 2035771A NL 2035771 B1 NL2035771 B1 NL 2035771B1
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NL
Netherlands
Prior art keywords
magnetic
target
magnetic field
target region
microcapsules
Prior art date
Application number
NL2035771A
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Dutch (nl)
Other versions
NL2035771A (en
Inventor
Xiang Xin
Xu Kaya
Liao Yidong
Song Wenxue
He Longcai
Cui Junshuan
Zeng Xi
Yang Hua
Wang Xudong
Chen Guangtang
Zhou Xingwang
Ming Jiang
Li Bowen
Wang Zili
Zhao Wenyong
Original Assignee
Affiliated Hospital Guizhou Med Univ
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Publication date
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Publication of NL2035771A publication Critical patent/NL2035771A/en
Application granted granted Critical
Publication of NL2035771B1 publication Critical patent/NL2035771B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery
    • A61B34/73—Manipulators for magnetic surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Robotics (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pathology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

The present invention discloses a precise dosing method for magnetic capsules, including the following steps: Sl, stereotactically positioning, by an operator, a patient's head in three—dimensional space through magnetic resonance and a head stereotactic device to determine a target site or target region to be treated; SZ, generating a gradient magnetic field by driving a magnetic generation assembly through a magnetic drive assembly after the target point or target region is determined, the magnetic drive assembly being capable of precisely controlling the gradient magnetic field and changing in real time; focusing the magnetic field by a magnetic lens and a space magnetic targeting control assembly, so that the magnetic field of the selected target site or target region is the strongest; then aggregating magnetic microcapsules by the focused magnetic attraction; finally delivering the magnetic microcapsules injected into a blood vessel to the target site or target region.

