NI200700311A - Derivados de tienopirimidina y tienopiridina como inhibidores de la cinasa de flt-3 - Google Patents
Derivados de tienopirimidina y tienopiridina como inhibidores de la cinasa de flt-3Info
- Publication number
- NI200700311A NI200700311A NI200700311A NI200700311A NI200700311A NI 200700311 A NI200700311 A NI 200700311A NI 200700311 A NI200700311 A NI 200700311A NI 200700311 A NI200700311 A NI 200700311A NI 200700311 A NI200700311 A NI 200700311A
- Authority
- NI
- Nicaragua
- Prior art keywords
- compounds
- kinase
- inhibitors
- tienopirimidine
- tienopiridine
- Prior art date
Links
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical class C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 abstract 1
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical compound C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
Abstract
La invención se refiere a compuestos de tienopirimidinas y tienopiridinas de Fórmula I y Fórmula II: donde R1, R3, B, Z, Q, p, q, y X son como se definen en presente documento, el uso de tales compuestos como moduladores de la proteína de tirosina cinasa, en particular inhibidores de FLT3, el uso de tales compuestos para reducir o inhibir la actividad de la cinasa de FLT3 en una célula o en un sujeto, y el uso de tales compuestos para prevenir o tratar en un sujeto un trastorno prolífero de célua y/o trastornos relacionados a FLT3. La presente invención también se refiere a composiciones farmacéuticas que comprenden los compuestos de la presente invención y a métodos para tratar condiciones tales como canceres y otros trastornos prolíferos de células.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68971005P | 2005-06-10 | 2005-06-10 | |
| US74694106P | 2006-05-10 | 2006-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI200700311A true NI200700311A (es) | 2009-03-03 |
Family
ID=37074647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI200700311A NI200700311A (es) | 2005-06-10 | 2006-06-07 | Derivados de tienopirimidina y tienopiridina como inhibidores de la cinasa de flt-3 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20060281768A1 (es) |
| EP (1) | EP1899355A1 (es) |
| JP (1) | JP2008543759A (es) |
| KR (1) | KR20080021126A (es) |
| AR (1) | AR057063A1 (es) |
| AU (1) | AU2006258049A1 (es) |
| BR (1) | BRPI0613644A2 (es) |
| CA (1) | CA2611587A1 (es) |
| CR (1) | CR9650A (es) |
| EA (1) | EA200800011A1 (es) |
| EC (1) | ECSP077992A (es) |
| IL (1) | IL187689A0 (es) |
| MX (1) | MX2007015741A (es) |
| NI (1) | NI200700311A (es) |
| NO (1) | NO20080162L (es) |
| PE (1) | PE20070070A1 (es) |
| TW (1) | TW200716651A (es) |
| UY (1) | UY29590A1 (es) |
| WO (1) | WO2006135639A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| EP2043655A2 (en) | 2006-04-25 | 2009-04-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| EP2013206A1 (en) * | 2006-04-25 | 2009-01-14 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US20080076770A1 (en) * | 2006-09-25 | 2008-03-27 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
| US8193178B2 (en) | 2007-09-14 | 2012-06-05 | Janssen Pharmaceutica Nv | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor |
| JP4705695B2 (ja) | 2007-10-11 | 2011-06-22 | アストラゼネカ アクチボラグ | プロテインキナーゼｂ阻害剤としてのピロロ［２，３−ｄ］ピリミジン誘導体 |
| JP6080837B2 (ja) | 2011-04-01 | 2017-02-15 | アストラゼネカ アクチボラグ | 療法的治療 |
| SI2712358T1 (sl) | 2011-05-13 | 2017-03-31 | Array Biopharma, Inc. | Spojine pirolidinil sečnine, pirolidinil tiosečnine in pirolidinil gvanidina kot inhibitorji kinaze trka |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| KR102035361B1 (ko) | 2011-11-30 | 2019-11-08 | 아스트라제네카 아베 | 암의 병용 치료 |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| PT3154959T (pt) | 2014-05-15 | 2019-09-24 | Array Biopharma Inc | 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)-pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)ureia como inibidor da cinase trka |
| WO2018118598A1 (en) * | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| EP3897630B1 (en) | 2018-12-21 | 2024-01-10 | Celgene Corporation | Thienopyridine inhibitors of ripk2 |
| PE20212153A1 (es) | 2019-02-22 | 2021-11-09 | Hanmi Pharm Ind Co Ltd | Composicion farmaceutica que comprende un inhibidor de flt3 y un agente hipometilante para tratar la leucemia mieloide aguda |
