MY136029A - Pharmaceutical compounds - Google Patents
Pharmaceutical compoundsInfo
- Publication number
- MY136029A MY136029A MYPI20005670A MYPI20005670A MY136029A MY 136029 A MY136029 A MY 136029A MY PI20005670 A MYPI20005670 A MY PI20005670A MY PI20005670 A MYPI20005670 A MY PI20005670A MY 136029 A MY136029 A MY 136029A
- Authority
- MY
- Malaysia
- Prior art keywords
- alkyl
- hydrogen
- unsubstituted
- substituted
- different
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 101710183280 Topoisomerase Proteins 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- -1 HYDROXY GROUP Chemical group 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- QDGSQQMUZONPER-UHFFFAOYSA-N benzo[a]phenazine-11-carboxamide Chemical class C1=CC=CC2=C(N=C3C(C(=O)N)=CC=CC3=N3)C3=CC=C21 QDGSQQMUZONPER-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical compound C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- DUAJIKVIRGATIW-UHFFFAOYSA-N trinitrogen(.) Chemical compound [N]=[N+]=[N-] DUAJIKVIRGATIW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/46—Phenazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A COMPOUND WHICH IS A BENZO[A]PHENAZINE-11-CARBOXAMIDE DERIVATIVE OF FORMULA (1) WHEREIN EACH OF R1 TO R4,WHICH ARE THE SAME OR DIFFERENT, IS SELECTED FROM HYDROGEN, HALOGEN, HYDROXYL, C1-C6 ALKOXY WHICH IS UNSUBSTITUTED OR SUBSTITUTED,HETEROARYLOXY, C1-C6 ALKYL WHICH IS UNSUBSTITUTED OR SUBSTITUTED, NITRO, CYANO, AZIDO,AMIDOXIME, CO2R10, CON(R12)2, OCON(R12), SR10, SOR11, SO2R11, SO2N(R12)2,N(R12), NR10SO2R11, N(SO2R11)2, NR10(CH2)N CN, NR10COR11, OCOR11 OR COR10;EACH OF R5 TO R7, WHICH ARE THE SAME OR DIFFERENT, IS SELECTED FROM HYDROGEN, HALOGEN, HYDROXY, C1-C6 ALKYL, SR10 AND N(R12)2; Q IS C1-C6 ALKYLENE WHICH IS UNSUBSTITUTED OR SUBSTITUTED BY (I) C1-C6 ALKYL WHICH IS UNSUBSTITUTED OR SUBSTITUTED, (ii) HYDROXY, PROVIDED THAT THE HYDROXY GROUP IS NOT a TO EITHER OF THE N ATOMS ADJACENT TO Q IN FORMULA (1), (iii)CO2R10, OR (iv)CON(R12); R8 AND R9, WHICH ARE THE SAME OR DIFFERENT, ARE EACH HYDROGEN OR C1-C6 ALKYL, OR R8 AND R9 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A SATURATED 5-OR 6-MEMBERED N-CONTAINING HETEROCYCLIC RING WHICH MAY INCLUDE ONE ADDITIONAL HETEROATOM SELECTED FROM O, N AND S, OR ONE OF R8 AND R9 IS AN ALKYLENE CHAIN OPTIONALLY INTERRUPTED BY O, N OR S, WHICH IS ATTACHED TO A CARBON ATOM ON THE ALKYLENE CHAIN REPRESENTED BY Q TO COMPLETE A SATURATED 5-OR 6-MEMBERED N-CONTAINING HETEROCYCLIC RING AS DEFINED ABOVE; R10 IS HYDROGEN, C1-C6 ALKYL, C3-C6 CYCLOALKYL, BENZYL OR PHENYL;R11 IS C1-C6 ALKYL, C3-C6 CYCLOALKYL, BENZYL OR PHENYL;EACH R12, WHICH ARE THE SAME OR DIFFERENT, IS HYDROGEN, C1-C6 ALKYL, CYCLOALKYL, BENZYL OR PHENYL, OR THE TWO R12 GROUPS FROM, TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED A 5- OR 6-MEMBERED SATURATED N-CONTAINING HETEROCYCLIC RING WHICH MAY INCLUDE 1 OR 2 ADDITIONAL HETEROATOMS SELECTED FROM O,N AND S; AND N IS 1, 2 OR 3 ;OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF;WITH THE PROVISO THAT AT LEAST ONE OF R1 TO R4 IS OTHER THAN HYDROGEN.THESE COMPOUNDS ARE INHIBITORS OF TOPOISOMERASE 1 AND/OR TOPOISOMERASE 11 AND CAN BE USED TO TREAT TOMOURS,INCLUDING TUMOURS WHICH EXPRESS MDR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9928542.1A GB9928542D0 (en) | 1999-12-02 | 1999-12-02 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY136029A true MY136029A (en) | 2008-07-31 |