Description

PRECISE DOSING METHOD FOR MAGNETIC CAPSULES
TECHNICAL FIELD
The present invention relates to the technical field of medi- cal treatment, and particularly to a precise dosing method for magnetic capsules.
BACKGROUND ART
Many diseases often stem from lesions in a certain organ, re- sulting in dysfunction of the entire system or the whole body. At present, most drugs for treatment are intravascular injection drugs or stem cells, which rely on the circulatory system to transport drugs to the whole body. Currently, there are certain targeted drugs available that can be used for targeted therapy by acting on biological target sites. However, most drugs are still administered systemically, which results in the need for higher drug doses and the increased occurrence of side effects. If tradi- tional drugs or stem cells can be transported to the lesion site more effectively and precisely, the above problems will be solved to some extent, thereby increasing drug efficacy, improving utili- zation, and reducing systemic reactions. Therefore, we propose a precise dosing method for magnetic capsules.
SUMMARY
It is an object of the present invention to provide a precise dosing method for magnetic capsules to solve the disadvantages of the prior art that traditional drugs or stem cells cannot be transported to the lesion site more efficiently and precisely.
In order to achieve the above object, the present invention adopts the following technical solutions.
A precise dosing method for magnetic capsules is provided.
The method includes: 31, stereotactically positioning, by an operator, a patient's head in three-dimensional space through magnetic resonance and a head stereotactic device to determine a target site or target re-
gion to be treated;
S2, generating a gradient magnetic field by driving a magnet- ic generation assembly through a magnetic drive assembly after the target point or target region is determined, the magnetic drive assembly being capable of precisely controlling the gradient mag- netic field and changing in real time; focusing the magnetic field by a magnetic lens and a space magnetic targeting control assem- bly, so that the magnetic field of the selected target site or target region is the strongest; then aggregating magnetic micro- capsules by the focused magnetic attraction; finally delivering the magnetic microcapsules injected into a blood vessel to the target site or target region, and targetedly releasing the content by the precise-release magnetic microcapsule device; and
S3, transmitting stereotactic space coordinate information of the stereotactic device into the space magnetic targeting control assembly, which is worn by the patient for a long time to form a continuous magnetic field attraction effect and achieve a long- time precise content release.
Preferably, the patient in S1 lies on a treatment couch, and the treatment couch may be moved by a treatment couch drive assem- bly according to the determination of the target site or target region to be treated, thereby achieving a better magnetic field focusing effect.
Preferably, the magnetic microcapsules are magnetic and may be magnetically guided, the diameters of the magnetic microcap- sules are nanoscale or microscale. The magnetic microcapsules may be introduced into a body through intravascular injection and reach various parts of the body through blood circulation, and may be guided to the target site or target region through targeted magnetic guidance and remain there for a long time, and may re- lease the content under a certain magnetic field intensity.
Preferably, the content is a drug or a stem cell.
Preferably, the stereotactic device may serve as a reference for magnetic resonance localization and may continue to serve as a reference for targeted localization during the treatment with the precise-release magnetic microcapsule device.
Preferably, the operator may further control the entire de-
vice by controlling a computer through an operating unit.
Compared to the prior art, the present invention has the fol- lowing beneficial effects: 1. in the present invention, the head is stereotactically po- sitioned in three-dimensional space through magnetic resonance and a head stereotactic device to determine a target site or target region to be treated; 2. in the present invention, targeted magnetic focusing is performed, and magnetic microcapsules injected into a blood vessel reach the target site or target region through the focused magnet- ic attraction, enabling targeted release of drugs or stem cells by the precise-release magnetic microcapsule device; 3. in the present invention, sterectactic space coordinate information of the stereotactic device is transmitted into a space magnetic targeting control assembly, which is worn by a patient for a long time to form a continuous magnetic field attraction ef- fect and achieve a long-time precise release of drugs or stem cells; thus, traditional drugs or stem cells may be more effec- tively and precisely transported to the lesion site, increasing the drug efficacy, improving utilization, and reducing systemic reactions.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a flowchart of a precise dosing method for magnetic capsules according to the present invention.
DETAILED DESCRIPTION OF THE EMBODIMENTS
The technical solutions in embodiments of the present inven- tion will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the embodiments described are only part of, but not all of, the embodiments of the present invention.
Referring to FIG. 1, a precise dosing method for magnetic capsules is provided. The method includes the following steps.
At S1, an operator may further control the entire device by controlling a computer through an operating unit, and the operator may stereotactically position a patient's head in three-
dimensional space through magnetic resonance and a head stereotac- tic device to determine a target site or target region to be treated. The patient lies on a treatment couch, and the treatment couch may be moved by a treatment couch drive assembly according to the determination of the target site or target region to be treated, thereby achieving a better magnetic field focusing ef- fect. The stereotactic device may serve as a reference for magnet- ic resonance localization, and may continue to serve as a refer- ence for targeted localization during the treatment with a pre- cise-release magnetic microcapsule device.
At 52, after the target point or target region is determined, a magnetic generation assembly is driven by a magnetic drive as- sembly to generate a gradient magnetic field, and the magnetic drive assembly may precisely control the gradient magnetic field and change in real time. The magnetic field is focused by a mag- netic lens and a space magnetic targeting control assembly, so that the magnetic field of the selected target site or target re- gion is the strongest. Then, magnetic microcapsules are aggregated by the focused magnetic attraction. Finally, the magnetic micro- capsules injected into a blood vessel are delivered to the target site or target region, and the content are targetedly released by the precise-release magnetic microcapsule device. The magnetic mi- crocapsules are magnetic and may be magnetically guided. The diam- eters of the magnetic microcapsules are nanoscale or microscale.
The magnetic microcapsules may be introduced into a body through intravascular injection and reach various parts of the body through blood circulation, and may be guided to the target site or target region through targeted magnetic guidance and remain there for a long time, and may release the content under a certain mag- netic field intensity. The content is a drug or a stem cell.
At S83, stereotactic space coordinate information of the ste- reotactic device is transmitted into a space magnetic targeting control assembly, which may be worn by the patient for a long time to form a continuous magnetic field attraction effect and achieve a long-time precise content release.
Working principle: the head is stereotactically positioned in three-dimensional space through magnetic resonance and a head ste-
reotactic device to determine a target site or target region to be treated. Then, targeted magnetic focusing is performed, and mag- netic microcapsules injected into a blood vessel are guided to the target site or target region through the focused magnetic attrac- 5 tion, enabling targeted release of drugs or stem cells by the pre- cise-release magnetic microcapsule device. Stereotactic space co- ordinate information of a stereotactic device is transmitted into a space magnetic targeting control assembly, which is worn by a patient for a long time to form a continuous magnetic field at- traction effect and achieve a long-time precise release of drugs or stem cells. Thus, traditional drugs or stem cells may be more effectively and precisely transported to the lesion site, increas- ing the drug efficacy, improving utilization, and reducing system- ic reactions.
In particular, the magnetic microcapsules of the present in- vention may also be magnetic vesicles.
The above descriptions are merely preferred embodiments of the present invention, but the protection scope of the present in- vention is not limited thereto. Any person skilled in the art, within the technical scope disclosed by the present invention, can make equivalent substitutions or modifications based on the tech- nical solution and inventive concept of the present invention, which shall all be encompassed within the protection scope of the present invention.

