MY135691A - Method for down-regulation of gdf-8 activity - Google Patents
Method for down-regulation of gdf-8 activityInfo
- Publication number
- MY135691A MY135691A MYPI20003324A MYPI20003324A MY135691A MY 135691 A MY135691 A MY 135691A MY PI20003324 A MYPI20003324 A MY PI20003324A MY PI20003324 A MYPI20003324 A MY PI20003324A MY 135691 A MY135691 A MY 135691A
- Authority
- MY
- Malaysia
- Prior art keywords
- gdf
- methods
- analogues
- vaccination
- homologous
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 230000003828 downregulation Effects 0.000 title 1
- 101150004578 gdf-8 gene Proteins 0.000 title 1
- 102000004472 Myostatin Human genes 0.000 abstract 9
- 108010056852 Myostatin Proteins 0.000 abstract 9
- 238000002255 vaccination Methods 0.000 abstract 3
- 230000003053 immunization Effects 0.000 abstract 2
- 238000002649 immunization Methods 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000016784 immunoglobulin production Effects 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
DISCLOSED ARE NOVEL METHODS FOR INCREASING MUSCLE MASS BY MEANS OF IMMUNIZATION AGAINST GROWTH DIFFERENTIATION FACTOR 8 (GDF-8, MYOSTATIN). IMMUNIZATION IS PREFERABLY AFFECTED BY ADMINISTRATION OF ANALOGUES OF GDF-8 WHICH ARE CAPABLE OF INDUCING ANTIBODY PRODUCTION AGAINST HOMOLOGOUS GDF-8. ESPECIALLY PREFERRED AS AN IMMUNOGEN IS HOMOLOGOUS GDF-8 WHICH HAS BEEN MODIFIED BY INTRODUCTION OF ONE SINGLE OR A FEW FOREIGN, IMMUNODOMINANT AND PROMISCUOUS T-CELL EPITOPES WHILE SUBSTANTIALLY PRESERVING THE TERTIARY STRUCTURE OF THE HOMOLOGOUS GDF-8. ALSO DISCLOSED ARE NUCLEIC ACID VACCINATION AGAINST GDF-8 AND VACCINATION USING LIVE VACCINES AS WELL AS METHODS AND MEANS USEFUL FOR THE VACCINATION. SUCH METHODS AND MEANS INCLUDE METHODS FOR IDENTIFICATION OF USEFUL IMMUNOGENIC GDF-8 ANALOGUES, METHODS FOR THE PREPARATION OF ANALOGUES AND PHARMACEUTICAL FORMULATIONS, AS WELL AS NUCLEIC ACID FRAGMENTS, VECTORS, TRANSFORMED CELLS, POLYPEPTIDES AND PHARMACEUTICAL FORMULATIONS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901014 | 1999-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY135691A true MY135691A (en) | 2008-06-30 |
Family
ID=44359331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20003324A MY135691A (en) | 1999-07-20 | 2000-07-20 | Method for down-regulation of gdf-8 activity |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR024808A1 (en) |
| MY (1) | MY135691A (en) |
| PE (1) | PE20010479A1 (en) |
| YU (1) | YU87201A (en) |
-
2000
- 2000-07-20 MY MYPI20003324A patent/MY135691A/en unknown
- 2000-07-20 PE PE2000000733A patent/PE20010479A1/en not_active Application Discontinuation
- 2000-07-20 YU YU87201A patent/YU87201A/en unknown
- 2000-07-20 AR ARP000103736A patent/AR024808A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR024808A1 (en) | 2002-10-23 |
| YU87201A (en) | 2004-09-03 |
| PE20010479A1 (en) | 2001-04-24 |
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