NL1005037C2 - Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten. - Google Patents

Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten. Download PDF

Info

Publication number: NL1005037C2
Authority: NL; Netherlands
Prior art keywords: casein; caseinate; protein; preparation; milk
Prior art date: 1997-01-17

Application number

NL1005037A

Other languages

English (en)

Dutch (nl)

Inventor

Emmerentia Catharin Beresteijn

Original Assignee

Nl Zuivelonderzoek Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-17

Filing date

1997-01-17

Publication date

1998-07-20

1997-01-17 Priority to NL1005037A priority Critical patent/NL1005037C2/nl

1997-01-17 Application filed by Nl Zuivelonderzoek Inst filed Critical Nl Zuivelonderzoek Inst

1998-01-16 Priority to EP98900763A priority patent/EP0959690A1/fr

1998-01-16 Priority to AU55780/98A priority patent/AU734222B2/en

1998-01-16 Priority to NZ336810A priority patent/NZ336810A/en

1998-01-16 Priority to EEP199900297A priority patent/EE9900297A/xx

1998-01-16 Priority to CA002277899A priority patent/CA2277899A1/fr

1998-01-16 Priority to BR9806911-0A priority patent/BR9806911A/pt

1998-01-16 Priority to IL13096998A priority patent/IL130969A/en

1998-01-16 Priority to US09/341,785 priority patent/US6451552B1/en

1998-01-16 Priority to PCT/NL1998/000025 priority patent/WO1998031239A1/fr

1998-01-16 Priority to JP53416898A priority patent/JP2001516204A/ja

1998-01-16 Priority to KR1019997006458A priority patent/KR20000070231A/ko

1998-07-20 Application granted granted Critical

1998-07-20 Publication of NL1005037C2 publication Critical patent/NL1005037C2/nl

1999-07-12 Priority to NO993424A priority patent/NO993424L/no

Links

BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 title claims description 190
102000011632 Caseins Human genes 0.000 title claims description 186
108010076119 Caseins Proteins 0.000 title claims description 186
235000021240 caseins Nutrition 0.000 title claims description 182
239000005018 casein Substances 0.000 title claims description 175
229940071162 caseinate Drugs 0.000 title claims description 74
108010011756 Milk Proteins Proteins 0.000 title claims description 61
102000014171 Milk Proteins Human genes 0.000 title claims description 59
235000021239 milk protein Nutrition 0.000 title claims description 59
238000000034 method Methods 0.000 title claims description 52
108010046377 Whey Proteins Proteins 0.000 title claims description 29
235000021119 whey protein Nutrition 0.000 title claims description 22
230000003301 hydrolyzing effect Effects 0.000 title claims description 5
238000002360 preparation method Methods 0.000 claims description 86
108091005804 Peptidases Proteins 0.000 claims description 64
102000035195 Peptidases Human genes 0.000 claims description 64
230000007062 hydrolysis Effects 0.000 claims description 59
238000006460 hydrolysis reaction Methods 0.000 claims description 59
235000018102 proteins Nutrition 0.000 claims description 58
102000004169 proteins and genes Human genes 0.000 claims description 58
108090000623 proteins and genes Proteins 0.000 claims description 57
235000004252 protein component Nutrition 0.000 claims description 54
235000019833 protease Nutrition 0.000 claims description 50
230000000890 antigenic effect Effects 0.000 claims description 41
108091003079 Bovine Serum Albumin Proteins 0.000 claims description 33
229940098773 bovine serum albumin Drugs 0.000 claims description 33
239000012634 fragment Substances 0.000 claims description 33
108700031875 bovine (152-168) serum albumin Proteins 0.000 claims description 28
238000000108 ultra-filtration Methods 0.000 claims description 27
239000012528 membrane Substances 0.000 claims description 21
239000008267 milk Substances 0.000 claims description 19
210000004080 milk Anatomy 0.000 claims description 19
235000013336 milk Nutrition 0.000 claims description 17
239000000243 solution Substances 0.000 claims description 14
102000007544 Whey Proteins Human genes 0.000 claims description 13
238000000926 separation method Methods 0.000 claims description 12
235000013305 food Nutrition 0.000 claims description 10
230000001900 immune effect Effects 0.000 claims description 10
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
239000003531 protein hydrolysate Substances 0.000 claims description 9
239000005862 Whey Substances 0.000 claims description 7