Claims (6)

© CONCLUSIES© CONCLUSIONS 1. Nauwkeurige doseringswerkwijze voor magnetische capsules, om- vattende de volgende stappen: Sl, het stereotactisch positioneren, door een operator, van het hoofd van een patiënt in driedimensionale ruimte door magnetische resonantie en een hoofdstereotactisch apparaat om een te behande- len doellocatie of doelregio te bepalen; S2, het genereren van een gradiënt magnetisch veld door het aan- drijven van een magnetische generatie samenstel door een magne- tisch aandrijfsamenstel te sturen nadat de doellocatie of de doel- regio is bepaald, het magnetische aandrijfsamenstel is in staat om het gradiënt magnetische veld nauwkeurig te regelen en in realtime te veranderen; het focussen van het magnetische veld door een mag- netische lens en een ruimtemagnetische doel besturingssamenstel, zodat het magnetische veld van de geselecteerde doellocatie of doelregio het sterkst is; vervolgens het aggregeren van magneti- sche microcapsules door de gefocuste magnetische aantrekkings- kracht; ten slotte de magnetische microcapsules afleveren die in een bloedvat zijn geïnjecteerd aan de doellocatie of doelregio, en het gericht afgeven van de content door het magnetische microcap- sule-apparaat voor precieze afgifte; en S3, het verzenden van stereotactische ruimte coördinaatinformatie van het stereotactische apparaat in de ruimte magnetische doel be- sturingssamenstel, die lang door de patiënt wordt gedragen om een continu magnetisch veldattractie-effect te vormen en een langdurig precieze inhoudsafgifte te bereiken.1. A precision dosing method for magnetic capsules, comprising the steps of: S1, stereotactically positioning, by an operator, a patient's head in three-dimensional space by magnetic resonance and a head stereotactic device to determine a target location or target region to be treated; S2, generating a gradient magnetic field by driving a magnetic generation assembly by controlling a magnetic drive assembly after the target location or target region is determined, the magnetic drive assembly being capable of accurately controlling and changing the gradient magnetic field in real time; focusing the magnetic field by a magnetic lens and a spatial magnetic target control assembly so that the magnetic field of the selected target location or target region is the strongest; then aggregating magnetic microcapsules by the focused magnetic attraction force; finally, delivering the magnetic microcapsules injected into a blood vessel to the target site or target region, and directionally delivering the contents by the magnetic microcapsule device for precise delivery; and S3, transmitting stereotactic space coordinate information of the stereotactic device into the space magnetic target control assembly, which is worn by the patient for a long time, to form a continuous magnetic field attraction effect and achieve long-term precise content delivery. 2. Werkwijze volgens claim 1, waarbij de patiënt in S1 op een be- handelbank ligt, en de behandelingsbank kan worden verplaatst door een behandelingsbankaandrijfsamenstel volgens de bepaling van de te behandelen doellocatie of doelregio, waarbij een beter focusse- rend effect van het magnetisch veld wordt verkregen.2. The method according to claim 1, wherein the patient in S1 lies on a treatment table, and the treatment table can be moved by a treatment table drive assembly according to the determination of the target location or target region to be treated, thereby obtaining a better focusing effect of the magnetic field. 3. Werkwijze volgens claim 1, waarbij de magnetische microcapsules magnetisch zijn en magnetisch kunnen worden geleid, de diameters van de magnetische microcapsules nanoschaal of microschaal zijn, waarbij de magnetische microcapsules in staat zijn om in een 1i- chaam te worden geintroduceerd door intravasculaire injectie en om verschillende delen van het lichaam te bereiken door bloedcircula- tie, en in staat zijn om door gerichte magnetische begeleiding naar de doellocatie of doelregio te worden geleid en er lang kun- nen blijven, en in staat zijn om de content vrij te maken onder een bepaalde magnetische veldintensiteit.3. The method of claim 1, wherein the magnetic microcapsules are magnetic and can be magnetically guided, the diameters of the magnetic microcapsules are nanoscale or microscale, the magnetic microcapsules are capable of being introduced into a body by intravascular injection and reaching different parts of the body by blood circulation, and are capable of being guided to the target location or target region by targeted magnetic guidance and can remain there for a long time, and are capable of releasing the contents under a certain magnetic field intensity. 4. Werkwijze volgens claim 1, waarbij de content een medicijn of een stamcel is.4. The method according to claim 1, wherein the content is a drug or a stem cell. 5. Werkwijze volgens claim 1, waarbij het stereotactische apparaat in staat is om als referentie te dienen voor magnetische resonan- tie-lokalisatie en in staat is om te blijven dienen als referentie voor gerichte lokalisatie tijdens de behandeling met de magneti- sche microcapsule-apparaat voor nauwkeurige afgifte.5. The method of claim 1, wherein the stereotactic device is capable of serving as a reference for magnetic resonance localization and is capable of continuing to serve as a reference for targeted localization during treatment with the magnetic microcapsule device for precise delivery. 6. Werkwijze volgens claim 1, waarbij de operator in staat is om het hele apparaat verder te besturen door een computer via een be- dieningseenheid.6. Method according to claim 1, wherein the operator is able to further control the entire apparatus by a computer via a control unit.
NL2035771A 2022-12-05 2023-09-08 Precise dosing method for magnetic capsules NL2035771B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202211551669.0A CN115779244A (en) 2022-12-05 2022-12-05 Accurate medication method of magnetic capsules