Family
ID=10865607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20005670A MY136029A (en) | 1999-12-02 | 2000-12-01 | Pharmaceutical compounds |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1240148A1 (en) |
| JP (1) | JP2003518103A (en) |
| KR (1) | KR100767613B1 (en) |
| CN (1) | CN1304380C (en) |
| AU (1) | AU784397B2 (en) |
| BR (1) | BR0016093A (en) |
| CA (1) | CA2392873A1 (en) |
| GB (2) | GB9928542D0 (en) |
| HK (1) | HK1046133B (en) |
| HU (1) | HUP0300392A3 (en) |
| MX (1) | MXPA02005476A (en) |
| MY (1) | MY136029A (en) |
| PL (1) | PL356482A1 (en) |
| TW (1) | TWI280242B (en) |
| WO (1) | WO2001046157A1 (en) |
| ZA (1) | ZA200204296B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2433071A (en) * | 2005-12-05 | 2007-06-13 | Kontrakt Technology Ltd | Organic acids comprising planar conjugated heterocyclic molecular system, & photoelectric layer thereof with rodlike supramolecules for use in solar cell |
| CN102898388B (en) * | 2012-09-26 | 2014-12-03 | 浙江工业大学 | Method for synthesizing substituted benzo[alpha]phenazine compound |
| CN103360329B (en) * | 2013-07-18 | 2015-11-18 | 中国科学院南海海洋研究所 | One class compound phenazine and preparing the application in antitumor drug |
| CN106554321B (en) * | 2015-09-25 | 2019-05-28 | 陆源 | A kind of azophenlyene substance, preparation method and its application |
| CN113461623A (en) * | 2021-07-14 | 2021-10-01 | 长江大学 | Antiviral compound and preparation method and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE195869T1 (en) * | 1992-05-28 | 2000-09-15 | Xenova Ltd | ACRIDINE CARBOXAMIDE FOR THE TREATMENT OF CANCER |
| US5696131A (en) * | 1993-01-22 | 1997-12-09 | Xenova Limited | Treatment of cancers |
| US5981541A (en) * | 1996-09-23 | 1999-11-09 | Rutgers, The State University Of New Jersey | Substituted heterocycles as anti-tumor agents |
| WO1998045272A1 (en) * | 1997-04-07 | 1998-10-15 | Latrobe University | Topoisomerase inhibitors |
-
1999
- 1999-12-02 GB GBGB9928542.1A patent/GB9928542D0/en not_active Ceased
-
2000
- 2000-12-01 AU AU17184/01A patent/AU784397B2/en not_active Ceased
- 2000-12-01 PL PL00356482A patent/PL356482A1/en not_active Application Discontinuation
- 2000-12-01 MX MXPA02005476A patent/MXPA02005476A/en not_active Application Discontinuation
- 2000-12-01 EP EP00979799A patent/EP1240148A1/en not_active Withdrawn
- 2000-12-01 KR KR1020027007033A patent/KR100767613B1/en not_active Expired - Fee Related
- 2000-12-01 MY MYPI20005670A patent/MY136029A/en unknown
- 2000-12-01 GB GB0215275A patent/GB2373499B/en not_active Expired - Fee Related
- 2000-12-01 CA CA002392873A patent/CA2392873A1/en not_active Abandoned
- 2000-12-01 BR BR0016093-8A patent/BR0016093A/en not_active IP Right Cessation
- 2000-12-01 WO PCT/GB2000/004609 patent/WO2001046157A1/en not_active Ceased
- 2000-12-01 HU HU0300392A patent/HUP0300392A3/en unknown
- 2000-12-01 HK HK02107392.7A patent/HK1046133B/en not_active IP Right Cessation
- 2000-12-01 JP JP2001547068A patent/JP2003518103A/en active Pending