230000008105 immune reaction Effects 0.000 claims description 7
102000008192 Lactoglobulins Human genes 0.000 claims description 6
108010060630 Lactoglobulins Proteins 0.000 claims description 6
239000007864 aqueous solution Substances 0.000 claims description 6
235000020247 cow milk Nutrition 0.000 claims description 6
235000013350 formula milk Nutrition 0.000 claims description 6
230000008569 process Effects 0.000 claims description 6
241000894006 Bacteria Species 0.000 claims description 5
239000000470 constituent Substances 0.000 claims description 5
235000014655 lactic acid Nutrition 0.000 claims description 5
239000004310 lactic acid Substances 0.000 claims description 5
241000283690 Bos taurus Species 0.000 claims description 4
238000010324 immunological assay Methods 0.000 claims description 4
230000002265 prevention Effects 0.000 claims description 4
102000004407 Lactalbumin Human genes 0.000 claims description 3
108090000942 Lactalbumin Proteins 0.000 claims description 3
208000009793 Milk Hypersensitivity Diseases 0.000 claims description 3
206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 3
235000021241 α-lactalbumin Nutrition 0.000 claims description 3
108060003951 Immunoglobulin Proteins 0.000 claims description 2
102000018358 immunoglobulin Human genes 0.000 claims description 2
244000005700 microbiome Species 0.000 claims description 2
101710089384 Extracellular protease Proteins 0.000 claims 1
241000194035 Lactococcus lactis Species 0.000 claims 1
201000010859 Milk allergy Diseases 0.000 claims 1
235000014897 Streptococcus lactis Nutrition 0.000 claims 1
239000000203 mixture Substances 0.000 description 17
229940027941 immunoglobulin g Drugs 0.000 description 14
102000004190 Enzymes Human genes 0.000 description 12
108090000790 Enzymes Proteins 0.000 description 12
229940088598 enzyme Drugs 0.000 description 12
238000002965 ELISA Methods 0.000 description 9
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 9
239000012465 retentate Substances 0.000 description 9
229940021722 caseins Drugs 0.000 description 8
239000012466 permeate Substances 0.000 description 8
230000002163 immunogen Effects 0.000 description 7
238000004007 reversed phase HPLC Methods 0.000 description 7
150000001413 amino acids Chemical class 0.000 description 6
239000000758 substrate Substances 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
238000004458 analytical method Methods 0.000 description 4
210000004027 cell Anatomy 0.000 description 4
235000013351 cheese Nutrition 0.000 description 4
206010012601 diabetes mellitus Diseases 0.000 description 4
230000000694 effects Effects 0.000 description 4
230000028993 immune response Effects 0.000 description 4
238000011534 incubation Methods 0.000 description 4
239000000047 product Substances 0.000 description 4
235000021247 β-casein Nutrition 0.000 description 4
JDIIGWSSTNUWGK-UHFFFAOYSA-N 1h-imidazol-3-ium;chloride Chemical compound [Cl-].[NH2+]1C=CN=C1 JDIIGWSSTNUWGK-UHFFFAOYSA-N 0.000 description 3
241000194034 Lactococcus lactis subsp. cremoris Species 0.000 description 3
235000014962 Streptococcus cremoris Nutrition 0.000 description 3
230000009471 action Effects 0.000 description 3
230000015556 catabolic process Effects 0.000 description 3
210000002421 cell wall Anatomy 0.000 description 3
238000006731 degradation reaction Methods 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 3
210000002237 B-cell of pancreatic islet Anatomy 0.000 description 2
108090000746 Chymosin Proteins 0.000 description 2
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 2
230000008901 benefit Effects 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
229940080701 chymosin Drugs 0.000 description 2
238000003776 cleavage reaction Methods 0.000 description 2
230000009260 cross reactivity Effects 0.000 description 2
235000013365 dairy product Nutrition 0.000 description 2
230000029087 digestion Effects 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
238000006911 enzymatic reaction Methods 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000001914 filtration Methods 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
230000000774 hypoallergenic effect Effects 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
230000000968 intestinal effect Effects 0.000 description 2
GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 2
