NI201000087A - Composiciones farmacéuticas que contienen antagonistas de bradiquinina y acido hialurónico y sus usos. - Google Patents
Composiciones farmacéuticas que contienen antagonistas de bradiquinina y acido hialurónico y sus usos.Info
- Publication number
- NI201000087A NI201000087A NI201000087A NI201000087A NI201000087A NI 201000087 A NI201000087 A NI 201000087A NI 201000087 A NI201000087 A NI 201000087A NI 201000087 A NI201000087 A NI 201000087A NI 201000087 A NI201000087 A NI 201000087A
- Authority
- NI
- Nicaragua
- Prior art keywords
- hyaluronic acid
- pharmaceutical compositions
- compositions containing
- bradichinin
- acid antagonists
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 201000008482 osteoarthritis Diseases 0.000 abstract 2
- 229940123765 Bradykinin B2 receptor antagonist Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003359 bradykinin B2 receptor antagonist Substances 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
La invención se refiere a las composiciones farmacéuticas que contienen, como ingredientes activos, una mezcla de un polímero de ácido hialurónico con un antagonista del receptor de bradiquinina B2. Se demuestra que dichas composiciones son especialmente efectivas para el tratamiento de enfermedades articulares degenerativas tales como osteoartritis usando inyecciones intraarticulares.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002225A ITMI20072225A1 (it) | 2007-11-23 | 2007-11-23 | "composizioni farmaceutiche a base di antagonisti della bradichinina ed acido ialuronico e loro uso" |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201000087A true NI201000087A (es) | 2011-07-18 |
Family
ID=40314753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201000087A NI201000087A (es) | 2007-11-23 | 2010-05-19 | Composiciones farmacéuticas que contienen antagonistas de bradiquinina y acido hialurónico y sus usos. |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9101627B2 (es) |
| EP (1) | EP2222275B1 (es) |
| JP (1) | JP5383695B2 (es) |
| KR (1) | KR101585868B1 (es) |
| CN (1) | CN101868225B (es) |
| AP (1) | AP2628A (es) |
| AR (1) | AR069407A1 (es) |
| AT (1) | ATE529096T1 (es) |
| AU (1) | AU2008328311B2 (es) |
| BR (1) | BRPI0820402A2 (es) |
| CA (1) | CA2706398C (es) |
| CL (1) | CL2008003475A1 (es) |
| CO (1) | CO6270301A2 (es) |
| CR (1) | CR11457A (es) |
| CY (1) | CY1112134T1 (es) |
| DK (1) | DK2222275T3 (es) |
| EA (1) | EA017626B1 (es) |
| EC (1) | ECSP10010153A (es) |
| ES (1) | ES2374861T3 (es) |
| GE (1) | GEP20125602B (es) |
| HN (1) | HN2010001037A (es) |
| HR (1) | HRP20110904T1 (es) |
| IL (1) | IL205860A (es) |
| IT (1) | ITMI20072225A1 (es) |
| MA (1) | MA31913B1 (es) |
| MX (1) | MX2010005484A (es) |
| MY (1) | MY148685A (es) |
| NI (1) | NI201000087A (es) |
| NZ (1) | NZ585514A (es) |
| PA (1) | PA8804801A1 (es) |
| PE (1) | PE20091422A1 (es) |
| PL (1) | PL2222275T3 (es) |
| PT (1) | PT2222275E (es) |
| RS (1) | RS52045B (es) |
| SI (1) | SI2222275T1 (es) |
| TN (1) | TN2010000215A1 (es) |
| TW (1) | TWI448292B (es) |
| UA (1) | UA97867C2 (es) |
| WO (1) | WO2009065507A2 (es) |
| ZA (1) | ZA201003586B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO131947A2 (ro) * | 2014-05-30 | 2017-06-30 | Nataliia Mykolaivna Derkach | Soluţie stabilizată bazată pe substanţe active, şi metodă de preparare a soluţiei stabilizate de substanţe active |
| WO2016104705A1 (ja) * | 2014-12-26 | 2016-06-30 | 生化学工業株式会社 | 眼の自覚症状を改善する剤および方法 |
