NL1002493C2 - Microkristallijne zetmeelproducten, werkwijze voor het bereiden daarvan alsmede de toepassing van die producten als tabletteerhulpstof. - Google Patents
Microkristallijne zetmeelproducten, werkwijze voor het bereiden daarvan alsmede de toepassing van die producten als tabletteerhulpstof. Download PDFInfo
- Publication number
- NL1002493C2 NL1002493C2 NL1002493A NL1002493A NL1002493C2 NL 1002493 C2 NL1002493 C2 NL 1002493C2 NL 1002493 A NL1002493 A NL 1002493A NL 1002493 A NL1002493 A NL 1002493A NL 1002493 C2 NL1002493 C2 NL 1002493C2
- Authority
- NL
- Netherlands
- Prior art keywords
- starch
- microcrystalline
- microcrystalline starch
- products
- dehydrated
- Prior art date
Links
- 229920002472 Starch Polymers 0.000 title claims description 115
- 235000019698 starch Nutrition 0.000 title claims description 111
- 239000008107 starch Substances 0.000 title claims description 101
- 238000000034 method Methods 0.000 title claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title description 7
- 108090000790 Enzymes Proteins 0.000 claims description 13
- 102000004190 Enzymes Human genes 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000018044 dehydration Effects 0.000 claims description 5
- 238000006297 dehydration reaction Methods 0.000 claims description 5
- 239000007900 aqueous suspension Substances 0.000 claims description 4
- 238000007792 addition Methods 0.000 claims 2
- 238000011835 investigation Methods 0.000 claims 1
- 230000000153 supplemental effect Effects 0.000 claims 1
- 239000000047 product Substances 0.000 description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 39
- 239000003826 tablet Substances 0.000 description 25
- 239000008187 granular material Substances 0.000 description 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 14
- 229940088598 enzyme Drugs 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000011230 binding agent Substances 0.000 description 9
- 239000000314 lubricant Substances 0.000 description 9
- 239000000945 filler Substances 0.000 description 8
- 239000012429 reaction media Substances 0.000 description 8
- 235000019359 magnesium stearate Nutrition 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229920002261 Corn starch Polymers 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 239000008120 corn starch Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 229920000945 Amylopectin Polymers 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 229940100486 rice starch Drugs 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 230000002255 enzymatic effect Effects 0.000 description 4
- 229920001592 potato starch Polymers 0.000 description 4
- 229940100445 wheat starch Drugs 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 229920000856 Amylose Polymers 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 241000209094 Oryza Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 240000008042 Zea mays Species 0.000 description 3
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- 102000004139 alpha-Amylases Human genes 0.000 description 3
- 108090000637 alpha-Amylases Proteins 0.000 description 3
- 229940024171 alpha-amylase Drugs 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 229940099112 cornstarch Drugs 0.000 description 3
- 238000007907 direct compression Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 235000009973 maize Nutrition 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920002245 Dextrose equivalent Polymers 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000007605 air drying Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000002178 crystalline material Substances 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 229960001375 lactose Drugs 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229940116317 potato starch Drugs 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003828 vacuum filtration Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
- 229920001685 Amylomaize Polymers 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000012431 aqueous reaction media Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000002363 herbicidal effect Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1002493A NL1002493C2 (nl) | 1996-02-29 | 1996-02-29 | Microkristallijne zetmeelproducten, werkwijze voor het bereiden daarvan alsmede de toepassing van die producten als tabletteerhulpstof. |
| AU22353/97A AU2235397A (en) | 1996-02-29 | 1997-02-28 | Use of microcrystalline starch products as tabletting excipient |
| PCT/NL1997/000097 WO1997031627A1 (fr) | 1996-02-29 | 1997-02-28 | Utilisation de produits a base d'amidon microcristallin en qualite d'excipients dans la fabrication de comprimes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1002493 | 1996-02-29 | ||
| NL1002493A NL1002493C2 (nl) | 1996-02-29 | 1996-02-29 | Microkristallijne zetmeelproducten, werkwijze voor het bereiden daarvan alsmede de toepassing van die producten als tabletteerhulpstof. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL1002493C2 true NL1002493C2 (nl) | 1997-09-01 |
Family
ID=19762419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1002493A NL1002493C2 (nl) | 1996-02-29 | 1996-02-29 | Microkristallijne zetmeelproducten, werkwijze voor het bereiden daarvan alsmede de toepassing van die producten als tabletteerhulpstof. |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2235397A (fr) |
| NL (1) | NL1002493C2 (fr) |
| WO (1) | WO1997031627A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2424776A1 (fr) * | 2000-10-06 | 2002-04-11 | Cooeperatieve Verkoop- En Productievereniging Van Aardappelmeel En Deriv Ten Avebe B.A. | Lavage et deshydratation de suspensions |
| US6890571B2 (en) | 2002-05-14 | 2005-05-10 | National Starch And Chemical Investment Holding Corporation | Slowly digestible starch product |
| US6929817B2 (en) | 2002-05-14 | 2005-08-16 | National Starch & Chemical Investment Holding Corporation | Slowly digestible starch product |
| US7081261B2 (en) | 2002-05-14 | 2006-07-25 | National Starch And Chemical Investment Holding Corporation | Resistant starch prepared by isoamylase debranching of low amylose starch |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0159631A2 (fr) * | 1984-04-23 | 1985-10-30 | National Starch and Chemical Corporation | Amidon compressible comme liant pour comprimés ou capsules |
| WO1989004842A1 (fr) * | 1987-11-20 | 1989-06-01 | Whistler Roy L | Composition en amidon granulaire pour matrices microporeuses |
| EP0539910A1 (fr) * | 1991-10-31 | 1993-05-05 | Director of National Food Research Institute Ministry of Agriculture Forestry and Fisheries | Procédé de préparation de granules modifiées d'amidon |
-
1996
- 1996-02-29 NL NL1002493A patent/NL1002493C2/nl not_active IP Right Cessation
-
1997
- 1997-02-28 WO PCT/NL1997/000097 patent/WO1997031627A1/fr not_active Ceased
- 1997-02-28 AU AU22353/97A patent/AU2235397A/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0159631A2 (fr) * | 1984-04-23 | 1985-10-30 | National Starch and Chemical Corporation | Amidon compressible comme liant pour comprimés ou capsules |
| WO1989004842A1 (fr) * | 1987-11-20 | 1989-06-01 | Whistler Roy L | Composition en amidon granulaire pour matrices microporeuses |
| EP0539910A1 (fr) * | 1991-10-31 | 1993-05-05 | Director of National Food Research Institute Ministry of Agriculture Forestry and Fisheries | Procédé de préparation de granules modifiées d'amidon |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997031627A1 (fr) | 1997-09-04 |
| AU2235397A (en) | 1997-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD2B | A search report has been drawn up | ||
| VD1 | Lapsed due to non-payment of the annual fee |
Effective date: 20000901 |