MY198553A - Pharmaceutical composition comprising metformin and lobeglitazone - Google Patents
Pharmaceutical composition comprising metformin and lobeglitazoneInfo
- Publication number
- MY198553A MY198553A MYPI2018700643A MYPI2018700643A MY198553A MY 198553 A MY198553 A MY 198553A MY PI2018700643 A MYPI2018700643 A MY PI2018700643A MY PI2018700643 A MYPI2018700643 A MY PI2018700643A MY 198553 A MY198553 A MY 198553A
- Authority
- MY
- Malaysia
- Prior art keywords
- pharmaceutical composition
- lobeglitazone
- metformin
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 5
- CHHXEZSCHQVSRE-UHFFFAOYSA-N lobeglitazone Chemical compound C1=CC(OC)=CC=C1OC1=CC(N(C)CCOC=2C=CC(CC3C(NC(=O)S3)=O)=CC=2)=NC=N1 CHHXEZSCHQVSRE-UHFFFAOYSA-N 0.000 title abstract 2
- 229950007685 lobeglitazone Drugs 0.000 title abstract 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003105 metformin Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002641 glycemic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a pharmaceutical composition comprising metformin or a pharmaceutically acceptable salt thereof and lobeglitazone or a pharmaceutically acceptable salt thereof and a pharmaceutical formulation comprising the same. The pharmaceutical composition can exhibit a synergistic effect on glycemic control and can block the potential of side effects, and the pharmaceutical formulation can be provided in the form of a combination formulation that is able to be administered once a day to thus improve medication compliance.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150150108A KR101750690B1 (en) | 2015-10-28 | 2015-10-28 | Pharmaceutical composition comprising metformin and lobeglitazone |
| PCT/KR2016/009393 WO2017073897A1 (en) | 2015-10-28 | 2016-08-24 | Pharmaceutical composition comprising metformin and lobeglitazone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY198553A true MY198553A (en) | 2023-09-05 |
Family
ID=58630531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2018700643A MY198553A (en) | 2015-10-28 | 2016-08-24 | Pharmaceutical composition comprising metformin and lobeglitazone |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR101750690B1 (en) |
| MY (1) | MY198553A (en) |
| PH (1) | PH12018500817B1 (en) |
| WO (1) | WO2017073897A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102369679B1 (en) * | 2017-09-29 | 2022-03-04 | 한미약품 주식회사 | Pharmaceutical combination comprising DAPAGLIFLOZIN L-PROLINE and METFORMIN |
| KR102070104B1 (en) * | 2018-06-05 | 2020-01-29 | 주식회사 종근당 | Controlled release pharmaceutical formulation comprising Lobeglitazone and Metformin |
| KR20240041755A (en) * | 2022-09-23 | 2024-04-01 | 주식회사 종근당 | Composition and combination therapy for treatment of type 2 diabetes mellitus |
| KR20240120463A (en) * | 2023-01-31 | 2024-08-07 | 주식회사 종근당 | Pharmaceutical composite formulation comprising lobeglitazone and sitagliptin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITFI20010230A1 (en) * | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TYPE II DIABETES |
| EP1539144B1 (en) * | 2002-09-20 | 2014-12-24 | Andrx Labs Llc | Multistage formulation containing a biguanide and a thiazolidinedione derivative |
| KR100812538B1 (en) | 2006-10-23 | 2008-03-11 | 한올제약주식회사 | Drug-controlled metformin-glymepiride combination |
-
2015
- 2015-10-28 KR KR1020150150108A patent/KR101750690B1/en active Active
-
2016
- 2016-08-24 PH PH1/2018/500817A patent/PH12018500817B1/en unknown
- 2016-08-24 MY MYPI2018700643A patent/MY198553A/en unknown
- 2016-08-24 WO PCT/KR2016/009393 patent/WO2017073897A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PH12018500817B1 (en) | 2023-08-18 |
| KR101750690B1 (en) | 2017-06-27 |
| KR20170049129A (en) | 2017-05-10 |
| WO2017073897A1 (en) | 2017-05-04 |
| PH12018500817A1 (en) | 2018-10-29 |
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