| KR20210002015A (ko) | 2019-06-27 | 2021-01-06 | 한미약품 주식회사 | Flt3 저해제 및 화학치료제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물 |
| WO2024248513A1 (en) * | 2023-05-31 | 2024-12-05 | Hanmi Pharm. Co., Ltd. | Solid dispersion of myeloid kinome inhibitors and pharmaceutical composition comprising the same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2131528C (en) * | 1992-03-05 | 2004-07-13 | Philip E. Thorpe | Methods and compositions for targeting the vasculature of solid tumors |
| US5474765A (en) * | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
| US5932765A (en) * | 1997-05-23 | 1999-08-03 | Merck Patent Gesellschaft Mit | Nitromethyl ketones, process for preparing them and compositions containing them |
| HUP0100287A3 (en) * | 1997-11-11 | 2003-04-28 | Pfizer Prod Inc | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| HUP0101810A3 (en) * | 1998-01-27 | 2002-05-28 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them |
| CN1308347C (zh) * | 1999-04-28 | 2007-04-04 | 德克萨斯大学董事会 | 用于通过选择性抑制vegf来治疗癌症的组合物和方法 |
| US6776796B2 (en) * | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
| DE10110750A1 (de) * | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| AR035885A1 (es) * | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
| US7105505B2 (en) * | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
| MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| WO2004016576A1 (ja) * | 2002-08-12 | 2004-02-26 | Takeda Pharmaceutical Company Limited | 縮合ベンゼン誘導体および用途 |
| AU2003280599A1 (en) * | 2002-10-29 | 2004-05-25 | Kirin Beer Kabushiki Kaisha | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF Flt3 AND MEDICINAL COMPOSITIONS CONTAINING THE SAME |
| US20050026944A1 (en) * | 2003-07-24 | 2005-02-03 | Patrick Betschmann | Thienopyridine and furopyridine kinase inhibitors |
| US20060281769A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators |
-
2006
- 2006-06-06 US US11/422,359 patent/US20060281768A1/en not_active Abandoned
- 2006-06-07 EA EA200800011A patent/EA200800011A1/ru unknown
- 2006-06-07 JP JP2008515879A patent/JP2008543759A/ja not_active Withdrawn
- 2006-06-07 EP EP06772445A patent/EP1899355A1/en not_active Withdrawn
- 2006-06-07 BR BRPI0613644-3A patent/BRPI0613644A2/pt not_active Application Discontinuation
- 2006-06-07 NI NI200700311A patent/NI200700311A/es unknown
- 2006-06-07 AU AU2006258049A patent/AU2006258049A1/en not_active Abandoned
- 2006-06-07 WO PCT/US2006/022151 patent/WO2006135639A1/en not_active Ceased
- 2006-06-07 MX MX2007015741A patent/MX2007015741A/es unknown
- 2006-06-07 CA CA002611587A patent/CA2611587A1/en not_active Abandoned
- 2006-06-07 KR KR1020087000618A patent/KR20080021126A/ko not_active Withdrawn
- 2006-06-08 UY UY29590A patent/UY29590A1/es unknown
- 2006-06-08 PE PE2006000640A patent/PE20070070A1/es not_active Application Discontinuation
- 2006-06-09 AR ARP060102425A patent/AR057063A1/es not_active Application Discontinuation
- 2006-06-09 TW TW095120482A patent/TW200716651A/zh unknown
-
2007
- 2007-11-27 IL IL187689A patent/IL187689A0/en unknown
- 2007-12-10 EC EC2007007992A patent/ECSP077992A/es unknown
-
2008
- 2008-01-09 NO NO20080162A patent/NO20080162L/no not_active Application Discontinuation
- 2008-01-09 CR CR9650A patent/CR9650A/es not_active Application Discontinuation
-
2009
- 2009-01-30 US US12/363,043 patent/US20090163710A1/en not_active Abandoned
- 2009-01-30 US US12/362,933 patent/US20090143378A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20080162L (no) | 2008-03-07 |
| KR20080021126A (ko) | 2008-03-06 |
| US20090143378A1 (en) | 2009-06-04 |
| BRPI0613644A2 (pt) | 2011-01-25 |
| MX2007015741A (es) | 2008-04-29 |
| AR057063A1 (es) | 2007-11-14 |
| JP2008543759A (ja) | 2008-12-04 |
| AU2006258049A8 (en) | 2006-12-21 |
| CA2611587A1 (en) | 2006-12-21 |
| ECSP077992A (es) | 2008-01-23 |
| IL187689A0 (en) | 2008-08-07 |
| TW200716651A (en) | 2007-05-01 |
| EA200800011A1 (ru) | 2008-06-30 |
| EP1899355A1 (en) | 2008-03-19 |
| AU2006258049A1 (en) | 2006-12-21 |
| US20060281768A1 (en) | 2006-12-14 |
| PE20070070A1 (es) | 2007-03-08 |
| CR9650A (es) | 2008-09-09 |
| US20090163710A1 (en) | 2009-06-25 |
| WO2006135639A1 (en) | 2006-12-21 |
| UY29590A1 (es) | 2006-10-02 |
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