235000019624 protein content Nutrition 0.000 description 2
238000011160 research Methods 0.000 description 2
230000007017 scission Effects 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
102000029816 Collagenase Human genes 0.000 description 1
108060005980 Collagenase Proteins 0.000 description 1
241000193159 Hathewaya histolytica Species 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
241000194105 Paenibacillus polymyxa Species 0.000 description 1
108010033276 Peptide Fragments Proteins 0.000 description 1
102000007079 Peptide Fragments Human genes 0.000 description 1
239000004365 Protease Substances 0.000 description 1
108010009736 Protein Hydrolysates Proteins 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
238000005571 anion exchange chromatography Methods 0.000 description 1
230000006472 autoimmune response Effects 0.000 description 1
235000008452 baby food Nutrition 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
239000003518 caustics Substances 0.000 description 1
230000006037 cell lysis Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000003593 chromogenic compound Substances 0.000 description 1
238000005352 clarification Methods 0.000 description 1
229960002424 collagenase Drugs 0.000 description 1
230000006378 damage Effects 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
108010007093 dispase Proteins 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
230000010354 integration Effects 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
239000000693 micelle Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000004682 mucosal barrier function Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
238000005086 pumping Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000005070 ripening Effects 0.000 description 1
238000005070 sampling Methods 0.000 description 1
230000008684 selective degradation Effects 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
-1 α-Lac Proteins 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Health & Medical Sciences (AREA)
Nutrition Science (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Peptides Or Proteins (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NL1005037A 1997-01-17 1997-01-17 Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten. NL1005037C2 (nl)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
NL1005037A NL1005037C2 (nl)	1997-01-17	1997-01-17	Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten.
US09/341,785 US6451552B1 (en)	1997-01-17	1998-01-16	Method for the selective degradation of milk protein in the presence of other milk proteins
NZ336810A NZ336810A (en)	1997-01-17	1998-01-16	Method for the selective degradation of casein or caseinate in the presence of other milk proteins
EEP199900297A EE9900297A (et)	1997-01-17	1998-01-16	Piimavalkude selektiivse lagundamise meetod teiste piimavalkude manulusel
CA002277899A CA2277899A1 (fr)	1997-01-17	1998-01-16	Procede de degradation selective de proteines du lait en presence d'autres proteines du lait
BR9806911-0A BR9806911A (pt)	1997-01-17	1998-01-16	Processos para hidrólise seletiva de caseina/caseinato, para preparar uma preparação de proteìna de leite hidrolisada, para preparar um hidrolisado de proteìna de leite, e para preparar uma preparação de proteìna que possui um nìvel de caseìna reduzido, uso de uma proteinase especìfica para caseìna/caseinato, hidrolisado de proteìna de leite, uso do mesmo, preparação de proteìna de leite esgotada de caseìna, e, uso da mesma.
EP98900763A EP0959690A1 (fr)	1997-01-17	1998-01-16	Procede de degradation selective de proteines du lait en presence d'autres proteines du lait
AU55780/98A AU734222B2 (en)	1997-01-17	1998-01-16	Method for the selective degradation of milk protein in the presence of other m ilk proteins
PCT/NL1998/000025 WO1998031239A1 (fr)	1997-01-17	1998-01-16	Procede de degradation selective de proteines du lait en presence d'autres proteines du lait
JP53416898A JP2001516204A (ja)	1997-01-17	1998-01-16	他の乳タンパクの存在下での乳タンパクの選択的分解方法
KR1019997006458A KR20000070231A (ko)	1997-01-17	1998-01-16	다른 우유 단백질 존재 하에 우유 단백질을 선택적으로 분해하는 방법
IL13096998A IL130969A (en)	1997-01-17	1998-01-16	A method for selective degradation of milk protein in the presence of other milk proteins
NO993424A NO993424L (no)	1997-01-17	1999-07-12	FremgangsmÕte til selektiv nedbrytning av melkeprotein i nærvær av andre melkeproteiner