- 2000-12-01 CN CNB008187096A patent/CN1304380C/en not_active Expired - Fee Related
- 2000-12-02 TW TW089125715A patent/TWI280242B/en not_active IP Right Cessation
-
2002
- 2002-05-29 ZA ZA200204296A patent/ZA200204296B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1046133B (en) | 2005-04-15 |
| GB9928542D0 (en) | 2000-02-02 |
| HUP0300392A3 (en) | 2003-09-29 |
| KR20020070305A (en) | 2002-09-05 |
| TWI280242B (en) | 2007-05-01 |
| KR100767613B1 (en) | 2007-10-19 |
| AU1718401A (en) | 2001-07-03 |
| HUP0300392A2 (en) | 2003-07-28 |
| ZA200204296B (en) | 2003-05-29 |
| WO2001046157A1 (en) | 2001-06-28 |
| CN1433406A (en) | 2003-07-30 |
| MXPA02005476A (en) | 2003-09-22 |
| BR0016093A (en) | 2002-08-20 |
| EP1240148A1 (en) | 2002-09-18 |
| CA2392873A1 (en) | 2001-06-28 |
| HK1046133A1 (en) | 2002-12-27 |
| GB2373499B (en) | 2004-11-17 |
| PL356482A1 (en) | 2004-06-28 |
| GB2373499A (en) | 2002-09-25 |
| JP2003518103A (en) | 2003-06-03 |
| AU784397B2 (en) | 2006-03-23 |
| CN1304380C (en) | 2007-03-14 |
| GB0215275D0 (en) | 2002-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EG20396A (en) | Process for preparing of 5-aryundole derivatives | |
| EA200200078A1 (en) | PETERIDINOES AS KINAZ INHIBITORS | |
| NZ332960A (en) | tetrahydro-cyclopropan[c]benz[e]-indol-4-one and tetrahydro-cyclopropan[c]benzo[e]-indole derivatives and medicaments | |
| NZ513393A (en) | Camptothecin derivatives having antitumor activity | |
| ES408565A1 (en) | Cyclic diamine derivatives | |
| WO1998050357A3 (en) | Substituted analogs of indole-3-carbinol and of diindolymethane as antiestrogens | |
| IL117875A0 (en) | Pharmaceutical compositions for inhibiting th growth of cancers | |
| ES395714A1 (en) | Pyridoquinoline dicarboxylic acid derivatives | |
| PE34996A1 (en) | NEW DERIVATIVE OF PIRROCARBAZOL | |
| SE8505715L (en) | indole derivatives | |
| MY136029A (en) | Pharmaceutical compounds | |
| MY131762A (en) | Pharmaceutical compounds | |
| CO5080785A1 (en) | HETEROCICLIC DERIVATIVES | |
| BR0208823A (en) | Compound, method of treating disorders that are remedied or alleviated by vasopressin agonist activity in a mammal in need thereof, and pharmaceutical composition | |
| ATE247660T1 (en) | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | |
| MY141374A (en) | Water soluble camptothecin derivatives | |
| FR2479219B1 (en) | ||
| ES2055651A1 (en) | Amidines derived from 3-aminoethyl indoles for the treatment of migraines. | |
| ES8101071A1 (en) | 2-(Pyrid-2-yl)tetrahydrothiophene derivatives | |
| ES8505653A1 (en) | Treatment of migraine with N-alkyl-piperidinyl benzoate derivatives. | |
| NZ335975A (en) | Heterocyclic substituted pyrrolidine amide derivatives useful in treating respiratory diseases | |
| ES306767A1 (en) | Procedure for the preparation of new basic derivatives of tiepine and oxepine. (Machine-translation by Google Translate, not legally binding) | |
| ES451293A1 (en) | A procedure for the preparation of tienotiacin derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES425576A1 (en) | Pyrazoles and process for their preparation | |
| ES395800A1 (en) | Procedure for the preparation of substitute 2,2'-biimidazoles. (Machine-translation by Google Translate, not legally binding) |