| US12371683B2 (en) | 2018-07-25 | 2025-07-29 | Alteogen Inc. | Hyaluronidase variants and pharmaceutical composition comprising the same |
| US11401303B2 (en) * | 2020-06-15 | 2022-08-02 | Taian City Qihang Biotechnology Co. | Synthetic peptide BRAP and application in preparation of anti-inflammatory drug for COVID-19 thereof |
| AU2021320569B2 (en) | 2020-08-07 | 2024-10-03 | Alteogen, Inc | Method for producing recombinant hyaluronidase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635489B2 (en) * | 2001-05-18 | 2009-12-22 | Leneau Holdings, Llc | Ingestion of hyaluronic acid for improved joint health |
| ITMI20021247A1 (it) * | 2002-06-07 | 2003-12-09 | Menarini Ricerche Spa | Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche |
| ITMI20041963A1 (it) * | 2004-10-15 | 2005-01-15 | Luso Farmaco Inst | "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche" |
-
2007
- 2007-11-23 IT IT002225A patent/ITMI20072225A1/it unknown
-
2008
- 2008-11-07 TW TW097142981A patent/TWI448292B/zh not_active IP Right Cessation
- 2008-11-10 CN CN2008801169202A patent/CN101868225B/zh not_active Expired - Fee Related
- 2008-11-10 AU AU2008328311A patent/AU2008328311B2/en not_active Ceased
- 2008-11-10 WO PCT/EP2008/009451 patent/WO2009065507A2/en not_active Ceased
- 2008-11-10 SI SI200830475T patent/SI2222275T1/sl unknown
- 2008-11-10 PT PT08853047T patent/PT2222275E/pt unknown
- 2008-11-10 AP AP2010005265A patent/AP2628A/xx active
- 2008-11-10 GE GEAP200811807A patent/GEP20125602B/en unknown
- 2008-11-10 CA CA2706398A patent/CA2706398C/en not_active Expired - Fee Related
- 2008-11-10 US US12/743,891 patent/US9101627B2/en not_active Expired - Fee Related
- 2008-11-10 AT AT08853047T patent/ATE529096T1/de active
- 2008-11-10 PL PL08853047T patent/PL2222275T3/pl unknown
- 2008-11-10 HR HR20110904T patent/HRP20110904T1/hr unknown
- 2008-11-10 ES ES08853047T patent/ES2374861T3/es active Active
- 2008-11-10 MY MYPI2010002358A patent/MY148685A/en unknown
- 2008-11-10 EA EA201000678A patent/EA017626B1/ru not_active IP Right Cessation
- 2008-11-10 NZ NZ585514A patent/NZ585514A/en not_active IP Right Cessation
- 2008-11-10 RS RS20110524A patent/RS52045B/sr unknown
- 2008-11-10 EP EP08853047A patent/EP2222275B1/en active Active
- 2008-11-10 JP JP2010534395A patent/JP5383695B2/ja not_active Expired - Fee Related
- 2008-11-10 KR KR1020107011164A patent/KR101585868B1/ko not_active Expired - Fee Related
- 2008-11-10 BR BRPI0820402-0A patent/BRPI0820402A2/pt not_active IP Right Cessation
- 2008-11-10 MX MX2010005484A patent/MX2010005484A/es active IP Right Grant
- 2008-11-10 DK DK08853047.2T patent/DK2222275T3/da active
- 2008-11-10 UA UAA201006127A patent/UA97867C2/ru unknown
- 2008-11-19 PE PE2008001955A patent/PE20091422A1/es not_active Application Discontinuation
- 2008-11-21 AR ARP080105077A patent/AR069407A1/es unknown
- 2008-11-21 CL CL2008003475A patent/CL2008003475A1/es unknown
- 2008-11-21 PA PA20088804801A patent/PA8804801A1/es unknown
-
2010
- 2010-05-05 EC EC2010010153A patent/ECSP10010153A/es unknown
- 2010-05-06 CO CO10054082A patent/CO6270301A2/es active IP Right Grant
- 2010-05-14 TN TN2010000215A patent/TN2010000215A1/fr unknown
- 2010-05-19 NI NI201000087A patent/NI201000087A/es unknown
- 2010-05-20 ZA ZA2010/03586A patent/ZA201003586B/en unknown
- 2010-05-20 HN HN2010001037A patent/HN2010001037A/es unknown
- 2010-05-20 IL IL205860A patent/IL205860A/en not_active IP Right Cessation