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL1005037A NL1005037C2 (nl)	1997-01-17	1997-01-17	Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten.
NL1005037		1997-01-17

Publications (1)

Publication Number	Publication Date
NL1005037C2 true NL1005037C2 (nl)	1998-07-20

Family

ID=19764239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1005037A NL1005037C2 (nl)	1997-01-17	1997-01-17	Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten.

Country Status (13)

Country	Link
US (1)	US6451552B1 (fr)
EP (1)	EP0959690A1 (fr)
JP (1)	JP2001516204A (fr)
KR (1)	KR20000070231A (fr)
AU (1)	AU734222B2 (fr)
BR (1)	BR9806911A (fr)
CA (1)	CA2277899A1 (fr)
EE (1)	EE9900297A (fr)
IL (1)	IL130969A (fr)
NL (1)	NL1005037C2 (fr)
NO (1)	NO993424L (fr)
NZ (1)	NZ336810A (fr)
WO (1)	WO1998031239A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9927603D0 (en) *	1999-11-22	2000-01-19	Nestle Sa	Use of a milk protein hydrolysate in the treatment of diabetes
AU2167901A (en) *	1999-12-17	2001-06-25	N.V. Nutricia	Use of modified foodstuff ingredients for preventing the development of a diabetes mellitus (iddm) with an existing epidemiologically established risk
US20030224096A1 (en) *	2002-06-04	2003-12-04	Novozymes A/S	Whey protein hydrolysate
US7393659B2 (en) *	2002-08-29	2008-07-01	Abbott Laboratories	Analytical method for the determination of infant formula protein digestibility in vitro
WO2005021589A1 (fr)	2003-08-30	2005-03-10	Nestec S.A.	Proteines solubles dans l'acide issues de caseine micellaire
WO2005072056A2 (fr)	2004-01-28	2005-08-11	Develogen Israel Ltd.	Therapie hsp associee a un regime a faible antigenicite
WO2007113279A1 (fr) *	2006-03-31	2007-10-11	Dsm Ip Assets B.V.	Procédé d'hydrolyse de protéines de lait
JP2008189637A (ja) *	2007-02-08	2008-08-21	Snow Brand Milk Prod Co Ltd	自己免疫疾患予防剤
BRPI0913178B1 (pt)	2008-06-03	2020-05-19	Novozymes As	método para produzir um hidrolisado de caseína, e, uso de um hidrolisado de caseína
EP2258208A1 (fr) *	2009-06-02	2010-12-08	University of Limerick	Produit de protéine avec une immunogénicité modifiée
EP2489281A1 (fr) *	2011-02-17	2012-08-22	University of Limerick	Hydrolysat de caséine
EP2583564A1 (fr) *	2011-10-21	2013-04-24	Nestec S.A.	Utilisation de micelles de protéine de lactosérum pour améliorer le profil d'insuline chez les patients diabétiques
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Also Published As

Publication number	Publication date
EE9900297A (et)	2000-02-15
AU5578098A (en)	1998-08-07
US6451552B1 (en)	2002-09-17
KR20000070231A (ko)	2000-11-25
AU734222B2 (en)	2001-06-07
JP2001516204A (ja)	2001-09-25
BR9806911A (pt)	2000-05-16
EP0959690A1 (fr)	1999-12-01
IL130969A (en)	2002-11-10
NO993424L (no)	1999-09-15
NZ336810A (en)	2001-08-31
IL130969A0 (en)	2001-01-28
US20020061548A1 (en)	2002-05-23
WO1998031239A1 (fr)	1998-07-23
NO993424D0 (no)	1999-07-12
CA2277899A1 (fr)	1998-07-23

Publication	Publication Date	Title
NL1005037C2 (nl)	1998-07-20	Werkwijze voor het selectief afbreken van melkeiwit, in het bijzonder voor het selectief hydrolyseren van caseïne/caseïnaat in aanwezigheid van andere melkeiwitten, in het bijzonder wei-eiwitten.
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RU2292155C2 (ru)	2007-01-27	Способ гидролиза молочных белков
CA1336307C (fr)	1995-07-11	Procede de preparation d'un peptide hydrosoluble thermoresistant non amer, produit obtenu par ce procede et produits nutritifs, breuvages et produits dietetiques en renfermant
AU2007343749B2 (en)	2013-01-10	Milk protein hydrolyzates with reduced immunogenic potential
JP5643099B2 (ja)	2014-12-17	改質乳の製造方法
EP0353122A1 (fr)	1990-01-31	Hydrolysat partiel de protéines de lactosérum, procédé enzymatique de préparation de cet hydrolysat, et aliment lacté diététique hypoallergénique le contenant
JP2001506858A (ja)	2001-05-29	タンパク質加水分解物の製造方法
WO1992013964A1 (fr)	1992-08-20	Preparations proteiques
Wohlrab et al.	1992	Purification and characterization of a dipeptidase from Lactobacillus delbrueckii subsp. bulgaricus
López-Fandiño et al.	1993	Comparative study by HPLC of caseinomacropeptides from cows', ewes' and goats' milk
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Exterkate et al.	1989	Characterization of the cell wall proteinase PIII of Lactococcus lactis subsp. cremoris strain AM1, and its relationship with the catalytically different cell wall proteinase PI/PII of strain HP
JP3071877B2 (ja)	2000-07-31	経口寛容誘導能を有する低アレルゲン性酵素分解ペプチド組成物
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JPH06343422A (ja)	1994-12-20	オリゴペプチド混合物及びその製造法
Alting et al.	1998	Selective hydrolysis of milk proteins to facilitate the elimination of the ABBOS epitope of bovine serum albumin and other immunoreactive epitopes
Donnelly	1991	Applications of biotechnology and separation technology in dairy processing
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RU2531164C1 (ru)	2014-10-20	Способ получения низкогидролизованной пептидной композиции из белков молочной сыворотки
JPH05137515A (ja)	1993-06-01	不快味のない低抗原性たん白質分解物及びその製造方法
JPH08126488A (ja)	1996-05-21	新規ジペプチダーゼ
JPH08245690A (ja)	1996-09-24	二糖類分解酵素活性促進ペプチド

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