Publications (2)

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NL2035771A NL2035771A (en) 2023-11-23
NL2035771B1 true NL2035771B1 (en) 2024-06-25

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Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62161721A (en) * 1986-01-07 1987-07-17 Gentaro Nakago Magnetic-force leadable capsule
CN1522665A (en) * 2003-09-04 2004-08-25 高春平 Stereo directed magnetic pharmaceutical preparation guidance system
WO2005065282A2 (en) * 2003-12-31 2005-07-21 The Regents Of The University Of California Remote magnetically induced treatment of cancer
JP4908356B2 (en) * 2007-09-11 2012-04-04 オリンパスメディカルシステムズ株式会社 Capsule guidance system
CN102139137B (en) * 2011-03-04 2013-01-09 上海交通大学 External magnetic control drug release capsule system based on digital image navigation
CN107174742B (en) * 2017-05-02 2024-05-07 商澎 Superconducting high magnetic field device for tumor treatment
CN108744257A (en) * 2018-03-30 2018-11-06 深圳海磁康科技有限责任公司 Magnetic and medicated targeting method for congregating and magnet structure
CN108969091A (en) * 2018-06-29 2018-12-11 安徽锐捷信息科技有限公司 A kind of system of tumor treatment
CN111657831B (en) * 2020-06-16 2023-02-28 支闻达 Magnetic control non-contact gastrointestinal endoscope capsule

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NL2035771A (en) 2023-11-23

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