- 2010-05-21 CR CR11457A patent/CR11457A/es unknown
- 2010-06-15 MA MA32913A patent/MA31913B1/fr unknown
-
2011
- 2011-11-30 CY CY20111101177T patent/CY1112134T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6771417A2 (es) | Antagonistas del receptor de ácido lisofosfatidico y su uso en el tratamiento de fibrosis | |
| CO6480918A2 (es) | Antagonistas policíclicos de receptores de ácido lisofosfatídico. | |
| PH12014500355A1 (en) | Lysophosphatidic acid receptor antagonists | |
| UY32926A (es) | Compuestos como antagonistas de los receptores de ácido lisofosfatídico | |
| EA201270467A1 (ru) | Полициклические соединения в качестве антагонистов рецепторов лизофосфатидной кислоты | |
| DOP2014000115A (es) | Uso de 4-fenil-piridinas sustituidas para la fabricación de medicamentos útiles en el tratamiento de enfermedades relacionadas con el receptor de nk1 | |
| EA201100691A1 (ru) | Антагонисты рецепторов лизофосфатидной кислоты | |
| BR112018004536A2 (pt) | peptídeos de endereçamento à cartilagem | |
| EA201270720A1 (ru) | Модуляторы рецептора андрогенов и их применение | |
| UY32629A (es) | Compuestos antivirales, composiciones y uso para la manufactura de un medicamento para el tratamiento de trastornos asociados con hepatitis c. | |
| BR112014012789A2 (pt) | agentes terapêuticos compreendendo sequências de aminoácidos de insulina | |
| ECSP10010439A (es) | Antagonistas n,n-disustituidos de aminoalquilbifenilo de receptores d2 de prostaglandina | |
| CL2008001632A1 (es) | Compuestos derivados de acidos benzoilamino-indan-2-carboxilicos sustituidos, inhibidores del receptor cxcr5; composicion farmaceutica; y su uso en el tratamiento de efecciones fisiologicas inflamatorias, tales como artritis reumatoidea y asma. | |
| MY161773A (en) | Amylin analogues and pharmaceutical compositions thereof | |
| CL2012003211A1 (es) | Compuestos derivados de lactamas sustituidas con piperidinilo, moduladores de gpr119; proceso para preparar los compuestos; composicion farmaceutica que comprende a los compuestos; y uso de los compuestos en la preparacion de medicamentos para el tratamiento o prevencion de diabetes tipo 2, obesidad y condiciones relacionadas | |
| EA201490152A1 (ru) | Антагонисты trpm8 и их применение при лечении | |
| CY1118858T1 (el) | Νεα παραγωγα πυριμιδινης, παρασκευη αυτων και φαρμακευτικη χρηση αυτων ως αναστολεων φωσφορυλιωσης ακτ(ρκβ) | |
| NI201000087A (es) | Composiciones farmacéuticas que contienen antagonistas de bradiquinina y acido hialurónico y sus usos. | |
| MX2015011536A (es) | Nuevos antagonistas de receptores trpa1 de sulfamidas. | |
| CO6321246A2 (es) | Compuestos novedosos activos como antagonistas de receptor muscarinico | |
| CL2009001006A1 (es) | Compuestos derivados del acido 4-dimetil-aminobutirico; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento o profilaxis de enfermedades tales como hiperglucemia, diabetes e hipertension entre otras. | |
| CL2007001857A1 (es) | Compuestos derivados del acido fenil-acetico, inhibidores de cox-2; metodo de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como artritis reumatoide, osteoartritis, dolor, entre otras. | |
| ECSP11010752A (es) | Composiciones farmacéuticas basadas en antagonistas del receptor de quinina b2 y corticosteroides | |
| UY32410A (es) | Azetidinas como antagonistas del receptor de histamina3 | |
| MX2013011728A (es) | Nuevos compuestos de benzofurano-piperidina. |